FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
WO2001077137A1
(en)
|
2000-04-12 |
2001-10-18 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US6605648B1
(en)
*
|
1999-04-06 |
2003-08-12 |
Phillips Plastics Corporation |
Sinterable structures and method
|
CN1191273C
(zh)
*
|
1999-05-17 |
2005-03-02 |
康久化学公司 |
长效促胰岛肽
|
US20090175821A1
(en)
*
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
US6514500B1
(en)
|
1999-10-15 |
2003-02-04 |
Conjuchem, Inc. |
Long lasting synthetic glucagon like peptide {GLP-!}
|
US6887470B1
(en)
*
|
1999-09-10 |
2005-05-03 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
US6849714B1
(en)
*
|
1999-05-17 |
2005-02-01 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
US20040266673A1
(en)
*
|
2002-07-31 |
2004-12-30 |
Peter Bakis |
Long lasting natriuretic peptide derivatives
|
US7601691B2
(en)
*
|
1999-05-17 |
2009-10-13 |
Conjuchem Biotechnologies Inc. |
Anti-obesity agents
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
US6447772B1
(en)
*
|
1999-10-01 |
2002-09-10 |
Klaire Laboratories, Inc. |
Compositions and methods relating to reduction of symptoms of autism
|
ES2311560T3
(es)
*
|
2000-12-07 |
2009-02-16 |
Eli Lilly And Company |
Proteinas de fusion glp-1.
|
JP2004520395A
(ja)
|
2001-02-02 |
2004-07-08 |
コンジュケム,インコーポレーテッド |
長期持続性成長ホルモン放出因子誘導体
|
EP1980572A1
(en)
*
|
2001-02-16 |
2008-10-15 |
ConjuChem Biotechnologies Inc. |
Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders
|
CN1162446C
(zh)
*
|
2001-05-10 |
2004-08-18 |
上海华谊生物技术有限公司 |
促胰岛素分泌肽衍生物
|
PT1479691E
(pt)
|
2001-05-31 |
2007-02-28 |
John Erickson |
Inibidores de péptido de fusão de longa duração para a infecção por hiv
|
US7576050B2
(en)
|
2001-07-31 |
2009-08-18 |
The United States Of America As Represented By The Department Of Health And Human Services |
GLP-1 exendin-4 peptide analogs and uses thereof
|
US6642003B2
(en)
|
2001-08-02 |
2003-11-04 |
Cedars-Sinai Medical Center |
Human glucose-dependent insulin-secreting cell line
|
US20030226155A1
(en)
*
|
2001-08-30 |
2003-12-04 |
Biorexis Pharmaceutical Corporation |
Modified transferrin-antibody fusion proteins
|
AU2002323501C1
(en)
*
|
2001-08-30 |
2010-04-29 |
Biorexis Technology, Inc |
Modified transferrin fusion proteins
|
US20070031440A1
(en)
*
|
2001-08-30 |
2007-02-08 |
Prior Christopher P |
Modified transferin-antibody fusion proteins
|
US8129504B2
(en)
|
2001-08-30 |
2012-03-06 |
Biorexis Technology, Inc. |
Oral delivery of modified transferrin fusion proteins
|
US7176278B2
(en)
*
|
2001-08-30 |
2007-02-13 |
Biorexis Technology, Inc. |
Modified transferrin fusion proteins
|
EP1463752A4
(en)
*
|
2001-12-21 |
2005-07-13 |
Human Genome Sciences Inc |
ALBUMIN FUSION PROTEINS
|
ES2545090T3
(es)
|
2001-12-21 |
2015-09-08 |
Human Genome Sciences, Inc. |
Proteínas de fusión de albúmina y GCSF
|
WO2003069306A2
(en)
*
|
2002-02-13 |
2003-08-21 |
Medbridge, Inc. |
Protein carrier system for therapeutic oligonucleotides
|
RU2332229C2
(ru)
*
|
2002-02-20 |
2008-08-27 |
Эмисфире Текнолоджис Инк. |
Способ введения молекул glp-1
|
US7141240B2
(en)
*
|
2002-03-12 |
2006-11-28 |
Cedars-Sinai Medical Center |
Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
|
EP1575490A4
(en)
*
|
2002-06-04 |
2007-08-08 |
Lilly Co Eli |
MODIFIED ANALOGUES OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)
|
EP1837031B1
(en)
*
|
2002-06-07 |
2009-10-14 |
Waratah Pharmaceuticals, Inc. |
Compositions and methods for treating diabetes
|
ES2327328T3
(es)
|
2002-07-04 |
2009-10-28 |
Zealand Pharma A/S |
Glp-1 y procedimientos para el tratamiento de la diabetes.
