DK1745075T3 - Poly-n-acetylglucosamin (pnag/dpnag)-bindende peptider og fremgangsmåder til anvendelse deraf - Google Patents
Poly-n-acetylglucosamin (pnag/dpnag)-bindende peptider og fremgangsmåder til anvendelse derafInfo
- Publication number
- DK1745075T3 DK1745075T3 DK05770709.3T DK05770709T DK1745075T3 DK 1745075 T3 DK1745075 T3 DK 1745075T3 DK 05770709 T DK05770709 T DK 05770709T DK 1745075 T3 DK1745075 T3 DK 1745075T3
- Authority
- DK
- Denmark
- Prior art keywords
- dpnag
- pnag
- acetylglucosamine
- poly
- procedures
- Prior art date
Links
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229950006780 n-acetylglucosamine Drugs 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56410504P | 2004-04-21 | 2004-04-21 | |
| PCT/US2005/013694 WO2005103084A2 (en) | 2004-04-21 | 2005-04-21 | Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1745075T3 true DK1745075T3 (da) | 2013-06-24 |
Family
ID=35197541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05770709.3T DK1745075T3 (da) | 2004-04-21 | 2005-04-21 | Poly-n-acetylglucosamin (pnag/dpnag)-bindende peptider og fremgangsmåder til anvendelse deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (13) | US7786255B2 (da) |
| EP (6) | EP2439213B1 (da) |
| JP (2) | JP5080243B2 (da) |
| CN (1) | CN101001874B (da) |
| AU (1) | AU2005236068C1 (da) |
| CA (1) | CA2567748A1 (da) |
| DK (1) | DK1745075T3 (da) |
| ES (2) | ES2738112T3 (da) |
| PL (1) | PL1745075T3 (da) |
| PT (1) | PT1745075E (da) |
| SI (1) | SI1745075T1 (da) |
| WO (1) | WO2005103084A2 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7252828B2 (en) | 1998-07-15 | 2007-08-07 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| US7047058B1 (en) | 2001-02-06 | 2006-05-16 | Medrad, Inc. | Apparatuses, systems and methods for extravasation detection |
| ES2648046T3 (es) * | 2002-11-12 | 2017-12-28 | The Brigham And Women's Hospital, Inc. | Vacuna de polisacárido para infecciones estafilocócicas |
| US7723087B2 (en) | 2002-11-12 | 2010-05-25 | The Brigham And Women's Hospital, Inc. | Nucleic acid molecules for enhanced production of a bacterial polysaccharide and methods of use thereof |
| ES2738112T3 (es) | 2004-04-21 | 2020-01-20 | Brigham & Womens Hospital Inc | Péptidos de fijación a la poli-N-acetil glucosamina (PNAG/dPNAG) y procedimientos para el uso de los mismos |
| EP2027155B1 (en) * | 2006-06-06 | 2016-01-27 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
| CN101460518B (zh) | 2006-06-06 | 2012-08-22 | 克鲁塞尔荷兰公司 | 针对肠球菌和金黄色葡萄球菌具有杀伤活性的人结合分子及其应用 |
| AU2012268821B2 (en) * | 2006-06-06 | 2016-06-02 | Janssen Vaccines & Prevention B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
| US8455623B2 (en) | 2008-05-21 | 2013-06-04 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| ES2660594T3 (es) | 2008-07-21 | 2018-03-23 | The Brigham And Women's Hospital, Inc. | Métodos y composiciones relacionados con oligosacáridos sintéticos de beta-1,6 glucosamina |
| EP2744517B1 (en) | 2011-08-15 | 2019-03-13 | The University of Chicago | Compositions and methods related to antibodies to staphylococcal protein a |
| EP3998018B1 (en) | 2011-09-02 | 2025-10-15 | Battelle Memorial Institute | Extravasation detection system |
| WO2013075740A1 (en) * | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
| US20150086601A1 (en) * | 2012-05-07 | 2015-03-26 | Sanofi | Methods for preventing biofilm formation |
| BR112014030025A2 (pt) * | 2012-05-30 | 2017-06-27 | Brigham & Womens Hospital Inc | composições de polissacarídeo e métodos de uso |
| HK1211298A1 (en) * | 2012-08-24 | 2016-05-20 | Sanofi | Anti-poly-n-acetyl glucosamine (pnag) monoclonal antibody and uses thereof for the prevention or treatment of pnag expressing bacterial infection |
| US10248868B2 (en) | 2012-09-28 | 2019-04-02 | Nec Corporation | Information processing apparatus, information processing method, and information processing program |
