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DK2184346T3 - Hurtig detektion af replikerende celler - Google Patents

Hurtig detektion af replikerende celler Download PDF

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Publication number
DK2184346T3
DK2184346T3 DK09166028.2T DK09166028T DK2184346T3 DK 2184346 T3 DK2184346 T3 DK 2184346T3 DK 09166028 T DK09166028 T DK 09166028T DK 2184346 T3 DK2184346 T3 DK 2184346T3
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DK
Denmark
Prior art keywords
microcolonies
instrument
category
cells
detection
Prior art date
Application number
DK09166028.2T
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English (en)
Inventor
Don Straus
Original Assignee
Rapid Micro Biosystems Inc
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Publication of DK2184346T3 publication Critical patent/DK2184346T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06—Quantitative determination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
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    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
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    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • G01N2333/245—Escherichia (G)
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/32—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bacillus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
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  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
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  • General Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Signal Processing (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (21)

1. Instrument til detektion af mikrokolonier af målceller i en prøve, hvilke instrument omfatter: (a) en fotoelektrisk array-detektor med samleoptik til detektion af et detektions-område med i det mindste én dimension, som er > 1 mm, uden forstørrelse af detek-tionsområdet med mere end 5 gange; (b) en belysningskilde, som belyser detektionsområdet; og (c) en computer, som er programmeret til at modtage data opsamlet af den fotoelektriske array-detektor, og som er programmeret til billedanalyse, omfattende analyse af de nævnte data for at detektere én eller flere mikrokolonier, som har et mål på mindre end 50 mikrometer i i det mindste to orthogonale dimensioner, og som er programmeret til at kvantificere antallet af mikrokolonier, som er detekteret i detektionsområdet, hvor instrumentet detekterer en intrinsisk optisk egenskab for mikrokolonierne og hvor cellerne i den ene eller flere mikrokolonier forbliver kompetente til at replikere efterfølgende detektion.
2. Instrument ifølge krav 1, som yderligere omfatter en inkubator til mikrobiel replikation.
3. Instrument ifølge krav 2, hvor instrumentet er i stand til at detektere detektionsområdet på adskillige tidspunkter under inkubering.
4. Instrument ifølge krav 1, som yderligere omfatter en automatisk fokus til at fokusere på detektionsområdet.
5. Instrument ifølge krav 1, hvor samleoptikken ikke forstørrer.
6. Instrument ifølge krav 1, hvor billedanalysen yderligere omfatter detektion af voksende mikrokolonier.
7. Instrument ifølge krav 1, hvor instrumentet er i stand til automatisk at indføre prøven.
8. Instrument ifølge krav 1, hvor detektionen detekterer lys udsendt, spredt, reflekteret eller absorberet som et resultat af belysning af den ene eller flere mikrokolonier.
9. Instrument ifølge krav 1, hvor detektionen detekterer autofluorescens udsendt af mikrokolonierne.
10. Instrument ifølge krav 1, hvor belysningskilden anvenden én eller flere lasere.
11. Instrument ifølge krav 1, som yderligere omfatter ét eller flere optiske filtre, som alene lader udvalgte bølgelængder af lys passere.
12. Instrument ifølge krav 1, hvor instrumentet er i stand til at oprette adskillige billeder af detektionsområdet via registreringsmarkeringer.
13. Instrument ifølge krav 1, hvor den fotoelektriske array-detektor omfatter en CCD-detektor, fotomultiplikatorrør-detektor, eller en fotodiode-detektor, især en kølet CCD-detektor.
14. Instrument ifølge krav 1, hvor detektionen omfatter bestemmelse af lokationerne i detektionsområdet af den nævnte ene eller flere mikrokolonier.
15. Instrument ifølge krav 1, hvor billedanalysen skelner mellem objekter, som ændrer størrelse med tiden og objekter, som ikke ændrer størrelse med tiden.
16. Instrument ifølge krav 1, som yderligere omfatter et automatiseret X-Y trin til positionering af prøven i forhold til belysningskilden og detektoren.
17. Instrument ifølge krav 1, hvor computeren er i stand til automatisk at gemme udgangsdata for søgning.
18. Instrument ifølge krav 1, hvor computeren er programmeret til at detektere de nævnte mikrokolonier via et objekt-findende program ("object-finding utility"), som forbinder sammenhængende pixler, som har en værdi over en automatisk eller brugerdefineret tærskel, for etablering af en konturlinie omkring omkredsen af objektet, hvor omkreds-pixler og pixler indvendigt er definerede som objektet.
19. Instrument ifølge krav 1, hvor samleoptikken omfatter en samlelinse og en fokuseringslinse.
20. Instrument ifølge krav 1, hvor instrumentet automatisk sporer prøven via en stregkode eller tilsvarende markering.
21. Instrument ifølge krav 1, hvor instrumentet belyser detektionsområdet med synligt lys.
DK09166028.2T 2001-09-06 2002-09-06 Hurtig detektion af replikerende celler DK2184346T3 (da)

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Application Number Priority Date Filing Date Title
US31765801P 2001-09-06 2001-09-06
EP02757646A EP1432786B1 (en) 2001-09-06 2002-09-06 Rapid detection of replicating cells

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DK2184346T3 true DK2184346T3 (da) 2017-06-26

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DK09166028.2T DK2184346T3 (da) 2001-09-06 2002-09-06 Hurtig detektion af replikerende celler
DK10013064.0T DK2311934T3 (da) 2001-09-06 2002-09-06 Hurtig påvisning af replicerende celler
DK02757646T DK1432786T3 (da) 2001-09-06 2002-09-06 Hurtig detektion af replikerede celler

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DK02757646T DK1432786T3 (da) 2001-09-06 2002-09-06 Hurtig detektion af replikerede celler

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US (7) US8021848B2 (da)
EP (6) EP1432786B1 (da)
JP (3) JP2005518553A (da)
CN (3) CN100354430C (da)
AT (2) ATE437216T1 (da)
AU (2) AU2002365913A1 (da)
CA (3) CA2459320C (da)
DE (2) DE60233060D1 (da)
DK (3) DK2184346T3 (da)
ES (3) ES2329986T3 (da)
WO (3) WO2003073817A2 (da)

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US6248542B1 (en) 1997-12-09 2001-06-19 Massachusetts Institute Of Technology Optoelectronic sensor
US7494817B2 (en) * 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
US7027628B1 (en) * 2000-11-14 2006-04-11 The United States Of America As Represented By The Department Of Health And Human Services Automated microscopic image acquisition, compositing, and display
CA2799371A1 (en) 2001-02-07 2002-08-29 Massachusetts Institute Of Technology Optoelectronic detection system
US8216797B2 (en) 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
US7422860B2 (en) 2001-02-07 2008-09-09 Massachusetts Institute Of Technology Optoelectronic detection system
DK2184346T3 (da) 2001-09-06 2017-06-26 Rapid Micro Biosystems Inc Hurtig detektion af replikerende celler
WO2003106697A2 (en) * 2002-03-21 2003-12-24 Gonet, Michael, J. Method and kit for identifying pseudomonas aeruginosa
EP2107120A1 (en) * 2002-07-24 2009-10-07 Board of Regents, The University of Texas System Capture and detection of microbes by membrane methods
WO2004013604A2 (en) * 2002-08-01 2004-02-12 Merck & Co., Inc. Novel procedure for growth, imaging, and enumeration of microbial colonies for serological or screening assays
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US8020433B2 (en) * 2003-03-25 2011-09-20 Tearlab Research, Inc. Systems and methods for a sample fluid collection device
US7197169B2 (en) * 2003-01-02 2007-03-27 Kuo-Jeng Wang Method for detecting a response of each probe zone on a test strip
WO2004072097A2 (en) * 2003-02-05 2004-08-26 The General Hospital Corporation A microchip-based system for hiv diagnostics
US7012583B2 (en) * 2003-02-07 2006-03-14 Shimadzu Corporation Apparatus and method for testing pixels of flat panel display
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20120077206A1 (en) * 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2956645A1 (en) * 2003-07-12 2005-03-31 David A. Goldberg Sensitive and rapid biodetection
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20050176029A1 (en) * 2003-10-20 2005-08-11 The Regents Of The University Of California Nanoscale transduction systems for detecting molecular interactions
KR101025770B1 (ko) * 2003-12-06 2011-04-04 삼성테크윈 주식회사 바이오 칩 스캐너
WO2005072622A1 (en) * 2004-01-26 2005-08-11 Anticancer, Inc. Whole body imaging using portable observation systems
WO2006033662A2 (en) * 2004-02-17 2006-03-30 Binax, Inc. Methods and kits for detection of multiple pathogens
US20050250141A1 (en) * 2004-03-30 2005-11-10 Lambert James L Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots
US20080032420A1 (en) * 2004-03-30 2008-02-07 Lambert James L Surface Enhanced Raman Scattering and Multiplexed Diagnostic Assays
US20050221504A1 (en) * 2004-04-01 2005-10-06 Petruno Patrick T Optoelectronic rapid diagnostic test system
US8128871B2 (en) 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US7521259B2 (en) * 2004-04-01 2009-04-21 Alverix, Inc. Assay test strips with multiple labels and reading same
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7815854B2 (en) * 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7771660B2 (en) 2004-05-04 2010-08-10 University Of North Carolina At Chapel Hill Electrophoretic interactive spectral methods and devices for the detection and/or characterization of biological particles
US20060281068A1 (en) * 2005-06-09 2006-12-14 Chemimage Corp. Cytological methods for detecting a disease condition such as malignancy by Raman spectroscopic imaging
US7697576B2 (en) * 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
WO2005123874A1 (ja) * 2004-06-22 2005-12-29 Fujifilm Corporation 蛍光体、蛍光体組成物及び蛍光検出方法
US20060035310A1 (en) * 2004-08-13 2006-02-16 Millipore Corporation Media for recovery of microorganism in the presence of antibiotics
US20060216696A1 (en) * 2004-08-23 2006-09-28 Goguen Jon D Rapid plague detection system
US7727471B2 (en) * 2004-09-09 2010-06-01 Palo Alto Research Center Incorporated Rare cell detection using flat-panel imager and chemiluminescent or radioisotopic tags
US20060240227A1 (en) * 2004-09-23 2006-10-26 Zhijun Zhang Nanocrystal coated surfaces