|
ATE473011T1
(de)
*
|
2002-08-30 |
2010-07-15 |
Biorexis Pharmaceutical Corp |
Modifizierte transferrin-fusionsproteine mit doppelten transferrin-amino- oder carboxy- terminalen domänen
|
EA007918B1
(ru)
*
|
2002-09-24 |
2007-02-27 |
Франтиэ Биотекнолоджиз Ко., Лтд. |
Пептидные производные-ингибиторы слияния при вич-инфекции
|
JP2006517908A
(ja)
*
|
2002-10-02 |
2006-08-03 |
ジーランド・ファーマ・ア/エス |
安定化したエキセンディン−4化合物
|
US20040229810A1
(en)
*
|
2002-10-22 |
2004-11-18 |
Antonio Cruz |
Gastrin compositions and formulations, and methods of use and preparation
|
US20040209803A1
(en)
*
|
2002-12-19 |
2004-10-21 |
Alain Baron |
Compositions for the treatment and prevention of nephropathy
|
US7790681B2
(en)
*
|
2002-12-17 |
2010-09-07 |
Amylin Pharmaceuticals, Inc. |
Treatment of cardiac arrhythmias with GLP-1 receptor ligands
|
US7731947B2
(en)
|
2003-11-17 |
2010-06-08 |
Intarcia Therapeutics, Inc. |
Composition and dosage form comprising an interferon particle formulation and suspending vehicle
|
US7314859B2
(en)
*
|
2002-12-27 |
2008-01-01 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
US7655618B2
(en)
*
|
2002-12-27 |
2010-02-02 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
CA2513213C
(en)
|
2003-01-22 |
2013-07-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20070060512A1
(en)
*
|
2003-03-04 |
2007-03-15 |
Homayoun Sadeghi |
Dipeptidyl-peptidase protected protein
|
KR20050122220A
(ko)
*
|
2003-03-25 |
2005-12-28 |
다케다 샌디에고, 인코포레이티드 |
디펩티딜 펩티다제 억제제
|
BRPI0408978B8
(pt)
*
|
2003-04-08 |
2021-07-27 |
Novo Nordisk As |
processos para regenerar uma fase estacionária cromatográfica
|
WO2004089985A1
(en)
*
|
2003-04-11 |
2004-10-21 |
Novo Nordisk A/S |
Stable pharmaceutical compositions
|
CA2523267C
(en)
|
2003-04-23 |
2013-09-03 |
Biovalve Technologies, Inc. |
Hydraulically actuated pump for long duration medicament administration
|
BRPI0410840A
(pt)
|
2003-05-30 |
2006-07-04 |
Ranbaxy Lab Ltd |
derivados substituìdos de pirrol, composição farmacêutica contendo os mesmos e processo para sua preparação
|
PT1641823E
(pt)
|
2003-06-12 |
2011-11-08 |
Lilly Co Eli |
Proteínas de fusão de análogos de glp-1
|
ATE433994T1
(de)
*
|
2003-07-25 |
2009-07-15 |
Conjuchem Biotechnologies Inc |
Insulinderivative mit langanhaltender wirkung und verfahren zu deren herstellung
|
CN1964989B
(zh)
*
|
2003-07-25 |
2012-02-01 |
康久化学生物技术公司 |
长效胰岛素衍生物及其方法
|
US20050065148A1
(en)
|
2003-08-13 |
2005-03-24 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
EP1663278A4
(en)
*
|
2003-08-28 |
2009-07-29 |
Biorexis Pharmaceutical Corp |
EPO MIMETIC PEPTIDES AND FUSION PROTEINS
|
US20060205037A1
(en)
*
|
2003-08-28 |
2006-09-14 |
Homayoun Sadeghi |
Modified transferrin fusion proteins
|
EP1663289A2
(en)
*
|
2003-08-29 |
2006-06-07 |
Amylin Pharmaceuticals, Inc. |
Methods for treating or ameliorating ghrelin-associated diseases and disorders
|
EP1699777B1
(en)
*
|
2003-09-08 |
2012-12-12 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
US7214190B1
(en)
|
2003-09-09 |
2007-05-08 |
Kitchener Clark Wilson |
Apparatus and method for noninvasive monitoring of analytes in body fluids
|
WO2005058958A2
(en)
|
2003-12-18 |
2005-06-30 |
Novo Nordisk A/S |
Novel glp-1 analogues linked to albumin-like agents
|
US20060286129A1
(en)
*
|
2003-12-19 |
2006-12-21 |
Emisphere Technologies, Inc. |
Oral GLP-1 formulations
|
EP1711532A4
(en)
*
|
2004-01-30 |
2009-09-16 |
Waratah Pharmaceuticals Inc |
USE OF A GLP-1 AGONIST WITH GASTRINIC COMPOUNDS
