[go: up one dir, main page]

DK1392642T3 - Hidtil ukendte forbindelser som anti-inflammatoriske, immunmodulatoriske og antiproliferative midler - Google Patents

Hidtil ukendte forbindelser som anti-inflammatoriske, immunmodulatoriske og antiproliferative midler

Info

Publication number
DK1392642T3
DK1392642T3 DK02758329.3T DK02758329T DK1392642T3 DK 1392642 T3 DK1392642 T3 DK 1392642T3 DK 02758329 T DK02758329 T DK 02758329T DK 1392642 T3 DK1392642 T3 DK 1392642T3
Authority
DK
Denmark
Prior art keywords
immunomodulatory
inflammatory
new compounds
antiproliferative agents
compounds
Prior art date
Application number
DK02758329.3T
Other languages
English (en)
Inventor
Bernd Kramer
Johann Leban
Gabriel Garcia
Wael Saeb
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Application granted granted Critical
Publication of DK1392642T3 publication Critical patent/DK1392642T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/59—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
DK02758329.3T 2001-07-10 2002-07-09 Hidtil ukendte forbindelser som anti-inflammatoriske, immunmodulatoriske og antiproliferative midler DK1392642T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2001/007948 WO2003006424A1 (en) 2001-07-10 2001-07-10 Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
PCT/EP2002/007655 WO2003006425A2 (en) 2001-07-10 2002-07-09 Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

Publications (1)

Publication Number Publication Date
DK1392642T3 true DK1392642T3 (da) 2010-03-08

Family

ID=8164500

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02758329.3T DK1392642T3 (da) 2001-07-10 2002-07-09 Hidtil ukendte forbindelser som anti-inflammatoriske, immunmodulatoriske og antiproliferative midler

Country Status (24)