US20060275310A1 (en) * 2004-09-30 2006-12-07 Nano Science Diagnostics, Inc. Method and detection and decontamination of antigens by nanoparticle-raman spectroscopy
ATE541821T1 (de) * 2004-10-12 2012-02-15 Schott Ag Gemultiplexter proteinadsorptions-assay
AU2005301045B2 (en) * 2004-11-01 2012-10-18 International Bio-Therapeutic Research Inc. Disposable immunodiagnostic test system
US8202479B1 (en) * 2004-11-09 2012-06-19 Applied Biosystems, Llc Light collection system
US7619008B2 (en) 2004-11-12 2009-11-17 Kimberly-Clark Worldwide, Inc. Xylitol for treatment of vaginal infections
US7417740B2 (en) * 2004-11-12 2008-08-26 Medeikon Corporation Single trace multi-channel low coherence interferometric sensor
US20060217446A1 (en) * 2005-03-28 2006-09-28 Kimberly-Clark Worldwide, Inc. Method for preventing and/or treating trichomonas vaginitis
US20060106117A1 (en) * 2004-11-12 2006-05-18 Kimberly-Clark Worldwide, Inc. Compound and method for prevention and/or treatment of vaginal infections
WO2007044029A2 (en) * 2004-12-03 2007-04-19 Nano Science Diagnostic, Inc. Method and apparatus for low quantity detection of bioparticles in small sample volumes
WO2006060646A2 (en) * 2004-12-03 2006-06-08 Board Of Regents, The University Of Texas System Cell microarray for profiling of cellular phenotypes and gene function
US20060128034A1 (en) * 2004-12-10 2006-06-15 Petruno Patrick T Diagnostic test using gated measurement of fluorescence from quantum dots
CA2589976A1 (en) * 2004-12-16 2006-06-22 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20060217893A1 (en) * 2005-01-07 2006-09-28 Yanbin Li Method for detecting an unknown contaminant concentration in a substance
US7310147B2 (en) * 2005-01-27 2007-12-18 Genetix Limited Robotic apparatus for picking of cells and other applications with integrated spectroscopic capability
US20060166305A1 (en) * 2005-01-27 2006-07-27 Genetix Limited Animal cell confluence detection method and apparatus
US8470608B2 (en) 2008-05-20 2013-06-25 Rapid Pathogen Screening, Inc Combined visual/fluorescence analyte detection test
US8669052B2 (en) 2008-06-10 2014-03-11 Rapid Pathogen Screening, Inc. Lateral flow nucleic acid detector
US8614101B2 (en) 2008-05-20 2013-12-24 Rapid Pathogen Screening, Inc. In situ lysis of cells in lateral flow immunoassays
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
WO2006086209A2 (en) * 2005-02-10 2006-08-17 Compass Genetics, Llc Genetic analysis by sequence-specific sorting
US7130041B2 (en) * 2005-03-02 2006-10-31 Li-Cor, Inc. On-chip spectral filtering using CCD array for imaging and spectroscopy
US20060217443A1 (en) * 2005-03-28 2006-09-28 Kimberly-Clark Worldwide, Inc. Method for preventing and/or treating vaginal and vulval infections
US20060223765A1 (en) * 2005-03-30 2006-10-05 Kimberly-Clark Worldwide, Inc. Method for inhibiting and/or treating vaginal infection
US9891217B2 (en) * 2005-04-22 2018-02-13 Alverix, Inc. Assay test strips with multiple labels and reading same
US7991242B2 (en) 2005-05-11 2011-08-02 Optosecurity Inc. Apparatus, method and system for screening receptacles and persons, having image distortion correction functionality
EP1886257A1 (en) 2005-05-11 2008-02-13 Optosecurity Inc. Method and system for screening luggage items, cargo containers or persons
AU2006247126B2 (en) * 2005-05-17 2010-12-23 Idexx Laboratories, Inc. Rapid bacterial quantification
AU2006309284B2 (en) 2005-05-31 2012-08-02 Board Of Regents, The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US7909773B2 (en) * 2005-06-03 2011-03-22 Tyco Healthcare Group Lp Post-operative bacteria test strip spool and method
US8253936B2 (en) * 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
CN104673905B (zh) * 2005-06-20 2016-09-07 领先细胞医疗诊断有限公司 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法
WO2007011746A2 (en) * 2005-07-15 2007-01-25 The University Of Vermont And State Agriculture College Highly sensitive immunoassays and antibodies for detection of blood factor viii
FR2888672B1 (fr) * 2005-07-18 2011-05-27 Mat Equipement Antenne a angle d'inclinaison et conformation du lobe de rayonnement reglables
US7786176B2 (en) 2005-07-29 2010-08-31 Kimberly-Clark Worldwide, Inc. Vaginal treatment composition containing xylitol
WO2007015105A2 (en) * 2005-08-04 2007-02-08 Thomas William Rademacher Nanoparticles comprising antibacterial ligands
US20070037220A1 (en) * 2005-08-09 2007-02-15 Genetix Limited Biomolecule specificity detection and selection method and apparatus
US20070111225A1 (en) * 2005-08-10 2007-05-17 California Institute Of Technology System and method for monitoring an analyte
WO2008048230A2 (en) * 2005-08-15 2008-04-24 Emory University Methods of identifying biological targets and instrumentation to identify biological targets
US7518721B2 (en) * 2005-09-09 2009-04-14 Ge Homeland Protection, Inc. Raman-active lateral flow device and methods of detection
EP1937829A4 (en) 2005-09-26 2011-08-03 Rapid Micro Biosystems Inc CASSETTE WITH GROWTH MEDIUM
US8131477B2 (en) * 2005-11-16 2012-03-06 3M Cogent, Inc. Method and device for image-based biological data quantification
WO2007065116A2 (en) * 2005-11-30 2007-06-07 Nano Science Diagnostics, Inc. Method for detection of antigens
MX2008006945A (es) * 2005-11-30 2008-10-02 Massachusetts Inst Technology Biosensor de deteccion de patogeno.
FI20051329A0 (fi) * 2005-12-27 2005-12-27 Wallac Oy Laitteisto ja menetelmä näytteiden optista mittausta varten
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US8460878B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for detecting cells and cellular components in small defined volumes
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
DE102006011828A1 (de) * 2006-03-13 2007-09-20 Gesellschaft für Schwerionenforschung mbH Bestrahlungsverifikationsvorrichtung für Strahlentherapieanlagen und Verfahren zur Handhabung derselben
SE531233C2 (sv) * 2006-03-28 2009-01-27 Hemocue Ab Anordning och förfarande för detektion av fluorecensmärkta biologiska komponenter
US8492168B2 (en) * 2006-04-18 2013-07-23 Advanced Liquid Logic Inc. Droplet-based affinity assays
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7851184B2 (en) * 2006-04-18 2010-12-14 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification method and apparatus
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
CA2584683A1 (en) * 2006-04-20 2007-10-20 Optosecurity Inc. Apparatus, method and system for screening receptacles and persons
US7899232B2 (en) 2006-05-11 2011-03-01 Optosecurity Inc. Method and apparatus for providing threat image projection (TIP) in a luggage screening system, and luggage screening system implementing same
US20090148870A1 (en) * 2006-05-18 2009-06-11 Ericson Daniel G Rapid Detection of Mycobacterium Tuberculosis and Antimicrobial Drug Resistance
HUP0600435A2 (en) * 2006-05-26 2007-11-28 3Dhistech Kft Method and system for digitizing a specimen having fluorescent target points
US7708944B1 (en) 2006-06-13 2010-05-04 Research Foundation Of State University Of New York Ultra-sensitive, portable capillary sensor
US20070292397A1 (en) * 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
JP5374809B2 (ja) * 2006-06-29 2013-12-25 パナソニック株式会社 微生物計測システム
US8494210B2 (en) 2007-03-30 2013-07-23 Optosecurity Inc. User interface for use in security screening providing image enhancement capabilities and apparatus for implementing same
US20120269728A1 (en) * 2006-08-02 2012-10-25 Antara Biosciences Inc. Methods and compositions for detecting one or more target agents using tracking components
US20100120016A1 (en) * 2006-09-01 2010-05-13 Yanbin Li Methods and systems for detection of contaminants
EP1933145B1 (en) * 2006-12-11 2011-09-28 AraGen Biotechnology Co. Ltd. Rapid immunochromatographic detection by amplification of the colloidal gold signal
EP1933141B1 (en) * 2006-12-11 2011-08-17 AraGen Biotechnology Co. Ltd. Antigen detection method involving an oligonucleotide enhanced collodial gold signal
EP1933140B1 (en) * 2006-12-11 2011-08-17 AraGen Biotechnology Co. Ltd. Antibody detection method involving an oligonucleotide enhanced collodial gold signal
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US7738094B2 (en) * 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
US7680553B2 (en) 2007-03-08 2010-03-16 Smp Logic Systems Llc Methods of interfacing nanomaterials for the monitoring and execution of pharmaceutical manufacturing processes
US8865454B2 (en) 2007-03-22 2014-10-21 Scandinavian Micro Biodevices Aps Flow through system, flow through device and a method of performing a test
EP2134857B8 (en) * 2007-03-22 2015-01-07 Nanologix, Inc. Detection and identification of microorganisms on transparent permeable membranes
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US8852875B2 (en) 2007-04-20 2014-10-07 The General Hospital Corporation Methods for counting cells
WO2009020479A2 (en) 2007-04-27 2009-02-12 The Regents Of The University Of California Device and methods for detection of airborne agents
CN103543093B (zh) * 2007-06-07 2016-08-10 技术研究及发展基金有限公司 细胞测量设备
US8936946B2 (en) * 2007-06-20 2015-01-20 Board Of Trustees Of Michigan State University Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications
GB2450351B (en) * 2007-06-20 2012-01-18 Cozart Bioscience Ltd Monitoring an Immunoassay
DE102007029772B4 (de) 2007-06-22 2011-12-08 Aj Innuscreen Gmbh Verfahren und Schnelltest zum Nachweis spezifischer Nukleinsäuresequenzen
CA2692259C (en) 2007-06-22 2012-07-31 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
EP2174115B1 (en) 2007-07-09 2013-08-28 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
JP5058711B2 (ja) * 2007-08-17 2012-10-24 サンプラスチックス株式会社 電気泳動解析による表面電位が変化した赤血球の測定方法及びその装置
JP5503540B2 (ja) 2007-08-30 2014-05-28 トラスティーズ・オブ・タフツ・カレッジ 溶液中の分析物濃度を決定する方法
US8059924B1 (en) * 2007-09-13 2011-11-15 Lawrence Livermore National Security, Llc Multiplexed photonic membranes and related detection methods for chemical and/or biological sensing applications
CA2701794C (en) * 2007-10-02 2017-10-31 Theranos, Inc. Modular point-of-care devices and uses thereof
PT2209893E (pt) 2007-10-12 2014-02-26 Pronota Nv Uso de aptâmeros em proteómica
CA2702367C (en) 2007-10-12 2012-08-21 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
BRPI0818877B1 (pt) * 2007-10-23 2019-06-18 Skannex As Método e sistema para análise semi-quantitativa ou quantitativa de ensaios
US8471725B2 (en) * 2007-10-26 2013-06-25 Markus Johannes Lenger Methods and supporting telemetry to determine, monitor and control the metagenomic and physical states of grease interceptors, FOGs, vaults and other waste collecting enclosures
US20110039280A1 (en) * 2007-10-29 2011-02-17 Purdue Research Foundation Hybrid microfluidic spr and molecular imaging device
US8791427B2 (en) * 2007-12-26 2014-07-29 Olympus Corporation Biological-specimen observation apparatus
