DE69812934D1 - Gemcitabin-derivate - Google Patents
Gemcitabin-derivateInfo
- Publication number
- DE69812934D1 DE69812934D1 DE69812934T DE69812934T DE69812934D1 DE 69812934 D1 DE69812934 D1 DE 69812934D1 DE 69812934 T DE69812934 T DE 69812934T DE 69812934 T DE69812934 T DE 69812934T DE 69812934 D1 DE69812934 D1 DE 69812934D1
- Authority
- DE
- Germany
- Prior art keywords
- eicosenoyl
- amides
- gemcitabine
- gemcitabine derivatives
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical class O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 title abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000004016 elaidoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- -1 trans-eicosenoyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9701427A GB2321454A (en) | 1997-01-24 | 1997-01-24 | Gemcitabine esters and amides |
| PCT/NO1998/000020 WO1998032762A1 (en) | 1997-01-24 | 1998-01-23 | Gemcitabine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69812934D1 true DE69812934D1 (de) | 2003-05-08 |
| DE69812934T2 DE69812934T2 (de) | 2004-01-29 |
Family
ID=26310850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69812934T Expired - Lifetime DE69812934T2 (de) | 1997-01-24 | 1998-01-23 | Gemcitabin-derivate |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6384019B1 (de) |
| EP (1) | EP0986570B9 (de) |
| JP (1) | JP4352115B2 (de) |
| KR (1) | KR100483256B1 (de) |
| AT (1) | ATE236188T1 (de) |
| AU (1) | AU720451B2 (de) |
| CA (1) | CA2278056C (de) |
| DE (1) | DE69812934T2 (de) |
| DK (1) | DK0986570T3 (de) |
| HU (1) | HU224918B1 (de) |
| NZ (1) | NZ336676A (de) |
| PL (1) | PL186888B1 (de) |
| SK (1) | SK283879B6 (de) |
| UA (1) | UA67736C2 (de) |
| WO (1) | WO1998032762A1 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| JP2005500988A (ja) * | 2001-03-23 | 2005-01-13 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | 脂肪族アミン薬物複合体 |
| CA2442849A1 (en) * | 2001-04-06 | 2002-10-17 | Wyeth | Antineoplastic combinations such as rapamycin together with gemcitabine or fluorouracil |
| DK1465615T3 (da) | 2002-01-15 | 2012-11-12 | Dartmouth College | Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf |
| WO2004041203A2 (en) * | 2002-11-04 | 2004-05-21 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| EP1734972A4 (de) * | 2004-03-29 | 2007-08-22 | Roswell Park Cancer Inst | Verfahren zur behandlung von soliden tumoren und leukämien unter verwendung einer kombinationstherapie aus vitamin d und antistoffwechsel-nukleosid-analogen |
| FR2874016B1 (fr) | 2004-06-30 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Nanoparticules de derives de la gemcitabine |
| KR100699099B1 (ko) * | 2004-07-29 | 2007-03-22 | 한미약품 주식회사 | 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법 |
| WO2006029081A2 (en) * | 2004-09-02 | 2006-03-16 | Neopharm, Inc. | Nucleoside-lipid conjugates, their method of preparation and uses thereof |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| CA2589850C (en) * | 2004-12-17 | 2012-05-01 | Eli Lilly And Company | Amide prodrug of gemcitabine, compositions and use thereof |
| NO322682B1 (no) * | 2005-03-18 | 2006-11-27 | Clavis Pharma Asa | Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer |
| KR100680765B1 (ko) * | 2005-04-28 | 2007-02-09 | 주식회사 삼천리제약 | 3'-아미노-2',3'-디데옥시구아노신의 제조 방법 |
| NO324263B1 (no) * | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
| US8497292B2 (en) | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| WO2007117760A2 (en) * | 2006-02-06 | 2007-10-18 | Dr. Reddy's Laboratories Ltd. | Preparation of gemcitabine |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| WO2007149891A2 (en) * | 2006-06-21 | 2007-12-27 | Eli Lilly And Company | Crystalline forms of gemcitabine amide prodrug, compositions and use thereof |
