DK1390525T3 - Pyrovatkinase som hidtil ukendt målmolekyle - Google Patents
Pyrovatkinase som hidtil ukendt målmolekyleInfo
- Publication number
- DK1390525T3 DK1390525T3 DK02748716T DK02748716T DK1390525T3 DK 1390525 T3 DK1390525 T3 DK 1390525T3 DK 02748716 T DK02748716 T DK 02748716T DK 02748716 T DK02748716 T DK 02748716T DK 1390525 T3 DK1390525 T3 DK 1390525T3
- Authority
- DK
- Denmark
- Prior art keywords
- kinase
- target molecule
- pyrovate
- novel target
- target
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01112601 | 2001-05-23 | ||
PCT/EP2002/005684 WO2002095063A1 (en) | 2001-05-23 | 2002-05-23 | Pyruvate-kinase as a novel target molecule |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1390525T3 true DK1390525T3 (da) | 2008-12-08 |
Family
ID=8177529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02748716T DK1390525T3 (da) | 2001-05-23 | 2002-05-23 | Pyrovatkinase som hidtil ukendt målmolekyle |
Country Status (10)
Country | Link |
---|---|
US (2) | US20040152648A1 (da) |
EP (2) | EP1990422A1 (da) |
AT (1) | ATE404691T1 (da) |
AU (1) | AU2002319180B2 (da) |
CA (1) | CA2448165A1 (da) |
DE (1) | DE60228233D1 (da) |
DK (1) | DK1390525T3 (da) |
ES (1) | ES2312595T3 (da) |
PT (1) | PT1390525E (da) |
WO (1) | WO2002095063A1 (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004016646A2 (en) * | 2002-08-12 | 2004-02-26 | Amynon Bio Tech Gmbh | Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk) |
WO2004058153A2 (en) * | 2002-12-20 | 2004-07-15 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476. |
DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
WO2006055880A2 (en) * | 2004-11-16 | 2006-05-26 | Genzyme Corporation | Diagnostic pkm2 methods and compositions |
US20060166236A1 (en) * | 2004-12-15 | 2006-07-27 | Chong-Sheng Yuan | Allosteric enzyme coupled immunoassay (AECIA) |
US8552050B2 (en) * | 2007-08-16 | 2013-10-08 | Beth Israel Deaconess Medical Center | Activators of pyruvate kinase M2 and methods of treating disease |
WO2010042867A2 (en) * | 2008-10-09 | 2010-04-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
CN102448951B (zh) | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
ES2619557T3 (es) | 2009-05-04 | 2017-06-26 | Agios Pharmaceuticals, Inc. | Activadores de PKM2 para uso en el tratamiento del cáncer |
JP5764555B2 (ja) | 2009-06-29 | 2015-08-19 | アジオス ファーマシューティカルズ, インコーポレイテッド | 治療組成物および関連する使用方法 |
BRPI1011587B1 (pt) | 2009-06-29 | 2020-03-24 | Agios Pharmaceuticals, Inc. | Compostos de quinolina sulfonamida com atividade moduladora de pmk2 e uso dos mesmos |
CA2793836C (en) | 2009-10-21 | 2020-03-24 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
ES2594402T3 (es) | 2009-10-21 | 2016-12-20 | Agios Pharmaceuticals, Inc. | Métodos y composiciones para trastornos relacionados con la proliferación celular |
EP2542267A4 (en) | 2010-03-05 | 2014-09-17 | Univ Columbia | THE RNA BINDEPROTEIN HNRNPA1, HNRNPA2 AND PTB-INHIBITING RNAS AND USES THEREOF |
JP2013525438A (ja) | 2010-04-29 | 2013-06-20 | アメリカ合衆国 | ヒトピルビン酸キナーゼ活性剤 |
