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DK169894B1 - Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne - Google Patents

Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne Download PDF

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Publication number
DK169894B1
DK169894B1 DK305885A DK305885A DK169894B1 DK 169894 B1 DK169894 B1 DK 169894B1 DK 305885 A DK305885 A DK 305885A DK 305885 A DK305885 A DK 305885A DK 169894 B1 DK169894 B1 DK 169894B1
Authority
DK
Denmark
Prior art keywords
tumor necrosis
necrosis factor
dna
cells
cell
Prior art date
Application number
DK305885A
Other languages
Danish (da)
English (en)
Other versions
DK305885A (da
DK305885D0 (da
Inventor
Bharat Bhushan Aggarwal
David Vannorman Goeddel
Sang He Lee
Glenn Evan Nedwin
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/677,257 external-priority patent/US4650674A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK305885D0 publication Critical patent/DK305885D0/da
Publication of DK305885A publication Critical patent/DK305885A/da
Application granted granted Critical
Publication of DK169894B1 publication Critical patent/DK169894B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C07K14/5255—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK305885A 1984-07-05 1985-07-04 Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne DK169894B1 (da)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US62806084A 1984-07-05 1984-07-05
US62805984A 1984-07-05 1984-07-05
US62795984A 1984-07-05 1984-07-05
US62805984 1984-07-05
US62795984 1984-07-05
US62806084 1984-07-05
US67715684A 1984-12-03 1984-12-03
US67745484A 1984-12-03 1984-12-03
US67725784 1984-12-03
US67715684 1984-12-03
US06/677,257 US4650674A (en) 1984-07-05 1984-12-03 Synergistic cytotoxic composition
US67745484 1984-12-03

Publications (3)

Publication Number Publication Date
DK305885D0 DK305885D0 (da) 1985-07-04
DK305885A DK305885A (da) 1986-03-14
DK169894B1 true DK169894B1 (da) 1995-03-27

Family

ID=27560190

Family Applications (2)

Application Number Title Priority Date Filing Date
DK305885A DK169894B1 (da) 1984-07-05 1985-07-04 Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne
DK075694A DK171418B1 (da) 1984-07-05 1994-06-24 Tumornecrosefaktorderivater, DNA som koder derfor, replikerbare udtrykkelsesvektorer indeholdende DNA'en, værtsceller transformeret dermed og en fremgangsmåde til fremstilling af tumornecrosefaktorderivaterne samt præparater omfattende tumornecrosefaktorderivaterne

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK075694A DK171418B1 (da) 1984-07-05 1994-06-24 Tumornecrosefaktorderivater, DNA som koder derfor, replikerbare udtrykkelsesvektorer indeholdende DNA'en, værtsceller transformeret dermed og en fremgangsmåde til fremstilling af tumornecrosefaktorderivaterne samt præparater omfattende tumornecrosefaktorderivaterne

Country Status (20)

Country Link
EP (1) EP0168214B1 (ja)
JP (4) JP2557341B2 (ja)
AT (1) ATE113295T1 (ja)
AU (1) AU599571B2 (ja)
BG (1) BG60250B1 (ja)
CZ (1) CZ283149B6 (ja)
DE (2) DE19975064I2 (ja)
DK (2) DK169894B1 (ja)
FI (2) FI95472C (ja)
GR (1) GR851626B (ja)
HU (1) HU209153B (ja)
IE (1) IE65426B1 (ja)
IL (2) IL105271A (ja)
LU (1) LU90456I2 (ja)
NL (1) NL990033I2 (ja)
NO (1) NO852673L (ja)
NZ (1) NZ212632A (ja)
PL (1) PL155778B1 (ja)
SK (1) SK279897B6 (ja)
YU (1) YU47968B (ja)

