[go: up one dir, main page]

DE60113445D1 - Substanzen mit verzweigten linkermolekülen - Google Patents

Substanzen mit verzweigten linkermolekülen

Info

Publication number
DE60113445D1
DE60113445D1 DE60113445T DE60113445T DE60113445D1 DE 60113445 D1 DE60113445 D1 DE 60113445D1 DE 60113445 T DE60113445 T DE 60113445T DE 60113445 T DE60113445 T DE 60113445T DE 60113445 D1 DE60113445 D1 DE 60113445D1
Authority
DE
Germany
Prior art keywords
branched
linkermolekülen
substances
branched linkers
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60113445T
Other languages
English (en)
Other versions
DE60113445T2 (de
Inventor
Herbert Andres
Hans-Peter Josel
Eva Hoess
Rupert Herrmann
Der Eltz Herbert Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Priority to DE60113445T priority Critical patent/DE60113445T2/de
Application granted granted Critical
Publication of DE60113445D1 publication Critical patent/DE60113445D1/de
Publication of DE60113445T2 publication Critical patent/DE60113445T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
DE60113445T 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen Expired - Lifetime DE60113445T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE60113445T DE60113445T2 (de) 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10048417A DE10048417A1 (de) 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker
DE10048417 2000-09-29
DE60113445T DE60113445T2 (de) 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen
PCT/EP2001/011118 WO2002027315A2 (en) 2000-09-29 2001-09-26 Compounds with a branched linker

Publications (2)

Publication Number Publication Date
DE60113445D1 true DE60113445D1 (de) 2005-10-20
DE60113445T2 DE60113445T2 (de) 2006-06-29

Family

ID=7658168

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10048417A Withdrawn DE10048417A1 (de) 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker
DE60113445T Expired - Lifetime DE60113445T2 (de) 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10048417A Withdrawn DE10048417A1 (de) 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker

Country Status (10)

Country Link
US (2) US20040086943A1 (de)
EP (1) EP1327146B1 (de)
JP (1) JP3647845B2 (de)
AT (1) ATE304709T1 (de)
AU (1) AU2002215904A1 (de)
CA (1) CA2423916C (de)
DE (2) DE10048417A1 (de)
DK (1) DK1327146T3 (de)
ES (1) ES2248405T3 (de)
WO (1) WO2002027315A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361933B1 (ko) 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
US6858210B1 (en) 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
CA2414076A1 (en) 2000-06-08 2001-12-13 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
DK1392359T4 (da) 2001-05-11 2013-06-10 Ludwig Inst For Cancer Res Ltd Specifikke bindingsproteiner og deres anvendelser.
US20030199466A1 (en) 2001-06-21 2003-10-23 Fearon Karen L. Chimeric immunomodulatory compounds and methods of using the same - ll
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
DE10393455D2 (de) * 2002-07-19 2005-06-16 Mologen Ag DNA-Expressionskonstrukt zur multiplen Genexpression
GB0329825D0 (en) * 2003-12-23 2004-01-28 Celltech R&D Ltd Biological products
CA2574683C (en) * 2004-07-30 2013-05-28 Advanced Life Science Institute, Inc. Probe complex
DE112006003704A5 (de) 2005-11-25 2008-10-23 Mologen Ag DNA-Konstrukte zur spezifischen Hemmung der Genexpression durch RNA-Interferenz
GB0607479D0 (en) * 2006-04-13 2006-05-24 Johnson Matthey Plc Adhesion promoting compound
EP2126127B1 (de) 2007-01-25 2016-09-28 Dana-Farber Cancer Institute, Inc. Verwendung von anti-egfr-antikörpern bei der behandlung von durch egfr-mutanten vermittelten krankheiten
AU2008227123B2 (en) 2007-03-15 2014-03-27 Ludwig Institute For Cancer Research Ltd. Treatment method using EGFR antibodies and src inhibitors and related formulations
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
EP2318051A4 (de) * 2008-07-14 2012-12-26 Andrew Metters In-vitro-diagnosekmarker mit kohlenstoffnanopartikeln und kits
CN103588801A (zh) * 2013-12-02 2014-02-19 天津大港油田圣达科技有限公司 一种微量元素井间示踪剂的使用方法
CN118362716A (zh) 2018-12-28 2024-07-19 雅培制药有限公司 微粒上的单分子的直接检测
WO2021127435A1 (en) * 2019-12-18 2021-06-24 Fluidigm Canada Inc. Mass cytometry reagents and methods for signal amplification

