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DK2231606T3 - Fremgangsmåder til fremstilling af cycloalkylcarboxamidopyridinbenzoesyrer - Google Patents

Fremgangsmåder til fremstilling af cycloalkylcarboxamidopyridinbenzoesyrer

Info

Publication number
DK2231606T3
DK2231606T3 DK08859582.2T DK08859582T DK2231606T3 DK 2231606 T3 DK2231606 T3 DK 2231606T3 DK 08859582 T DK08859582 T DK 08859582T DK 2231606 T3 DK2231606 T3 DK 2231606T3
Authority
DK
Denmark
Prior art keywords
cycloalkylcarboxamidopyridine
preparation
methods
benzoic acids
benzoic
Prior art date
Application number
DK08859582.2T
Other languages
English (en)
Inventor
David Siesel
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of DK2231606T3 publication Critical patent/DK2231606T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Catalysts (AREA)
DK08859582.2T 2007-12-07 2008-12-04 Fremgangsmåder til fremstilling af cycloalkylcarboxamidopyridinbenzoesyrer DK2231606T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1218107P 2007-12-07 2007-12-07
US10957308P 2008-10-30 2008-10-30
PCT/US2008/085458 WO2009076142A2 (en) 2007-12-07 2008-12-04 Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids

Publications (1)

Publication Number Publication Date
DK2231606T3 true DK2231606T3 (da) 2013-05-13

Family

ID=40329178

Family Applications (4)

Application Number Title Priority Date Filing Date
DK12196539.6T DK2639224T3 (da) 2007-12-07 2008-12-04 Fremgangsmåde til fremstilling af cycloalkylcarboxiamido-pyridinbenzoesyrer
DK08859582.2T DK2231606T3 (da) 2007-12-07 2008-12-04 Fremgangsmåder til fremstilling af cycloalkylcarboxamidopyridinbenzoesyrer
DK12196511.5T DK2639223T3 (da) 2007-12-07 2008-12-04 Fremgangsmåde til fremstilling af cycloalkylcarboxiamido-pyridinbenzosyrer
DK12196502.4T DK2639222T3 (da) 2007-12-07 2008-12-04 Fremgangsmåder til fremstilling af cycloalkylcarboxamido-pyridinbenzoesyrer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK12196539.6T DK2639224T3 (da) 2007-12-07 2008-12-04 Fremgangsmåde til fremstilling af cycloalkylcarboxiamido-pyridinbenzoesyrer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK12196511.5T DK2639223T3 (da) 2007-12-07 2008-12-04 Fremgangsmåde til fremstilling af cycloalkylcarboxiamido-pyridinbenzosyrer
DK12196502.4T DK2639222T3 (da) 2007-12-07 2008-12-04 Fremgangsmåder til fremstilling af cycloalkylcarboxamido-pyridinbenzoesyrer

Country Status (25)

Country Link
US (4) US8124781B2 (da)
EP (4) EP2639222B1 (da)
JP (4) JP5702149B2 (da)
KR (3) KR101674404B1 (da)
CN (2) CN101910134B (da)
AU (1) AU2008335440B2 (da)
BR (1) BRPI0820902A2 (da)
CA (3) CA2989620C (da)
CL (1) CL2010000631A1 (da)
CY (4) CY1113985T1 (da)
DK (4) DK2639224T3 (da)
EA (1) EA201070700A1 (da)
ES (4) ES2406940T3 (da)
HR (4) HRP20130418T1 (da)
HU (3) HUE029775T2 (da)
IL (4) IL206205A (da)
LT (3) LT2639222T (da)
MX (4) MX364936B (da)
NZ (3) NZ612635A (da)
PL (4) PL2639223T3 (da)
PT (4) PT2639223T (da)
RS (4) RS55360B1 (da)
SI (4) SI2231606T1 (da)
WO (1) WO2009076142A2 (da)
ZA (1) ZA201003624B (da)

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KR20110063578A (ko) 2008-09-29 2011-06-10 버텍스 파마슈티칼스 인코포레이티드 3－（6－（1－（2,2－디플루오로벤조［ｄ］［1,3］디옥솔－5－일）사이클로프로판카복스아미도）－3－메틸피리딘－2－일）벤조산의 투여 단위
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