|
CN102816241B
(zh)
|
2004-02-09 |
2015-07-22 |
人类基因科学公司 |
清蛋白融合蛋白
|
US8076288B2
(en)
*
|
2004-02-11 |
2011-12-13 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides having glucose lowering activity
|
CN102079743B
(zh)
*
|
2004-03-15 |
2020-08-25 |
武田药品工业株式会社 |
二肽基肽酶抑制剂
|
DE602005014969D1
(de)
*
|
2004-04-23 |
2009-07-30 |
Conjuchem Biotechnologies Inc |
Verfahren zur aufreinigung von albumin-konjugaten
|
CN1318587C
(zh)
*
|
2004-04-30 |
2007-05-30 |
成都芝田生物工程有限公司 |
酰胺化Exendin-4多肽的重组制备方法
|
US9089636B2
(en)
|
2004-07-02 |
2015-07-28 |
Valeritas, Inc. |
Methods and devices for delivering GLP-1 and uses thereof
|
AU2012202855B2
(en)
*
|
2004-09-03 |
2015-02-26 |
Philipps-Universitat Marburg |
GLP-1 and exendin related invention
|
DE102004043153B4
(de)
*
|
2004-09-03 |
2013-11-21 |
Philipps-Universität Marburg |
Erfindung betreffend GLP-1 und Exendin
|
JP5107713B2
(ja)
*
|
2004-10-07 |
2012-12-26 |
ノヴォ ノルディスク アー/エス |
遅延性のエキセンディン−4化合物
|
US7893017B2
(en)
|
2004-10-07 |
2011-02-22 |
Novo Nordisk A/S |
Protracted GLP-1 compounds
|
CN101056650A
(zh)
*
|
2004-11-12 |
2007-10-17 |
诺和诺德公司 |
促胰岛素肽的稳定制剂
|
US7872124B2
(en)
*
|
2004-12-21 |
2011-01-18 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
US8716221B2
(en)
*
|
2005-01-14 |
2014-05-06 |
Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. |
Modified exendins and uses thereof
|
TWI376234B
(en)
|
2005-02-01 |
2012-11-11 |
Msd Oss Bv |
Conjugates of a polypeptide and an oligosaccharide
|
US11246913B2
(en)
|
2005-02-03 |
2022-02-15 |
Intarcia Therapeutics, Inc. |
Suspension formulation comprising an insulinotropic peptide
|
WO2006083761A2
(en)
|
2005-02-03 |
2006-08-10 |
Alza Corporation |
Solvent/polymer solutions as suspension vehicles
|
TWI362392B
(en)
|
2005-03-18 |
2012-04-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
US8603972B2
(en)
|
2005-03-18 |
2013-12-10 |
Novo Nordisk A/S |
Extended GLP-1 compounds
|
CA2617649A1
(en)
*
|
2005-08-11 |
2007-02-22 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
SI1931350T2
(sl)
*
|
2005-09-14 |
2021-11-30 |
Takeda Pharmaceutical Company Limited |
Uporaba inhibitorjev dipeptidil peptidaze
|
US20070060529A1
(en)
*
|
2005-09-14 |
2007-03-15 |
Christopher Ronald J |
Administration of dipeptidyl peptidase inhibitors
|
PT1942898E
(pt)
|
2005-09-14 |
2011-12-20 |
Takeda Pharmaceutical |
Inibidores da dipeptidilpeptidase para o tratamento da diabetes
|
TW200745079A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|
EP1924567B1
(en)
*
|
2005-09-16 |
2012-08-22 |
Takeda Pharmaceutical Company Limited |
Process for the preparation of pyrimidinedione derivatives
|
TW200745080A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
|
WO2007051987A1
(en)
*
|
2005-11-01 |
2007-05-10 |
Activotec Spp Limited |
Insulinotropic compounds and uses thereof
|
KR101329112B1
(ko)
|
2005-11-08 |
2013-11-14 |
랜박시 래보러터리스 리미티드 |
(3r,5r)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
|
WO2007053946A1
(en)
*
|
2005-11-09 |
2007-05-18 |
Conjuchem Biotechnologies Inc. |
Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
|
US20080280328A1
(en)
*
|
2005-11-18 |
2008-11-13 |
Novozymes A/S |
Glucoamylase Variants
|
CA2634495A1
(en)
*
|
2005-12-22 |
2007-06-28 |
Conjuchem Biotechnologies Inc. |
Process for the production of preformed conjugates of albumin and a therapeutic agent
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
ES2364982T3
(es)
|
2006-02-08 |
2011-09-20 |
Lonza Ag |
Síntesis de péptidos similares a glucagón.