| CA2887825A1 (en) | 2012-10-23 | 2014-05-01 | The Board Of Regents Of The University Of Texas System | Engineered igg fc domains |
| US9809645B2 (en) | 2013-03-12 | 2017-11-07 | Zenyaku Kogyo Kabushikikaisha | Anti-Staphylococcus antibody, method for manufacturing same, and usage of same |
| NO2994485T3 (da) | 2013-05-06 | 2018-06-09 | ||
| EP2889311B1 (en) * | 2013-12-30 | 2018-03-21 | Albert-Ludwigs-Universität Freiburg | Opsonic and protective monoclonal antibodies against gram-positive pathogens |
| KR102702078B1 (ko) | 2016-08-24 | 2024-09-04 | 테네오바이오, 인코포레이티드 | 변형된 중쇄-단독 항체를 생산하는 형질전환 비-인간 동물 |
| EP3618857A1 (en) | 2017-05-04 | 2020-03-11 | City of Hope | Antibody variable domains and antibody constructs |
| EP3546475A1 (en) | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| US12397014B2 (en) | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| MA54945A (fr) | 2019-02-12 | 2021-12-22 | Regeneron Pharma | Compositions et procédés d'utilisation d'anticorps bispécifiques pour lier un complément et un antigène cible |
| CN110184231B (zh) * | 2019-05-31 | 2021-02-12 | 杭州丰海生物科技有限公司 | 一种胞外分泌pnag多糖的重组枯草芽孢杆菌及其应用 |
| CN114929750B (zh) | 2019-09-13 | 2024-11-22 | 芝加哥大学 | 用于治疗葡萄球菌感染的方法和组合物 |
| US11173199B2 (en) | 2019-11-13 | 2021-11-16 | Alopexx Inc. | Low contaminant compositions |
| KR20220107001A (ko) * | 2019-11-22 | 2022-08-01 | 알로펙스, 인크. | Pnag 포함 미생물에 대한 연속 치료를 제공하는 방법 |
| US10828360B1 (en) | 2020-02-04 | 2020-11-10 | OneBioPharma, Inc. | Methods for inhibiting biofilm formation |
| WO2023173020A1 (en) * | 2022-03-11 | 2023-09-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody materials and methods targeting microbial polysaccharides |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US213668A (en) | 1879-03-25 | Improvement in ice-making apparatus | ||
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| JPS5452794A (en) | 1977-09-30 | 1979-04-25 | Kousaku Yoshida | Extracting of polysacchride from capusle containing epidermis staphylococus |
| US4285936A (en) | 1979-12-10 | 1981-08-25 | The United States Of America As Represented By The Secretary Of The Army | Method for producing a vaccine against bacterial infections caused by pseudomonas aeruginosa |
| US4355023A (en) | 1980-09-30 | 1982-10-19 | The Massachusetts General Hospital | Antibody fragment compositions and process |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4443549A (en) | 1981-10-19 | 1984-04-17 | Molecular Genetics, Inc. | Production of monoclonal antibodies against bacterial adhesins |
| US4470925A (en) | 1982-05-05 | 1984-09-11 | E. I. Du Pont De Nemours And Company | Immunoglobulin half-molecules and process for producing hybrid antibodies |
| US4462334A (en) | 1982-08-19 | 1984-07-31 | Kim Ho K | Solar animal structure |
| US4465776A (en) * | 1982-09-27 | 1984-08-14 | Research Corporation | Monoclonal antibodies to vitamin B6 and immunoassay method |
| US4652448A (en) | 1982-10-07 | 1987-03-24 | Molecular Genetics, Inc. | Use of monoclonal antibodies against bacterial adhesins |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US4578458A (en) | 1983-03-23 | 1986-03-25 | Brigham And Women's Hospital | Mucoid exopolysaccharide vaccine against Pseudomonas aeruginosa |
| DK219084D0 (da) | 1984-05-02 | 1984-05-02 | Frederik Carl Peter Lindberg | Antigen |
| JPS6191131A (ja) | 1984-10-09 | 1986-05-09 | Chugai Pharmaceut Co Ltd | 医薬品の吸着防止方法および組成物 |
| GB8426463D0 (en) | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
| NZ214503A (en) | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| FR2581877B1 (fr) | 1985-05-14 | 1987-12-18 | Louvain Universite Catholique | Conjugue constitue d'une adhesine de paroi de s. mutans, de nature proteique et d'un polysaccharide de s. mutans, sa preparation et son utilisation notamment dans des vaccins anti-caries |