WO2009094773A1 (en) * 2008-01-31 2009-08-06 Genesis Group Inc. Method of depositing a polymer micropattern on a substrate
JP5463621B2 (ja) 2008-02-27 2014-04-09 ソニー株式会社 標的物質の定量方法
US8008068B2 (en) * 2008-02-29 2011-08-30 Light Pointe Medical, Inc. Nonhemolytic optical sensor with enhanced reflectance
US20090219509A1 (en) * 2008-02-29 2009-09-03 Hiroshi Nomura Optical sensor with enhanced reflectance
JP5539314B2 (ja) * 2008-04-09 2014-07-02 アボット ポイント オブ ケア インコーポレイテッド 薄厚チャンバに含まれる薄膜状体液試料中の極めて低レベルの分析物を検出する方法
US9068981B2 (en) 2009-12-04 2015-06-30 Rapid Pathogen Screening, Inc. Lateral flow assays with time delayed components
US8609433B2 (en) 2009-12-04 2013-12-17 Rapid Pathogen Screening, Inc. Multiplanar lateral flow assay with sample compressor
US8962260B2 (en) 2008-05-20 2015-02-24 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
US9797898B2 (en) 2008-05-20 2017-10-24 Rapid Pathogen Screening, Inc. Methods and devices for using mucolytic agents including N-acetyl cysteine (NAC)
US8815609B2 (en) 2008-05-20 2014-08-26 Rapid Pathogen Screening, Inc. Multiplanar lateral flow assay with diverting zone
US9910036B2 (en) 2008-05-20 2018-03-06 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
US20130196310A1 (en) 2008-05-20 2013-08-01 Rapid Pathogen Screening, Inc. Method and Device for Combined Detection of Viral and Bacterial Infections
US8983581B2 (en) * 2008-05-27 2015-03-17 Massachusetts Institute Of Technology System and method for large field of view, single cell analysis
FR2931966A1 (fr) * 2008-05-30 2009-12-04 Novacyt Procede d'analyse cellulaire d'un prelevement au moyen d'une plaque d'analyse virtuelle
US20110086359A1 (en) 2008-06-10 2011-04-14 Rapid Pathogen Screening, Inc. Lateral flow assays
CA2729023C (en) 2008-06-25 2013-02-26 Fio Corporation Bio-threat alert system
US20100036261A1 (en) * 2008-08-05 2010-02-11 Weinberg Medical Physics Llc Method and device for image guided surgery
US8416405B2 (en) * 2008-08-08 2013-04-09 Chemimage Corporation Raman chemical imaging of implantable drug delivery devices
US20100047858A1 (en) * 2008-08-20 2010-02-25 Albano Maria S High throughput system for cfu assay by the use of high resolution digital imaging, differential staining and automated laboratory system
US9459200B2 (en) 2008-08-29 2016-10-04 Fio Corporation Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples
US8947657B2 (en) 2008-09-08 2015-02-03 Lawrence Livermore National Security, Llc Methods for isolation and viability assessment of biological organisms
US8830450B2 (en) * 2009-12-02 2014-09-09 Lawrence Livermore National Security, Llc Methods and systems for Raman and optical cross-interrogation in flow-through silicon membranes
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
CN107121396B (zh) * 2008-09-24 2020-06-30 曙光生命科学公司 用于检测分析物的方法
US20100136608A1 (en) * 2008-10-20 2010-06-03 Photonic Biosystems, Inc. Multiple Filter Array Assay
EP2350309A4 (en) * 2008-10-20 2012-12-05 Photonic Biosystems Inc FILTER TEST METHOD AND DEVICE
US9068976B2 (en) * 2008-10-20 2015-06-30 Photonic Biosystems Inc. Integrated filtration bioanalyzer
US8748122B2 (en) * 2008-12-16 2014-06-10 BIO MéRIEUX, INC. Methods for the characterization of microorganisms on solid or semi-solid media
US8358411B2 (en) * 2008-12-18 2013-01-22 Biovigilant Systems, Inc. Integrated microbial collector
EP2204686B9 (en) 2008-12-30 2012-11-14 Cellavision AB Analyser for optical analysis of a biological specimen
EP2387721A4 (en) 2009-01-13 2014-05-14 Fio Corp PORTABLE DIAGNOSTIC TEST DEVICE AND METHOD FOR USE WITH AN ELECTRONIC DEVICE AND TEST CARTRIDGE FOR QUICK DIAGNOSTIC TESTS
WO2010083417A1 (en) * 2009-01-16 2010-07-22 Angros Lee H Encapsulated reagents and methods of use
US8167871B2 (en) 2009-02-25 2012-05-01 The Invention Science Fund I, Llc Device for actively removing a target cell from blood or lymph of a vertebrate subject
US8317737B2 (en) * 2009-02-25 2012-11-27 The Invention Science Fund I, Llc Device for actively removing a target component from blood or lymph of a vertebrate subject
JP4676539B2 (ja) * 2009-02-25 2011-04-27 古河電気工業株式会社 ラテラルフロー型蛍光イムノクロマト法用の標的物質を定量的に検出する装置及びその方法
JP2010261791A (ja) * 2009-05-01 2010-11-18 Fujikura Kasei Co Ltd 標的物質の検出方法
BRPI1011413B1 (pt) * 2009-05-05 2021-09-14 Lumito Ab Sistema, método e marcador luminescente para geração de imagem luminescente difusa melhorada ou tomografia em meio de dispersão
DE102009023279A1 (de) * 2009-05-29 2010-12-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Bestimmung von einer Keimverteilung abhängigen Information auf einem Trägersubstrat und Verfahren zum Bestimmen derselben
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9024766B2 (en) * 2009-08-28 2015-05-05 The Invention Science Fund, Llc Beverage containers with detection capability
US8898069B2 (en) * 2009-08-28 2014-11-25 The Invention Science Fund I, Llc Devices and methods for detecting an analyte in salivary fluid
DE102009043537B4 (de) 2009-09-30 2012-03-22 Siemens Aktiengesellschaft Verfahren und Anordnung zur Bestimmung von Zell-Vitalitäten
FR2951542B1 (fr) * 2009-10-16 2011-12-02 Commissariat Energie Atomique Procede de detection optique d'objets micrometriques en solution
US8468104B1 (en) * 2009-12-02 2013-06-18 Hrl Laboratories, Llc System for anomaly detection
US8786852B2 (en) * 2009-12-02 2014-07-22 Lawrence Livermore National Security, Llc Nanoscale array structures suitable for surface enhanced raman scattering and methods related thereto
DE102009058295A1 (de) * 2009-12-10 2011-06-16 Biostep Gmbh Transilluminator
EP2526188A4 (en) * 2010-01-22 2013-08-14 Hitachi Chemical Co Ltd METHOD FOR DETECTING MULTIPLE PATHOGENS
AU2011209940B2 (en) 2010-02-01 2015-08-20 Ferring Microbiome Inc. Bacteriotherapy for clostridium difficile colitis
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US10267808B2 (en) 2010-03-08 2019-04-23 California Institute Of Technology Molecular indicia of cellular constituents and resolving the same by super-resolution technologies in single cells
US10266876B2 (en) 2010-03-08 2019-04-23 California Institute Of Technology Multiplex detection of molecular species in cells by super-resolution imaging and combinatorial labeling
WO2011133540A2 (en) * 2010-04-19 2011-10-27 Research Foundation Of State University Of New York Capillary biosensor system and its method of use
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US9442106B2 (en) * 2010-05-08 2016-09-13 Universiteit Twente Simple and affordable method for immunophenotyping using a microfluidic chip sample preparation with image cytometry
US8666673B2 (en) 2010-05-14 2014-03-04 Biomerieux, Inc Identification and/or characterization of a microbial agent using taxonomic hierarchical classification
US9228240B2 (en) * 2010-06-03 2016-01-05 California Institute Of Technology Methods for detecting and quantifying viable bacterial endo-spores
WO2011156713A1 (en) 2010-06-11 2011-12-15 Vanderbilt University Multiplexed interferometric detection system and method
CN103080331B (zh) * 2010-06-23 2014-07-09 株式会社N－Tech 微生物检测方法、微生物检测设备和程序
KR101381604B1 (ko) * 2010-08-31 2014-04-11 한국전자통신연구원 고분자 박막 및 자기비드를 이용한 바이오 물질 측정방법
FR2964980B1 (fr) * 2010-09-22 2014-05-16 Commissariat Energie Atomique Dispositif de detection et d'imagerie d'elements biocontaminants
EP3034625B1 (en) 2010-10-21 2017-10-04 Advanced Cell Diagnostics, Inc. An ultra sensitive method for in situ detection of nucleic acids
EP2455454A1 (en) * 2010-11-19 2012-05-23 Albert-Ludwigs-Universität Freiburg Method for introducing a polynucleotide into plant protoplast cells
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012108961A1 (en) * 2011-02-09 2012-08-16 The United States Of America As Represented By The Secretary Of The Navy Detection of hepatitis b virus in blood using lamp method
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
US8597884B2 (en) 2011-03-09 2013-12-03 Becton, Dickinson And Company Process controls for molecular assay
ES2608313T3 (es) * 2011-03-18 2017-04-07 Miacom Diagnostics Gmbh Identificación de resistencia antibiótica en microorganismos
US9145361B2 (en) * 2011-03-25 2015-09-29 Life Technologies Corporation SDP-containing heterobifunctional agents
CN103460045B (zh) * 2011-04-05 2016-01-20 奥林巴斯株式会社 胰脏检查方法及胰脏检查试剂盒
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
KR101224600B1 (ko) 2011-05-09 2013-01-22 (주)나노스토리지 바이오칩 검출장치
US9238133B2 (en) 2011-05-09 2016-01-19 The Invention Science Fund I, Llc Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
US8690934B2 (en) 2011-05-09 2014-04-08 The Invention Science Fund I, Llc Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
DE102011076221B3 (de) * 2011-05-20 2012-07-12 Siemens Aktiengesellschaft Automatisierter CTC Nachweis
DE102011076238A1 (de) 2011-05-20 2012-11-22 Siemens Ag Anordnung und Verfahren zur optischen Analyse und spezifischen Isolierung von biologischen Proben
US8859297B2 (en) 2011-05-23 2014-10-14 Board Of Trustees Of Michigan State University Detection of conductive polymer-labeled analytes
US9459257B2 (en) * 2011-05-29 2016-10-04 Korea Research Institute Of Chemical Technology High-speed screening apparatus for a Raman analysis-based high-speed multiple drug
US10190986B2 (en) * 2011-06-06 2019-01-29 Abbott Laboratories Spatially resolved ligand-receptor binding assays
CN102230938B (zh) * 2011-06-22 2013-10-30 中国科学院武汉病毒研究所 一种基于免疫磁珠富集的甲型流感病毒检测试剂盒及方法
US20130005048A1 (en) * 2011-06-29 2013-01-03 Monika Felten Indicator device
US9599613B2 (en) 2011-07-20 2017-03-21 University Of Washington Through Its Center For Commercialization Photonic blood typing
CN103813845B (zh) * 2011-07-22 2016-08-17 生物梅里埃有限公司 从培养物离析微生物的方法和试剂盒
US8960294B2 (en) 2011-08-05 2015-02-24 Halliburton Energy Services, Inc. Methods for monitoring fluids within or produced from a subterranean formation during fracturing operations using opticoanalytical devices
US9206386B2 (en) 2011-08-05 2015-12-08 Halliburton Energy Services, Inc. Systems and methods for analyzing microbiological substances
US9222892B2 (en) 2011-08-05 2015-12-29 Halliburton Energy Services, Inc. Systems and methods for monitoring the quality of a fluid
US9395306B2 (en) 2011-08-05 2016-07-19 Halliburton Energy Services, Inc. Methods for monitoring fluids within or produced from a subterranean formation during acidizing operations using opticoanalytical devices
US9261461B2 (en) 2011-08-05 2016-02-16 Halliburton Energy Services, Inc. Systems and methods for monitoring oil/gas separation processes
US9222348B2 (en) 2011-08-05 2015-12-29 Halliburton Energy Services, Inc. Methods for monitoring the formation and transport of an acidizing fluid using opticoanalytical devices
US9441149B2 (en) 2011-08-05 2016-09-13 Halliburton Energy Services, Inc. Methods for monitoring the formation and transport of a treatment fluid using opticoanalytical devices