Country Link
US (2) US7176241B2 (da)
EP (2) EP2093214A1 (da)
JP (1) JP2004536122A (da)
KR (2) KR20080093077A (da)
CN (1) CN100462352C (da)
AT (1) ATE451349T1 (da)
AU (1) AU2002325315C1 (da)
BR (1) BRPI0211055B8 (da)
CA (1) CA2452491C (da)
CY (1) CY1109886T1 (da)
DE (1) DE60234690D1 (da)
DK (1) DK1392642T3 (da)
ES (1) ES2337239T3 (da)
HU (1) HU229869B1 (da)
IL (2) IL159418A0 (da)
MX (1) MXPA04000224A (da)
NO (1) NO331013B1 (da)
NZ (1) NZ530304A (da)
PL (1) PL211388B1 (da)
PT (1) PT1392642E (da)
RU (1) RU2309946C2 (da)
SI (1) SI1392642T1 (da)
WO (2) WO2003006424A1 (da)
ZA (1) ZA200309887B (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
WO2006006948A2 (en) 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
US8090542B2 (en) 2002-11-14 2012-01-03 Dharmacon Inc. Functional and hyperfunctional siRNA
EP1541198A1 (en) * 2003-12-05 2005-06-15 4Sc Ag Cycloalkyl compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7247736B2 (en) 2002-12-23 2007-07-24 4Sc Ag Method of identifying inhibitors of DHODH
PL209303B1 (pl) * 2002-12-23 2011-08-31 4Sc Ag Związek aromatyczny, kompozycja farmaceutyczna zawierająca związek aromatyczny i zastosowanie związku aromatycznego jako środka przeciwzapalnego, immunomodulującego i antyproliferacyjnego
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
AU2003300530A1 (en) * 2002-12-23 2004-07-14 4Sc Ag Dhodh-inhibitors and method for their identification
SE0400234D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New compounds, methods for their preparation and use thereof
US7605250B2 (en) 2004-05-12 2009-10-20 Dharmacon, Inc. siRNA targeting cAMP-specific phosphodiesterase 4D
MXPA06013435A (es) * 2004-05-21 2007-03-23 Uab Research Foundation Composiciones y metodos referentes a inhibidores de sintesis de pirimidina.
WO2006022442A1 (ja) * 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
US20070299114A1 (en) * 2004-10-05 2007-12-27 Shionogi & Co., Ltd. Biaryl Derivatives
WO2006051937A1 (ja) * 2004-11-15 2006-05-18 Shionogi & Co., Ltd. ヘテロ５員環誘導体
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN101563082A (zh) * 2006-09-05 2009-10-21 窦德献 治疗免疫介导性皮肤病的组合物和方法
ES2319596B1 (es) * 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
ES2327372B1 (es) * 2007-04-23 2010-08-24 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
CA2677457A1 (en) 2007-02-06 2008-08-14 Helen Tuvesson Andersson New compounds, methods for their preparation and use thereof
EP2100881A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Pyrimidyl- or pyridinylaminobenzoic acid derivatives
UY31272A1 (es) * 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
EP2135610A1 (en) * 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US20120028985A1 (en) * 2008-11-07 2012-02-02 4Sc Ag Combinational therapy for treating autoimmune disease
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
EP2228367A1 (en) 2009-03-13 2010-09-15 Almirall, S.A. Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors
EP2230232A1 (en) 2009-03-13 2010-09-22 Almirall, S.A. Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
TWI530286B (zh) * 2009-05-04 2016-04-21 帕納特斯製藥格斯有限公司 作為抑制病毒化合物之抗發炎劑
EP2314577A1 (en) 2009-10-16 2011-04-27 Almirall, S.A. Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
NZ599298A (en) 2009-11-27 2014-11-28 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
US8686048B2 (en) * 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
AU2011270872A1 (en) 2010-06-24 2013-01-31 Allergan, Inc. Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity
UA108760C2 (uk) * 2010-07-01 2015-06-10 Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби
EP2444086A1 (en) 2010-10-22 2012-04-25 Almirall, S.A. Combinations comprising DHODH inhibitors and COX inhibitors
EP2444088A1 (en) * 2010-10-22 2012-04-25 Almirall, S.A. Amino derivatives for the treatment of proliferative skin disorders
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
WO2012109329A2 (en) 2011-02-08 2012-08-16 Children's Medical Center Corporation Methods for treatment of melanoma
US10016402B2 (en) 2011-02-08 2018-07-10 Children's Medical Center Corporation Methods for treatment of melanoma
US8492556B2 (en) * 2011-11-10 2013-07-23 Allergan, Inc. 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
MX2016013341A (es) 2014-04-11 2017-09-01 Panoptes Pharma Gmbh Agentes antiinflamatorios como compuestos virostaticos.
WO2016200778A1 (en) * 2015-06-08 2016-12-15 Children's Medical Center Corporation Methods for treatment of melanoma
EP3368896A1 (en) 2015-10-30 2018-09-05 FMC Corporation Dihydroorotate dehydrogenase inhibitor compositions effective as herbicides
US20190025313A1 (en) * 2015-12-30 2019-01-24 Agios Pharmaceuticals, Inc. Treatment of tumors incorporating mutant isocitrate dehydrogenase
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合
CN114921391B (zh) 2016-10-27 2024-01-02 拜耳股份有限公司 4,5-环状1,2,4-三唑酮
WO2018136009A1 (en) 2017-01-20 2018-07-26 Aslan Pharmaceuticals Pte Ltd Combination therapy
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
SG11201909718QA (en) * 2017-04-24 2019-11-28 Aurigene Discovery Tech Ltd Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
JP7231628B2 (ja) 2017-11-23 2023-03-01 イミュニック アクチェンゲゼルシャフト 慢性炎症性疾患および／または自己免疫疾患の予防または治療における使用のためのビドフルジムス（Ｖｉｄｏｆｌｕｄｉｍｕｓ）の投与レジメン
MA51897A (fr) 2018-02-20 2020-12-30 Agios Pharmaceuticals Inc Procédés d'utilisation de dérivés de benzotriazole trisubstitués
SMT202400200T1 (it) 2018-03-16 2024-07-09 Immunic Ag Nuovi polimorfi di sale di calcio come agenti antinfiammatori, immunomodulatori e antiproliferativi
CN111018836A (zh) * 2019-12-31 2020-04-17 南京福斯特牧业科技有限公司 一种增效磺胺类药物作用的嘧啶制剂及其制法
JP2023522245A (ja) 2020-04-21 2023-05-29 イミュニック アクチェンゲゼルシャフト ウイルス性疾患の治療又は予防において使用するためのビドフルジムス
JP2024515062A (ja) 2021-04-09 2024-04-04 イミュニック アクチェンゲゼルシャフト 重水素化ｄｈｏｄｈ阻害剤
TW202333706A (zh) 2021-11-01 2023-09-01 德商埃慕尼克股份公司 Ｎ—羥基胞磷膽鹼（ｃｉｔｉｃｏｌｉｎｅ）化合物的醫藥用途
EP4452929A1 (en) 2021-12-23 2024-10-30 Immunic AG Dhodh inhibitors containing a carboxylic acid bioisostere
IL317127A (en) 2022-06-01 2025-01-01 Immunic Ag Ulcerative colitis treatment containing vidoplodimes or its pharmaceutical salt
TW202444688A (zh) 2023-03-29 2024-11-16 德商埃慕尼克股份公司 作為nurr1激動劑之維多氟地莫(vidofludimus)及相關結構
WO2025003402A1 (en) 2023-06-28 2025-01-02 Immunic Ag Heteroaromatic dhodh inhibitors
WO2025036941A1 (en) 2023-08-15 2025-02-20 Immunic Ag Oral pharmaceutical dosage form providing immediate release of vidofludimus