|
JP2009531456A
(ja)
*
|
2006-03-28 |
2009-09-03 |
武田薬品工業株式会社 |
(r)−3−アミノピペリジン二塩酸塩の調製
|
CA2646324C
(en)
|
2006-03-30 |
2016-06-07 |
Valeritas, Llc |
Multi-cartridge fluid delivery device
|
JP5143131B2
(ja)
|
2006-05-30 |
2013-02-13 |
インターシア セラピューティクス,インコーポレイティド |
浸透圧送出システムの二片構成内部チャネル型の流れモジュレータ
|
KR100886783B1
(ko)
|
2006-06-12 |
2009-03-04 |
성균관대학교산학협력단 |
N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도
|
KR20090039787A
(ko)
|
2006-07-18 |
2009-04-22 |
센토코 인코포레이티드 |
인간 glp-1 모방체, 조성물, 방법 및 용도
|
CN101511868B
(zh)
|
2006-07-24 |
2013-03-06 |
比奥雷克西斯制药公司 |
毒蜥外泌肽融合蛋白
|
JP5048773B2
(ja)
|
2006-08-09 |
2012-10-17 |
インターシア セラピューティクス,インコーポレイティド |
浸透圧式デリバリーシステム及びピストンアセンブリー
|
CL2007002634A1
(es)
*
|
2006-09-13 |
2008-05-16 |
Smithkline Beecham Corp |
Uso de una composicion que comprende al menos un polipeptido que tiene actividad de peptido-1 semejante a glucagon (glp-1) como agente hipoglucemiante de larga duracion.
|
KR102062824B1
(ko)
*
|
2006-09-13 |
2020-01-07 |
다케다 야쿠힌 고교 가부시키가이샤 |
2-[6-(3-아미노-피페리딘-1-일)-3-메틸-2,4-디옥소-3,4-디하이드로-2h-피리미딘-1-일메틸]-4-플루오로-벤조니트릴의 용도
|
US8324383B2
(en)
|
2006-09-13 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
|
TW200838536A
(en)
*
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
AU2011254001B2
(en)
*
|
2007-01-05 |
2012-08-02 |
Covx Technologies Ireland Limited |
Glucagon-like protein-1 receptor (GLP-1R) agonist compounds
|
US20090098130A1
(en)
*
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
US20090099074A1
(en)
*
|
2007-01-10 |
2009-04-16 |
Conjuchem Biotechnologies Inc. |
Modulating food intake
|
GEP20135944B
(en)
|
2007-02-15 |
2013-10-25 |
Indiana Unversity Research And Tech Corporation |
Glucagon/glp-1 receptor co-agonists
|
US8093236B2
(en)
|
2007-03-13 |
2012-01-10 |
Takeda Pharmaceuticals Company Limited |
Weekly administration of dipeptidyl peptidase inhibitors
|
RU2440097C2
(ru)
|
2007-04-23 |
2012-01-20 |
Интарсия Терапьютикс, Инк. |
Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
|
WO2008154619A1
(en)
*
|
2007-06-12 |
2008-12-18 |
Smithkline Beecham Corporation |
Methods for detecting protein in plasma
|
US20090054332A1
(en)
*
|
2007-06-21 |
2009-02-26 |
Conjuchem Biotechnologies, Inc. |
Thombopoietin peptide conjugates
|
US7960336B2
(en)
*
|
2007-08-03 |
2011-06-14 |
Pharmain Corporation |
Composition for long-acting peptide analogs
|
EP2190460B1
(en)
|
2007-09-05 |
2014-12-17 |
Novo Nordisk A/S |
Peptides derivatized with a-b-c-d- and their therapeutical use
|
ES2550363T3
(es)
|
2007-09-05 |
2015-11-06 |
Novo Nordisk A/S |
Derivados truncados de GLP-1 y su uso terapéutico
|
CN101868476B
(zh)
|
2007-09-05 |
2015-02-25 |
诺沃-诺迪斯克有限公司 |
胰高血糖素样肽-1衍生物及其制药用途
|
CN101835794A
(zh)
*
|
2007-10-27 |
2010-09-15 |
霍夫曼-拉罗奇有限公司 |
使用固相和溶液相组合技术的促胰岛素肽合成法
|
US20090186819A1
(en)
*
|
2007-12-11 |
2009-07-23 |
Marieve Carrier |
Formulation of insulinotropic peptide conjugates
|
EP2240155B1
(en)
|
2008-02-13 |
2012-06-06 |
Intarcia Therapeutics, Inc |
Devices, formulations, and methods for delivery of multiple beneficial agents
|
WO2009143285A2
(en)
|
2008-05-21 |
2009-11-26 |
Amylin Pharmaceuticals, Inc. |
Exendins to lower cholestrol and triglycerides
|
EA019203B9
(ru)
|
2008-06-17 |
2014-03-31 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Коагонисты глюкагонового рецептора/glp-1-рецептора
|
KR20110040760A
(ko)
|
2008-06-17 |
2011-04-20 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
대사 질환 및 비만 치료용 gip-기초된 혼합형 항진제
|
CN105727261A
(zh)
|
2008-06-27 |
2016-07-06 |
杜克大学 |
包含弹性蛋白样肽的治疗剂
|
EP2323694A1
(en)
|
2008-08-06 |
2011-05-25 |
Novo Nordisk Health Care AG |
Conjugated proteins with prolonged in vivo efficacy
|
TW201012829A
(en)
*
|
2008-09-22 |
2010-04-01 |
Ipsen Mfg Ireland Ltd |
Process for the synthesis of (Aib8,35)hGLP-1(7-36)-NH2
|
JP2012505637A
(ja)
|
2008-10-15 |
2012-03-08 |
アンジオケム,インコーポレーテッド |
Glp−1アゴニストのコンジュゲート及びその使用
|
MX349717B
(es)
|
2008-10-17 |
2017-08-09 |
Sanofi Aventis Deutschland |
Combinación de una insulina y un agonista de glp-1.