US9464512B2 (en) 2011-08-05 2016-10-11 Halliburton Energy Services, Inc. Methods for fluid monitoring in a subterranean formation using one or more integrated computational elements
US8997860B2 (en) 2011-08-05 2015-04-07 Halliburton Energy Services, Inc. Methods for monitoring the formation and transport of a fracturing fluid using opticoanalytical devices
US9182355B2 (en) 2011-08-05 2015-11-10 Halliburton Energy Services, Inc. Systems and methods for monitoring a flow path
US9297254B2 (en) 2011-08-05 2016-03-29 Halliburton Energy Services, Inc. Methods for monitoring fluids within or produced from a subterranean formation using opticoanalytical devices
US10739337B2 (en) 2011-08-30 2020-08-11 Board Of Trustees Of Michigan State University Extraction and detection of pathogens using carbohydrate-functionalized biosensors
ES2675308T3 (es) 2011-09-07 2018-07-10 Rapiscan Systems, Inc. Sistema de inspección de rayos X que integra datos de manifiesto con procesamiento de obtención de imágenes/detección
JP5580267B2 (ja) 2011-09-08 2014-08-27 大日本スクリーン製造株式会社 検出方法
WO2013038925A1 (ja) * 2011-09-13 2013-03-21 国立大学法人大阪大学 細菌または真菌の抗菌薬感受性の検査方法およびそれに用いるシステム
JP5615247B2 (ja) 2011-09-27 2014-10-29 大日本スクリーン製造株式会社 撮像装置、検出装置および撮像方法
WO2013056137A1 (en) * 2011-10-12 2013-04-18 Brown University Systems and methods enabling high-throughput, real time detection of analytes
HUE036509T2 (hu) 2011-11-07 2018-07-30 Rapid Micro Biosystems Inc Kazetta sterilitási vizsgálathoz
US20140315748A1 (en) * 2011-11-14 2014-10-23 Kellbenx, Inc. Detection, isolation and analysis of rare cells in biological fluids
CN103917870B (zh) * 2011-11-16 2016-04-13 贝克顿·迪金森公司 用于检测样品中的分析物的方法和系统
BR112014013745B1 (pt) * 2011-12-09 2022-06-14 Institut Pasteur Método de teste in vitro, kit de detecção e seu uso, método in vitro de diagnóstico, método de fabricação de kit, e teste de imunosseleção multiplex
CN104169719B (zh) 2011-12-29 2017-03-08 思迪赛特诊断有限公司 用于检测生物样品中病原体的方法和系统
EP2805164B1 (en) * 2012-01-16 2017-11-08 Koninklijke Philips N.V. Determining a presence of target molecules in a body fluid comprising cells
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
FR2986237A1 (fr) * 2012-01-27 2013-08-02 Advencis Dispositif de detection rapide de micro-organismes
US10725033B2 (en) 2012-01-31 2020-07-28 Regents Of The University Of Minnesota Lateral flow assays with thermal contrast readers
US10816492B2 (en) 2012-01-31 2020-10-27 Regents Of The University Of Minnesota Lateral flow assays with thermal contrast readers
EP2810052B1 (en) 2012-01-31 2017-12-06 Regents of the University of Minnesota Thermal contrast assay and reader
US9395304B2 (en) 2012-03-01 2016-07-19 Lawrence Livermore National Security, Llc Nanoscale structures on optical fiber for surface enhanced Raman scattering and methods related thereto
US9058648B2 (en) 2012-03-15 2015-06-16 Bio-Rad Laboratories, Inc. Image acquisition for chemiluminescent samples
CN104303047B (zh) * 2012-03-15 2018-01-09 生物辐射实验室股份有限公司 用于化学发光样本的图像获取
KR101359379B1 (ko) 2012-03-28 2014-02-07 광주과학기술원 Ｃｍｏｓ 이미지 센서의 픽셀 분석을 이용한 고감도 바이오센서
US9678923B2 (en) 2012-04-12 2017-06-13 Bio-Rad Laboratories, Inc. Particle dispensing apparatus and method
EP4060016A1 (en) 2012-04-16 2022-09-21 Rapid Micro Biosystems, Inc. Cell culturing device
CA2872149C (en) 2012-05-02 2019-03-19 Charles River Laboratories, Inc. Viability staining method
JP6240162B2 (ja) 2012-05-02 2017-11-29 チャールズ リバー ラボラトリーズ， インコーポレイテッド 細胞収集システムおよびその使用
CN104755931B (zh) * 2012-05-02 2016-08-31 查尔斯河实验室公司 用于检测细胞样品中的活细胞的方法
US9052315B2 (en) 2012-05-09 2015-06-09 Advanced Animal Diagnostics, Inc. Rapid detection of analytes in liquid samples
CN102721640B (zh) * 2012-05-28 2014-05-14 浙江大学 一种快速测定水样中微囊藻细胞数目的方法
US20130330711A1 (en) * 2012-06-06 2013-12-12 National Taiwan University Sensor for detection of a target of interest
US20130330814A1 (en) * 2012-06-06 2013-12-12 National Taiwan University Sensor for detection of a target of interest
WO2013192195A1 (en) 2012-06-18 2013-12-27 Greenonyx Ltd. A compact apparatus for continuous production of a product substance from a starter material grown in aquaculture conditions
WO2013192567A1 (en) * 2012-06-22 2013-12-27 Wayne State University Automated viability testing system
CN104603600B (zh) * 2012-07-01 2017-09-01 卢米托股份有限公司 用于散射介质中改进的扩散发光成像或者断层照相的系统和方法
US10359614B2 (en) 2012-07-03 2019-07-23 Advanced Animal Diagnostics, Inc. Diagnostic apparatus
JP5728042B2 (ja) 2012-08-20 2015-06-03 株式会社Ｓｃｒｅｅｎホールディングス 撮像装置
WO2014042933A1 (en) * 2012-09-14 2014-03-20 Halliburton Energy Services, Inc. Systems and methods for analyzing microbiological substances
US9982292B2 (en) 2012-09-28 2018-05-29 Src, Inc. Detecting chemical and biological agents using textile-based sensors
CN102890061B (zh) * 2012-10-12 2014-08-13 江南大学 一种运用圆二色光谱高灵敏检测银离子的方法
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
FR2997502B1 (fr) * 2012-10-29 2014-12-26 Commissariat Energie Atomique Procede d'observation d'especes biologiques.
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9551704B2 (en) * 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
FR3000209B1 (fr) 2012-12-26 2017-02-24 Biomerieux Sa Procede et systeme pour detecter et mesurer des signaux de fluorescence
ES2692407T3 (es) 2013-01-11 2018-12-03 Becton, Dickinson And Company Dispositivo de ensayo de punto de cuidado de bajo coste
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
CN103115901B (zh) * 2013-01-23 2015-05-20 中国科学院长春应用化学研究所 基于共振光散射检测生物芯片的装置
GB201302292D0 (en) * 2013-02-08 2013-03-27 Whatman Gmbh Medical diagnostic test systems,and a matrix therefor
WO2014145620A2 (en) * 2013-03-15 2014-09-18 The Broad Institute, Inc. Novel hybridization probes and uses thereof
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
KR101414248B1 (ko) * 2013-03-27 2014-07-01 (주)로고스바이오시스템스 형광 이미징 장치
FI2992115T4 (fi) * 2013-04-30 2025-05-15 California Institute Of Technology Molekyylien limitetty leimaus sekventiaalisella hybridisaatioviivakoodauksella
US10510435B2 (en) 2013-04-30 2019-12-17 California Institute Of Technology Error correction of multiplex imaging analysis by sequential hybridization
US9797893B2 (en) 2013-05-09 2017-10-24 Advanced Animal Diagnostics, Inc. Rapid detection of analytes in liquid samples
FR3005736B1 (fr) * 2013-05-17 2016-02-12 Commissariat Energie Atomique Procede d'observation d'organismes et systeme associe.
US9694039B2 (en) 2013-06-05 2017-07-04 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US10383901B2 (en) 2013-06-05 2019-08-20 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511100B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511099B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
LT3003330T (lt) 2013-06-05 2018-10-25 Rebiotix, Inc. Mikrobiotos atstatymo terapija (mat), kompozicijos ir gamybos būdai
US9782445B2 (en) 2013-06-05 2017-10-10 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
WO2015000720A1 (en) * 2013-07-01 2015-01-08 Koninklijke Philips N.V. System for determining a quantitative number being indicative of the concentration of target elements in a fluid
US10422806B1 (en) 2013-07-25 2019-09-24 Theranos Ip Company, Llc Methods for improving assays of biological samples
US10215753B2 (en) * 2013-08-05 2019-02-26 University Of Rochester Method for the topographically-selective passivation of micro- and nanoscale devices
EP3036531B1 (de) 2013-08-20 2023-06-07 Chembio Diagnostics GmbH Vorrichtung zur digitalen ablesung für schnelltests
US10831013B2 (en) 2013-08-26 2020-11-10 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
EP3051276B2 (en) * 2013-09-27 2026-01-21 Nikon Corporation Analysis device, microscope device, analysis method, and program
CN103499685B (zh) * 2013-10-15 2015-09-09 牛远杰 人泌尿系统病原菌感染临床诊断的免疫荧光诊断试剂的制备方法
KR101463005B1 (ko) * 2013-10-15 2014-11-18 (주)한국해양기상기술 특정 파장에 대한 형광 특성을 갖는 미생물 검사방법
CN103529203A (zh) * 2013-10-16 2014-01-22 北京华卫博沃生物科技有限公司 检测结核分枝杆菌的方法及量子点标记免疫层析试纸及其制备方法
WO2015066721A1 (en) 2013-11-04 2015-05-07 Charles River Laboratories, Inc. Filtration system and use thereof
JP6632525B2 (ja) 2013-11-06 2020-01-22 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ マイクロ流体デバイスならびにその製造方法および使用方法
WO2015073384A1 (en) 2013-11-13 2015-05-21 Becton, Dickinson And Company Microimager analysis system comprising optics and methods of use thereof
JP6687524B2 (ja) 2014-01-30 2020-04-22 ビーディー キエストラ ベスローテン フェンノートシャップ スーパバイズされた高品質撮像を用いた画像取得のシステム及び方法
CN103886366B (zh) * 2014-02-21 2017-04-05 华南理工大学 基于粒子群算法的全自动酶免疫仪工序调度方法
WO2015130792A1 (en) * 2014-02-25 2015-09-03 Rutgers, The State University Of New Jersey Methods for the identification and quantification of pathogens using imaging and microscopy techniques
US10039244B2 (en) 2014-03-04 2018-08-07 Greenonyx Ltd Systems and methods for cultivating and distributing aquatic organisms
JP6619544B2 (ja) 2014-03-19 2019-12-11 株式会社日立ハイテクノロジーズ 検査装置
JP6122817B2 (ja) 2014-03-26 2017-04-26 株式会社Ｓｃｒｅｅｎホールディングス スフェロイドの評価方法およびスフェロイド評価装置
FR3019556A1 (fr) 2014-04-07 2015-10-09 Advencis Dispositif d’incubation et de detection
JP6550076B2 (ja) * 2014-04-22 2019-07-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ サンプルの膜またはアガロース媒体上で増殖する微小コロニーを検出する方法および無菌テスト装置
US20160130553A1 (en) 2014-05-15 2016-05-12 Kellbenx Incorporated PREPARATION OF FETAL NUCLEATED RED BLOOD CELLS (NRBCs) FOR DIAGNOSTIC TESTING
EP3151906B1 (en) 2014-06-03 2019-12-11 Pop Test Abuse Deterrent Technology LLC Drug device configured for wireless communication
EP3074539B1 (en) 2014-06-13 2018-01-10 Q-Linea AB Method for detecting and characterising a microorganism
US9436866B2 (en) 2014-08-01 2016-09-06 General Electric Company High sensitivity flat panel microbiology detection and enumeration system
EP3198257B1 (en) 2014-09-23 2020-08-12 Tearlab Research, Inc. System for integration of microfluidic tear collection and lateral flow analysis of analytes of interest
US20160131650A1 (en) * 2014-10-03 2016-05-12 Emory University Virus-detection kits and methods of making and using the same
DE102014220306B3 (de) * 2014-10-07 2015-09-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Automatisches Verfahren zur Beobachtung von Zellkulturwachstum
CN104263837B (zh) * 2014-10-13 2016-03-23 江南大学 基于三重信标修饰的金纳米粒子三聚体的表面增强拉曼散射效应检测水溶液中Hg2+和/或Ag+的方法
AU2015334046B2 (en) 2014-10-14 2017-04-13 Becton, Dickinson And Company Blood sample management using open cell foam
WO2016060793A1 (en) 2014-10-14 2016-04-21 Becton, Dickinson And Company Blood sample management using open cell foam
US20160116466A1 (en) * 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
EP3213081A4 (en) * 2014-10-30 2018-08-15 Sightline Innovation Inc. System, method and apparatus for pathogen detection
US12202890B1 (en) 2014-11-07 2025-01-21 Kellbenx Incorporated Antibodies for detection and enrichment of fetal cells and their use
FR3028866B1 (fr) * 2014-11-26 2018-03-09 bioMérieux Procede, systeme et produit-programme d'ordinateur pour determiner la croissance de micro-organismes