| US4786592A (en) | 1986-06-18 | 1988-11-22 | Scripps Clinic And Research Foundation | Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin |
| US5589591A (en) | 1986-07-03 | 1996-12-31 | Advanced Magnetics, Inc. | Endotoxin-free polysaccharides |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8621910D0 (en) | 1986-09-11 | 1986-10-15 | Technology Licence Co Ltd | Monoclonal antibodies |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| FR2619122B1 (fr) | 1987-08-03 | 1990-03-09 | Pasteur Institut | Procede d'obtention de polyosides capsulaires de staphylocoques, polyosides obtenus, applications de ces polyosides et souches pour la mise en oeuvre du procede |
| US4859449A (en) | 1987-09-14 | 1989-08-22 | Center For Molecular Medicine And Immunology | Modified antibodies for enhanced hepatocyte clearance |
| CA1340506C (en) | 1987-11-24 | 1999-04-20 | Nicholas H. Carbonetti | Production of gonorrheal pi proteins and vaccines |
| US5055455A (en) | 1988-09-28 | 1991-10-08 | Brigham And Women's Hospital | Capsular polysaccharide adhesin antigen, preparation, purification and use |
| US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
| FR2640628A1 (fr) | 1988-12-16 | 1990-06-22 | Commissariat Energie Atomique | Oligosaccharides lies (beta)-(1 -> 6) en particulier des 2-acetamido-2-desoxy-glucoses ou - galactoses et leur preparation |
| ES2070312T5 (es) | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5571511A (en) | 1990-10-22 | 1996-11-05 | The U.S. Government | Broadly reactive opsonic antibodies that react with common staphylococcal antigens |
| WO1993001276A1 (en) | 1991-07-12 | 1993-01-21 | Smithkline Beecham Corporation | Continuous cell line and vaccine against avian coccidia |
| ES2198405T3 (es) | 1991-11-22 | 2004-02-01 | Nabi Biopharmaceuticals | Antigenos de superficie de tipo i asociados a staphylococcus epidermis. |
| US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| US5872215A (en) * | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
| ATE156368T1 (de) | 1991-12-06 | 1997-08-15 | North Shore Univ Hospital | Verfahren zum vermindern von durch medizinische vorrichtungen bedingten infektionen |
| DE69329642T3 (de) | 1992-03-19 | 2009-05-20 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Breitreaktive opsonische antikörper die mit gemeinsamen antigenen von staphylococcus reagieren |
| US5362754A (en) | 1992-11-12 | 1994-11-08 | Univ. Of Tx Md Anderson Cancer Center | M-EDTA pharmaceutical preparations and uses thereof |
| US5688516A (en) | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
| CA2153661A1 (en) | 1993-01-12 | 1994-07-21 | Anthony George Gristina | Methods and compositions for the direct concentrated delivery of passive immunity |
| US5718694A (en) | 1993-11-09 | 1998-02-17 | The Board Of Regents Of The University Of Nebraska | Inhibition of adherence of microorganisms to biomaterial surfaces by treatment with carbohydrates |
| US5858350A (en) | 1993-12-01 | 1999-01-12 | Marine Polymer Technologies | Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system |
| EP0804249A2 (en) | 1994-03-15 | 1997-11-05 | Brown University Research Foundation | Polymeric gene delivery system |
| DE69529649T2 (de) * | 1994-03-17 | 2003-12-18 | Merck Patent Gmbh | Anti-egfr einkettige fvs und anti-egfr antikoerper |
| US5945311A (en) | 1994-06-03 | 1999-08-31 | GSF--Forschungszentrumfur Umweltund Gesundheit | Method for producing heterologous bi-specific antibodies |
| JPH0840932A (ja) | 1994-07-29 | 1996-02-13 | Kitasato Inst:The | スタフイロコッカス属菌感染症の予防ワクチン及び治療用抗体並びにそれの製造法 |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US5830539A (en) | 1995-11-17 | 1998-11-03 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods for functionalizing and coating substrates and devices made according to the methods |
| US6245735B1 (en) | 1996-07-29 | 2001-06-12 | The Brigham And Women's Hospital, Inc. | Methods and products for treating pseudomonas infection |
