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FI951554A0 - Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita - Google Patents

Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita

Info

Publication number
FI951554A0
FI951554A0 FI951554A FI951554A FI951554A0 FI 951554 A0 FI951554 A0 FI 951554A0 FI 951554 A FI951554 A FI 951554A FI 951554 A FI951554 A FI 951554A FI 951554 A0 FI951554 A0 FI 951554A0
Authority
FI
Finland
Prior art keywords
imidazole
protein transferase
transferase inhibitors
farnesyl protein
containing farnesyl
Prior art date
Application number
FI951554A
Other languages
English (en)
Swedish (sv)
Other versions
FI951554A (fi
Inventor
John T Hunt
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FI951554A0 publication Critical patent/FI951554A0/fi
Publication of FI951554A publication Critical patent/FI951554A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI951554A 1994-03-31 1995-03-31 Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita FI951554A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22115394A 1994-03-31 1994-03-31
US29291694A 1994-08-19 1994-08-19

Publications (2)

Publication Number Publication Date
FI951554A0 true FI951554A0 (fi) 1995-03-31
FI951554A FI951554A (fi) 1995-10-01

Family

ID=26915545

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951554A FI951554A (fi) 1994-03-31 1995-03-31 Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita

Country Status (13)

Country Link
EP (1) EP0675112A1 (fi)
JP (1) JPH07304750A (fi)
KR (1) KR950032174A (fi)
CN (1) CN1112117A (fi)
AU (1) AU1615895A (fi)
CA (1) CA2146059A1 (fi)
CZ (1) CZ82195A3 (fi)
FI (1) FI951554A (fi)
HU (1) HUT72440A (fi)
IL (1) IL113196A0 (fi)
NO (1) NO951266L (fi)
PL (1) PL307950A1 (fi)
RU (1) RU95104898A (fi)

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US5972966A (en) * 1996-12-05 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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JPH02193971A (ja) 1989-01-20 1990-07-31 Yamanouchi Pharmaceut Co Ltd トリ置換―２，３，４，５―テトラヒドロベンズアゼピン誘導体とその中間体
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Also Published As

Publication number Publication date
CZ82195A3 (en) 1996-09-11
CA2146059A1 (en) 1995-10-01
KR950032174A (ko) 1995-12-20
AU1615895A (en) 1995-10-12
IL113196A0 (en) 1995-06-29
JPH07304750A (ja) 1995-11-21
HU9500934D0 (en) 1995-05-29
CN1112117A (zh) 1995-11-22
FI951554A (fi) 1995-10-01
NO951266L (no) 1995-10-02
HUT72440A (en) 1996-04-29
RU95104898A (ru) 1996-12-27
NO951266D0 (no) 1995-03-31
EP0675112A1 (en) 1995-10-04
PL307950A1 (en) 1995-10-02

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