EP3227684B1 (en) 2014-12-03 2019-10-02 Isoplexis Corporation Analysis and screening of cell secretion profiles
WO2016094459A2 (en) * 2014-12-09 2016-06-16 Berkeley Lights, Inc. Automated detection and repositioning of micro-objects in microfluidic devices
US10545158B2 (en) * 2014-12-29 2020-01-28 North Carolina State University Multiplexed diagnostic to recognize concentrations of related proteins and peptides
WO2016115537A2 (en) 2015-01-15 2016-07-21 Massachusetts Institute Of Technology Systems, methods, and apparatus for in vitro single-cell identification and recovery
EP3247988A4 (en) 2015-01-23 2018-12-19 Vanderbilt University A robust interferometer and methods of using same
JP6616574B2 (ja) * 2015-01-30 2019-12-04 倉敷紡績株式会社 目視判定可能な遺伝子検査
JP6634566B2 (ja) * 2015-03-06 2020-01-22 株式会社森永生科学研究所 コントロールスライド及びコントロール実験の方法
ES2688270T3 (es) 2015-03-10 2018-10-31 Becton, Dickinson And Company Dispositivo de gestión de micromuestras de fluidos biológicos
CN119064246A (zh) * 2015-03-23 2024-12-03 赛多利斯生物分析仪器股份有限公司 用于评估生物材料中的流感病毒类型的非缔合的病毒尺寸颗粒的流式细胞术方法
KR20170132856A (ko) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. 신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US9867250B1 (en) 2015-04-20 2018-01-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence
EP3286730A2 (en) * 2015-04-21 2018-02-28 Joseph Paul Robinson Culture detection and measurement over time
ES2826400T3 (es) * 2015-04-23 2021-05-18 Bd Kiestra Bv Recolección de contraste de colonias
CN114723741B (zh) * 2015-04-23 2025-05-23 Bd科斯特公司 用于自动计数微生物菌落的方法和系统
CN107810060A (zh) 2015-04-24 2018-03-16 美飒生物技术公司 流体检测盒
CN104792772A (zh) * 2015-04-24 2015-07-22 张萍 一种电化学发光传感器及其免疫分析方法
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
CN104865186B (zh) * 2015-05-29 2017-08-25 重庆大学 便携式致病菌快速检测方法
US10828340B2 (en) 2015-06-09 2020-11-10 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
KR102175829B1 (ko) 2015-06-09 2020-11-06 리바이오틱스, 인코퍼레이티드 미생물상 복원 치료(ｍｒｔ) 조성물 및 제조 방법
US10799539B2 (en) 2015-06-09 2020-10-13 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US10905726B2 (en) 2015-06-09 2021-02-02 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US9874693B2 (en) 2015-06-10 2018-01-23 The Research Foundation For The State University Of New York Method and structure for integrating photonics with CMOs
US10545139B2 (en) * 2015-06-16 2020-01-28 Curiox Biosystems Pte Ltd. Methods and devices for performing biological assays using magnetic components
KR101658874B1 (ko) * 2015-08-03 2016-09-22 부경대학교 산학협력단 광 산란 패턴을 이용한 박테리아 분별 장치
EP3344390B1 (en) 2015-09-01 2021-01-20 Becton, Dickinson and Company Depth filtration device for separating specimen phases
FR3040999B1 (fr) * 2015-09-11 2020-01-31 Etablissement Francais Du Sang Procede et dispositif pour le genotypage de snp
AU2016322966B2 (en) 2015-09-17 2021-10-14 S.D. Sight Diagnostics Ltd Methods and apparatus for detecting an entity in a bodily sample
US10563164B1 (en) 2015-10-08 2020-02-18 Charm Sciences, Inc. Plate reader
ES2893100T3 (es) 2015-10-12 2022-02-08 Advanced Cell Diagnostics Inc Detección in situ de variantes de nucleótidos en muestras con un elevado nivel de ruido, y composiciones y métodos relacionados con ésta
US10808287B2 (en) 2015-10-23 2020-10-20 Rapid Pathogen Screening, Inc. Methods and devices for accurate diagnosis of infections
KR102255060B1 (ko) * 2015-10-26 2021-05-24 프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝에 파우 생물학적 시료의 움직임 및/또는 생물학적 시료 성분의 움직임에 대한 광학적인 시험관내 검출 방법 및 장치
US20170153431A1 (en) * 2015-12-01 2017-06-01 ZebraSci, Inc High-definition particle detection during centrifugation
CN105388302A (zh) * 2015-12-22 2016-03-09 中国医学科学院输血研究所 一种人免疫球蛋白制品中Tau蛋白抗体含量的检测方法
US9834808B2 (en) 2016-01-21 2017-12-05 SeLux Diagnostics, Inc. Methods for rapid antibiotic susceptibility testing
DE112016006056T5 (de) * 2016-01-27 2018-09-06 Hitachi High-Technologies Corporation Betrachtungsvorrichtung
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
DE102016202014B4 (de) * 2016-02-10 2019-05-29 E.G.O. Elektro-Gerätebau GmbH Pumpe, Haushaltsgerät mit einer Pumpe und Verfahren zum Betrieb eines solchen Haushaltsgeräts
EP3772702A3 (en) 2016-02-22 2021-05-19 Rapiscan Systems, Inc. Methods for processing radiographic images
WO2017159384A1 (ja) * 2016-03-14 2017-09-21 日本電気株式会社 物体管理装置
CA3018536A1 (en) 2016-03-30 2017-10-05 S.D. Sight Diagnostics Ltd Distinguishing between blood sample components
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
CN113916788B (zh) * 2016-04-22 2024-12-10 伊鲁米那股份有限公司 在发光成像中使用的设备和组成物及使用其的方法
US10495563B1 (en) 2016-04-28 2019-12-03 Charm Sciences, Inc. Plate reader observation methods and operation
CN109564209B (zh) 2016-05-11 2022-05-31 思迪赛特诊断有限公司 对样品实施的光学测量
EP3455610B1 (en) 2016-05-11 2023-01-04 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
JPWO2017200066A1 (ja) * 2016-05-18 2019-03-22 国立大学法人三重大学 がん検査装置、がん検査方法、および、がん検査用の染色剤
GB201610426D0 (en) * 2016-06-15 2016-07-27 Q-Linea Ab Sample holder for image based analysis of samples
EP3483592B1 (en) * 2016-07-05 2020-07-22 Konica Minolta, Inc. Biological material quantifying method, image processing device, pathological diagnosis support system and program
US12421540B2 (en) 2016-08-01 2025-09-23 California Institute Of Technology Sequential probing of molecular targets based on pseudo-color barcodes with embedded error correction mechanism
US20200166518A1 (en) 2016-09-12 2020-05-28 IsoPlexis Corporation System and methods for multiplexed analysis of cellular and other immunotherapeutics
RU2638970C1 (ru) * 2016-09-27 2017-12-19 Наталья Бегиевна Мигачева Способ сбора материала с поверхности кожи для микробиологического исследования у детей первого года жизни и устройство для его осуществления
NL2017705B1 (en) 2016-11-02 2018-05-18 Lumicks Tech B V Method and system for studying biological cells
DE102016121455A1 (de) * 2016-11-09 2018-05-09 Forschungszentrum Jülich GmbH Ultrasensitiver Nachweis von Virus- und Virus-ähnlichen Partikeln
EP3538891B1 (en) 2016-11-11 2022-01-05 Isoplexis Corporation Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
CN110225980B (zh) 2016-11-21 2023-01-06 纳米线科技公司 化学组合物及其使用方法
CN110268414B (zh) 2016-12-01 2023-08-01 伯克利之光生命科技公司 微流体装置中的微物体的自动检测和重新定位
US11085039B2 (en) 2016-12-12 2021-08-10 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
EP3551745A4 (en) 2016-12-12 2020-07-15 Xcella Biosciences, Inc. SCREENING METHODS AND SYSTEMS USING MICROCAPILLARY NETWORKS
US10324041B2 (en) 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
JP6422616B1 (ja) 2016-12-22 2018-11-14 国立大学法人 筑波大学 データ作成方法及びデータ使用方法
CN110382439A (zh) 2016-12-30 2019-10-25 埃克切拉生物科学公司 多级样品回收系统
US11428690B2 (en) * 2017-01-30 2022-08-30 University Of Miami Portable plasmonic system for disease detection
US11047854B2 (en) 2017-02-06 2021-06-29 Abbott Japan Llc Methods for reducing noise in signal-generating digital assays
CN108459001B (zh) * 2017-02-20 2020-10-27 中国科学院青岛生物能源与过程研究所 一种快速定量评价不同抗菌药物作用效果的方法
US11530438B2 (en) 2017-03-01 2022-12-20 The Board Of Trustees Of The Leland Stanford Junior University Highly specific circular proximity ligation assay
US10787695B2 (en) 2017-06-01 2020-09-29 General Electric Company Systems and methods for rapidly sensing microbial metabolism
FR3067110A1 (fr) * 2017-06-01 2018-12-07 Centre National De La Recherche Scientifique (Cnrs) Dispositif et procede de detection et d'imagerie d’elements biocontaminants
WO2019023320A1 (en) 2017-07-25 2019-01-31 Arizona Board Of Regents On Behalf Of Arizona State University FAST ANTIBIOTIC SENSITIVITY TESTING BY MONITORING THE SUBMICRON SCALE MOVEMENT OF SIMPLE BACTERIAL CELLS
EP3675835A4 (en) 2017-08-28 2021-06-09 Matthias Wagner MICROFLUIDIC LASER ACTIVATED INTRACELLULAR DELIVERY SYSTEMS AND METHODS
ES2702432B2 (es) * 2017-08-31 2019-08-05 Venegas Pedro Manuel Medina Método y dispositivo para el análisis de ácidos nucleicos
CN107723344B (zh) * 2017-09-05 2020-12-08 西北工业大学 基于dPCR的新型全自动荧光信号采集分析方法
US11181482B1 (en) * 2017-10-02 2021-11-23 University Of South Florida Mobile colorimetric assay device
JP7214729B2 (ja) 2017-11-14 2023-01-30 エス．ディー．サイト ダイアグノスティクス リミテッド 光学測定用試料収容器
WO2019100012A1 (en) * 2017-11-20 2019-05-23 Nano Global Corp. Data collection & analytics based on detection of biological cells or biological substances
KR102098030B1 (ko) * 2017-12-11 2020-04-07 주식회사 딕스젠 결핵진단용 조성물 및 광학적 특성 변화에 기반한 결핵 진단방법
CN107884380B (zh) * 2017-12-19 2020-05-12 西北工业大学 一种微反应腔阵列式芯片的全自动快速荧光分析方法
GB201721430D0 (en) * 2017-12-20 2018-01-31 Q-Linea Ab Method and device for microscopy-based imaging of samples
FR3075824B1 (fr) * 2017-12-21 2022-01-14 Biomerieux Sa Procede d'identification d'une levure ou d'une bacterie
FR3075825B1 (fr) 2017-12-21 2022-01-21 Biomerieux Sa Procede et systeme d'identificationdu type de gram d'une bacterie
CN108362629B (zh) * 2018-02-09 2021-02-05 中国计量科学研究院 大肠杆菌o157:h7单个活菌的快速检测方法及试剂盒
CN108436253B (zh) * 2018-02-26 2020-07-17 北京航空航天大学 一种sers-荧光双模式金属增强基底的制备方法
JP7032216B2 (ja) * 2018-04-04 2022-03-08 株式会社日立ハイテク 細菌検査装置および細菌検査方法
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
US12031985B2 (en) 2018-04-19 2024-07-09 First Light Diagnostics, Inc. Detection of targets
AT521238B1 (de) * 2018-05-09 2020-02-15 Lifetaq Analytics Gmbh In-situ zellanalyse im zellkultursystem
KR102893736B1 (ko) 2018-05-14 2025-11-28 브루커 스페이셜 바이올로지, 인크. 화학 조성물 및 이의 사용 방법
WO2019219393A1 (en) * 2018-05-17 2019-11-21 Unilever N.V. Evaluating the efficacy of leave-on cosmetic compositions to protect from pollutants
CN108896363A (zh) * 2018-05-28 2018-11-27 杭州智微信息科技有限公司 一种骨髓涂片数字化的流程方法
CA3100701A1 (en) 2018-05-31 2019-12-05 Berkeley Lights, Inc. Automated detection and characterization of micro-objects in microfluidic devices
US11525153B2 (en) 2018-07-19 2022-12-13 Battelle Memorial Institute Methods and systems of characterizing and counting microbiological colonies
CN109187937B (zh) * 2018-08-20 2020-03-13 河南科技大学第一附属医院 毛细管式癌细胞培养检测生长装置
AU2019329686A1 (en) 2018-08-27 2020-12-03 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
CN112888929B (zh) 2018-08-29 2024-09-13 快速微型生物系统公司 使用清洁且干燥的气体以用于颗粒物移除和用于其的组件
EP3973271A1 (en) 2018-09-14 2022-03-30 Unilever IP Holdings B.V. Evaluating the efficacy of leave-on cosmetic compositions to protect skin from pollutants
AU2019353145B2 (en) 2018-10-04 2025-12-04 First Light Diagnostics, Inc. Microbial analysis without cell purification
FR3086951B1 (fr) * 2018-10-05 2021-02-26 Redberry Methode et dispositif pour la detection d'au moins un microorganisme selon sa cinetique de marquage, et support de detection
WO2020097083A1 (en) 2018-11-06 2020-05-14 Cellino Biotech, Inc. Systems for cell control
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
CN111220589A (zh) * 2018-11-23 2020-06-02 上海氘峰医疗器械有限公司 病原微生物的快速鉴定仪器及鉴定方法
CA3121423A1 (en) 2018-11-29 2020-06-04 La Trobe University Method of identifying a structure
