DK0714911T3 - Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger - Google Patents

Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger

Info

Publication number: DK0714911T3
Authority: DK; Denmark
Prior art keywords: well; chelating groups; containing chelating; somatostatin analogues; analogues containing
Prior art date: 1994-09-06

Application number

DK95810545T

Other languages

English (en)

Inventor

Rainer Albert

Christian Bruns

Peter Smith-Jones

Barbara Stolz

Gisbert Weckbecker

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-06

Filing date

1995-09-04

Publication date

2001-07-09

1995-09-04 Application filed by Novartis Ag filed Critical Novartis Ag

2001-07-09 Application granted granted Critical

2001-07-09 Publication of DK0714911T3 publication Critical patent/DK0714911T3/da

Links

239000000203 mixture Substances 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229940075620 somatostatin analogue Drugs 0.000 title 1
150000001768 cations Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940121896 radiopharmaceutical Drugs 0.000 abstract 1
239000012217 radiopharmaceutical Substances 0.000 abstract 1
230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK95810545T 1994-09-06 1995-09-04 Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger DK0714911T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9417873A GB9417873D0 (en)	1994-09-06	1994-09-06	Organic compounds

Publications (1)

Publication Number	Publication Date
DK0714911T3 true DK0714911T3 (da)	2001-07-09

Family

ID=10760870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95810545T DK0714911T3 (da)	1994-09-06	1995-09-04	Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger

Country Status (31)