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075447A (en) * 1984-09-17 1991-12-24 Hoffmann-La Roche Inc. Ruthenium complexes useful as carriers for immunologically active materials
DK365785A (da) * 1984-09-17 1986-03-18 Hoffmann La Roche Metalcomplexer
FR2579224B1 (fr) * 1985-03-25 1987-05-22 Genetica Procede de preparation microbiologique de la serum-albumine humaine
US5750409A (en) * 1991-11-18 1998-05-12 Boehringer Mannheim Gmbh Pentacyclic compounds and their use as absorption or fluorescent dyes
GB9215780D0 (en) * 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
DE4310141A1 (de) * 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Homobidentale trifunktionelle Linker
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
CA2172145C (en) * 1994-07-25 2010-09-21 Hans-Peter Josel Metal complexes with a charged linker
AU684992B2 (en) * 1994-07-25 1998-01-08 Boehringer Mannheim Gmbh Hapten-marked peptides
EP0772616B1 (de) * 1994-07-25 1999-12-15 Roche Diagnostics GmbH Hydrophile metallkomplexe
WO1996003651A1 (de) * 1994-07-25 1996-02-08 Boehringer Mannheim Gmbh Metallchelat-markierte peptide
EP0772774B1 (de) * 1994-07-25 2006-06-28 Roche Diagnostics GmbH Bestimmung von spezifischem immunglobulin unter verwendung multipler antigene
US5718915A (en) * 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
DE19519973A1 (de) * 1995-05-31 1996-12-05 Boehringer Mannheim Gmbh Entstörungsreagenz für die Bestimmung eines Analyten mit einem lumineszenzfähigen Metallkomplex
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
WO1998019705A1 (en) * 1996-11-05 1998-05-14 Bristol-Myers Squibb Company Branched peptide linkers
US6362254B2 (en) * 1998-03-12 2002-03-26 Shearwater Corporation Poly(ethylene glycol) derivatives with proximal reactive groups
DE19811582A1 (de) * 1998-03-17 1999-09-23 Roche Diagnostics Gmbh Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
CN1178800C (zh) * 1998-09-29 2004-12-08 惠普公司 加工小册子的方法和设备
GB2413081A (en) * 2004-04-13 2005-10-19 Sca Hygiene Prod Ab Absorbant article with folded side flap portions and method of manufacture

Also Published As

Publication number Publication date
ES2248405T3 (es) 2006-03-16
DE60113445T2 (de) 2006-06-29
EP1327146B1 (de) 2005-09-14
EP1327146A2 (de) 2003-07-16
JP2004510160A (ja) 2004-04-02
DE10048417A1 (de) 2002-04-11
ATE304709T1 (de) 2005-09-15
CA2423916C (en) 2009-02-03
WO2002027315A3 (en) 2002-07-11
US20040086943A1 (en) 2004-05-06
WO2002027315A2 (en) 2002-04-04
JP3647845B2 (ja) 2005-05-18
CA2423916A1 (en) 2002-04-04
US20090264618A1 (en) 2009-10-22
DK1327146T3 (da) 2006-01-23
AU2002215904A1 (en) 2002-04-08

Similar Documents

Publication Publication Date Title
DE60113445D1 (de) Substanzen mit verzweigten linkermolekülen
DE60010098D1 (de) 28-epirapaloge
BR0208338A (pt) Derivados de piridina
NO20010729D0 (no) Fremgangsmåte for komplettering av löse, produserende soner i undergrunnen
DE69907977D1 (de) Pyrrolobenzodiazepine
MA26886A1 (fr) Acides malonamiques et leurs derives, utiles comme ligands de recepteurs thyroidiens.
DK1053256T3 (da) Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf
NO20020348L (no) Peptid acceptor ligeringsmetoder
TR200103525T2 (tr) Bisiklik poliaminosit metal kompleksleri, bunları hazırlamak için yöntem ve bunların tıbbi görüntülemede kullanımı.
BR0306905A (pt) Vacinas de flavivìrus
CY1108377T1 (el) Χρηση ενωσεων 1-φαινυλο-3-διμεθυλαμινο-προπανιου για τη θεραπεια της ακρατειας ουρων
SE9904377D0 (sv) Pharmaceutical combinations
SE0003476D0 (sv) Compounds
DE69921486D1 (de) Dextran-leptin konjugate, pharmazeutische zusammentsetzungen und verbundene verfahren
DE60134414D1 (de) 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden
CY1105317T1 (el) Χρηση υποκατεστημενων ενωσεων 6-διμεθυλαμινομεθυλο-1-φαινυλο-κυκλοεξανιου για τη θepαπεια της ακρατειας ουρων
DK1163231T3 (da) Perfluoralkylamider, deres fremstilling og deres anvendelse inden for diagnostikken
DE50101479D1 (de) Fluoresceinisothiocyanat-(fitc)-sinistrin, seine herstellung und verwendung
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
TR200402030T4 (tr) İkame edilen I-aminobutan-3-ol-türevleri
EE200300129A (et) Distamütsiini alfa-halogenoakrüloüülderivaadi kasutamine
TR200103125T2 (tr) Otizmin iyileştirilmesinde kullanıma yönelik antikonvülsan türevleri.
DE69840673D1 (de) Modifizierte polysaccharide mit veränderter biologischer erkennung
ATE306283T1 (de) Biotin-derivate und ihre konjugaten mit chelatierungsmitteln
SE9802507D0 (sv) Novel salts

Legal Events

Date Code Title Description
8364 No opposition during term of opposition