CA3121434A1 (en) 2018-11-29 2020-06-04 La Trobe University Microscopy method and system
SG11202105280QA (en) * 2018-11-29 2021-06-29 Univ La Trobe Method of identifying a structure
EP3887799B1 (en) 2018-11-29 2024-04-24 La Trobe University Automated method of identifying a structure
DK3890876T3 (da) 2018-12-06 2024-07-22 Xcella Biosciences Inc Lateral påfyldning af mikrokapillære arrays
LU101073B1 (en) * 2018-12-21 2020-06-24 Luxembourg Inst Science & Tech List Dna aptamers specific of adenovirus types
EP3899011A4 (en) * 2018-12-21 2022-08-31 Qvella Corporation SYSTEMS AND METHODS FOR MICROCOLLY GROWTH AND MICROBIAL CELL CHARACTERIZATION
US12298244B2 (en) 2019-02-04 2025-05-13 Life Technologies Holdings Pte Ltd Method of analyzing samples, analyzing device and computer program
WO2020168284A1 (en) * 2019-02-15 2020-08-20 The Regents Of The University Of California Systems and methods for digital pathology
FR3094988A1 (fr) * 2019-04-12 2020-10-16 Commissariat à l'Energie Atomique et aux Energies Alternatives Procédé d'observation précoce de colonies de microorganismes
EP3963091A4 (en) 2019-04-29 2023-07-19 Nautilus Biotechnology, Inc. METHODS AND SYSTEMS FOR ON-CHIP INTEGRATED SINGLE MOLECULE DETECTION
CN113906286B (zh) * 2019-07-02 2024-09-20 株式会社堀场先进技术 生物体样品分析装置及生物体样品分析方法
CN110487704A (zh) * 2019-07-08 2019-11-22 暨南大学 免疫荧光分析装置与免疫荧光分析方法
JP7518073B2 (ja) * 2019-07-11 2024-07-17 シチズン時計株式会社 被測定物質の検知装置
US10820847B1 (en) 2019-08-15 2020-11-03 Talis Biomedical Corporation Diagnostic system
CN110658177B (zh) * 2019-09-25 2021-11-23 暨南大学 一种苯酚识别sers探针及其制备、应用和基于sers通用超灵敏免疫分析方法
EP4039790A4 (en) * 2019-10-04 2023-10-04 Kyocera Corporation PH MEASUREMENT METHOD PH MEASUREMENT DEVICE
CN110967087B (zh) * 2019-10-11 2021-07-09 广东中烟工业有限责任公司 一种爆珠滤嘴渗出液体体积的测定方法
US10613012B1 (en) * 2019-10-17 2020-04-07 Horiba Instruments Incorporated Apparatus and method for observation of microscopic movements and counting of particles in colloids
CA3154848A1 (en) * 2019-10-18 2021-04-22 General Automation Lab Technologies Inc. Use of resorufin for monitoring metabolic activity of cells under anaerobic condition
US20220381672A1 (en) 2019-10-22 2022-12-01 S.D. Sight Diagnostics Ltd. Accounting for errors in optical measurements
WO2021097492A1 (en) * 2019-11-13 2021-05-20 Essenlix Corporation Rapid intra-cellular assay and use of the same
EP4073566B1 (en) 2019-12-12 2025-04-23 S.D. Sight Diagnostics Ltd. Artificial generation of color blood smear image
WO2021116959A1 (en) 2019-12-12 2021-06-17 S.D. Sight Diagnostics Ltd Analyzing an analyte disposed within a medium
US12523579B2 (en) 2019-12-12 2026-01-13 S.D. Sight Diagnostics Ltd. Detecting platelets in a blood sample
US11053540B1 (en) 2020-01-17 2021-07-06 Element Biosciences, Inc. High performance fluorescence imaging module for genomic testing assay
KR102298771B1 (ko) * 2020-02-21 2021-09-07 (주)오상헬스케어 형광염료의 종류에 따라 촬영방식을 선택하는 크로마토그래피 검사장치 및 그 제어방법
CN111381023A (zh) * 2020-03-16 2020-07-07 廖世奇 一种适配体快速筛查呼气中病原体的方法及系统
US12194157B2 (en) 2020-04-09 2025-01-14 Finncure Oy Carrier for targeted delivery to a host
EP4132478A1 (en) 2020-04-09 2023-02-15 Finncure Oy Mimetic nanoparticles for preventing the spreading and lowering the infection rate of novel coronaviruses
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
JP2021196241A (ja) * 2020-06-12 2021-12-27 株式会社エフ・ピー・エス 光標識物質を利用した検査方法及び検査キット
WO2021258223A1 (en) 2020-06-25 2021-12-30 Qvella Corporation Systems and methods for classification of microbial cells grown in microcolonies
CA3173599A1 (en) * 2020-06-26 2021-12-30 Najeeb Ashraf Khalid Pathogen detection using aptamer molecular photonic beacons
CN111721269B (zh) * 2020-06-30 2021-01-05 扬州大学 一种小麦幼苗格局特征的量化评价方法
CN111855542A (zh) * 2020-07-02 2020-10-30 江南大学 一种快速细胞计数装置及计数方法
US11501853B2 (en) * 2020-07-20 2022-11-15 Recursion Pharmaceuticals, Inc. Preemptible-based scaffold hopping
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN111862346B (zh) * 2020-07-29 2023-11-07 重庆邮电大学 基于虚拟现实及互联网的高锰酸钾制取氧气实验教学方法
US11914131B1 (en) * 2020-08-16 2024-02-27 Gregory Dimitrenko Optical testing system for detecting infectious disease, testing device, specimen collector and related methods
JP2023545069A (ja) * 2020-10-08 2023-10-26 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 共振型ナノフォトニックバイオセンサ
US11692217B2 (en) * 2020-11-11 2023-07-04 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
US11603551B2 (en) * 2020-12-02 2023-03-14 Steritec Products Mfg. Co., Inc. Biological indicators, and systems and methods for determining efficacy of sterilization
JP7414029B2 (ja) * 2021-02-26 2024-01-16 横河電機株式会社 測定方法及び測定システム
CA3210010A1 (en) 2021-03-07 2022-09-15 Matthias Wagner Platforms and systems for automated cell culture
US12461029B2 (en) * 2021-03-10 2025-11-04 Northeastern University Continuous flow air sampling and rapid pathogen detection system
JP7206533B2 (ja) * 2021-03-22 2023-01-18 ダイキン工業株式会社 検査システム及び検査方法
CN112986743B (zh) * 2021-03-31 2022-07-22 国网河南省电力公司电力科学研究院 一种主动干预型消弧装置测试系统功能体系
CN113083386B (zh) * 2021-04-02 2023-04-18 重庆大学 一种液样简便、快速离散化芯片及其使用方法
WO2022232510A1 (en) 2021-04-30 2022-11-03 Root Applied Sciences Inc. Device for collecting material from air
JP7190534B1 (ja) * 2021-06-14 2022-12-15 アサヒ飲料株式会社 微生物の検出方法
KR20240063107A (ko) 2021-07-21 2024-05-10 엘리먼트 바이오사이언스, 인크. 핵산 시퀀싱을 위한 광학 시스템 및 이의 방법
CN113676538B (zh) * 2021-08-19 2023-10-17 湖南翰坤实业有限公司 一种基于物联网的病毒监测设备、方法和系统
US11931737B2 (en) 2021-09-02 2024-03-19 Cellino Biotech, Inc. Platforms and systems for automated cell culture
IT202200005669A1 (it) 2022-03-22 2023-09-22 Copan Italia Spa Dispositivo e metodo per l’acquisizione di immagini di campioni biologici
IT202200005660A1 (it) 2022-03-22 2023-09-22 Copan Italia Spa Dispositivo e metodo per l’acquisizione di immagini di campioni biologici
IT202200005672A1 (it) 2022-03-22 2023-09-22 Copan Italia Spa Dispositivo e metodo per l’acquisizione di immagini di campioni biologici
US20250378552A1 (en) * 2022-06-29 2025-12-11 The Regents Of The University Of California Stain-free, rapid, and quantitative viral plaque assay using deep learning and holography
EP4310192A1 (en) * 2022-07-21 2024-01-24 C4Diagnostics Method of determining the existence and/or degree of resistance of microorganisms to antimicrobial agents
IT202200019200A1 (it) 2022-09-19 2024-03-19 Copan Italia Spa Dispositivo per l’acquisizione di immagini di campioni di materiale biologico e metodo associato
CN115980011A (zh) * 2022-12-23 2023-04-18 西安迈高生物科技有限公司 一种基于荧光标记的生殖道致病微生物的检测试剂盒及检测方法
WO2024138466A1 (zh) * 2022-12-28 2024-07-04 深圳华大生命科学研究院 检测组合物及蛋白捕获检测方法
US20250109218A1 (en) 2023-09-29 2025-04-03 Formosa Plastics Corporation, U.S.A. Method for preparing catalyst component for polymerization of polyolefin without the use of internal electron donors
DE102024202119A1 (de) 2024-03-07 2025-09-11 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung und Verfahren zur Trennung von Zellen
WO2025265099A1 (en) * 2024-06-21 2025-12-26 Arizona Board Of Regents On Behalf Of Arizona State University Rapid tuberculosis and mycobacteria phenotypic drug susceptibility testing with scattering imaging and particle tracking
FR3165073A1 (fr) * 2024-07-25 2026-01-30 Spore Biotechnologies Dispositif de détection de bactéries dans un échantillon
CN120160961B (zh) * 2025-03-25 2026-02-03 北京大学第三医院（北京大学第三临床医学院） 一种全光谱流式检测细胞代谢的新探针组合及其应用
JP7774757B1 (ja) * 2025-04-17 2025-11-21 アサヒ飲料株式会社 バックグラウンド蛍光の低減方法及び微生物の検出方法
CN120427583A (zh) * 2025-05-15 2025-08-05 广州翰德泽信医药科技有限公司 多重真菌荧光染色液在制备快速鉴别真菌存活/耐药试剂盒中的应用

Family Cites Families (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2672431A (en) 1949-11-25 1954-03-16 Goetz Alexander Means for performing microbiological assays of aerosols and hydrosols
US2761813A (en) * 1953-01-21 1956-09-04 Goetz Alexander Means and method of producing and controlling cultures of microorganisms
US2781813A (en) 1955-02-14 1957-02-19 Arthur D Ferguson Traction wheel construction
US3981776A (en) 1967-02-16 1976-09-21 Rolf Saxholm Magnetically responsive, biologically active substance and associated methods and apparatus
US3493772A (en) 1967-05-29 1970-02-03 Palo Alto Medical Research Fou Bacterial counting machine and method
US3694317A (en) 1968-05-31 1972-09-26 Stanley Scher Method of and instrument for micro-biological analysis
US4097586A (en) 1970-06-11 1978-06-27 Biological Developments, Inc. Immunochemical assay method
US4587213A (en) * 1971-09-29 1986-05-06 Malecki George J Methods and means of determining microorganism population
US3811036A (en) 1972-09-19 1974-05-14 Artek Syst Corp Micro-biological colony counter
GB1566098A (en) 1975-11-14 1980-04-30 Nat Res Dev Separation of solid and liquid components of mixtures
GB1575805A (en) 1976-03-12 1980-10-01 Technicon Instr Automatic diagnostic apparatus
US4157323A (en) 1976-06-09 1979-06-05 California Institute Of Technology Metal containing polymeric functional microspheres
GB1582956A (en) 1976-07-30 1981-01-21 Ici Ltd Composite magnetic particles
US4086060A (en) 1976-10-22 1978-04-25 Jocelyn Dickson Disposable manipulative laboratory device for transferring biological fluids
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4115535A (en) 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4222744A (en) 1978-09-27 1980-09-16 Becton Dickinson & Company Assay for ligands
DE3070333D1 (en) 1979-11-13 1985-04-25 Technicon Instr Test-tube assembly, kit for making it and method of manual immunoassay
US4565783A (en) * 1981-01-27 1986-01-21 Minnesota Mining And Manufacturing Company Dry culture media
US4614585A (en) 1981-03-02 1986-09-30 Sybron Corporation Frangible bonded disposable filtration unit with recoverable filter
US4454233A (en) 1981-10-21 1984-06-12 Wang Associates Method of tagged immunoassay
US4436826A (en) 1981-10-21 1984-03-13 Wang Associates Tagged immunoassay
AU7891581A (en) 1981-11-04 1983-05-18 K.A. Youssef Prolonged incubation microbiological culture plates
US4477578A (en) 1982-03-04 1984-10-16 Medical & Scientific, Inc. Method and apparatus for performing assays
US4455370A (en) 1982-05-17 1984-06-19 E. I. Du Pont De Nemours And Company Transferring separated components in gel electrophoresis via nylon membrane
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4582810A (en) 1983-09-30 1986-04-15 Becton, Dickinson And Company Immuno-agglutination particle suspensions
US4693972A (en) 1984-01-16 1987-09-15 Becton, Dickinson And Company Composition and method for rapid detection of microorganisms in clinical samples
GB8401368D0 (en) 1984-01-19 1984-02-22 Amersham Int Plc Assay method
FR2558847B1 (fr) * 1984-01-31 1986-06-20 Millipore Sa Dispositif et procede de controle microbiologique de liquides
US4568157A (en) * 1984-07-11 1986-02-04 Board Of Regents, The University Of Texas System Goniotomy lens
FI842992A0 (fi) 1984-07-26 1984-07-26 Labsystems Oy Immunologiskt definitionsfoerfarande.
