DE69520256D1 - Chelatbildende Gruppen enthaltende Somastotatin-Analoge und deren radiomarkierteZusammensetzungen - Google Patents

Chelatbildende Gruppen enthaltende Somastotatin-Analoge und deren radiomarkierteZusammensetzungen

Info

Publication number: DE69520256D1
Authority: DE; Germany
Prior art keywords: somastotatin; chelating groups; analogs containing; containing chelating; radiolabeled compositions
Prior art date: 1994-09-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69520256T

Other languages

English (en)

Other versions

DE69520256T2 (de

Inventor

Rainer Albert

Christian Bruns

Peter Smith-Jones

Barbara Stolz

Gisbert Weckbecker

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-06

Filing date

1995-09-04

Publication date

2001-04-12

1995-09-04 Application filed by Novartis AG filed Critical Novartis AG

2001-04-12 Application granted granted Critical

2001-04-12 Publication of DE69520256D1 publication Critical patent/DE69520256D1/de

2001-08-09 Publication of DE69520256T2 publication Critical patent/DE69520256T2/de

2015-09-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69520256T 1994-09-06 1995-09-04 Chelatbildende Gruppen enthaltende Somastotatin-Analoge und deren radiomarkierteZusammensetzungen Expired - Lifetime DE69520256T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9417873A GB9417873D0 (en)	1994-09-06	1994-09-06	Organic compounds

Publications (2)

Publication Number	Publication Date
DE69520256D1 true DE69520256D1 (de)	2001-04-12
DE69520256T2 DE69520256T2 (de)	2001-08-09

Family

ID=10760870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69520256T Expired - Lifetime DE69520256T2 (de)	1994-09-06	1995-09-04	Chelatbildende Gruppen enthaltende Somastotatin-Analoge und deren radiomarkierteZusammensetzungen

Country Status (31)

