DK1465615T3 - Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf - Google Patents
Tricykliske bisenonderivater og fremgangsmåder til anvendelse herafInfo
- Publication number
- DK1465615T3 DK1465615T3 DK03729681.1T DK03729681T DK1465615T3 DK 1465615 T3 DK1465615 T3 DK 1465615T3 DK 03729681 T DK03729681 T DK 03729681T DK 1465615 T3 DK1465615 T3 DK 1465615T3
- Authority
- DK
- Denmark
- Prior art keywords
- bisonone
- tricyclic
- derivatives
- methods
- tricyclic bisonone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/38—Unsaturated compounds containing keto groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
- C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
- C07C225/12—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms being part of rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34859402P | 2002-01-15 | 2002-01-15 | |
| US37604002P | 2002-04-26 | 2002-04-26 | |
| US40296602P | 2002-08-13 | 2002-08-13 | |
| PCT/US2003/001307 WO2003059339A1 (en) | 2002-01-15 | 2003-01-15 | Tricyclic-bis-enone derivatives and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1465615T3 true DK1465615T3 (da) | 2012-11-12 |
Family
ID=27407852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03729681.1T DK1465615T3 (da) | 2002-01-15 | 2003-01-15 | Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7176237B2 (da) |
| EP (1) | EP1465615B1 (da) |
| AU (1) | AU2003235676A1 (da) |
| CA (1) | CA2472581C (da) |
| DK (1) | DK1465615T3 (da) |
| WO (1) | WO2003059339A1 (da) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US7435755B2 (en) * | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| CA2472581C (en) | 2002-01-15 | 2012-06-26 | Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| CA2670099A1 (en) * | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| WO2008064132A2 (en) * | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| WO2009023845A2 (en) * | 2007-08-15 | 2009-02-19 | The Board Of Regents Of The University Of Texas System | Combination therapy with synthetic triterpenoids and gemcitabine |
| WO2009058849A1 (en) * | 2007-10-29 | 2009-05-07 | University Of Rochester | Use of electrophilic compounds for inducing platelet production or maintaining platelet function |
| TW201216958A (en) | 2008-01-11 | 2012-05-01 | Reata Pharmaceuticals Inc | Synthetic triterpenoids and methods of use in the treatment of disease |
| US8124799B2 (en) | 2008-04-18 | 2012-02-28 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
| CN104250280A (zh) | 2008-04-18 | 2014-12-31 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物 |
| US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| TW201006474A (en) | 2008-04-18 | 2010-02-16 | Reata Pharmaceuticals Inc | Natural products including an anti-flammatory pharmacore and methods of use |
| CN102164941B (zh) | 2008-04-18 | 2015-05-27 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物 |
| CA2731650A1 (en) * | 2008-07-22 | 2010-01-28 | Tadashi Honda | Monocyclic cyanoenones and methods of use thereof |
| EP2334279A4 (en) * | 2008-10-16 | 2013-03-20 | Novan Inc | STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS |
| EP4249001A3 (en) | 2009-08-21 | 2023-11-29 | Novan, Inc. | Topical gels |
| CN102695528B (zh) | 2009-08-21 | 2016-07-13 | 诺万公司 | 创伤敷料、其使用方法及其形成方法 |
| EP2488591A1 (en) * | 2009-10-13 | 2012-08-22 | Novan, Inc. | Nitric oxide-releasing coatings |
| KR101819699B1 (ko) | 2010-04-12 | 2018-01-17 | 리아타 파마슈티컬즈, 아이엔씨. | 항산화성 염증 조절제를 이용하여 비만을 치료하는 방법 |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| BR112013015241B1 (pt) | 2010-12-17 | 2022-03-29 | Reata Pharmaceuticals, Inc | Compostos de enonas tricíclicas de pirazolila e pirimidinila e composição farmacêutica |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| LT2683731T (lt) | 2011-03-11 | 2019-07-10 | Reata Pharmaceuticals, Inc. | C4-monometiltriterpenoido dariniai ir jų panaudojimo būdai |
| PL2841445T3 (pl) | 2012-04-27 | 2017-10-31 | Reata Pharmaceuticals Inc | Pochodne 2,2-difluoropropionamidowe bardoksolonu metylu, formy polimorficzne oraz sposoby ich stosowania |
| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| EP2892912B1 (en) | 2012-09-10 | 2019-04-24 | Reata Pharmaceuticals, Inc. | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| WO2014151181A1 (en) * | 2013-03-15 | 2014-09-25 | The Research Foundation For The State University Of New York | A novel method for synthesizing tbe-31 |
| UY35534A (es) | 2013-04-24 | 2014-10-31 | Abbvie Inc | Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso |
| EP3035937A1 (en) | 2013-08-23 | 2016-06-29 | Reata Pharmaceuticals, Inc. | Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof |
| US9290455B2 (en) | 2014-02-11 | 2016-03-22 | Trustees Of Dartmouth College | CDDO-Me amino acid conjugates and methods of use |
| JP6748652B2 (ja) | 2015-02-12 | 2020-09-02 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化性炎症調節剤としてのイミダゾリル三環式エノン |
| CA2998681C (en) | 2015-09-23 | 2024-02-06 | Reata Pharmaceuticals, Inc. | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
| NZ753546A (en) | 2016-11-08 | 2022-10-28 | Reata Pharmaceuticals Holdings Llc | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| US11286226B2 (en) | 2017-09-21 | 2022-03-29 | Northwestern University | Polycyclic carbogenic molecules and uses thereof as anti-cancer agents |
| CA3103726A1 (en) | 2018-06-15 | 2019-12-19 | Reata Pharmaceuticals, Inc. | Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma |
| WO2019246461A1 (en) | 2018-06-20 | 2019-12-26 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| CN109761927B (zh) * | 2018-11-26 | 2022-10-11 | 河南师范大学 | 一种高对映选择性含环己烯酮类三环结构化合物、其制备方法及应用 |
| JP2023526567A (ja) | 2020-05-09 | 2023-06-21 | リアタ ファーマシューティカルズ ホールディングス リミテッド ライアビリティ カンパニー | バルドキソロンメチルまたはそのアナログを用いてｃｏｖｉｄ－１９を処置する方法 |
| WO2022126129A1 (en) | 2020-12-11 | 2022-06-16 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids for use in therapy |
| CN115724760B (zh) * | 2021-08-30 | 2024-02-02 | 珂阑(上海)医药科技有限公司 | 一种三环二萜类似物及其合成和应用 |
| CN118255685A (zh) * | 2022-12-27 | 2024-06-28 | 珂阑(上海)医药科技有限公司 | 三环类化合物、其药物组合物及其应用 |
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| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
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| CA1312599C (en) | 1988-02-16 | 1993-01-12 | Larry Wayne Hertel | 2',3'dideoxy-2',2'difluoronucleosides |
| US5064823A (en) * | 1988-08-24 | 1991-11-12 | Research Triangle Institute | Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers |
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| US5426183A (en) * | 1992-06-22 | 1995-06-20 | Eli Lilly And Company | Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
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| US5401838A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| DE4308042C2 (de) * | 1993-03-13 | 2000-10-12 | Alstom Energy Syst Gmbh | Wälzmühle |
| US6025395A (en) * | 1994-04-15 | 2000-02-15 | Duke University | Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders |
| US5972703A (en) * | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
| US5521294A (en) * | 1995-01-18 | 1996-05-28 | Eli Lilly And Company | 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides |
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| US20050276836A1 (en) * | 1997-06-11 | 2005-12-15 | Michelle Wilson | Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents |
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| US7435755B2 (en) * | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| EP1395255A4 (en) | 2000-11-28 | 2007-09-12 | Univ Texas | CDDO COMPOUNDS AND ASSOCIATED POLYTHERAPIES |
| MXPA04004882A (es) | 2001-11-23 | 2005-04-11 | Chugai Pharmaceutical Co Ltd | Metodo para la identificacion de enzimas que tienen como objetivo tumores. |
| CA2472581C (en) | 2002-01-15 | 2012-06-26 | Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| CA2485565A1 (en) * | 2002-05-13 | 2004-08-05 | Trustees Of Dartmouth College | Inhibitors and methods of use thereof |
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-
2003
- 2003-01-15 CA CA2472581A patent/CA2472581C/en not_active Expired - Fee Related
- 2003-01-15 AU AU2003235676A patent/AU2003235676A1/en not_active Abandoned
- 2003-01-15 EP EP03729681A patent/EP1465615B1/en not_active Expired - Lifetime
- 2003-01-15 DK DK03729681.1T patent/DK1465615T3/da active
- 2003-01-15 WO PCT/US2003/001307 patent/WO2003059339A1/en not_active Application Discontinuation
- 2003-01-15 US US10/345,053 patent/US7176237B2/en not_active Expired - Fee Related
-
2007
- 2007-02-07 US US11/672,449 patent/US7678830B2/en not_active Expired - Fee Related
-
2010
- 2010-03-11 US US12/722,053 patent/US8067465B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7678830B2 (en) | 2010-03-16 |
| WO2003059339A1 (en) | 2003-07-24 |
| US20070155742A1 (en) | 2007-07-05 |
| CA2472581C (en) | 2012-06-26 |
| US8067465B2 (en) | 2011-11-29 |
| EP1465615A4 (en) | 2006-09-06 |
| AU2003235676A1 (en) | 2003-07-30 |
| US7176237B2 (en) | 2007-02-13 |
| US20100261930A1 (en) | 2010-10-14 |
| CA2472581A1 (en) | 2003-07-24 |
| EP1465615A1 (en) | 2004-10-13 |
| EP1465615B1 (en) | 2012-08-01 |
| US20030232786A1 (en) | 2003-12-18 |
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