EP0171174A3 (en) 1984-08-06 1986-04-23 James W. Gorman Petri dish which can be locked in different positions to admit ambient atmosphere at different rates
FI844027A7 (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
US5958790A (en) 1984-12-20 1999-09-28 Nycomed Imaging As Solid phase transverse diffusion assay
US5073497A (en) * 1989-06-30 1991-12-17 Caribbean Microparticles Corporation Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbeads
FI850481A0 (fi) 1985-02-06 1985-02-06 Labsystems Oy Foerfarande foer bestaemning av motmedel eller antigener.
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5238810A (en) 1986-09-22 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus thereof
FR2605330B1 (fr) 1986-10-20 1989-01-20 Millipore Sa Recipient destine a recevoir un ou plusieurs milieux de culture pour microorganismes.
US4922092A (en) 1986-11-26 1990-05-01 Image Research Limited High sensitivity optical imaging apparatus
US4750820A (en) 1987-04-01 1988-06-14 Minnesota Mining And Manufacturing Company Zoom lens having magnification factors in the range of 20X to 47X for micrographic applications
WO1989000526A1 (fr) 1987-07-10 1989-01-26 Hannes Marker Dispositif d'accouplement d'un greement avec une planche a voile
DE3855762T2 (de) 1987-11-05 1997-05-07 James D Berg Direkte Methode zum Nachweis von sehr niedrigerem Grad der Coliform-Kontamination
US4988618A (en) 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
EP0344276B1 (en) 1987-12-01 1993-06-23 Boehringer Mannheim Corporation Methods and devices for conducting assays
US4959301A (en) 1988-04-22 1990-09-25 Massachusetts Institute Of Technology Process for rapidly enumerating viable entities
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
FR2638101B1 (fr) 1988-10-21 1991-09-06 Biocom Sa Dispositif de filtration parallele d'une pluralite d'echantillons avec controle automatique des volumes filtres et du colmatage ainsi qu'avec indexation du filtre, et procede de filtration
FR2638240B1 (fr) * 1988-10-21 1991-10-18 Biocom Sa Platine pour l'analyse rapide et indexee sous microscope de filtres et d'autres supports porteurs d'echantillons multiples et procede d'analyse de ces echantillons utilisant cette platine
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5089413A (en) * 1989-05-19 1992-02-18 Minnesota Mining And Manufacturing Company Method and apparatus for culturing with microbiological dry culture medium
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US4988302A (en) 1989-06-08 1991-01-29 Difco Laboratories Incorporated Culture media package
JPH0383596A (ja) 1989-08-28 1991-04-09 Fuji Yakuhin Kogyo Kk 抗ｒｉｇポリペプチド抗体、その製法およびｒｉｇポリペプチドの免疫学的測定法
JPH0383598A (ja) * 1989-08-29 1991-04-09 Sapporo Breweries Ltd 微生物の迅速検査法
CA2022614A1 (en) * 1989-08-31 1991-03-01 Richard R. Matner Colony blotting method and device
JPH03102240A (ja) 1989-09-14 1991-04-26 Toshiba Corp 粒径測定装置
US5130733A (en) * 1989-11-24 1992-07-14 Minolta Camera Kabushiki Kaisha Camera having a pseudo format
GB9020352D0 (en) 1990-09-18 1990-10-31 Anagen Ltd Assay or reaction apparatus
FR2657543B1 (fr) 1990-01-26 1992-12-18 Biocom Sa Dispositif modulaire pour le recueil, l'incubation, la filtration d'echantillons multiples.
EP0493745A1 (en) 1990-12-21 1992-07-08 Dojindo Laboratories Fluorescent compound, complex, reagent, and specific binding assay employing said reagent
US5258284A (en) * 1991-01-22 1993-11-02 University Of Maryland, School Of Medicine Nucleic acid probes specific for pathogenic strains of vibrio vulnificus and method employing the same
US5464749A (en) 1991-07-22 1995-11-07 Bayer Corporation Immunoassay of free substances in biological fluids
FR2679660B1 (fr) 1991-07-22 1993-11-12 Pasteur Diagnostics Procede et dispositif magnetique d'analyse immunologique sur phase solide.
US5290701A (en) 1991-08-28 1994-03-01 Wilkins Judd R Microbial detection system and process
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5232838A (en) * 1991-12-09 1993-08-03 Minnesota Mining And Manufacturing Company Culture media device and method of use
US5541069A (en) * 1992-02-28 1996-07-30 Quidel Corporation Assay having improved dose response curve
EP0563858B1 (en) 1992-04-01 1997-07-09 Nihon Millipore Kogyo Kabushiki Kaisha Method of determining viable count
AU4681393A (en) 1992-07-17 1994-02-14 Aprogenex, Inc. Background-reducing compounds for probe-mediated in-situ fluorimetric assays
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
JP3228812B2 (ja) 1993-02-10 2001-11-12 日本マイクロリス株式会社 生菌数を測定する方法
EP0698084B1 (en) 1993-05-14 1998-06-24 Minnesota Mining And Manufacturing Company Method for rapid quantification of microorganism growth
US5552272A (en) 1993-06-10 1996-09-03 Biostar, Inc. Detection of an analyte by fluorescence using a thin film optical device
US5681530A (en) * 1993-06-11 1997-10-28 Ortho Diagnostic Systems Inc. Transport system for fluid analysis instrument
US5474910A (en) 1993-10-15 1995-12-12 Alfano; Robert R. Method and device for detecting biological molecules and/or microorganisms within a desired area or space
US5744322A (en) 1993-12-17 1998-04-28 Minnesota Mining And Manufacturing Company Automated incubating and imaging system for a disposable microorganism culturing device and method of use
FR2716003B1 (fr) 1994-02-04 1996-04-26 Biocom Sa Procédé d'analyse automatique d'éléments en faible concentration sur un support d'objets de faible occurrence et dispositif pour la mise en Óoeuvre dudit procédé.
FR2719602B1 (fr) 1994-05-05 1996-07-26 Biocom Sa Procédé et installation pour la numérisation de cellules et micro-organismes, notamment des produits alimentaires ou des fluides biologiques.