Country	Link
US (2)	US6183721B1 (da)
EP (1)	EP0714911B1 (da)
JP (1)	JP3054346B2 (da)
KR (1)	KR100364111B1 (da)
CN (1)	CN1185252C (da)
AT (1)	ATE199561T1 (da)
AU (1)	AU703057B2 (da)
BR (1)	BR9503936A (da)
CA (1)	CA2157530C (da)
CO (1)	CO4410344A1 (da)
CZ (1)	CZ287012B6 (da)
DE (1)	DE69520256T2 (da)
DK (1)	DK0714911T3 (da)
ES (1)	ES2157309T3 (da)
FI (1)	FI117424B (da)
GB (1)	GB9417873D0 (da)
GR (1)	GR3035997T3 (da)
HU (1)	HU218284B (da)
IL (1)	IL115154A (da)
NO (1)	NO316569B1 (da)
NZ (1)	NZ272919A (da)
PE (1)	PE41496A1 (da)
PL (1)	PL182434B1 (da)
PT (1)	PT714911E (da)
RU (1)	RU2156774C2 (da)
SG (1)	SG50356A1 (da)
SI (1)	SI0714911T1 (da)
SK (1)	SK283774B6 (da)
TR (1)	TR199501094A2 (da)
TW (1)	TW387898B (da)
ZA (1)	ZA957475B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds
AT405906B (de) *	1997-03-14	1999-12-27	Irene Dr Virgolini	Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
US6358491B1 (en)	1999-08-27	2002-03-19	Berlex Laboratories, Inc.	Somatostatin analogs
EP3406249A1 (en)	2001-02-19	2018-11-28	Novartis AG	Treatment of breast tumors with a rapamycin derivative in combination with an aromatase inhibitor
US6713042B2 (en)	2001-02-26	2004-03-30	Bristol-Myers Squibb Pharma Company	Ascorbic acid analogs for metalloradiopharmaceuticals
ITMI20011708A1 (it) *	2001-08-03	2003-02-03	Bracco Imaging Spa	Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
JP2006501196A (ja)	2002-07-18	2006-01-12	へリックスバイオファーマコーポレイション	癌細胞増殖を阻害するためのウレアーゼの使用
CA2518406A1 (en) *	2003-03-10	2004-09-23	Biogen Idec Ma Inc.	Thiol-mediated drug attachment to targeting peptides
WO2006009901A2 (en)	2004-06-18	2006-01-26	Ambrx, Inc.	Novel antigen-binding polypeptides and their uses
EP1831241A2 (en) *	2004-11-24	2007-09-12	AplaGen GmbH	Method for solid-phase peptide synthesis and purification
CA2699394C (en)	2007-09-17	2020-03-24	The Regents Of The University Of California	Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
CN103518135B (zh)	2011-03-11	2016-08-17	内布拉斯加大学董事委员会	冠状动脉疾病的生物标志物
EP2922578B1 (en)	2012-11-21	2018-12-12	Serene, Llc	Tin-117m comprising somatostatin receptor binding compounds
CN103275189B (zh) *	2013-06-06	2014-08-06	深圳翰宇药业股份有限公司	一种用于肽树脂的裂解液及其在固相裂解合成生长抑素中的应用
ES2977715T3 (es) *	2013-10-18	2024-08-29	Novartis Ag	Inhibidores marcados de antígeno prostático específico de membrana (psma), su uso como agentes formadores de imágenes y agentes farmacéuticos para el tratamiento de cáncer de próstata
JP6983779B2 (ja)	2015-11-30	2021-12-17	ザリージェンツオブザユニバーシティオブカリフォルニアThe Regents Of The University Of California	非常に特異的な腫瘍細胞表面抗原を標的とするヒト抗体を用いた腫瘍特異的ペイロード送達及び免疫活性化
EP4529966A2 (en)	2016-08-29	2025-04-02	Fred Hutchinson Cancer Center	Chelating platform for delivery of radionuclides
US12049511B2 (en)	2016-11-10	2024-07-30	Fortis Therapeutics, Inc.	Engineered CD46-specific effector cells and uses thereof in the treatment of cancer
PL3568205T3 (pl)	2017-01-12	2024-03-18	Radiomedix Inc.	Leczenie komórek nowotworowych z nadekspresją receptorów somatostatyny z użyciem pochodnych okreotydu chelatowanych z radioizotopami
TW202017600A (zh) *	2018-06-21	2020-05-16	法商艾普森藥品公司	用於放射性醫藥之含有體抑素類似物之組成物
TW202015744A (zh) *	2018-06-21	2020-05-01	法商艾普森藥品公司	用於放射性醫藥之含有體抑素類似物之組成物
TW202019489A (zh)	2018-07-25	2020-06-01	義大利商先進艾斯雷特應用（義大利）公司	穩定的、濃縮的放射性核種錯合物溶液
US10596276B2 (en)	2018-07-25	2020-03-24	Advanced Accelerator Applications (Italy) S.R.L.	Stable, concentrated radionuclide complex solutions
US10596278B2 (en)	2018-07-25	2020-03-24	Advanced Accelerator Applications (Italy) S.R.L.	Stable, concentrated radionuclide complex solutions
US11484604B2 (en)	2020-08-07	2022-11-01	Fortis Therapeutics, Inc.	Immunoconjugates targeting CD46 and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5006643A (en)	1987-06-24	1991-04-09	The Dow Chemical Company	Process for preparing isothiocyanato functionalized metal complexes
DE3728600A1 (de)	1987-08-27	1989-03-09	Hoechst Ag	Verfahren zur markierung von substanzen mit technetium oder rhenium
JPH0720989B2 (ja) *	1988-05-25	1995-03-08	アメリカ合衆国	大環状キレート化合物の抱合体と診断的テスト方法
MY106120A (en) *	1988-12-05	1995-03-31	Novartis Ag	Peptide derivatives.
GB9111199D0 (en) *	1991-05-23	1991-07-17	Sandoz Ltd	Improvements in or relating to organic compounds
CA2066031C (en)	1989-09-29	2001-02-27	Mary A. Gray	Methods for reducing non-target retention of immunoconjugates and metabolites thereof
EP0636032A1 (en) *	1992-03-25	1995-02-01	Mallinckrodt Medical, Inc.	Method of intraoperatively detecting and locating tumoral tissues
EP0607103A3 (en) *	1993-01-12	1997-07-09	Sandoz Ltd	Somatostatin analogs containing chelating groups and their radiolabeled compositions.
US5650134A (en) *	1993-01-12	1997-07-22	Novartis Ag (Formerly Sandoz Ltd.)	Peptides
US5705143A (en) *	1994-01-12	1998-01-06	Amersham International Plc	Biological targeting agents
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds

1994
- 1994-09-06 GB GB9417873A patent/GB9417873D0/en active Pending
1995
- 1995-09-04 NZ NZ272919A patent/NZ272919A/en not_active IP Right Cessation
- 1995-09-04 SG SG1995001282A patent/SG50356A1/en unknown
- 1995-09-04 PT PT95810545T patent/PT714911E/pt unknown
- 1995-09-04 PL PL95310274A patent/PL182434B1/pl unknown
- 1995-09-04 IL IL11515495A patent/IL115154A/xx not_active IP Right Cessation
- 1995-09-04 ES ES95810545T patent/ES2157309T3/es not_active Expired - Lifetime
- 1995-09-04 CZ CZ19952263A patent/CZ287012B6/cs not_active IP Right Cessation
- 1995-09-04 DE DE69520256T patent/DE69520256T2/de not_active Expired - Lifetime
- 1995-09-04 PE PE1995277844A patent/PE41496A1/es not_active IP Right Cessation
- 1995-09-04 DK DK95810545T patent/DK0714911T3/da active
- 1995-09-04 AU AU30414/95A patent/AU703057B2/en not_active Expired
- 1995-09-04 RU RU95114740/04A patent/RU2156774C2/ru active
- 1995-09-04 EP EP95810545A patent/EP0714911B1/en not_active Expired - Lifetime
- 1995-09-04 SI SI9530491T patent/SI0714911T1/xx unknown
- 1995-09-04 FI FI954147A patent/FI117424B/fi not_active IP Right Cessation
- 1995-09-04 HU HU9502577A patent/HU218284B/hu unknown
- 1995-09-04 AT AT95810545T patent/ATE199561T1/de active
- 1995-09-04 SK SK1088-95A patent/SK283774B6/sk not_active IP Right Cessation
- 1995-09-04 NO NO953457A patent/NO316569B1/no not_active IP Right Cessation
- 1995-09-05 CN CNB951156101A patent/CN1185252C/zh not_active Expired - Lifetime
- 1995-09-05 CO CO95040393A patent/CO4410344A1/es unknown
- 1995-09-05 CA CA002157530A patent/CA2157530C/en not_active Expired - Lifetime
- 1995-09-05 KR KR1019950028905A patent/KR100364111B1/ko not_active Expired - Lifetime
- 1995-09-05 BR BR9503936-8A patent/BR9503936A/pt not_active IP Right Cessation
- 1995-09-05 JP JP7227906A patent/JP3054346B2/ja not_active Expired - Lifetime
- 1995-09-06 TR TR95/01094A patent/TR199501094A2/xx unknown
- 1995-09-06 ZA ZA957475A patent/ZA957475B/xx unknown
- 1995-09-08 TW TW084109395A patent/TW387898B/zh not_active IP Right Cessation
1997
- 1997-04-23 US US08/842,125 patent/US6183721B1/en not_active Expired - Lifetime
2000
- 2000-07-05 US US09/609,844 patent/US6277356B1/en not_active Expired - Lifetime
2001
- 2001-06-06 GR GR20010400850T patent/GR3035997T3/el unknown

Also Published As

Publication number	Publication date
NO953457L (no)	1996-03-07
CZ226395A3 (en)	1996-03-13
ES2157309T3 (es)	2001-08-16
PE41496A1 (es)	1996-10-14
TW387898B (en)	2000-04-21
HU9502577D0 (en)	1995-11-28
PL310274A1 (en)	1996-03-18
ATE199561T1 (de)	2001-03-15
HUT72895A (en)	1996-06-28
CN1185252C (zh)	2005-01-19
PL182434B1 (pl)	2002-01-31
NO316569B1 (no)	2004-02-23
GB9417873D0 (en)	1994-10-26
SK108895A3 (en)	1996-06-05
CN1127259A (zh)	1996-07-24
JPH0881498A (ja)	1996-03-26
IL115154A (en)	2000-08-13
CA2157530A1 (en)	1996-03-07
US6277356B1 (en)	2001-08-21
KR960010683A (ko)	1996-04-20
SG50356A1 (en)	2000-11-21
JP3054346B2 (ja)	2000-06-19
PT714911E (pt)	2001-08-30
SI0714911T1 (en)	2001-08-31
FI117424B (fi)	2006-10-13
HU218284B (en)	2000-07-28
EP0714911A2 (en)	1996-06-05
NZ272919A (en)	1996-12-20
GR3035997T3 (en)	2001-09-28
NO953457D0 (no)	1995-09-04
SK283774B6 (sk)	2004-01-08
CO4410344A1 (es)	1997-01-09
KR100364111B1 (ko)	2003-02-05
FI954147A0 (fi)	1995-09-04
AU3041495A (en)	1996-03-21
RU2156774C2 (ru)	2000-09-27
BR9503936A (pt)	1996-09-24
ZA957475B (en)	1997-03-06
DE69520256D1 (de)	2001-04-12
EP0714911A3 (en)	1996-08-21
EP0714911B1 (en)	2001-03-07
DE69520256T2 (de)	2001-08-09
CA2157530C (en)	2007-04-03
TR199501094A2 (tr)	1996-06-21
IL115154A0 (en)	1995-12-31
CZ287012B6 (en)	2000-08-16
FI954147L (fi)	1996-03-07
AU703057B2 (en)	1999-03-11
US6183721B1 (en)	2001-02-06

