DK1015466T3 - Derivater af 9-hydrazon og 9-azinerythromycin og en fremgangsmåde til fremstilling af samme - Google Patents
Derivater af 9-hydrazon og 9-azinerythromycin og en fremgangsmåde til fremstilling af sammeInfo
- Publication number
- DK1015466T3 DK1015466T3 DK98944641T DK98944641T DK1015466T3 DK 1015466 T3 DK1015466 T3 DK 1015466T3 DK 98944641 T DK98944641 T DK 98944641T DK 98944641 T DK98944641 T DK 98944641T DK 1015466 T3 DK1015466 T3 DK 1015466T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrazone
- derivatives
- same
- azinerythromycin
- preparing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 4
- 229960003276 erythromycin Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid Thermionic Cathode (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/927,057 US5929219A (en) | 1997-09-10 | 1997-09-10 | 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same |
| PCT/US1998/018115 WO1999012946A1 (en) | 1997-09-10 | 1998-09-01 | 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1015466T3 true DK1015466T3 (da) | 2003-09-01 |
Family
ID=25454102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98944641T DK1015466T3 (da) | 1997-09-10 | 1998-09-01 | Derivater af 9-hydrazon og 9-azinerythromycin og en fremgangsmåde til fremstilling af samme |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5929219A (pt) |
| EP (1) | EP1015466B1 (pt) |
| JP (1) | JP2001515914A (pt) |
| KR (1) | KR100553468B1 (pt) |
| AT (1) | ATE239751T1 (pt) |
| AU (1) | AU9213698A (pt) |
| CA (1) | CA2301639C (pt) |
| DE (1) | DE69814422T2 (pt) |
| DK (1) | DK1015466T3 (pt) |
| ES (1) | ES2198745T3 (pt) |
| IL (2) | IL134468A0 (pt) |
| PT (1) | PT1015466E (pt) |
| WO (1) | WO1999012946A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL124084A0 (en) * | 1998-04-14 | 1999-04-11 | Chemagis Ltd | Erythromycin a derivatives and methods for the preparation thereof |
| IL125372A0 (en) * | 1998-07-15 | 1999-03-12 | Chemagis Ltd | Erythromycin derivatives and methods for the preparation thereof |
| KR100317907B1 (ko) * | 1998-11-24 | 2001-12-24 | 김 완 주 | 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법 |
| US6437106B1 (en) | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| AU2001225787C1 (en) * | 2000-02-29 | 2006-09-21 | Teva Pharmaceutical Industries Ltd. | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same |
| US6605707B1 (en) | 2000-03-23 | 2003-08-12 | Abbott Laboratories | Process for the preparation of 6-O-propargyl erythromycin derivatives |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US7435805B2 (en) | 2003-05-30 | 2008-10-14 | Glaxpsmithkline Istrazivacki | O-alkyl macrolide and azalide derivatives and regioselective process for their preparation |
| EP1648407A4 (en) | 2003-07-21 | 2011-08-31 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION |
| CA2533358C (en) | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| EP1648415A4 (en) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| US8758820B2 (en) | 2003-08-11 | 2014-06-24 | Shionogi Inc. | Robust pellet |
| CA2535398C (en) | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| CA2535780A1 (en) | 2003-08-29 | 2005-03-17 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| EP1663169A4 (en) | 2003-09-15 | 2010-11-24 | Middlebrook Pharmaceuticals In | ANTIBIOTICS, ITS USE AND FORMULATION |
| WO2006014427A1 (en) | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
| FI117133B (fi) * | 2004-10-19 | 2006-06-30 | Auramo Oy | Menetelmä ja pihtilaite kuormien käsittelemiseksi |
| ES2261090B1 (es) * | 2005-04-25 | 2007-06-16 | Ercros Industrial, S.A. | Procedimiento de obtencion de derivados de eritromicina a y compuestos obtenidos. |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| JP5126685B2 (ja) * | 2006-05-01 | 2013-01-23 | 大正製薬株式会社 | マクロライド誘導体 |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| US20090054634A1 (en) * | 2007-08-09 | 2009-02-26 | Vinod Kumar Kansal | Process for the preparation of clarithromycin |
| CN102382157B (zh) * | 2010-09-03 | 2015-04-08 | 上海医药工业研究院 | 一种红霉素a衍生物及其制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759252A (fr) | 1969-11-21 | 1971-05-21 | Lilly Co Eli | Erytromycyl b amine |