US5573950A (en) 1994-05-11 1996-11-12 Minnesota Mining And Manufacturing Company Cassette for disposable microorganism culturing media and automated scanning system
AU2636995A (en) * 1994-05-18 1995-12-05 Research And Development Institute, Inc. Simple, rapid method for the detection, identification and enumeration of specific viable microorganisms
US5538857A (en) 1994-06-01 1996-07-23 Isolab, Inc. Assay for enzyme activity from a red blood sample using a direct microfluorometric assay
US5624850A (en) 1994-06-06 1997-04-29 Idetek, Inc. Immunoassays in capillaries
US5792617A (en) 1994-08-18 1998-08-11 Rotman; M. Boris Cell proliferation-based amplified detection of analytes
US5861270A (en) 1994-11-07 1999-01-19 Universiteit Gent Enzymatic method for detecting coliform bacteria or E. coli
EP0713087B1 (en) * 1994-11-17 1999-04-14 Chemunex Apparatus and process for rapid and ultrasensitive detection and counting of microorganisms by fluorescence
WO1996018205A1 (en) 1994-12-08 1996-06-13 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
US5694478A (en) 1994-12-15 1997-12-02 Minnesota Mining And Manufacturing Company Method and apparatus for detecting and identifying microbial colonies
US5606413A (en) * 1995-01-19 1997-02-25 Northrop Grumman Corporation Real time spectroscopic imaging system and method
US5993740A (en) 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
EP0744656A1 (en) 1995-05-20 1996-11-27 Agfa-Gevaert N.V. Apparatus for the wet processing of photographic sheet material
US5681712A (en) * 1995-06-02 1997-10-28 Minnesota Mining And Manufacturing Company Surface colony counting device and method of use
US5843766A (en) 1995-06-07 1998-12-01 Advanced Tissue Sciences, Inc. Apparatus for the growth and packaging of three dimensional tissue cultures
FR2735255B1 (fr) * 1995-06-12 1998-06-19 Biocom Sa Procede de numerisation de particules faiblement luminescentes
US6573063B2 (en) 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
JPH09180797A (ja) * 1995-12-22 1997-07-11 Furukawa Electric Co Ltd:The フラットケーブル用接続端子
DE19608320A1 (de) 1996-02-22 1997-08-28 Biosquant Gmbh Schnellverfahren zur Bestimmung der mikrobiellen Qualität von Wasser und wasserhaltigen Proben
US5736405A (en) 1996-03-21 1998-04-07 Nalco Chemical Company Monitoring boiler internal treatment with fluorescent-tagged polymers
DE69737513T2 (de) * 1996-04-25 2007-12-13 Genicon Sciences Corp., San Diego Teilchenförmiges markierungsmittel verwendendes analytassay
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6139350A (en) 1996-05-20 2000-10-31 Siemens Aktiengesellschaft Latching system for a pin-and-socket connector
AU2961397A (en) * 1996-05-23 1997-12-09 Inverness Medical Switzerland Gmbh Improvements in or relating to specific binding assays
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
DE19631997C2 (de) 1996-08-08 2001-04-19 Dornier Gmbh Vorrichtung zur mikrogravitationstauglichen Prozessierung von Zellkulturen
US5861251A (en) 1996-10-15 1999-01-19 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
US6122396A (en) 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US5804386A (en) 1997-01-15 1998-09-08 Incyte Pharmaceuticals, Inc. Sets of labeled energy transfer fluorescent primers and their use in multi component analysis
US6358730B1 (en) 1997-01-29 2002-03-19 Pall Corporation Filtration assembly and culture device
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
WO1998038490A1 (en) 1997-02-27 1998-09-03 Cellomics, Inc. A system for cell-based screening
US5958704A (en) 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
ATE251306T1 (de) 1997-03-25 2003-10-15 Immunivest Corp Gerät und methoden zum einfnag und zur analyse von partikel-einheiten
US5852498A (en) 1997-04-04 1998-12-22 Kairos Scientific Inc. Optical instrument having a variable optical filter
JP3529014B2 (ja) 1997-04-24 2004-05-24 株式会社 シナップス 細胞培養容器
EP1180677A3 (en) 1997-05-05 2003-05-21 ChemoMetec A/S A method and a system for determination of particles in a liquid sample
US6259807B1 (en) 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6002789A (en) 1997-06-24 1999-12-14 Pilot Industries, Inc. Bacteria colony counter and classifier
US6258326B1 (en) * 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
US5985675A (en) 1997-12-31 1999-11-16 Charm Sciences, Inc. Test device for detection of an analyte
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
EP1002297A1 (en) 1997-08-07 2000-05-24 Imaging Research, Inc. A digital imaging system for assays in well plates, gels and blots
US6048723A (en) 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
FR2773218B1 (fr) 1997-12-31 2000-03-10 Stago International Dispositif, procede et appareil de mise en oeuvre du procede, pour effectuer un dosage d'au moins un composant particulier dans un echantillon de produit
US6180418B1 (en) 1998-01-20 2001-01-30 The United States Of America As Represented By The Secretary Of The Navy Force discrimination assay
CA2318779C (en) * 1998-01-22 2009-08-25 Luminex Corporation Microparticles with multiple fluorescent signals
JPH11216210A (ja) 1998-02-02 1999-08-10 Mizuno Corp キャディバッグ用の芯材
US6792132B1 (en) * 1998-02-03 2004-09-14 Hakuju Institute For Health Science Co., Ltd. Inspection method for microorganisms and the like, and unit therefor
US20020028471A1 (en) 1998-02-20 2002-03-07 Oberhardt Bruce J. Cell analysis methods and apparatus
US6140653A (en) 1998-03-27 2000-10-31 Vysis, Inc. Large-field fluorescence imaging apparatus
US5968766A (en) 1998-03-31 1999-10-19 B.E. Safe Method and apparatus for sensing the presence of microbes
US6171180B1 (en) * 1998-03-31 2001-01-09 Cypress Semiconductor Corporation Planarizing a trench dielectric having an upper surface within a trench spaced below an adjacent polish stop surface
US5914245A (en) 1998-04-20 1999-06-22 Kairos Scientific Inc. Solid phase enzyme kinetics screening in microcolonies
US6472163B1 (en) * 1998-04-20 2002-10-29 Kairos Scientific, Inc. Solid phase enzyme kinetics screening in microcolonies
US6014891A (en) 1998-05-08 2000-01-18 Conal Engineering Inc. On-line leak tested and container ends
JP2002526743A (ja) * 1998-05-13 2002-08-20 アクセラ８ テクノロジー コーポレイション アナライト検出算出法
US6306589B1 (en) 1998-05-27 2001-10-23 Vysis, Inc. Biological assays for analyte detection
JPH11346795A (ja) 1998-06-05 1999-12-21 Nikken Seibutsu Igaku Kenkyusho:Kk 細菌の検出方法
US6093869A (en) 1998-06-29 2000-07-25 The Procter & Gamble Company Disposable article having a responsive system including a feedback control loop
US6627446B1 (en) 1998-07-02 2003-09-30 Amersham Biosciences (Sv) Corp Robotic microchannel bioanalytical instrument
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6051395A (en) 1998-08-25 2000-04-18 Biometric Imaging, Inc. Method and compound for detecting low levels of microorganisms
US5972641A (en) 1998-08-28 1999-10-26 Colifast Systems Asa Rapid coliform detection system
ATE296677T1 (de) 1998-08-28 2005-06-15 Febit Ag Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers
US6130931A (en) 1998-09-17 2000-10-10 Process Control, Inc. X-ray fluorescence elemental analyzer
GB9902919D0 (en) 1999-02-09 1999-03-31 Isis Innovation Modulator of inflammation
GB9902971D0 (en) * 1999-02-11 1999-03-31 Zeneca Ltd Assay
JP2000270840A (ja) 1999-03-29 2000-10-03 Elmex Ltd コロニー計数装置およびその使用方法
US6235540B1 (en) * 1999-03-30 2001-05-22 Coulter International Corp. Semiconductor nanoparticles for analysis of blood cell populations and methods of making same
EP1246751B3 (en) 2000-01-13 2010-05-26 Vestdavit AS Davit device
US20020004246A1 (en) 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
EP1254273B1 (en) * 2000-02-08 2008-09-17 Millipore Corporation Process for the enumeration and identification of microorganisms
WO2001061348A1 (en) 2000-02-16 2001-08-23 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
US6472166B1 (en) 2000-02-17 2002-10-29 Wardlaw Partners Lp Method for determining the effects of a growth-altering agent on a microbial colony
FR2808276B1 (fr) 2000-04-26 2004-04-02 Renaud Nalin Procede d'extraction indirecte de l'adn d'organismes non cultivables et adn susceptible d'etre obtenu par ledit procede
JP2001224355A (ja) 2000-05-25 2001-08-21 Kyodo Seihin Kk 両面シャーレ
JP3762862B2 (ja) 2000-10-26 2006-04-05 株式会社 シナップス 細胞培養容器
EP1207394B1 (en) 2000-11-14 2009-12-30 Roche Diagnostics GmbH Immunoassay for HIV protease inhibitors
GB0029154D0 (en) 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies
US20020137106A1 (en) 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
US6664528B1 (en) 2001-07-06 2003-12-16 Palantyr Research, Llc Imaging system and methodology employing reciprocal space optical design
WO2003053535A2 (en) 2001-08-03 2003-07-03 Nanosphere, Inc. Nanoparticle imaging system and method
DK2184346T3 (da) 2001-09-06 2017-06-26 Rapid Micro Biosystems Inc Hurtig detektion af replikerende celler
EP1438582A1 (en) 2001-09-16 2004-07-21 ChemoMetec A/S Method and a system for detecting and optionally isolating a rare event particle
JP2003294596A (ja) 2002-03-29 2003-10-15 Asahi Kasei Corp 混合機構
US8663909B2 (en) 2002-05-09 2014-03-04 Nanologix, Inc. Device for rapid detection and identification of single microorganisms without preliminary growth
US6852527B2 (en) 2002-06-06 2005-02-08 Inovyx, Inc. Apparatus and method for the measurement of cells in biological samples
US7261900B2 (en) 2002-08-09 2007-08-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant modified Bacillus anthracis protective antigen for use in vaccines
FR2855613B1 (fr) 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
US7381370B2 (en) 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
US20050042145A1 (en) 2003-08-22 2005-02-24 Sysmex Corporation Container for analyzer, detection container, reaction container and packing container for storing detection container
US20050226779A1 (en) * 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
JP3102240U (ja) 2003-12-12 2004-07-02 友訊科技股▲分▼有限公司 アンテナと固定台座の回転定位置構造
EP1727473B1 (en) 2004-02-23 2012-03-28 Ethicon, Inc. Diagnostic swab and biopsy punch systems
WO2005085850A1 (en) 2004-02-27 2005-09-15 Tianxin Wang Methods for multiplexed analyte detection
US20050220670A1 (en) 2004-03-31 2005-10-06 Thomas Palmieri Multipath access system for use in an automated immunoassay analyzer
WO2005121864A2 (en) 2004-06-07 2005-12-22 Fluidigm Corporation Optical lens system and method for microfluidic devices
US20060129327A1 (en) 2004-07-29 2006-06-15 Kim Myung L Ultrasensitive sensor and rapid detection of analytes
US20060216696A1 (en) 2004-08-23 2006-09-28 Goguen Jon D Rapid plague detection system
US20070212681A1 (en) 2004-08-30 2007-09-13 Benjamin Shapiro Cell canaries for biochemical pathogen detection
US7727471B2 (en) 2004-09-09 2010-06-01 Palo Alto Research Center Incorporated Rare cell detection using flat-panel imager and chemiluminescent or radioisotopic tags
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
US7745207B2 (en) 2006-02-03 2010-06-29 IntegenX, Inc. Microfluidic devices
JP2006087336A (ja) 2004-09-22 2006-04-06 Shimadzu Corp 細胞分析装置
US20060121055A1 (en) 2004-12-06 2006-06-08 Becton, Dickinson And Company, Inc. Compositions with enhanced immunogenicity
JP2006162466A (ja) 2004-12-08 2006-06-22 Kyowa Medex Co Ltd 測定すべき物質の測定方法および測定試薬
WO2006084132A2 (en) 2005-02-01 2006-08-10 Agencourt Bioscience Corp. Reagents, methods, and libraries for bead-based squencing
CA2600934A1 (en) 2005-03-07 2006-09-14 Novx Systems Inc. Automated analyzer
US20070014695A1 (en) 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
US9488665B2 (en) 2005-09-13 2016-11-08 Chrome Red Technologies, Llc Magnetic particle tagged reagents and techniques
EP1937829A4 (en) 2005-09-26 2011-08-03 Rapid Micro Biosystems Inc CASSETTE WITH GROWTH MEDIUM
US7820430B2 (en) 2005-11-28 2010-10-26 Industrial Technology Research Institute Micro device for cell culture
CA2533219A1 (en) 2005-12-02 2007-06-02 Hudson Control Group, Inc. Systems and methods for automated proteomics research
EP2021491A4 (en) 2006-05-10 2010-02-24 Univ Texas PROOF OF TUMOR BIOMARKERS IN ORAL CANCER
WO2008005998A2 (en) 2006-07-07 2008-01-10 Georgia Tech Research Corporation Centimeter-scale, integrated diagnostics incubator for biological culturing
US8131476B2 (en) 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
JP2008096223A (ja) 2006-10-10 2008-04-24 Sysmex Corp 分析装置
US7863035B2 (en) 2007-02-15 2011-01-04 Osmetech Technology Inc. Fluidics devices
JP2008209330A (ja) 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 磁気分離器およびそれを用いた分析装置
US7763405B2 (en) 2007-03-23 2010-07-27 Xerox Corporation Photoconductors containing fluorinated components
CN107121396B (zh) 2008-09-24 2020-06-30 曙光生命科学公司 用于检测分析物的方法
FR2957932B1 (fr) 2010-03-24 2012-04-13 Biomerieux Sa Boite de petri comportant des moyens de retenue du milieu de culture gelose
HUE036509T2 (hu) 2011-11-07 2018-07-30 Rapid Micro Biosystems Inc Kazetta sterilitási vizsgálathoz
US9621921B2 (en) 2012-04-16 2017-04-11 Qualcomm Incorporated Coefficient groups and coefficient coding for coefficient scans
EP4060016A1 (en) 2012-04-16 2022-09-21 Rapid Micro Biosystems, Inc. Cell culturing device

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AU2002365913A8 (en) 2003-09-16
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