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US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
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WO1986003751A2 (en) * 1984-12-21 1986-07-03 Biogen N.V. Purification, production and use of tumor necrosis factors
JPS61155330A (ja) * 1984-12-28 1986-07-15 Denichi Mizuno 蛋白質標品
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US4870163A (en) * 1985-08-29 1989-09-26 New York Blood Center, Inc. Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
NZ219027A (en) * 1986-01-24 1989-09-27 Genentech Inc Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin
ATE116367T1 (de) * 1986-02-04 1995-01-15 Den Ichi Mizuno Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe.
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
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JPH0817712B2 (ja) * 1986-06-20 1996-02-28 大日本製薬株式会社 新規ヒトｔｎｆポリペプチド変異体
EP0251037B1 (en) * 1986-06-20 1994-06-15 Dainippon Pharmaceutical Co., Ltd. Novel human TNF polypeptide mutants and DNAs encoding said mutants
US4857314A (en) * 1986-07-18 1989-08-15 Health Research , Inc. C-reactive proteins in treatment of animal and human cancers
CA1340698C (en) * 1986-07-25 1999-08-10 Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo Preparation and uses of interferon-gamma
DD263234A5 (de) * 1986-07-31 1988-12-28 Genentech,Inc.,Us Verfahren zur herstellung von arzneimitteln zur behandlung oder vorbeugung von retroviralen infektionen
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US4777242A (en) * 1986-10-10 1988-10-11 Phillips Petroleum Company Purification of recombinant tumor necrosis factor
WO1988006625A2 (en) * 1987-02-26 1988-09-07 Cetus Corporation Arginine-depleted human tumor necrosis factor
US4894225A (en) * 1987-03-02 1990-01-16 Cetus Corporation Combination therapy using antitumor immunotoxins with tumor necrosis factor
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217325B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene for tumour necrosis factor alpha.
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
ES2097766T3 (es) 1989-08-16 1997-04-16 Chiron Corp Composiciones para la inhibicion de la formacion de hormonas proteicas y sus usos.
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
WO1991013908A1 (en) * 1990-03-12 1991-09-19 Peptide Technology Ltd. Neutrophil stimulating peptides
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
AU6001094A (en) * 1993-02-03 1994-08-29 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
CA2185162A1 (en) 1994-03-07 1995-09-14 Robert F. Halenback (Deceased) Compositions for the inhibition of tnf formation and uses thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
IL120979A0 (en) * 1997-06-02 1997-11-20 Interpharm Lab Ltd Glycosylated TNF
DK2953634T3 (da) 2013-02-07 2021-08-30 Massachusetts Gen Hospital Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler

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NO163060C (no) * 1981-03-13 1990-03-28 Damon Biotech Inc Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer.
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Also Published As

Publication number Publication date
JP2614989B2 (ja) 1997-05-28
DK305885A (da) 1986-03-14
BG60250B2 (bg) 1994-03-24
PL155778B1 (pl) 1992-01-31
DE3587939T2 (de) 1995-04-27
NL990033I2 (nl) 2000-11-01
FI95472B (fi) 1995-10-31
CZ283149B6 (cs) 1998-01-14
AU599571B2 (en) 1990-07-26
NO852673L (no) 1986-01-06
FI852626A0 (fi) 1985-07-03
HU209153B (en) 1994-03-28
SK506785A3 (en) 1999-05-07
YU47968B (sh) 1996-08-13
JPH0928387A (ja) 1997-02-04
JPH07291997A (ja) 1995-11-07
IL105271A (en) 1995-07-31
JPH083061A (ja) 1996-01-09
JPS6140221A (ja) 1986-02-26
GR851626B (ja) 1985-11-26
FI943750A (fi) 1994-08-15
FI852626L (fi) 1986-01-06
HUT38125A (en) 1986-04-28
FI943750A0 (fi) 1994-08-15
DE19975064I1 (de) 2005-09-29
FI98217B (fi) 1997-01-31
PL254399A1 (en) 1986-06-17
FI98217C (fi) 1997-05-12
CZ506785A3 (en) 1997-07-16
DK305885D0 (da) 1985-07-04
SK279897B6 (sk) 1999-05-07
DE19975064I2 (de) 2005-11-03
IE851691L (en) 1986-01-05
IE65426B1 (en) 1995-11-01
DE3587939D1 (de) 1994-12-01
BG60250B1 (bg) 1994-03-24
EP0168214B1 (en) 1994-10-26
LU90456I2 (fr) 1999-12-06
NZ212632A (en) 1991-05-28
IL75717A (en) 1994-11-28
DK75694A (da) 1994-06-24
FI95472C (fi) 1996-02-12
EP0168214A2 (en) 1986-01-15
EP0168214A3 (en) 1987-12-16
AU4465285A (en) 1986-01-09
ATE113295T1 (de) 1994-11-15
JP2557341B2 (ja) 1996-11-27
NL990033I1 (nl) 1999-12-01
IL75717A0 (en) 1985-11-29
DK171418B1 (da) 1996-10-21
YU113285A (en) 1991-04-30

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Free format text: CA 1999 00024, 19991011, EXPIRES: 20100704

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