|
AU2009322043A1
(en)
|
2008-12-05 |
2011-07-07 |
Angiochem Inc. |
Conjugates of neurotensin or neurotensin analogs and uses thereof
|
WO2010068735A1
(en)
|
2008-12-10 |
2010-06-17 |
Glaxosmithkline Llc. |
Pharmaceutical compositions
|
AU2010207725B2
(en)
|
2009-01-22 |
2015-06-11 |
Novo Nordisk Health Care Ag |
Stable growth hormone compounds
|
MX2011008913A
(es)
|
2009-02-25 |
2011-09-08 |
Merck Sharp & Dohme |
Diseño metabolico de una via de asimilacion de galactosa en la levadura pichia pastoris glucodiseñada.
|
JP2012523434A
(ja)
|
2009-04-10 |
2012-10-04 |
アミリン・ファーマシューティカルズ,インコーポレイテッド |
エストロゲン欠乏哺乳類のためのアミリンアゴニスト化合物
|
MX2011013625A
(es)
|
2009-06-16 |
2012-01-20 |
Univ Indiana Res & Tech Corp |
Compuestos glucagon activo de receptor de gip.
|
CN102596993A
(zh)
*
|
2009-07-02 |
2012-07-18 |
安吉奥开米公司 |
多聚体肽结合物以及其应用
|
CN101987868B
(zh)
*
|
2009-07-30 |
2013-09-04 |
江苏豪森医药集团有限公司 |
Glp-1类似物的衍生物或其可药用盐和用途
|
CN102612376A
(zh)
|
2009-08-06 |
2012-07-25 |
诺沃-诺迪斯克保健股份有限公司 |
具有延长的体内功效的生长激素
|
US8298561B2
(en)
|
2009-09-28 |
2012-10-30 |
Intarcia Therapeutics, Inc. |
Rapid establishment and/or termination of substantial steady-state drug delivery
|
EP2484386B1
(en)
*
|
2009-09-30 |
2019-04-17 |
Kyoto University |
Molecular probe for pancreatic islets imaging and use of said probe
|
EP2491054A2
(en)
|
2009-10-22 |
2012-08-29 |
Cadila Healthcare Limited |
Short chain peptidomimetics based orally active glp-1 agonist and glucagon receptor antagonist
|
KR101915454B1
(ko)
|
2009-11-13 |
2018-11-06 |
사노피-아벤티스 도이칠란트 게엠베하 |
Glp-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
|
PE20121362A1
(es)
|
2009-11-13 |
2012-10-17 |
Sanofi Aventis Deutschland |
Composicion farmaceutica que comprende despro36exendina-4(1-39)-lys6-nh2, insulina gly(a21)-arg(b31)-arg(b32) y metionina
|
JP2013511287A
(ja)
|
2009-11-23 |
2013-04-04 |
アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー |
ポリペプチド・コンジュゲート
|
SI2525834T1
(sl)
|
2010-01-22 |
2019-10-30 |
Novo Nordisk Healthcare Ag |
Rastni hormoni s podaljšano in vivo učinkovitostjo
|
MX338357B
(es)
|
2010-01-22 |
2016-04-13 |
Novo Nordisk Healthcare Ag |
Compuestos estables de la hormona de crecimiento.
|
RU2012136450A
(ru)
|
2010-01-27 |
2014-03-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Конъюгаты антагонист глюкагона - агонист gip и композиции для лечения метаболических расстройств и ожирения
|
JP5976549B2
(ja)
|
2010-02-24 |
2016-08-24 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ピチア・パストリスにおいて産生される治療用糖タンパク質上のn−グリコシル化部位占拠を増加させるための方法
|
CA2792663A1
(en)
*
|
2010-03-26 |
2011-09-29 |
Novo Nordisk A/S |
Novel glucagon analogues
|
WO2011123943A1
(en)
|
2010-04-09 |
2011-10-13 |
Mount Sinai Hospital |
Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
|
CA2797133C
(en)
|
2010-04-27 |
2019-08-06 |
Zealand Pharma A/S |
Peptide conjugates of glp-1 receptor agonists and gastrin and their use
|
JP2013525491A
(ja)
|
2010-05-04 |
2013-06-20 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
心血管障害を治療または予防し心血管保護を提供する方法
|
BR112012028707A2
(pt)
|
2010-05-13 |
2019-09-24 |
Univ Indiana Res & Tech Corp |
composto de glucagon da superfamília de peptídeos exibindo atividade do receptor g com proteína acoplada, pró farmaco, dímero ou multímro, composição farmacêutica que o compreendem e método de administração do mesmo.
