DK2215121T3 - Anti-mesothelin-antistoffer og anvendelser deraf - Google Patents
Anti-mesothelin-antistoffer og anvendelser deraf Download PDFInfo
- Publication number
- DK2215121T3 DK2215121T3 DK08855189.0T DK08855189T DK2215121T3 DK 2215121 T3 DK2215121 T3 DK 2215121T3 DK 08855189 T DK08855189 T DK 08855189T DK 2215121 T3 DK2215121 T3 DK 2215121T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (12)
1. Isoleret humant antistof eller funktionelt fragment deraf, der omfatter en antigenbindende region, der er specifik for mesothelin ifølge SEQ ID NO: 370, hvor antistoffet eller det funktionelle fragment deraf genkender en epitop på mesothelin, der ikke er dækket af cancerantigen 125 (CA125), og hvor antistoffet eller det funktionelle fragment deraf internaliserer ind i mesothelin-udtrykkende celler og har en antigenbindende region, hvor den antistofbindende region inkluderer en HCDR 1, HCDR 2, HCDR 3, LCDR 1, LCDR 2 og LCDR 3, hvor: a) HCDR1 er SEQ ID NO: 5, b) HCDR2 er SEQ ID NO: 39, c) HCDR3 er SEQ ID NO: 71, d) LCDR1 er SEQ ID NO: 103, e) LCDR2 er SEQ ID NO: 133 og f) LCDR3 er SEQ ID NO: 169.
2. Antistof ifølge krav 1, som omfatter en aminosyresekvens for en variabel tung kæde ifølge SEQ ID NO: 212.
3. Antistof ifølge krav 1, som omfatter en aminosyresekvens for en variabel let kæde ifølge MF-T VL i tabel 4.
4. Antistof ifølge et hvilket som helst af kravene 1 til 3, som er et IgG.
5. Isoleret funktionelt fragment af et antistof ifølge et hvilket som helst af kravene 1-3, som er et Fab- eller scFv-antistoffragment.
6. Isoleret nukleinsyresekvens, der koder for en antigenbindende region af et humant antistof eller funktionelt fragment deraf ifølge et hvilket som helst af kravene 1-5.
7. Vektor, der omfatter en nukleinsyresekvens ifølge krav 6.
8. Isoleret celle, der omfatter en vektor ifølge krav 7.
9. Isoleret celle ifølge krav 9, hvor cellen er en bakterieeller mammaliacelle.
10. Farmaceutisk sammensætning, der omfatter et antistof eller et funktionelt fragment ifølge et hvilket som helst af kravene 1-5 og et farmaceutisk acceptabelt bæremateriale eller excipiens derfor.
11. Antistof eller fragment ifølge et hvilket som helst af kravene 1-5 til anvendelse som et lægemiddel.
12. Humant antistof ifølge et hvilket som helst af kravene 1-5, hvor det humane antistof er et syntetisk humant antistof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US437807P | 2007-11-26 | 2007-11-26 | |
| PCT/EP2008/009756 WO2009068204A1 (en) | 2007-11-26 | 2008-11-19 | Anti-mesothelin antibodies and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2215121T3 true DK2215121T3 (da) | 2016-05-02 |
Family
ID=40351874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08855189.0T DK2215121T3 (da) | 2007-11-26 | 2008-11-19 | Anti-mesothelin-antistoffer og anvendelser deraf |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US9023351B2 (da) |
| EP (3) | EP2634196A1 (da) |
| JP (3) | JP5608091B2 (da) |
| KR (1) | KR101559599B1 (da) |
| CN (2) | CN104151429B (da) |
| AU (1) | AU2008329221B2 (da) |
| BR (1) | BRPI0819909B8 (da) |
| CA (1) | CA2706529C (da) |
| CO (1) | CO6280409A2 (da) |
| CR (1) | CR11456A (da) |
| CU (1) | CU23833A3 (da) |
| CY (1) | CY1117437T1 (da) |
| DK (1) | DK2215121T3 (da) |
| DO (1) | DOP2010000150A (da) |
| EC (1) | ECSP10010191A (da) |
| ES (1) | ES2569513T3 (da) |
| GT (1) | GT201000148A (da) |
| HK (2) | HK1148541A1 (da) |
| HN (1) | HN2010001062A (da) |
| HR (1) | HRP20160485T1 (da) |
| HU (1) | HUE027358T2 (da) |
| IL (1) | IL205681A0 (da) |
| MA (1) | MA31862B1 (da) |
| MX (1) | MX2010005603A (da) |
| MY (1) | MY157164A (da) |
| NZ (1) | NZ585551A (da) |
| PL (1) | PL2215121T3 (da) |
| SI (1) | SI2215121T1 (da) |
| TN (1) | TN2010000234A1 (da) |
| UA (1) | UA106036C2 (da) |
| WO (1) | WO2009068204A1 (da) |
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