Publication	Publication Date	Title
DK0714911T3 (da)	2001-07-09	Somatostatinanaloge, der indeholder chelatdannende grupper samt deres radiomærkede sammensætninger
ATE52275T1 (de)	1990-05-15	Waeschereinigungsmittel.
IT1153878B (it)	1987-01-21	Composizione di resina contenente una resina fenolo-aldeide granulare oppure polverulenta
BR8702835A (pt)	1988-03-01	Composicao de resina absorvente de agua
IE791203L (en)	1979-12-28	Radioactive scanning agents with hydroquinone as stabilizer
AU3602795A (en)	1996-05-06	Tc or re radiolabelled somatostatin analogs
NO934468D0 (no)	1993-12-08	Tannprotesestabiliserende blandinger med forbedret hold
GB2179364B (en)	1990-03-21	Built detergent compositions containing stabilizing agents
DE3583334D1 (de)	1991-08-01	Borverbindungen enthaltende polycarbonatzusammensetzungen.
AU560024B2 (en)	1987-03-26	Technetium-99m radiopharmaceutical composition
DE3784566D1 (de)	1993-04-15	Bisphenolverbindungen enthaltende zusammensetzungen.
IT1157349B (it)	1987-02-11	Composizioni induribili contenenti epossidi
DK164320C (da)	1992-11-02	Thioxanthonderivater, der omfatter en kvaternaer-ammoniumsubstituent, fremgangsmaade til fremstilling deraf samt vandige fotopolymeriserbare kompositioner indeholdende derivaterne
ES2173661T3 (es)	2002-10-16	Agente de lavado liquidos de baja concentracion alatamente viscosos.
FR2582306B1 (fr)	1988-08-26	Sels d'acides n-acyl-thiazolidine-4-carboxyliques et de 6-piperidino-2,4-diaminopyrimidine-3-oxyde et compositions a usage cosmetique-dermatologique les contenant
EP0154460A3 (en)	1986-04-30	Fluoroelastomer compositions containing fluoroaliphatic sulfonamides as curing agents
IT1233872B (it)	1992-04-21	Composizione acquosa termoreattiva contenente un composto isocianico bloccato
NO154754C (no)	1986-12-17	Stoepeasfaltblanding inneholdende syntetisk zeolitt.
IL74067A0 (en)	1985-04-30	Compositions containing quaternary ammonium compounds
ZA865751B (en)	1988-03-30	Built detergent compositions containing stabilizing agents
HK1004269A1 (en)	1998-11-20	Substituted saccharin compounds and curable compositions containing same
HUT50137A (en)	1989-12-28	Growth-controlling and herbicide compositions containing heterocyclic-substituted phenoxy-sulfonyl-urea i sposob poluchenija these compounds
IT1163888B (it)	1987-04-08	Una composizione di rivestimento induribile sopra i 50 gradi c contenente una resina epossidica idrolizzata
AR242594A1 (es)	1993-04-30	Una composicion de goma no curada, procedimiento para su obtencion; vulcanizados y neumaticos preparados a partir de dicha composicion.
IT1148192B (it)	1986-11-26	Composizioni flemmatizzate contenenti composti suscettibili di esplosione