[go: up one dir, main page]

DK1390525T3 - Pyrovatkinase som hidtil ukendt målmolekyle - Google Patents

Pyrovatkinase som hidtil ukendt målmolekyle

Info

Publication number
DK1390525T3
DK1390525T3 DK02748716T DK02748716T DK1390525T3 DK 1390525 T3 DK1390525 T3 DK 1390525T3 DK 02748716 T DK02748716 T DK 02748716T DK 02748716 T DK02748716 T DK 02748716T DK 1390525 T3 DK1390525 T3 DK 1390525T3
Authority
DK
Denmark
Prior art keywords
kinase
target molecule
pyrovate
novel target
target
Prior art date
Application number
DK02748716T
Other languages
English (en)
Inventor
Gyoergy Keri
Axel Ullrich
Attila Stetak
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK1390525T3 publication Critical patent/DK1390525T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK02748716T 2001-05-23 2002-05-23 Pyrovatkinase som hidtil ukendt målmolekyle DK1390525T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112601 2001-05-23
PCT/EP2002/005684 WO2002095063A1 (en) 2001-05-23 2002-05-23 Pyruvate-kinase as a novel target molecule

Publications (1)

Publication Number Publication Date
DK1390525T3 true DK1390525T3 (da) 2008-12-08

Family

ID=8177529

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02748716T DK1390525T3 (da) 2001-05-23 2002-05-23 Pyrovatkinase som hidtil ukendt målmolekyle

Country Status (10)

Country Link
US (2) US20040152648A1 (da)
EP (2) EP1990422A1 (da)
AT (1) ATE404691T1 (da)
AU (1) AU2002319180B2 (da)
CA (1) CA2448165A1 (da)
DE (1) DE60228233D1 (da)
DK (1) DK1390525T3 (da)
ES (1) ES2312595T3 (da)
PT (1) PT1390525E (da)
WO (1) WO2002095063A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004016646A2 (en) * 2002-08-12 2004-02-26 Amynon Bio Tech Gmbh Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk)
WO2004058153A2 (en) * 2002-12-20 2004-07-15 Millennium Pharmaceuticals, Inc. Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476.
DE10356218A1 (de) * 2003-12-03 2005-06-30 Bayer Cropscience Ag Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen
WO2006055880A2 (en) * 2004-11-16 2006-05-26 Genzyme Corporation Diagnostic pkm2 methods and compositions
US20060166236A1 (en) * 2004-12-15 2006-07-27 Chong-Sheng Yuan Allosteric enzyme coupled immunoassay (AECIA)
US8552050B2 (en) * 2007-08-16 2013-10-08 Beth Israel Deaconess Medical Center Activators of pyruvate kinase M2 and methods of treating disease
WO2010042867A2 (en) * 2008-10-09 2010-04-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
CN102448951B (zh) 2009-04-06 2017-05-10 安吉奥斯医药品有限公司 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法
ES2619557T3 (es) 2009-05-04 2017-06-26 Agios Pharmaceuticals, Inc. Activadores de PKM2 para uso en el tratamiento del cáncer
JP5764555B2 (ja) 2009-06-29 2015-08-19 アジオス ファーマシューティカルズ, インコーポレイテッド 治療組成物および関連する使用方法
BRPI1011587B1 (pt) 2009-06-29 2020-03-24 Agios Pharmaceuticals, Inc. Compostos de quinolina sulfonamida com atividade moduladora de pmk2 e uso dos mesmos
CA2793836C (en) 2009-10-21 2020-03-24 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
ES2594402T3 (es) 2009-10-21 2016-12-20 Agios Pharmaceuticals, Inc. Métodos y composiciones para trastornos relacionados con la proliferación celular
EP2542267A4 (en) 2010-03-05 2014-09-17 Univ Columbia THE RNA BINDEPROTEIN HNRNPA1, HNRNPA2 AND PTB-INHIBITING RNAS AND USES THEREOF
JP2013525438A (ja) 2010-04-29 2013-06-20 アメリカ合衆国 ヒトピルビン酸キナーゼ活性剤
JP5837091B2 (ja) 2010-12-17 2015-12-24 アジオス ファーマシューティカルズ, インコーポレイテッド ピルビン酸キナーゼm2(pkm2)調節剤としての新規n−(4−(アゼチジン−1−カルボニル)フェニル)−(ヘテロ−)アリールスルホンアミド誘導体
WO2012088314A1 (en) 2010-12-21 2012-06-28 Agios Pharmaceuticals, Inc. Bicyclic pkm2 activators
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
SMT201800354T1 (it) 2011-05-03 2018-09-13 Agios Pharmaceuticals Inc Attivatori della piruvato chinasi per uso in terapia
JP7320339B2 (ja) 2015-06-11 2023-08-03 アジオス ファーマシューティカルズ, インコーポレイテッド ピルビン酸キナーゼ活性化因子を使用する方法
RU2707751C1 (ru) 2017-03-20 2019-11-29 Форма Терапьютикс, Инк. Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr)
US12122778B2 (en) 2018-09-19 2024-10-22 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN113166060B (zh) 2018-09-19 2024-01-09 诺沃挪第克健康护理股份公司 用丙酮酸激酶激活化合物治疗镰状细胞病
KR20220066058A (ko) 2019-09-19 2022-05-23 포르마 세라퓨틱스 인크. 피루베이트 키나제 r(pkr) 활성화 조성물
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821254A (en) * 1995-02-17 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer
WO1998035032A2 (en) * 1997-02-11 1998-08-13 The Regents Of The University Of California Methods of inducing cell cycle stasis
US7074895B2 (en) * 1997-08-21 2006-07-11 Quark Biotech, Inc. Sequences characteristic of hypoxia-regulated gene transcription
US5948628A (en) * 1997-09-05 1999-09-07 The Board Of Regents Of The University Of Oklahoma Methods of screening for compounds which mimic galectin-1
US6458538B1 (en) * 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay

Also Published As

Publication number Publication date
ATE404691T1 (de) 2008-08-15
EP1390525B8 (en) 2009-03-04
US20080021116A1 (en) 2008-01-24
EP1390525A1 (en) 2004-02-25
WO2002095063A1 (en) 2002-11-28
EP1990422A1 (en) 2008-11-12
US20040152648A1 (en) 2004-08-05
PT1390525E (pt) 2008-11-25
CA2448165A1 (en) 2002-11-28
AU2002319180B2 (en) 2007-07-05
EP1390525B1 (en) 2008-08-13
ES2312595T3 (es) 2009-03-01
DE60228233D1 (de) 2008-09-25

Similar Documents

Publication Publication Date Title
DK1390525T3 (da) Pyrovatkinase som hidtil ukendt målmolekyle
DK1392642T3 (da) Hidtil ukendte forbindelser som anti-inflammatoriske, immunmodulatoriske og antiproliferative midler
EA200601313A1 (ru) Варианты участка f
DK1532269T3 (da) 1L1RL-1 som markør for kardiovaskulær sygdom
SE0202838D0 (sv) Chemical compounds
ATE455092T1 (de) Substituierte tetracyclin-verbindungen zur behandlung von malaria
MXPA03010232A (es) Compuestos de arilsulfonamida, para el tratamiento de la obesidad, de la diabetes tipo ii y de trastornos del sistema nervioso central.
NO20035474D0 (no) Prodrugs av GABA-analoger, sammensetninger og anvendelse derav
BR122012023120B8 (pt) Composto inibidor da recaptação de serotonina
NO20033918L (no) Ny anvendelse av peptidklasse av forbindelser for behandling av allodyni eller andre typer av kronisk smerte eller fantomsmerte
BR0209127A (pt) compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
BR0214230A (pt) Compostos e processos de fabricação de compostos
DK1066056T3 (da) Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernmangel, ...
BR0316723A (pt) Derivados de anilinopirazol úteis para o tratamento de diabetes
ATE264299T1 (de) Peroxycarbonsäure und ihre wässrigen zusammensetzungen
DE60205888D1 (de) Das citrat-salz des 5,8,14,-triazatetracyclo(10.3.1.02,11.04,9)-hexadeca-2(11),3,5,7,9-pentaens
DK1222860T3 (da) Bolsje med ru konsistens beregnet til behandling af halitose
SE0101082D0 (sv) Novel use
ITGE20020050A0 (it) Procedimento per il trattamento di filati mediante agugliatura.
BR0211620A (pt) Imidazopiridinas substituìdas por alquila para o tratamento de distúrbios gastrointestinais
NO20033401L (no) Kjemiske forbindelser
SE0301798D0 (sv) New use IV
Ochs Systematic Theology. Vol. 2, The Works of God
ZA200308097B (en) Substituted sulfonamide compounds, process for their use as medicament for the treatment of CNS disorders, obesity and type II diabetes.
TH67349A (th) สารประกอบชนิดใหม่