|
CN103079587B
(zh)
|
2010-05-13 |
2016-05-11 |
印第安纳大学研究及科技有限公司 |
呈现核激素受体活性的胰高血糖素超家族肽
|
BR112013004756B1
(pt)
|
2010-08-30 |
2020-04-28 |
Sanofi Aventis Deutschland |
uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
|
EP3326620B1
(en)
|
2010-12-16 |
2020-03-04 |
Novo Nordisk A/S |
Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2- hydroxybenzoyl)amino)caprylic acid
|
BR112013015389A2
(pt)
|
2010-12-22 |
2016-11-22 |
Univ Indiana Res & Tech Corp |
análogo de glucagon exibindo atividade de receptor gip
|
US20120208755A1
(en)
|
2011-02-16 |
2012-08-16 |
Intarcia Therapeutics, Inc. |
Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
|
AU2012225749B2
(en)
|
2011-03-04 |
2015-01-22 |
Intrexon Corporation |
Vectors conditionally expressing protein
|
KR101972836B1
(ko)
|
2011-04-12 |
2019-04-29 |
노보 노르디스크 에이/에스 |
이중 아실화된 glp-1 유도체
|
US9821032B2
(en)
|
2011-05-13 |
2017-11-21 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
|
AU2012273365A1
(en)
|
2011-06-22 |
2014-01-16 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
MX347703B
(es)
|
2011-06-22 |
2017-05-09 |
Univ Indiana Res & Tech Corp |
Co-agonistas del receptor de glucagon/glp-1.
|
KR101357117B1
(ko)
|
2011-06-28 |
2014-02-06 |
비앤엘델리팜 주식회사 |
폴리에틸렌글라이콜 또는 이의 유도체로 페길화된 엑센딘-4 유사체, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨병 예방 또는 치료용 약학적 조성물
|
WO2013030160A1
(en)
|
2011-08-29 |
2013-03-07 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
|
TWI559929B
(en)
|
2011-09-01 |
2016-12-01 |
Sanofi Aventis Deutschland |
Pharmaceutical composition for use in the treatment of a neurodegenerative disease
|
CN103189389B
(zh)
*
|
2011-09-03 |
2017-08-11 |
深圳市健元医药科技有限公司 |
新的glp‑ⅰ类似物及其制备方法和用途
|
CN102286092B
(zh)
*
|
2011-09-14 |
2014-01-01 |
深圳翰宇药业股份有限公司 |
利拉鲁肽的固相合成方法
|
CA2849673A1
(en)
|
2011-09-23 |
2013-03-28 |
Novo Nordisk A/S |
Novel glucagon analogues
|
JP6359972B2
(ja)
|
2011-11-03 |
2018-07-18 |
ジーランド ファーマ アクティーゼルスカブ |
Glp−1受容体アゴニストペプチドガストリンコンジュゲート
|
US9499587B2
(en)
|
2012-01-23 |
2016-11-22 |
University Of South Florida |
Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
|
SMT201800491T1
(it)
|
2012-03-22 |
2018-11-09 |
Novo Nordisk As |
Composizioni di peptidi glp-1 e relativa preparazione
|
TR201903918T4
(tr)
|
2012-03-22 |
2019-04-22 |
Novo Nordisk As |
Bir dağıtım ajanı içeren bileşimler ve bunların hazırlanması.