| EP0826696B1 (de) | 1996-09-03 | 2002-05-29 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität |
| EP0962467A4 (en) * | 1996-09-26 | 2002-10-30 | Chugai Pharmaceutical Co Ltd | Antibody against human parathormone related peptides |
| US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| TW586934B (en) | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
| WO1999008705A1 (en) | 1997-08-20 | 1999-02-25 | Brigham And Women's Hospital | Capsular polysaccharides from enterococci |
| IT1298539B1 (it) | 1998-02-03 | 2000-01-12 | Bracco Spa | Metodo per la determinazione di infezioni da protesi |
| JP2002511259A (ja) * | 1998-04-09 | 2002-04-16 | ジェンセット | 5’estおよびコードされるヒトタンパク質 |
| AU4919699A (en) | 1998-07-11 | 2000-02-01 | Mhm Holdings Limited | Vehicle seat, vehicle seat table and vehicle communication system |
| WO2000003745A2 (en) | 1998-07-15 | 2000-01-27 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| US7252828B2 (en) | 1998-07-15 | 2007-08-07 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| DE69942840D1 (de) | 1998-12-16 | 2010-11-18 | Tno | Saure superabsorbierende polysaccharide |
| AU2002309567A1 (en) * | 2001-05-16 | 2002-12-03 | The Children's Hospital Of Philadelphia | Dna-antibody complexes to enhance gene transfer |
| US6962813B2 (en) | 2001-05-21 | 2005-11-08 | The Brigham And Women's Hospital, Inc. | P. aeruginosa mucoid exopolysaccharide specific binding peptides |
| US7119172B2 (en) | 2001-05-21 | 2006-10-10 | The Brigham And Women's Hospital, Inc. | P. aeruginosa mucoid exopolysaccharide specific binding peptides |
| US7378091B2 (en) | 2001-12-03 | 2008-05-27 | Amgen Fremont Inc. | Antibodies against carbonic anhydrase IX (CA IX) tumor antigen |
| CA2469132A1 (en) | 2001-12-11 | 2003-07-03 | Merck & Co., Inc. | Staphylococcus aureus exopolysaccharide and process |
| EP1470146B8 (en) * | 2001-12-28 | 2007-09-12 | Amgen Fremont Inc. | Antibodies against the muc18 antigen |
| KR100708398B1 (ko) | 2002-03-22 | 2007-04-18 | (주) 에이프로젠 | 인간화 항체 및 이의 제조방법 |
| EP1497445A2 (en) | 2002-04-01 | 2005-01-19 | Human Genome Sciences, Inc. | Antibodies that specifically bind to gmad |
| DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
| AU2003279308A1 (en) | 2002-11-04 | 2004-06-07 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 73a (gpr73a) |
| ES2648046T3 (es) | 2002-11-12 | 2017-12-28 | The Brigham And Women's Hospital, Inc. | Vacuna de polisacárido para infecciones estafilocócicas |
| US7723087B2 (en) | 2002-11-12 | 2010-05-25 | The Brigham And Women's Hospital, Inc. | Nucleic acid molecules for enhanced production of a bacterial polysaccharide and methods of use thereof |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| ES2738112T3 (es) | 2004-04-21 | 2020-01-20 | Brigham & Womens Hospital Inc | Péptidos de fijación a la poli-N-acetil glucosamina (PNAG/dPNAG) y procedimientos para el uso de los mismos |
| US8510225B2 (en) | 2004-09-01 | 2013-08-13 | Research In Motion Limited | Split channel authenticity queries in multi-party dialog |
| EP2410044B1 (en) | 2004-12-29 | 2022-06-22 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
| AR060187A1 (es) | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| ES2660594T3 (es) | 2008-07-21 | 2018-03-23 | The Brigham And Women's Hospital, Inc. | Métodos y composiciones relacionados con oligosacáridos sintéticos de beta-1,6 glucosamina |
| KR101656252B1 (ko) | 2009-02-20 | 2016-09-09 | 유겐가이샤 메이쇼 | 면역 증강 조성물 및 그것을 제조하는 방법 |
| WO2012099805A2 (en) | 2011-01-19 | 2012-07-26 | Ocean Nanotech, Llc | Nanoparticle based immunological stimulation |
| BR112014030025A2 (pt) | 2012-05-30 | 2017-06-27 | Brigham & Womens Hospital Inc | composições de polissacarídeo e métodos de uso |
| CN105102629B (zh) | 2013-01-22 | 2019-10-18 | 艾米克罗齐公司 | 用于检测病原体的快速方法 |
-
2005
- 2005-04-21 ES ES11185020T patent/ES2738112T3/es not_active Expired - Lifetime
- 2005-04-21 EP EP11185025.1A patent/EP2439213B1/en not_active Expired - Lifetime
- 2005-04-21 ES ES05770709T patent/ES2415358T3/es not_active Expired - Lifetime
- 2005-04-21 EP EP05770709A patent/EP1745075B1/en not_active Expired - Lifetime
- 2005-04-21 EP EP11185022.8A patent/EP2455401B1/en not_active Expired - Lifetime
- 2005-04-21 US US11/111,688 patent/US7786255B2/en active Active
- 2005-04-21 DK DK05770709.3T patent/DK1745075T3/da active
- 2005-04-21 EP EP11185027A patent/EP2455402A1/en not_active Withdrawn
- 2005-04-21 EP EP11185030A patent/EP2468769A1/en not_active Withdrawn
- 2005-04-21 SI SI200531737T patent/SI1745075T1/sl unknown
- 2005-04-21 JP JP2007509650A patent/JP5080243B2/ja not_active Expired - Fee Related
- 2005-04-21 WO PCT/US2005/013694 patent/WO2005103084A2/en not_active Ceased
- 2005-04-21 EP EP11185020.2A patent/EP2455400B1/en not_active Expired - Lifetime
- 2005-04-21 AU AU2005236068A patent/AU2005236068C1/en not_active Ceased
- 2005-04-21 PT PT57707093T patent/PT1745075E/pt unknown
- 2005-04-21 CN CN2005800203560A patent/CN101001874B/zh not_active Expired - Fee Related
- 2005-04-21 CA CA002567748A patent/CA2567748A1/en not_active Abandoned
- 2005-04-21 PL PL05770709T patent/PL1745075T3/pl unknown
-
2010
- 2010-06-28 US US12/824,510 patent/US8084595B2/en not_active Expired - Fee Related
-
2011
- 2011-05-09 US US13/103,532 patent/US8252894B2/en not_active Expired - Fee Related
- 2011-08-08 JP JP2011173372A patent/JP5717582B2/ja not_active Expired - Lifetime
- 2011-12-22 US US13/334,869 patent/US8410249B2/en not_active Expired - Fee Related
- 2011-12-22 US US13/334,807 patent/US8435515B2/en not_active Expired - Fee Related
- 2011-12-22 US US13/334,775 patent/US8350017B2/en not_active Expired - Fee Related
- 2011-12-22 US US13/334,840 patent/US8461319B2/en not_active Expired - Fee Related
-
2013
- 2013-01-07 US US13/735,531 patent/US8912314B2/en not_active Expired - Fee Related
-
2014
- 2014-11-19 US US14/548,173 patent/US9458227B2/en not_active Expired - Fee Related
-
2016
- 2016-09-20 US US15/270,461 patent/US10017563B2/en not_active Expired - Fee Related
-
2018
- 2018-06-11 US US16/005,647 patent/US10906962B2/en not_active Expired - Fee Related
-
2020
- 2020-12-22 US US17/131,613 patent/US20210363228A1/en not_active Abandoned
-
2022
- 2022-08-17 US US17/820,406 patent/US20230382980A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1745075T3 (da) | Poly-n-acetylglucosamin (pnag/dpnag)-bindende peptider og fremgangsmåder til anvendelse deraf | |
| DK1877090T3 (da) | Trimert ox40-immunoglobulin-fusionsprotein og fremgangsmåder til anvendelse heraf | |
| DK1965763T3 (da) | Stabile enzympræparater og fremgangsmåder til anvendelse heraf | |
| DK1937276T3 (da) | Forbedret testosterongel og fremgangsmåde til anvendelse deraf | |
| DK1817055T3 (da) | Ovr110-antistofsammensætninger og fremgangsmåder til anvendelse heraf | |
| IS7572A (is) | Aðferð og efni til lækninga | |
| DK1840121T3 (da) | Glycinderivat og anvendelse heraf | |
| DK1662867T3 (da) | Insekticid-forbindelser og fremgangsmåder til valg deraf | |
| DK1768691T3 (da) | Aequorinholdige præparater og fremgangsmåder til anvendelse af samme | |
| GB0417887D0 (en) | Protein | |
| GB0511846D0 (en) | Protein crystal | |
| NO20044457D0 (no) | Kombi-Brodd og Kombi-Brodd-System for Rollotorer | |
| GB0404929D0 (en) | Protein | |
| GB0416035D0 (en) | Protein | |
| GB0401882D0 (en) | Protein | |
| DK1833847T3 (da) | IFG-1fusionspolypeptider og terapeutiske anvendelser deraf | |
| GB0406485D0 (en) | Detox bracelet | |
| GB0518136D0 (en) | Protein crystal | |
| GB0518358D0 (en) | Protein crystal | |
| GB0408439D0 (en) | Protein | |
| GB0421200D0 (en) | Protein | |
| GB0405512D0 (en) | Protein | |
| GB0405644D0 (en) | Protein | |
| GB0408217D0 (en) | Protein | |
| GB0403979D0 (en) | Protein |