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DK0986570T3 - Gemcitabinderivat - Google Patents

Gemcitabinderivat

Info

Publication number
DK0986570T3
DK0986570T3 DK98901592T DK98901592T DK0986570T3 DK 0986570 T3 DK0986570 T3 DK 0986570T3 DK 98901592 T DK98901592 T DK 98901592T DK 98901592 T DK98901592 T DK 98901592T DK 0986570 T3 DK0986570 T3 DK 0986570T3
Authority
DK
Denmark
Prior art keywords
gemcita
eicosenoyl
amides
binder
derivative
Prior art date
Application number
DK98901592T
Other languages
Danish (da)
English (en)
Inventor
Finn Myhren
Are Dalen
Marit Liland Sandvold
Bernt Borretzen
Original Assignee
Conpharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9701427A external-priority patent/GB2321454A/en
Application filed by Conpharma As filed Critical Conpharma As
Application granted granted Critical
Publication of DK0986570T3 publication Critical patent/DK0986570T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
DK98901592T 1997-01-24 1998-01-23 Gemcitabinderivat DK0986570T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9701427A GB2321454A (en) 1997-01-24 1997-01-24 Gemcitabine esters and amides
PCT/NO1998/000020 WO1998032762A1 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives

Publications (1)

Publication Number Publication Date
DK0986570T3 true DK0986570T3 (da) 2003-07-28

Family

ID=26310850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98901592T DK0986570T3 (da) 1997-01-24 1998-01-23 Gemcitabinderivat

Country Status (15)

Country Link
US (1) US6384019B1 (ja)
EP (1) EP0986570B9 (ja)
JP (1) JP4352115B2 (ja)
KR (1) KR100483256B1 (ja)
AT (1) ATE236188T1 (ja)
AU (1) AU720451B2 (ja)
CA (1) CA2278056C (ja)
DE (1) DE69812934T2 (ja)
DK (1) DK0986570T3 (ja)
HU (1) HU224918B1 (ja)
NZ (1) NZ336676A (ja)
PL (1) PL186888B1 (ja)
SK (1) SK283879B6 (ja)
UA (1) UA67736C2 (ja)
WO (1) WO1998032762A1 (ja)

Families Citing this family (79)

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US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
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EP1465615B1 (en) 2002-01-15 2012-08-01 Trustees of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
AU2003291726A1 (en) 2002-11-04 2004-06-07 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
AU2005228447A1 (en) * 2004-03-29 2005-10-13 Roswell Park Cancer Institute Method of treating solid tumors and leukemias using combination therapy of vitamin D and anti-metabolic nucleoside analogs
FR2874016B1 (fr) * 2004-06-30 2006-11-24 Centre Nat Rech Scient Cnrse Nanoparticules de derives de la gemcitabine
KR100699099B1 (ko) * 2004-07-29 2007-03-22 한미약품 주식회사 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
WO2006029081A2 (en) * 2004-09-02 2006-03-16 Neopharm, Inc. Nucleoside-lipid conjugates, their method of preparation and uses thereof
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NZ554732A (en) * 2004-12-17 2010-09-30 Lilly Co Eli Amide prodrug of gemcitabine, 1-(2,2-difluoro-2-deoxy-beta-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one, compositions and use thereof
NO322682B1 (no) * 2005-03-18 2006-11-27 Clavis Pharma Asa Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer
KR100680765B1 (ko) * 2005-04-28 2007-02-09 주식회사 삼천리제약 3'-아미노-2',3'-디데옥시구아노신의 제조 방법
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US8497292B2 (en) * 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
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US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
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DK2203439T3 (da) 2007-09-14 2011-04-18 Ortho Mcneil Janssen Pharm 1',3'-disubstituerede 4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']-bipyridinyl-2'-oner
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WO2009042766A1 (en) * 2007-09-26 2009-04-02 Mount Sinai School Of Medicine Azacytidine analogues and uses thereof
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LT2252283T (lt) 2008-01-11 2019-03-25 Reata Pharmaceuticals, Inc. Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą
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US9693957B2 (en) 2011-07-08 2017-07-04 The University Of North Carolina At Chapel Hill Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
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CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN102617679B (zh) * 2012-03-13 2014-11-26 北京大学 一种共轭亚油酸与吉西他滨连接的前体药物制备方法及其应用
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CN105873569B (zh) 2013-11-06 2020-07-28 芝加哥大学 用于化疗剂、核酸和光敏剂的递送或共递送的纳米级载体
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UA128346C2 (uk) 2014-01-21 2024-06-19 Янссен Фармацевтика Нв Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування
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CN110054659B (zh) * 2019-05-05 2020-09-11 中国医学科学院医药生物技术研究所 提高药物抗肿瘤活性的方法
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Also Published As

Publication number Publication date
CA2278056A1 (en) 1998-07-30
WO1998032762A1 (en) 1998-07-30
JP2001509160A (ja) 2001-07-10
PL334856A1 (en) 2000-03-27
KR20000070351A (ko) 2000-11-25
EP0986570B9 (en) 2004-01-02
HUP0000721A3 (en) 2002-12-28
HU224918B1 (en) 2006-04-28
CA2278056C (en) 2006-12-12
NZ336676A (en) 2000-01-28
SK102999A3 (en) 2000-05-16
DE69812934T2 (de) 2004-01-29
EP0986570A1 (en) 2000-03-22
KR100483256B1 (ko) 2005-04-15
US6384019B1 (en) 2002-05-07
JP4352115B2 (ja) 2009-10-28
AU720451B2 (en) 2000-06-01
DE69812934D1 (de) 2003-05-08
PL186888B1 (pl) 2004-03-31
UA67736C2 (uk) 2004-07-15
EP0986570B1 (en) 2003-04-02
HUP0000721A2 (hu) 2001-05-28
ATE236188T1 (de) 2003-04-15
AU5782798A (en) 1998-08-18
SK283879B6 (sk) 2004-04-06
US20020042391A1 (en) 2002-04-11

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