JP5837091B2 (ja) | 2010-12-17 | 2015-12-24 | アジオス ファーマシューティカルズ, インコーポレイテッド | ピルビン酸キナーゼm2(pkm2)調節剤としての新規n−(4−(アゼチジン−1−カルボニル)フェニル)−(ヘテロ−)アリールスルホンアミド誘導体 |
WO2012088314A1 (en) | 2010-12-21 | 2012-06-28 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
SMT201800354T1 (it) | 2011-05-03 | 2018-09-13 | Agios Pharmaceuticals Inc | Attivatori della piruvato chinasi per uso in terapia |
JP7320339B2 (ja) | 2015-06-11 | 2023-08-03 | アジオス ファーマシューティカルズ, インコーポレイテッド | ピルビン酸キナーゼ活性化因子を使用する方法 |
RU2707751C1 (ru) | 2017-03-20 | 2019-11-29 | Форма Терапьютикс, Инк. | Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr) |
US12122778B2 (en) | 2018-09-19 | 2024-10-22 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
CN113166060B (zh) | 2018-09-19 | 2024-01-09 | 诺沃挪第克健康护理股份公司 | 用丙酮酸激酶激活化合物治疗镰状细胞病 |
KR20220066058A (ko) | 2019-09-19 | 2022-05-23 | 포르마 세라퓨틱스 인크. | 피루베이트 키나제 r(pkr) 활성화 조성물 |
US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821254A (en) * | 1995-02-17 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer |
WO1998035032A2 (en) * | 1997-02-11 | 1998-08-13 | The Regents Of The University Of California | Methods of inducing cell cycle stasis |
US7074895B2 (en) * | 1997-08-21 | 2006-07-11 | Quark Biotech, Inc. | Sequences characteristic of hypoxia-regulated gene transcription |
US5948628A (en) * | 1997-09-05 | 1999-09-07 | The Board Of Regents Of The University Of Oklahoma | Methods of screening for compounds which mimic galectin-1 |
US6458538B1 (en) * | 1999-12-14 | 2002-10-01 | Ptc Therapeutics, Inc. | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay |
-
2002
- 2002-05-23 CA CA002448165A patent/CA2448165A1/en not_active Abandoned
- 2002-05-23 AU AU2002319180A patent/AU2002319180B2/en not_active Ceased
- 2002-05-23 US US10/478,679 patent/US20040152648A1/en not_active Abandoned
- 2002-05-23 AT AT02748716T patent/ATE404691T1/de not_active IP Right Cessation
- 2002-05-23 DE DE60228233T patent/DE60228233D1/de not_active Expired - Lifetime
- 2002-05-23 PT PT02748716T patent/PT1390525E/pt unknown
- 2002-05-23 DK DK02748716T patent/DK1390525T3/da active
- 2002-05-23 ES ES02748716T patent/ES2312595T3/es not_active Expired - Lifetime
- 2002-05-23 EP EP08014232A patent/EP1990422A1/en not_active Withdrawn
- 2002-05-23 EP EP02748716A patent/EP1390525B8/en not_active Expired - Lifetime
- 2002-05-23 WO PCT/EP2002/005684 patent/WO2002095063A1/en active IP Right Grant
-
2007
- 2007-06-29 US US11/771,462 patent/US20080021116A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE404691T1 (de) | 2008-08-15 |
EP1390525B8 (en) | 2009-03-04 |
US20080021116A1 (en) | 2008-01-24 |
EP1390525A1 (en) | 2004-02-25 |
WO2002095063A1 (en) | 2002-11-28 |
EP1990422A1 (en) | 2008-11-12 |
US20040152648A1 (en) | 2004-08-05 |
PT1390525E (pt) | 2008-11-25 |
CA2448165A1 (en) | 2002-11-28 |
AU2002319180B2 (en) | 2007-07-05 |
EP1390525B1 (en) | 2008-08-13 |
ES2312595T3 (es) | 2009-03-01 |
DE60228233D1 (de) | 2008-09-25 |
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