| GB1344629A (en) | 1970-09-30 | 1974-01-23 | Lilly Industries Ltd | Erythromycin azine derivatives |
| US3869444A (en) | 1972-10-10 | 1975-03-04 | Abbott Lab | Esters of erythromycin oxime |
| FR2473525A1 (fr) | 1980-01-11 | 1981-07-17 | Roussel Uclaf | Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US4331803A (en) * | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| US4336368A (en) | 1981-04-20 | 1982-06-22 | Pfizer Inc. | 4 Deoxy-4-methylene oleandomycin and derivatives thereof |
| JPS5896095A (ja) | 1981-11-30 | 1983-06-07 | Taisho Pharmaceut Co Ltd | １１−ｏ−アルキルエリスロマイシンａ誘導体 |
| JPS5896097A (ja) | 1981-12-01 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンｂ誘導体 |
| JPS5896098A (ja) | 1981-12-03 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンａ誘導体 |
| US4526889A (en) | 1982-11-15 | 1985-07-02 | Pfizer Inc. | Epimeric azahomoerythromycin A derivative, intermediates and method of use |
| JPS60214796A (ja) * | 1984-04-06 | 1985-10-28 | Taisho Pharmaceut Co Ltd | ６−０−メチルエリスロマイシン類の製法 |
| JPS61103890A (ja) * | 1984-10-26 | 1986-05-22 | Taisho Pharmaceut Co Ltd | ６−０−メチルエリスロマイシンａ誘導体 |
| GR860655B (en) | 1985-03-12 | 1986-07-11 | Beecham Group Plc | Chemical compounds |
| GB8506380D0 (en) | 1985-03-12 | 1985-04-11 | Beecham Group Plc | Chemical compounds |
| US4670549A (en) * | 1985-03-18 | 1987-06-02 | Taisho Pharmaceutical Co., Ltd. | Method for selective methylation of erythromycin a derivatives |
| JPS61229895A (ja) * | 1985-04-03 | 1986-10-14 | Nippon Zeon Co Ltd | 保護化デス−ｎ−メチルエリスロマイシン誘導体 |
| US4640910A (en) | 1985-11-12 | 1987-02-03 | Abbott Laboratories | Erythromycin A silylated compounds and method of use |
| US4833236A (en) | 1986-05-02 | 1989-05-23 | Taisho Pharmaceutical Co., Ltd. | Erythromycin derivatives |
| US4740502A (en) | 1986-06-20 | 1988-04-26 | Abbott Laboratories | Semisynthetic erythromycin antibiotics |
| EP0260938B1 (en) * | 1986-09-18 | 1992-12-09 | Taisho Pharmaceutical Co. Ltd | Erythromycin a derivatives and method for preparing the same |
| KR960000434B1 (ko) * | 1986-12-17 | 1996-01-06 | 다이쇼 세이야꾸 가부시끼가이샤 | 에리스로마이신 a유도체 및 그의 제조 방법 |
| GB8721165D0 (en) * | 1987-09-09 | 1987-10-14 | Beecham Group Plc | Chemical compounds |
| JP2751385B2 (ja) * | 1988-05-19 | 1998-05-18 | 大正製薬株式会社 | エリスロマイシンａオキシム及びその塩の製造方法 |
| US5302705A (en) | 1989-10-07 | 1994-04-12 | Taisho Pharmaceutical Co., Ltd. | 6-O-methylerythromycin a oxime derivatives |
-
1997
- 1997-09-10 US US08/927,057 patent/US5929219A/en not_active Ceased
-
1998
- 1998-09-01 CA CA002301639A patent/CA2301639C/en not_active Expired - Fee Related
- 1998-09-01 AU AU92136/98A patent/AU9213698A/en not_active Abandoned
- 1998-09-01 JP JP2000510752A patent/JP2001515914A/ja active Pending
- 1998-09-01 ES ES98944641T patent/ES2198745T3/es not_active Expired - Lifetime
- 1998-09-01 KR KR1020007002435A patent/KR100553468B1/ko not_active IP Right Cessation
- 1998-09-01 AT AT98944641T patent/ATE239751T1/de not_active IP Right Cessation
- 1998-09-01 EP EP98944641A patent/EP1015466B1/en not_active Expired - Lifetime
- 1998-09-01 WO PCT/US1998/018115 patent/WO1999012946A1/en active IP Right Grant
- 1998-09-01 PT PT98944641T patent/PT1015466E/pt unknown
- 1998-09-01 IL IL13446898A patent/IL134468A0/xx unknown
- 1998-09-01 DK DK98944641T patent/DK1015466T3/da active
- 1998-09-01 DE DE69814422T patent/DE69814422T2/de not_active Expired - Fee Related
-
2000
- 2000-02-09 IL IL134468A patent/IL134468A/en not_active IP Right Cessation
-
2004
- 2004-03-05 US US10/794,595 patent/USRE39531E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69814422T2 (de) | 2004-05-06 |
| WO1999012946A1 (en) | 1999-03-18 |
| EP1015466B1 (en) | 2003-05-07 |
| DE69814422D1 (de) | 2003-06-12 |
| CA2301639C (en) | 2007-06-26 |
| CA2301639A1 (en) | 1999-03-18 |
| ATE239751T1 (de) | 2003-05-15 |
| IL134468A (en) | 2009-09-01 |
| ES2198745T3 (es) | 2004-02-01 |
| EP1015466A1 (en) | 2000-07-05 |
| USRE39531E1 (en) | 2007-03-27 |
| PT1015466E (pt) | 2003-09-30 |
| IL134468A0 (en) | 2001-04-30 |
| AU9213698A (en) | 1999-03-29 |
| US5929219A (en) | 1999-07-27 |
| JP2001515914A (ja) | 2001-09-25 |
| KR100553468B1 (ko) | 2006-02-22 |
| KR20010023778A (ko) | 2001-03-26 |
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