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3726881A (en) 1970-12-28 1973-04-10 Richter Gedeon Vegyeszet N-aminoxy-acetyl-n'-isonicotinoyl-hydrazine and the pharmaceutically acceptable salts thereof
JPS50121428A (da) * 1974-03-12 1975-09-23
NL186239B (nl) 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
IL56012A (en) * 1977-11-29 1983-07-31 Takeda Chemical Industries Ltd N-(2-fluoro-4-bromo(or chloro)phenyl)-3,4,5,6-tetrahydrophthalamic acid derivatives,their preparation,and herbicidal compositions comprising them
JPS54154737A (en) * 1978-05-25 1979-12-06 Mitsubishi Chem Ind Ltd Cyclohexenedicarboxylic acid diamide and herbicide
JPS5547668A (en) 1978-09-30 1980-04-04 Taisho Pharmaceut Co Ltd Epoxysuccinamic acid
JPS55157547A (en) * 1979-05-28 1980-12-08 Takeda Chem Ind Ltd Tetrahydrophthalamide derivative, its preparation and herbicide
AU1526483A (en) * 1982-06-14 1983-12-22 Nippon Kayaku Kabushiki Kaisha N-substituted-3,4,5,6-tetrahydrophthalamic acids
JPS59118750A (ja) * 1982-12-27 1984-07-09 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体
DE3332780A1 (de) 1983-09-10 1985-03-28 Hoechst Ag, 6230 Frankfurt 6-sulfoxyphenolderivate, ihre herstellung und ihre verwendung als cytoprotekiva
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
IL110427A (en) 1993-08-11 1998-10-30 Rohm & Haas Process for the preparation of 1,2-diacyl-T-2-alkyl hydrazides
GB9320299D0 (en) 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
AUPN191295A0 (en) 1995-03-23 1995-04-27 Unisearch Limited Microbiocide or microbial regulator
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
WO1998058075A2 (en) 1997-06-18 1998-12-23 The Research And Development Institute, Inc. Homoserine lactones biofilm regulating compounds and their methods of use
GB9725599D0 (en) 1997-12-04 1998-02-04 Univ Nottingham Control of biofilm formation
AU2108099A (en) 1998-01-30 1999-08-16 Procept, Inc. Immunosuppressive agents
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
AUPP303498A0 (en) 1998-04-17 1998-05-14 Unisearch Limited Inhibition of gram positive bacteria
CA2326757A1 (en) 1998-04-27 1999-11-04 President And Fellows Of Harvard College Regulation of biofilm formation
AU752209B2 (en) 1998-08-27 2002-09-12 Dow Agrosciences Llc Process for substituted hydrazides using carboxylic acids
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
GB2356398A (en) 1999-11-18 2001-05-23 Lilly Dev Ct S A Preparation of arylsulfamides
DE60131138T2 (de) 2000-01-13 2008-08-14 Amgen Inc., Thousand Oaks Antibakterielle mittel
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