| US8299046B2 (en) | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| EP2094651A1 (de) | 2006-11-17 | 2009-09-02 | Trustees Of Dartmouth College | Synthese und biologische wirkungen neuer tricyclischer bis-enone (tbes) |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| KR100957756B1 (ko) * | 2007-12-12 | 2010-05-12 | 동우신테크 주식회사 | 2'-데옥시-2',2'-다이플루오로사이티딘의 제조 방법 |
| US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
| ATE516272T1 (de) | 2007-09-14 | 2011-07-15 | Ortho Mcneil Janssen Pharm | 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one |
| EP2205073A4 (de) * | 2007-09-26 | 2013-03-06 | Sinai School Medicine | Azacytidin-analoge und ihre verwendungen |
| ES2402138T3 (es) * | 2007-12-28 | 2013-04-29 | Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts | Terapia contra el cáncer con un parvovirus combinado con quimioterapia |
| US8129429B2 (en) | 2008-01-11 | 2012-03-06 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids and methods of use in the treatment of disease |
| CA2721838C (en) | 2008-04-18 | 2017-05-23 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| NZ588708A (en) | 2008-04-18 | 2012-09-28 | Reata Pharmaceuticals Inc | 2-cyano steroid derivatives including an anti-inflammatory pharmacore |
| EA022588B1 (ru) | 2008-04-18 | 2016-01-29 | Ритэ Фамэсутикл, Инк. | Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце |
| US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| CA2721666C (en) | 2008-04-18 | 2017-05-23 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
| FR2931152B1 (fr) * | 2008-05-16 | 2010-07-30 | Centre Nat Rech Scient | Nouveau systeme de transfert d'acide nucleique |
| WO2010011782A1 (en) | 2008-07-22 | 2010-01-28 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| CN102143955B (zh) | 2008-09-02 | 2013-08-14 | Omj制药公司 | 作为代谢型谷氨酸受体调节剂的3-氮杂二环[3.1.0]己烷衍生物 |
| WO2010039039A1 (en) * | 2008-10-03 | 2010-04-08 | Clavis Pharma Asa | Oral formulations of gemcitabine derivatives |
| CA2744138C (en) | 2008-11-28 | 2015-08-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| CN101525361B (zh) | 2009-04-21 | 2010-11-17 | 济南圣鲁金药物技术开发有限公司 | 基于吉西他滨结构的前药及其合成方法及应用 |
| GB0907551D0 (en) | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| NZ596053A (en) | 2009-05-12 | 2013-05-31 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| KR20120086729A (ko) * | 2009-11-20 | 2012-08-03 | 클라비스 파마 에이에스에이 | 젬시타빈 유도체의 비경구적 제제 |
| GB201006181D0 (en) | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
| US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| EP2661435B1 (de) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| US20130116209A1 (en) * | 2011-08-02 | 2013-05-09 | Ventana Medical Systems, Inc. | Method for selection of chemotherapeutic agents for adenocarcinoma cancer |
| CN102432654A (zh) * | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| CN102617679B (zh) * | 2012-03-13 | 2014-11-26 | 北京大学 | 一种共轭亚油酸与吉西他滨连接的前体药物制备方法及其应用 |
| TR201809231T4 (tr) | 2012-04-04 | 2018-07-23 | Halozyme Inc | Hiyalüronidaz ve bir tümör-güdümlü taksan ile kombinasyon terapisi. |
| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| BR112015010941A2 (pt) | 2012-11-13 | 2017-07-11 | Boyen Therapeutics Inc | pró-fármacos de gemcitabina e suas utilizações |
| CN103130854A (zh) * | 2013-01-31 | 2013-06-05 | 华东师范大学 | 维生素e琥珀酸酯化吉西他滨前药及应用 |
| CN103265594B (zh) * | 2013-03-28 | 2016-05-04 | 东华大学 | 一种藤黄酸酰胺类衍生物及其制备方法和用途 |
| CN103159814B (zh) * | 2013-03-28 | 2015-12-23 | 东华大学 | 一种藤黄酸酯类衍生物及其制备方法和用途 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| WO2015059072A1 (en) * | 2013-10-21 | 2015-04-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of polyomavirus infections |
| EP3065713B1 (de) | 2013-11-06 | 2024-03-06 | The University of Chicago | Nanoskalige träger zur freisetzung oder gemeinsamen abgabe von chemotherapeutika, nukleinsäuren und photosensibilisatoren |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
| KR102461134B1 (ko) | 2014-01-21 | 2022-10-28 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| WO2015116782A1 (en) | 2014-01-29 | 2015-08-06 | Board Of Regents, The University Of Texas System | Nucleobase analogue derivatives and their applications |
| WO2016057825A1 (en) * | 2014-10-08 | 2016-04-14 | Epigenetics Pharma Llc | Vitamin e-nucleoside prodrugs |
| US11246877B2 (en) | 2016-05-20 | 2022-02-15 | The University Of Chicago | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
| CN111194232B (zh) | 2017-08-02 | 2023-01-31 | 芝加哥大学 | 纳米级金属有机层和金属有机纳米片 |
| EP3746134A1 (de) | 2018-02-02 | 2020-12-09 | Maverix Oncology, Inc. | Kleinmolekülige wirkstoffkonjugate von gemcitabinmonophosphat |
| EP3784681A4 (de) * | 2018-04-26 | 2022-10-26 | NanoMed Holdings Pty Ltd | Gemcitabin-amphiphil-prodrugs |
| WO2019222435A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
| EP3820879B1 (de) | 2018-06-29 | 2024-11-06 | Changchun Changcheng Pharmaceutical Technology Co., LTD | Phosphorhaltige prodrugs von gemcitabin |
| CN110054659B (zh) * | 2019-05-05 | 2020-09-11 | 中国医学科学院医药生物技术研究所 | 提高药物抗肿瘤活性的方法 |
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Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| CA1264738A (en) * | 1984-12-04 | 1990-01-23 | Eli Lilly And Company | Treatment of tumors in mammals |
| ZA859008B (en) * | 1984-12-04 | 1987-07-29 | Lilly Co Eli | The treatment of tumors in mammals |
| FI95384C (fi) * | 1989-04-06 | 1996-01-25 | Squibb Bristol Myers Co | Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita |
| RU2085557C1 (ru) * | 1991-09-30 | 1997-07-27 | Санкио Компани Лимитед | Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения |
| US5401838A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| GB9515279D0 (en) * | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
-
1998
- 1998-01-23 CA CA002278056A patent/CA2278056C/en not_active Expired - Lifetime
- 1998-01-23 DE DE69812934T patent/DE69812934T2/de not_active Expired - Lifetime
- 1998-01-23 HU HU0000721A patent/HU224918B1/hu not_active IP Right Cessation
- 1998-01-23 JP JP53186298A patent/JP4352115B2/ja not_active Expired - Lifetime
- 1998-01-23 SK SK1029-99A patent/SK283879B6/sk not_active IP Right Cessation
- 1998-01-23 AT AT98901592T patent/ATE236188T1/de active
- 1998-01-23 WO PCT/NO1998/000020 patent/WO1998032762A1/en active IP Right Grant
- 1998-01-23 NZ NZ336676A patent/NZ336676A/xx not_active IP Right Cessation
- 1998-01-23 KR KR10-1999-7006584A patent/KR100483256B1/ko not_active Expired - Fee Related
- 1998-01-23 US US09/355,112 patent/US6384019B1/en not_active Expired - Lifetime
- 1998-01-23 AU AU57827/98A patent/AU720451B2/en not_active Expired
- 1998-01-23 DK DK98901592T patent/DK0986570T3/da active
- 1998-01-23 PL PL98334856A patent/PL186888B1/pl unknown
- 1998-01-23 UA UA99084763A patent/UA67736C2/uk unknown
- 1998-01-23 EP EP98901592A patent/EP0986570B9/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ336676A (en) | 2000-01-28 |
| JP4352115B2 (ja) | 2009-10-28 |
| US20020042391A1 (en) | 2002-04-11 |
| JP2001509160A (ja) | 2001-07-10 |
| EP0986570B1 (de) | 2003-04-02 |
| SK102999A3 (en) | 2000-05-16 |
| EP0986570B9 (de) | 2004-01-02 |
| PL186888B1 (pl) | 2004-03-31 |
| US6384019B1 (en) | 2002-05-07 |
| DE69812934T2 (de) | 2004-01-29 |
| AU720451B2 (en) | 2000-06-01 |
| DK0986570T3 (da) | 2003-07-28 |
| WO1998032762A1 (en) | 1998-07-30 |
| PL334856A1 (en) | 2000-03-27 |
| HUP0000721A3 (en) | 2002-12-28 |
| HU224918B1 (en) | 2006-04-28 |
| UA67736C2 (uk) | 2004-07-15 |
| HUP0000721A2 (hu) | 2001-05-28 |
| SK283879B6 (sk) | 2004-04-06 |
| KR100483256B1 (ko) | 2005-04-15 |
| CA2278056C (en) | 2006-12-12 |
| CA2278056A1 (en) | 1998-07-30 |
| EP0986570A1 (de) | 2000-03-22 |
| KR20000070351A (ko) | 2000-11-25 |
| AU5782798A (en) | 1998-08-18 |
| ATE236188T1 (de) | 2003-04-15 |
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