DE60228233D1 - Pyruvat-kinase als einem neuen zielmolekül - Google Patents
Pyruvat-kinase als einem neuen zielmolekülInfo
- Publication number
- DE60228233D1 DE60228233D1 DE60228233T DE60228233T DE60228233D1 DE 60228233 D1 DE60228233 D1 DE 60228233D1 DE 60228233 T DE60228233 T DE 60228233T DE 60228233 T DE60228233 T DE 60228233T DE 60228233 D1 DE60228233 D1 DE 60228233D1
- Authority
- DE
- Germany
- Prior art keywords
- target molecule
- new target
- pyruvate kinase
- pyruvate
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01112601 | 2001-05-23 | ||
PCT/EP2002/005684 WO2002095063A1 (en) | 2001-05-23 | 2002-05-23 | Pyruvate-kinase as a novel target molecule |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60228233D1 true DE60228233D1 (de) | 2008-09-25 |
Family
ID=8177529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60228233T Expired - Lifetime DE60228233D1 (de) | 2001-05-23 | 2002-05-23 | Pyruvat-kinase als einem neuen zielmolekül |
Country Status (10)
Country | Link |
---|---|
US (2) | US20040152648A1 (de) |
EP (2) | EP1390525B8 (de) |
AT (1) | ATE404691T1 (de) |
AU (1) | AU2002319180B2 (de) |
CA (1) | CA2448165A1 (de) |
DE (1) | DE60228233D1 (de) |
DK (1) | DK1390525T3 (de) |
ES (1) | ES2312595T3 (de) |
PT (1) | PT1390525E (de) |
WO (1) | WO2002095063A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004016646A2 (en) * | 2002-08-12 | 2004-02-26 | Amynon Bio Tech Gmbh | Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk) |
US20040235071A1 (en) * | 2002-12-20 | 2004-11-25 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476, 62113, 64316, 12264, 32362, 58198, 2887, 3205, 8557, 9600, 9693, 44867, 53058, 55556, 57658, 2208, 10252, 10302, 14218, 33877, 10317, 10485, 25964, 14815, 1363, 1397, 14827, 21708, 3801, 64698, 2179 or 13249 |
DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
WO2006055880A2 (en) * | 2004-11-16 | 2006-05-26 | Genzyme Corporation | Diagnostic pkm2 methods and compositions |
WO2006065967A2 (en) * | 2004-12-15 | 2006-06-22 | General Atomics | Allosteric enzyme coupled immunoassay (aecia) |
WO2009025781A1 (en) * | 2007-08-16 | 2009-02-26 | Beth Israel Deaconess Medical Center | Activators of pyruvate kinase m2 and methods of treating disease |
EP2344453B1 (de) | 2008-10-09 | 2016-12-28 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Aktivatoren der humanen pyruvatkinase |
CN102448951B (zh) | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
CA2760929C (en) | 2009-05-04 | 2018-01-02 | Agios Pharmaceuticals, Inc. | Pkm2 activators for use in the treatment of cancer |
JP5764555B2 (ja) | 2009-06-29 | 2015-08-19 | アジオス ファーマシューティカルズ, インコーポレイテッド | 治療組成物および関連する使用方法 |
AR077292A1 (es) | 2009-06-29 | 2011-08-17 | Agios Pharmaceuticals Inc | Derivados de piperazin - quinolin sulfonamidas y composiciones farmaceuticas |
EP2525790B1 (de) | 2009-10-21 | 2020-05-27 | Agios Pharmaceuticals, Inc. | Verfahren und zusammensetzungen für zellproliferationsbedingte erkrankungen |
CA2793835C (en) | 2009-10-21 | 2021-07-20 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
US9206426B2 (en) | 2010-03-05 | 2015-12-08 | The Trustees Of Columbia University In The City Of New York | Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof |
EP2563761A1 (de) | 2010-04-29 | 2013-03-06 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Aktivatoren der menschlichen pyruvatkinase |
CA2821975A1 (en) | 2010-12-17 | 2012-06-21 | Shunqi Yan | N-(4-(azetidine-1-carbonyl)phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase m2 pkm2 modulators |
CA2822432C (en) | 2010-12-21 | 2019-09-24 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
EP3406251B1 (de) | 2011-05-03 | 2023-11-29 | Agios Pharmaceuticals, Inc. | Pyruvatkinaseaktivatoren zur verwendung in der therapie |
JP7320339B2 (ja) | 2015-06-11 | 2023-08-03 | アジオス ファーマシューティカルズ, インコーポレイテッド | ピルビン酸キナーゼ活性化因子を使用する方法 |
DK3483164T3 (da) | 2017-03-20 | 2020-03-23 | Forma Therapeutics Inc | Pyrrolopyrrolsammensætninger som pyruvatkinase (pkr) aktivatorer |
US10675274B2 (en) | 2018-09-19 | 2020-06-09 | Forma Therapeutics, Inc. | Activating pyruvate kinase R |
EP3852791B1 (de) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Aktivierung von pyruvatkinase r |
BR112022004715A2 (pt) | 2019-09-19 | 2022-06-14 | Forma Therapeutics Inc | Composições de ativação de piruvato quinase r (pkr) |
US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821254A (en) * | 1995-02-17 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer |
WO1998035032A2 (en) * | 1997-02-11 | 1998-08-13 | The Regents Of The University Of California | Methods of inducing cell cycle stasis |
US7074895B2 (en) * | 1997-08-21 | 2006-07-11 | Quark Biotech, Inc. | Sequences characteristic of hypoxia-regulated gene transcription |
US5948628A (en) * | 1997-09-05 | 1999-09-07 | The Board Of Regents Of The University Of Oklahoma | Methods of screening for compounds which mimic galectin-1 |
US6458538B1 (en) * | 1999-12-14 | 2002-10-01 | Ptc Therapeutics, Inc. | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay |
-
2002
- 2002-05-23 AT AT02748716T patent/ATE404691T1/de not_active IP Right Cessation
- 2002-05-23 DK DK02748716T patent/DK1390525T3/da active
- 2002-05-23 AU AU2002319180A patent/AU2002319180B2/en not_active Ceased
- 2002-05-23 PT PT02748716T patent/PT1390525E/pt unknown
- 2002-05-23 WO PCT/EP2002/005684 patent/WO2002095063A1/en active IP Right Grant
- 2002-05-23 US US10/478,679 patent/US20040152648A1/en not_active Abandoned
- 2002-05-23 CA CA002448165A patent/CA2448165A1/en not_active Abandoned
- 2002-05-23 DE DE60228233T patent/DE60228233D1/de not_active Expired - Lifetime
- 2002-05-23 EP EP02748716A patent/EP1390525B8/de not_active Expired - Lifetime
- 2002-05-23 EP EP08014232A patent/EP1990422A1/de not_active Withdrawn
- 2002-05-23 ES ES02748716T patent/ES2312595T3/es not_active Expired - Lifetime
-
2007
- 2007-06-29 US US11/771,462 patent/US20080021116A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1390525A1 (de) | 2004-02-25 |
PT1390525E (pt) | 2008-11-25 |
ES2312595T3 (es) | 2009-03-01 |
DK1390525T3 (da) | 2008-12-08 |
WO2002095063A1 (en) | 2002-11-28 |
US20040152648A1 (en) | 2004-08-05 |
EP1390525B8 (de) | 2009-03-04 |
ATE404691T1 (de) | 2008-08-15 |
CA2448165A1 (en) | 2002-11-28 |
AU2002319180B2 (en) | 2007-07-05 |
EP1990422A1 (de) | 2008-11-12 |
EP1390525B1 (de) | 2008-08-13 |
US20080021116A1 (en) | 2008-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |