DK1094839T3 - Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber - Google Patents

Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber

Info

Publication number: DK1094839T3
Authority: DK; Denmark
Prior art keywords: protein transferase; transferase inhibitors; farnesyl protein; radiosensitizing properties; vivo
Prior art date: 1998-07-06

Application number

DK99931229T

Other languages

English (en)

Inventor

Ginckel Robert Franciscus Van

Wim Joanna Floren

David William End

Walter Boudewijn Leopo Wouters

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-06-30

Publication date

2003-08-18

1999-06-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-08-18 Application granted granted Critical

2003-08-18 Publication of DK1094839T3 publication Critical patent/DK1094839T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

DK99931229T 1998-07-06 1999-06-30 Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber DK1094839T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98202257		1998-07-06
EP98204330		1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number	Publication Date
DK1094839T3 true DK1094839T3 (da)	2003-08-18

Family

ID=26150503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99931229T DK1094839T3 (da)	1998-07-06	1999-06-30	Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber

Country Status (31)

Country	Link
US (1)	US6545020B1 (da)
EP (1)	EP1094839B1 (da)
JP (1)	JP4530537B2 (da)
KR (1)	KR100591603B1 (da)
CN (1)	CN1152716C (da)
AP (1)	AP1599A (da)
AT (1)	ATE238811T1 (da)
AU (1)	AU762423B2 (da)
BG (1)	BG64941B1 (da)
BR (1)	BR9911861A (da)
CA (1)	CA2336624C (da)
CZ (1)	CZ300968B6 (da)
DE (1)	DE69907461T2 (da)
DK (1)	DK1094839T3 (da)
EA (1)	EA003877B1 (da)
EE (1)	EE04582B1 (da)
ES (1)	ES2199579T3 (da)
HK (1)	HK1034451A1 (da)
HR (1)	HRP20000903A2 (da)
HU (1)	HU229076B1 (da)
ID (1)	ID26987A (da)
IL (2)	IL140721A0 (da)
MY (1)	MY126519A (da)
NO (1)	NO328178B1 (da)
PL (1)	PL193464B1 (da)
PT (1)	PT1094839E (da)
SI (1)	SI1094839T1 (da)
SK (1)	SK284723B6 (da)
TR (1)	TR200003879T2 (da)
TW (1)	TW586937B (da)
WO (1)	WO2000001411A1 (da)

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ATE238811T1 (de)	1998-07-06	2003-05-15	Janssen Pharmaceutica Nv	Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften
SI1094815T1 (en)	1998-07-06	2004-04-30	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitors for treating arthropathies
CA2396865C (en) *	2000-02-04	2009-04-14	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitors for treating breast cancer
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EP1322636A1 (en)	2000-09-25	2003-07-02	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6- (substituted phenyl)methyl]-quinoline and quinazoline derivatives
WO2002024687A1 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
ES2261476T3 (es)	2000-09-25	2006-11-16	Janssen Pharmaceutica N.V.	Derivados de quinolina y quinazolina que inhiben la farnesil-tranferasa como inhibidores de farnesil-tranferasa.
EP1322650B1 (en)	2000-09-25	2008-09-24	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
DE60139080D1 (de)	2000-11-21	2009-08-06	Janssen Pharmaceutica Nv	Farnesyltransferase hemmende benzoheterocyclische derivate
DE60117847T2 (de)	2000-12-27	2006-11-16	Janssen Pharmaceutica N.V.	Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
JP4351444B2 (ja) *	2000-12-27	2009-10-28	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する４−ヘテロシクリル−キノリンおよびキナゾリン誘導体
EP1408971A4 (en)	2001-06-21	2006-01-25	Ariad Pharma Inc	NEW QUINOLINES AND THEIR USES
CA2469275C (en)	2001-12-19	2011-09-06	Janssen Pharmaceutica N.V.	1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
JP4450628B2 (ja)	2002-03-22	2010-04-14	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼインヒビターとして使用するためのベンジルイミダゾリル置換２−キノリンおよびキナゾリン誘導体
EP1497295B1 (en)	2002-04-15	2006-08-16	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
CA2546727C (en)	2003-11-20	2012-10-02	Children's Hospital Medical Center	Gtpase inhibitors and methods of use
EP1687277B1 (en) *	2003-11-20	2018-04-04	Janssen Pharmaceutica NV	6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
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EP1744751A4 (en) *	2004-03-18	2010-03-10	Brigham & Womens Hospital	TREATMENT OF SYNUCLEINOPATHIES
CA2559221A1 (en) *	2004-03-18	2005-09-29	Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
WO2005089515A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20050272068A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	UCH-L1 expression and cancer therapy
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
WO2007016539A2 (en)	2005-07-29	2007-02-08	Children's Hospital Medical Center	Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
JP2009521470A (ja)	2005-12-23	2009-06-04	リンクメディシンコーポレイション	シヌクレイン障害の治療
CA2687976C (en) *	2007-05-23	2015-04-07	Allergan, Inc.	Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
US8232402B2 (en) *	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
ATE555384T1 (de)	2008-06-26	2012-05-15	Spherotec Gmbh	Verfahren zum testen der reaktion von zellen auf die einwirkung von therapeutika
US8343996B2 (en) *	2008-11-13	2013-01-01	Astrazeneca Ab	Azaquinolinone derivatives and uses thereof
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
WO2013166043A1 (en)	2012-05-02	2013-11-07	Children's Hospital Medical Center	Rejuvenation of precursor cells
SMT201700347T1 (it)	2012-10-16	2017-09-07	Janssen Pharmaceutica Nv	Modulatori di ror-gamma-t chinolinilici legati a metilene
ES2619610T3 (es)	2012-10-16	2017-06-26	Janssen Pharmaceutica Nv	Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo
JP6251277B2 (ja)	2012-10-16	2017-12-20	ヤンセンファーマシューティカエヌ．ベー．	ＲＯＲ−ガンマ−ｔのフェニル結合キノリニルモジュレーター
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
WO2015057626A1 (en)	2013-10-15	2015-04-23	Janssen Pharmaceutica Nv	QUINOLINYL MODULATORS OF RORyT
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
CN105873439A (zh)	2013-10-15	2016-08-17	詹森药业有限公司	RORγt的烷基连接的喹啉基调节剂
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
CN114107497A (zh)	2015-08-17	2022-03-01	库拉肿瘤学公司	法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
WO2017184968A1 (en)	2016-04-22	2017-10-26	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
MY190861A (en)	2016-11-03	2022-05-12	Kura Oncology Inc	Farnesyltransferase inhibitors for use in methods of treating cancer
US10137121B2 (en)	2017-02-21	2018-11-27	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
CA3053795A1 (en)	2017-02-21	2018-08-30	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
AU2018313738B2 (en)	2017-08-07	2024-07-04	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2019113269A1 (en)	2017-12-08	2019-06-13	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
CA3117968A1 (en)	2018-11-01	2020-05-07	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US20220142983A1 (en)	2019-03-01	2022-05-12	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
TW202108170A (zh)	2019-03-15	2021-03-01	美商庫拉腫瘤技術股份有限公司	以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症患者之方法
WO2020205486A1 (en)	2019-03-29	2020-10-08	Kura Oncology, Inc.	Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
US20220168296A1 (en)	2019-04-01	2022-06-02	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2020223583A1 (en)	2019-05-02	2020-11-05	Kura Oncology, Inc.	Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
CN114450027A (zh)	2019-08-16	2022-05-06	儿童医院医疗中心	用cdc42特异性抑制剂治疗受试者的方法

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1999
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/xx unknown
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 CA CA002336624A patent/CA2336624C/en not_active Expired - Lifetime
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/en active IP Right Grant
- 1999-06-30 EP EP99931229A patent/EP1094839B1/en not_active Expired - Lifetime
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active IP Right Cessation
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
2000
- 2000-12-28 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation
- 2001-07-18 HK HK01105023A patent/HK1034451A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1094839E (pt)	2003-09-30
CN1152716C (zh)	2004-06-09
TW586937B (en)	2004-05-11
TR200003879T2 (tr)	2007-01-22
AU762423B2 (en)	2003-06-26
IL140721A (en)	2008-11-26
NO20010082L (no)	2001-01-05
AU4780599A (en)	2000-01-24
NO328178B1 (no)	2009-12-28
HU229076B1 (en)	2013-07-29
AP1599A (en)	2006-04-27
CN1311692A (zh)	2001-09-05
SK19862000A3 (sk)	2001-12-03
WO2000001411A1 (en)	2000-01-13
HUP0103689A2 (hu)	2002-02-28
EE04582B1 (et)	2006-02-15
BG105108A (en)	2001-11-30
HK1034451A1 (en)	2001-10-26
PL193464B1 (pl)	2007-02-28
DE69907461D1 (de)	2003-06-05
BG64941B1 (bg)	2006-10-31
CA2336624A1 (en)	2000-01-13
HRP20000903A2 (en)	2001-12-31
HUP0103689A3 (en)	2003-01-28
JP2002519389A (ja)	2002-07-02
JP4530537B2 (ja)	2010-08-25
SK284723B6 (sk)	2005-10-06
MY126519A (en)	2006-10-31
US6545020B1 (en)	2003-04-08
KR20010052770A (ko)	2001-06-25
NO20010082D0 (no)	2001-01-05
ATE238811T1 (de)	2003-05-15
EP1094839B1 (en)	2003-05-02
CA2336624C (en)	2008-10-21
SI1094839T1 (en)	2003-12-31
KR100591603B1 (ko)	2006-06-20
PL347979A1 (en)	2002-05-06
EP1094839A1 (en)	2001-05-02
IL140721A0 (en)	2002-02-10
EA200100111A1 (ru)	2001-06-25
CZ20004777A3 (en)	2001-05-16
AP2001002057A0 (en)	2001-03-31
ES2199579T3 (es)	2004-02-16
ID26987A (id)	2001-02-22
EE200000794A (et)	2002-06-17
BR9911861A (pt)	2001-03-20
DE69907461T2 (de)	2004-02-19
EA003877B1 (ru)	2003-10-30
CZ300968B6 (cs)	2009-09-30

Publication	Publication Date	Title
DK1094839T3 (da)	2003-08-18	Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber
EE04309B1 (et)	2004-06-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
DE69924876D1 (de)	2005-05-25	Farnesyl protein transferase inhibitoren
IS6183A (is)	2001-11-29	Díamínóþíazol og notagildi þeirra til að hindra prótín kínasa
NO996571D0 (no)	1999-12-30	Inhibitorer for farnesyl-protein-transferase
ATE546139T1 (de)	2012-03-15	Isoprentransferase proteine inhibitoren
CY2014034I1 (el)	2016-04-13	Υποκατεστημενες 3-κυανοκινολινες ως αναστολεις κινασων πρωτεϊνης τυροσινης
EE200300085A (et)	2004-12-15	Pürasooli derivaadid ja nende kasutamine proteiini kinaasi inhibiitoritena
FI951554A0 (fi)	1995-03-31	Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita
ATE255114T1 (de)	2003-12-15	Tricyclische proteinkinasehemmer
ATE273299T1 (de)	2004-08-15	Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung
NO20012961D0 (no)	2001-06-15	Trisykliske farnesylproteintransferase-inhibitorer
ATE317386T1 (de)	2006-02-15	Dihydroindol- und tetrahydrochinolinderivate
IS6358A (is)	2002-04-23	Farnasýl transferasa latar
AU3514302A (en)	2002-06-11	0ovel farnesyl protein transferase inhibitors
DK1087981T3 (da)	2006-05-15	Prenyltransferaseinhibitorer
NO20022923L (no)	2002-06-18	Inhibitorer av farnesyl-protein-transferase