|
US20150111246A1
(en)
*
|
2012-04-24 |
2015-04-23 |
Astrazeneca Pharmaceuticals Lp |
Site-specific enzymatic modification of exendins and analogs thereof
|
KR102434075B1
(ko)
|
2012-05-17 |
2022-08-19 |
익스텐드 바이오사이언시즈, 인크. |
개선된 약물 전달용 캐리어
|
ES2871328T3
(es)
|
2012-06-20 |
2021-10-28 |
Novo Nordisk As |
Formulación de comprimido que comprende un péptido y un agente de suministro
|
ES2602486T3
(es)
|
2012-06-21 |
2017-02-21 |
Indiana University Research And Technology Corporation |
Análogos de glucagón que muestran actividad de receptor de GIP
|
EP2863954A1
(en)
|
2012-06-21 |
2015-04-29 |
Indiana University Research and Technology Corporation |
Incretin receptor ligand polypeptide fc-region fusion polypeptides and conjugates with altered fc-effector function
|
JP6534927B2
(ja)
|
2012-07-23 |
2019-06-26 |
ジーランド ファーマ アクティーゼルスカブ |
グルカゴン類似体
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
PE20151239A1
(es)
|
2012-12-21 |
2015-09-08 |
Sanofi Sa |
Derivados de exendina-4 funcionalizada
|
TWI780236B
(zh)
|
2013-02-04 |
2022-10-11 |
法商賽諾菲公司 |
胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
|
PL2956476T4
(pl)
|
2013-02-18 |
2020-09-21 |
Vegenics Pty Limited |
Cząsteczki wiążące ligand i ich zastosowania
|
WO2014158900A1
(en)
|
2013-03-14 |
2014-10-02 |
Indiana University Research And Technology Corporation |
Insulin-incretin conjugates
|
CN104650212A
(zh)
*
|
2013-03-15 |
2015-05-27 |
深圳君圣泰生物技术有限公司 |
一种多肽、多肽衍生物、多肽的可药用盐、药物组合物及其应用
|
CN104592380A
(zh)
*
|
2013-03-15 |
2015-05-06 |
深圳君圣泰生物技术有限公司 |
一种多肽、多肽衍生物、多肽的可药用盐、药物组合物及其应用
|
AR095986A1
(es)
*
|
2013-04-03 |
2015-11-25 |
Sanofi Sa |
Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas
|
WO2014166836A1
(en)
|
2013-04-05 |
2014-10-16 |
Novo Nordisk A/S |
Growth hormone compound formulation
|
SI2986313T1
(sl)
|
2013-04-18 |
2019-09-30 |
Novo Nordisk A/S |
Stabilni koagonisti GLP-1 / glukagonskega receptorja z dolgotrajnim učinkom za medicinsko uporabo
|
ES2688462T3
(es)
|
2013-05-02 |
2018-11-02 |
Novo Nordisk A/S |
Dosificación oral de compuestos de GLP-1
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
EA034322B1
(ru)
|
2013-10-17 |
2020-01-28 |
Зилэнд Фарма А/С |
Ацилированные аналоги глюкагона
|
BR112016009889B1
(pt)
|
2013-11-06 |
2023-11-28 |
Zealand Pharma A/S |
Análogo do gip, composição farmacêutica compreendendo um análogo do gip, ou um sal farmaceuticamente aceitável do mesmo, e seu uso
|
US10131702B2
(en)
|
2013-11-06 |
2018-11-20 |
Zealand Pharma A/S |
Glucagon-GLP-1-GIP triple agonist compounds
|
EP3080154B1
(en)
|
2013-12-13 |
2018-02-07 |
Sanofi |
Dual glp-1/gip receptor agonists
|
WO2015086733A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Dual glp-1/glucagon receptor agonists
|
TW201609796A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
非醯化之艾塞那肽-4(exendin-4)胜肽類似物
|
TW201609795A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物
|
WO2015095684A1
(en)
|
2013-12-20 |
2015-06-25 |
Indiana University Research And Technology Corporation |
Lipidated incretin receptor ligand human immunoglobulin fc-region fusion polypeptides
|
CA2932873A1
(en)
|
2014-01-09 |
2015-07-16 |
Sanofi |
Stabilized pharmaceutical formulations of insulin aspart
|
KR20160104724A
(ko)
|
2014-01-09 |
2016-09-05 |
사노피 |
인슐린 유사체 및/또는 인슐린 유도체의 안정화된 약제학적 제형
|
JP6723921B2
(ja)
|
2014-01-09 |
2020-07-15 |
サノフイSanofi |
インスリンアナログおよび/またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤
|
US11299528B2
(en)
|
2014-03-11 |
2022-04-12 |
D&D Pharmatech Inc. |
Long acting TRAIL receptor agonists for treatment of autoimmune diseases
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自exendin-4之雙重glp-1/升糖素受體促效劑
|
WO2015185640A1
(en)
|
2014-06-04 |
2015-12-10 |
Novo Nordisk A/S |
Glp-1/glucagon receptor co-agonists for medical use
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
GB201415598D0
(en)
|
2014-09-03 |
2014-10-15 |
Univ Birmingham |
Elavated Itercranial Pressure Treatment
|
US10232020B2
(en)
|
2014-09-24 |
2019-03-19 |
Indiana University Research And Technology Corporation |
Incretin-insulin conjugates
|
US9889085B1
(en)
|
2014-09-30 |
2018-02-13 |
Intarcia Therapeutics, Inc. |
Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
US9616109B2
(en)
|
2014-10-22 |
2017-04-11 |
Extend Biosciences, Inc. |
Insulin vitamin D conjugates
|
JP6946182B2
(ja)
|
2014-10-22 |
2021-10-06 |
エクステンド バイオサイエンシズ インコーポレーテッドExtend Biosciences, Inc |
治療用ビタミンdコンジュゲート
|
RU2716985C2
(ru)
|
2014-10-29 |
2020-03-17 |
Зилэнд Фарма А/С |
Соединения-агонисты gip и способы
|
LT3229828T
(lt)
|
2014-12-12 |
2023-06-12 |
Sanofi-Aventis Deutschland Gmbh |
Insulino glargino/liksisenatido fiksuoto santykio kompozicija
|
TWI748945B
(zh)
|
2015-03-13 |
2021-12-11 |
德商賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患治療
|
TW201705975A
(zh)
|
2015-03-18 |
2017-02-16 |
賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患之治療
|
TWI707867B
(zh)
|
2015-04-16 |
2020-10-21 |
丹麥商西蘭製藥公司 |
醯化之昇糖素類似物
|
MX2017015504A
(es)
|
2015-06-03 |
2018-05-15 |
Intarcia Therapeutics Inc |
Sistemas de colocacion y remoción de implante.