Also Published As

Publication number Publication date
US20060199856A1 (en) 2006-09-07
ES2337239T3 (es) 2010-04-22
JP2004536122A (ja) 2004-12-02
RU2004103741A (ru) 2005-06-20
ZA200309887B (en) 2004-07-20
HUP0400998A3 (en) 2009-01-28
US7176241B2 (en) 2007-02-13
US7423057B2 (en) 2008-09-09
WO2003006425A2 (en) 2003-01-23
HU229869B1 (en) 2014-10-28
HUP0400998A2 (hu) 2004-09-28
PL366590A1 (en) 2005-02-07
BR0211055A (pt) 2004-07-20
WO2003006424A1 (en) 2003-01-23
PT1392642E (pt) 2010-02-24
CN100462352C (zh) 2009-02-18
NZ530304A (en) 2006-02-24
NO331013B1 (no) 2011-09-05
WO2003006425A3 (en) 2003-11-27
PL211388B1 (pl) 2012-05-31
IL159418A0 (en) 2004-06-01
SI1392642T1 (sl) 2010-04-30
KR100891571B1 (ko) 2009-04-03
BRPI0211055B1 (pt) 2018-03-20
US20030203951A1 (en) 2003-10-30
EP2093214A1 (en) 2009-08-26
CN1525954A (zh) 2004-09-01
AU2002325315B2 (en) 2008-08-07
EP1392642A2 (en) 2004-03-03
CA2452491A1 (en) 2003-01-23
CA2452491C (en) 2013-04-30
MXPA04000224A (es) 2005-07-25
KR20040029357A (ko) 2004-04-06
WO2003006425A9 (en) 2004-02-26
CY1109886T1 (el) 2014-09-10
RU2309946C2 (ru) 2007-11-10
NO20040100L (no) 2004-03-09
IL159418A (en) 2011-03-31
EP1392642B1 (en) 2009-12-09
KR20080093077A (ko) 2008-10-17
BRPI0211055B8 (pt) 2021-05-25
AU2002325315C1 (en) 2009-03-26
ATE451349T1 (de) 2009-12-15
DE60234690D1 (de) 2010-01-21

Similar Documents

Publication Publication Date Title
DK1392642T3 (da) Hidtil ukendte forbindelser som anti-inflammatoriske, immunmodulatoriske og antiproliferative midler
CY1106247T1 (el) Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες
DK1385514T5 (da) Spiroinden- og spiroindanforbindelser
SE0100902D0 (sv) Compounds
NO20041493L (no) Kjemiske forbindelser.
ES2172864T3 (es) 2-metoxibenzofenonas fungicidas.
BR0314688A (pt) Novos derivados de piperidina para utilização no tratamento de estados de doença mediados pela quimiocina
ATE403429T1 (de) Spiropyrazol-verbindungen
NO20034661L (no) Nociceptin-analoger
DK1975164T3 (da) Octahydrobenzimidazolon-forbindelser som analgetika
ATE264299T1 (de) Peroxycarbonsäure und ihre wässrigen zusammensetzungen
NO20043016L (no) 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
ATE411287T1 (de) Neue metallproteinaseinhibitoren
NO20054787D0 (no) Indenderivater som farmasotiske midler
NO20052907L (no) Sykloalkylendikarboksylsyreforbindelser som antiinflammatoriske, immunmodulatoriske og antiproliferative midler
BR0206922A (pt) Compostos orgânicos
DE60330038D1 (de) Neue alpha-ketoamidderivate und deren verwendung
ATE303390T1 (de) Sulfat von cephemverbindung
ATE478155T1 (de) Glycopeptidantibiotika