|
AR105319A1
(es)
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
WO2016205367A1
(en)
|
2015-06-15 |
2016-12-22 |
Angiochem Inc. |
Methods for the treatment of leptomeningeal carcinomatosis
|
AR105284A1
(es)
|
2015-07-10 |
2017-09-20 |
Sanofi Sa |
Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
|
JP6797203B2
(ja)
|
2015-12-17 |
2020-12-09 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
デスレセプターアゴニストによる全身性硬化症の改善
|
ES2968038T3
(es)
|
2015-12-23 |
2024-05-06 |
Univ Johns Hopkins |
Agonista GLP-1R de acción prolongada como terapia de afecciones neurológicas y neurodegenerativas
|
US11084879B2
(en)
|
2016-04-07 |
2021-08-10 |
The Johns Hopkins University |
Compositions and methods for treating pancreatitis and pain with death receptor agonists
|
TWI754643B
(zh)
|
2016-05-16 |
2022-02-11 |
美商因塔希亞治療公司 |
升糖素受體選擇性多肽和彼之使用方法
|
USD860451S1
(en)
|
2016-06-02 |
2019-09-17 |
Intarcia Therapeutics, Inc. |
Implant removal tool
|
USD840030S1
(en)
|
2016-06-02 |
2019-02-05 |
Intarcia Therapeutics, Inc. |
Implant placement guide
|
CN108070030B
(zh)
*
|
2016-11-17 |
2023-06-23 |
江苏豪森药业集团有限公司 |
洛塞那肽及其类似物的制备方法
|
EP3551651B1
(en)
|
2016-12-09 |
2024-03-06 |
Zealand Pharma A/S |
Acylated glp-1/glp-2 dual agonists
|
IL307966A
(en)
|
2017-01-03 |
2023-12-01 |
Intarcia Therapeutics Inc |
Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug
|
JOP20180028A1
(ar)
|
2017-03-31 |
2019-01-30 |
Takeda Pharmaceuticals Co |
مركب ببتيد
|
CN109503700A
(zh)
*
|
2017-09-14 |
2019-03-22 |
南京安吉生物科技有限公司 |
马来酰亚胺基团修饰的血管生成抑制剂hm-1及其应用
|
US10905750B2
(en)
|
2017-11-10 |
2021-02-02 |
Donald J. Davidson |
GRP78 antagonist that block binding of receptor tyrosine kinase orphan receptors as immunotherapy anticancer agents
|
MA53076B1
(fr)
|
2018-02-02 |
2023-11-30 |
Novo Nordisk As |
Compositions solides comportant un agoniste glp-1, du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate et un lubrifiant
|
WO2019200594A1
(zh)
|
2018-04-19 |
2019-10-24 |
杭州先为达生物科技有限公司 |
酰化的glp-1衍生物
|
BR112021006823A2
(pt)
|
2018-10-11 |
2021-07-27 |
Intarcia Therapeutics, Inc. |
polipeptídeos análogos de amilina humana e métodos de uso
|
CN109400695B
(zh)
|
2018-10-31 |
2020-06-30 |
中南大学湘雅医院 |
一种多肽的修饰方法及应用
|
CN110183531A
(zh)
*
|
2019-05-17 |
2019-08-30 |
河北常山生化药业股份有限公司 |
一种艾本那肽前体的制备方法
|
CN111333714A
(zh)
*
|
2020-03-05 |
2020-06-26 |
成都奥达生物科技有限公司 |
一种长效glp-1化合物
|
EP4126907A1
(en)
*
|
2020-03-27 |
2023-02-08 |
Epivax, Inc. |
Tregitope constructs useful in the prevention and treatment of type 1 diabetes
|
WO2024072637A2
(en)
|
2022-09-30 |
2024-04-04 |
Extend Biosciences, Inc. |
Long-acting parathyroid hormone
|
WO2024123812A1
(en)
|
2022-12-05 |
2024-06-13 |
Shattuck Labs, Inc. |
Fusion proteins for the treatment of cardiometabolic diseases
|
WO2025069009A1
(en)
|
2023-09-29 |
2025-04-03 |
Graviton Bioscience Bv |
Rock2 inhibitors in the treatment of obesity
|