Country	Link
US (2)	US6183721B1 (de)
EP (1)	EP0714911B1 (de)
JP (1)	JP3054346B2 (de)
KR (1)	KR100364111B1 (de)
CN (1)	CN1185252C (de)
AT (1)	ATE199561T1 (de)
AU (1)	AU703057B2 (de)
BR (1)	BR9503936A (de)
CA (1)	CA2157530C (de)
CO (1)	CO4410344A1 (de)
CZ (1)	CZ287012B6 (de)
DE (1)	DE69520256T2 (de)
DK (1)	DK0714911T3 (de)
ES (1)	ES2157309T3 (de)
FI (1)	FI117424B (de)
GB (1)	GB9417873D0 (de)
GR (1)	GR3035997T3 (de)
HU (1)	HU218284B (de)
IL (1)	IL115154A (de)
NO (1)	NO316569B1 (de)
NZ (1)	NZ272919A (de)
PE (1)	PE41496A1 (de)
PL (1)	PL182434B1 (de)
PT (1)	PT714911E (de)
RU (1)	RU2156774C2 (de)
SG (1)	SG50356A1 (de)
SI (1)	SI0714911T1 (de)
SK (1)	SK283774B6 (de)
TR (1)	TR199501094A2 (de)
TW (1)	TW387898B (de)
ZA (1)	ZA957475B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds
AT405906B (de) *	1997-03-14	1999-12-27	Irene Dr Virgolini	Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
US6358491B1 (en)	1999-08-27	2002-03-19	Berlex Laboratories, Inc.	Somatostatin analogs
SI3143995T1 (sl)	2001-02-19	2019-02-28	Novartis Ag	Derivat rapamicina za zdravljenje pljučnega raka
CN1503680A (zh) *	2001-02-26	2004-06-09	��˹�ж�-��˹˹��ҩƷ��˾	用于金属放射性药物的抗坏血酸类似物
ITMI20011708A1 (it) *	2001-08-03	2003-02-03	Bracco Imaging Spa	Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
BR0312664A (pt)	2002-07-18	2005-05-03	Helix Biopharma Corp	Composição farmacêutica e uso da enzima urease para a fabricação de um medicamento para o tratamento de células cancerìgenas em um indivìduo
EP1610805A2 (de) *	2003-03-10	2006-01-04	Biogen Idec Inc.	Thiol-vermittelte wirkstoffanbindung an targeting-peptide
JP2008503217A (ja)	2004-06-18	2008-02-07	アンブレツクス・インコーポレイテツド	新規抗原結合ポリペプチド及びそれらの使用
EP1831241A2 (de) *	2004-11-24	2007-09-12	AplaGen GmbH	Verfahren zur festphasenpeptidsynthese und -aufreinigung
CA2699394C (en)	2007-09-17	2020-03-24	The Regents Of The University Of California	Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
AU2012229156A1 (en)	2011-03-11	2013-10-31	Board Of Regents Of The University Of Nebraska	Biomarker for coronary artery disease
EP2922578B1 (de)	2012-11-21	2018-12-12	Serene, Llc	Tin-117m-somatostatinrezeptor-bindende verbindungen
CN103275189B (zh) *	2013-06-06	2014-08-06	深圳翰宇药业股份有限公司	一种用于肽树脂的裂解液及其在固相裂解合成生长抑素中的应用
HRP20240398T1 (hr) *	2013-10-18	2024-06-07	Novartis Ag	Označeni inhibitori prostata specifičnog membranskog antigena (psma), njihova upotreba kao sredstava za snimanje i farmaceutska sredstva za liječenje raka prostate
FI3383920T3 (fi)	2015-11-30	2024-04-10	Univ California	Kasvainspesifinen hyötyaineen antaminen ja immuuniaktivointi käyttämällä erittäin spesifiseen kasvainsolun pinta-antigeeniin kohdentuvaa ihmisen vasta-ainetta
EP3503930B1 (de)	2016-08-29	2024-12-11	Fred Hutchinson Cancer Center	Chelatbildende plattform zur abgabe von radionukliden
EP3538551A4 (de)	2016-11-10	2020-11-11	Fortis Therapeutics, Inc.	Cd46-specifische effektorzellen und verwendungen davon
PL3568205T3 (pl)	2017-01-12	2024-03-18	Radiomedix Inc.	Leczenie komórek nowotworowych z nadekspresją receptorów somatostatyny z użyciem pochodnych okreotydu chelatowanych z radioizotopami
TW202017600A (zh) *	2018-06-21	2020-05-16	法商艾普森藥品公司	用於放射性醫藥之含有體抑素類似物之組成物
TW202015744A (zh) *	2018-06-21	2020-05-01	法商艾普森藥品公司	用於放射性醫藥之含有體抑素類似物之組成物
TW202019489A (zh)	2018-07-25	2020-06-01	義大利商先進艾斯雷特應用（義大利）公司	穩定的、濃縮的放射性核種錯合物溶液
US10596276B2 (en)	2018-07-25	2020-03-24	Advanced Accelerator Applications (Italy) S.R.L.	Stable, concentrated radionuclide complex solutions
US10596278B2 (en)	2018-07-25	2020-03-24	Advanced Accelerator Applications (Italy) S.R.L.	Stable, concentrated radionuclide complex solutions
IL300528A (en)	2020-08-07	2023-04-01	Fortis Therapeutics Inc	Immune conjugates targeting cd46 and methods of using them

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5006643A (en)	1987-06-24	1991-04-09	The Dow Chemical Company	Process for preparing isothiocyanato functionalized metal complexes
DE3728600A1 (de)	1987-08-27	1989-03-09	Hoechst Ag	Verfahren zur markierung von substanzen mit technetium oder rhenium
AU630362B2 (en) *	1988-05-25	1992-10-29	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Macrocyclic chelates & methods of use thereof
MY106120A (en) *	1988-12-05	1995-03-31	Novartis Ag	Peptide derivatives.
GB9111199D0 (en) *	1991-05-23	1991-07-17	Sandoz Ltd	Improvements in or relating to organic compounds
DE69026387T2 (de)	1989-09-29	1996-11-28	Neorx Corp., Seattle, Wash.	Reduktion der nichtzielspezifischen retention von immunokonjugaten und ihren metaboliten
CA2131315A1 (en) *	1992-03-25	1993-09-30	Geert J. Ensing	Method of intraoperatively detecting and locating tumoral tissues
HUT66294A (en) *	1993-01-12	1994-11-28	Sandoz Ag	Polypeptides and process for producing them
US5650134A (en) *	1993-01-12	1997-07-22	Novartis Ag (Formerly Sandoz Ltd.)	Peptides
CA2179990A1 (en) *	1994-01-12	1995-07-20	Gary Robert Bower	Biological targeting agents
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds

1994
- 1994-09-06 GB GB9417873A patent/GB9417873D0/en active Pending
1995
- 1995-09-04 PE PE1995277844A patent/PE41496A1/es not_active IP Right Cessation
- 1995-09-04 NO NO953457A patent/NO316569B1/no not_active IP Right Cessation
- 1995-09-04 AU AU30414/95A patent/AU703057B2/en not_active Expired
- 1995-09-04 FI FI954147A patent/FI117424B/fi not_active IP Right Cessation
- 1995-09-04 AT AT95810545T patent/ATE199561T1/de active
- 1995-09-04 RU RU95114740/04A patent/RU2156774C2/ru active
- 1995-09-04 SG SG1995001282A patent/SG50356A1/en unknown
- 1995-09-04 DE DE69520256T patent/DE69520256T2/de not_active Expired - Lifetime
- 1995-09-04 CZ CZ19952263A patent/CZ287012B6/cs not_active IP Right Cessation
- 1995-09-04 IL IL11515495A patent/IL115154A/xx not_active IP Right Cessation
- 1995-09-04 EP EP95810545A patent/EP0714911B1/de not_active Expired - Lifetime
- 1995-09-04 SK SK1088-95A patent/SK283774B6/sk not_active IP Right Cessation
- 1995-09-04 PT PT95810545T patent/PT714911E/pt unknown
- 1995-09-04 ES ES95810545T patent/ES2157309T3/es not_active Expired - Lifetime
- 1995-09-04 NZ NZ272919A patent/NZ272919A/en not_active IP Right Cessation
- 1995-09-04 PL PL95310274A patent/PL182434B1/pl unknown
- 1995-09-04 HU HU9502577A patent/HU218284B/hu unknown
- 1995-09-04 SI SI9530491T patent/SI0714911T1/xx unknown
- 1995-09-04 DK DK95810545T patent/DK0714911T3/da active
- 1995-09-05 CN CNB951156101A patent/CN1185252C/zh not_active Expired - Lifetime
- 1995-09-05 CO CO95040393A patent/CO4410344A1/es unknown
- 1995-09-05 CA CA002157530A patent/CA2157530C/en not_active Expired - Lifetime
- 1995-09-05 KR KR1019950028905A patent/KR100364111B1/ko not_active Expired - Lifetime
- 1995-09-05 JP JP7227906A patent/JP3054346B2/ja not_active Expired - Lifetime
- 1995-09-05 BR BR9503936-8A patent/BR9503936A/pt not_active IP Right Cessation
- 1995-09-06 ZA ZA957475A patent/ZA957475B/xx unknown
- 1995-09-06 TR TR95/01094A patent/TR199501094A2/xx unknown
- 1995-09-08 TW TW084109395A patent/TW387898B/zh not_active IP Right Cessation
1997
- 1997-04-23 US US08/842,125 patent/US6183721B1/en not_active Expired - Lifetime
2000
- 2000-07-05 US US09/609,844 patent/US6277356B1/en not_active Expired - Lifetime
2001
- 2001-06-06 GR GR20010400850T patent/GR3035997T3/el unknown

Also Published As

Publication number	Publication date
NO953457D0 (no)	1995-09-04
AU3041495A (en)	1996-03-21
KR100364111B1 (ko)	2003-02-05
ES2157309T3 (es)	2001-08-16
SK108895A3 (en)	1996-06-05
EP0714911A3 (de)	1996-08-21
SK283774B6 (sk)	2004-01-08
RU2156774C2 (ru)	2000-09-27
CN1127259A (zh)	1996-07-24
NZ272919A (en)	1996-12-20
IL115154A (en)	2000-08-13
EP0714911A2 (de)	1996-06-05
BR9503936A (pt)	1996-09-24
GB9417873D0 (en)	1994-10-26
PL310274A1 (en)	1996-03-18
ATE199561T1 (de)	2001-03-15
HU218284B (en)	2000-07-28
NO953457L (no)	1996-03-07
CN1185252C (zh)	2005-01-19
US6277356B1 (en)	2001-08-21
IL115154A0 (en)	1995-12-31
PL182434B1 (pl)	2002-01-31
PT714911E (pt)	2001-08-30
TW387898B (en)	2000-04-21
CZ287012B6 (en)	2000-08-16
TR199501094A2 (tr)	1996-06-21
FI954147A0 (fi)	1995-09-04
DE69520256T2 (de)	2001-08-09
NO316569B1 (no)	2004-02-23
HU9502577D0 (en)	1995-11-28
CO4410344A1 (es)	1997-01-09
DK0714911T3 (da)	2001-07-09
ZA957475B (en)	1997-03-06
HUT72895A (en)	1996-06-28
SI0714911T1 (en)	2001-08-31
US6183721B1 (en)	2001-02-06
GR3035997T3 (en)	2001-09-28
CA2157530A1 (en)	1996-03-07
FI954147L (fi)	1996-03-07
CA2157530C (en)	2007-04-03
FI117424B (fi)	2006-10-13
EP0714911B1 (de)	2001-03-07
JP3054346B2 (ja)	2000-06-19
AU703057B2 (en)	1999-03-11
PE41496A1 (es)	1996-10-14
SG50356A1 (en)	2000-11-21
CZ226395A3 (en)	1996-03-13
JPH0881498A (ja)	1996-03-26
KR960010683A (ko)	1996-04-20

Publication	Publication Date	Title
DE69520256D1 (de)	2001-04-12	Chelatbildende Gruppen enthaltende Somastotatin-Analoge und deren radiomarkierteZusammensetzungen
IT1170852B (it)	1987-06-03	Composizione imbiancante contenente perossido d'idrogeno
FR2458574B1 (fr)	1986-02-07	Composition d'organopolysiloxane durcissable contenant des microcapsules
NZ216632A (en)	1990-03-27	Multi-component, aqueous polymer compositions containing c 16 + aliphatic surface active compound as evaporation retarding agent
DE3583334D1 (de)	1991-08-01	Borverbindungen enthaltende polycarbonatzusammensetzungen.
AU560024B2 (en)	1987-03-26	Technetium-99m radiopharmaceutical composition
FR2582306B1 (fr)	1988-08-26	Sels d'acides n-acyl-thiazolidine-4-carboxyliques et de 6-piperidino-2,4-diaminopyrimidine-3-oxyde et compositions a usage cosmetique-dermatologique les contenant
GR3034023T3 (en)	2000-11-30	Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
IL74067A0 (en)	1985-04-30	Compositions containing quaternary ammonium compounds
IT1190386B (it)	1988-02-16	Composizioni covulcanizzabili di fluoroelastomeri a migliorata stabilita' chimica
FR2575637B1 (fr)	1990-05-18	Compositions effervescentes chlorees pour des pastilles a usage de desinfection
GB8530541D0 (en)	1986-01-22	Compounds & compositions
GB8530540D0 (en)	1986-01-22	Compounds & compositions
EP0179481A3 (en)	1988-03-02	Stable stannous chloride composition for labeling with radioactive technetium
GB8531160D0 (en)	1986-01-29	Organic compounds
HK1004269A1 (en)	1998-11-20	Substituted saccharin compounds and curable compositions containing same
GB8814422D0 (en)	1988-07-20	Analgesic compounds & compositions
IL75365A0 (en)	1985-09-29	Soluble copper salt containing compositions useful for forming technetium labelled radiodiagnostic agents
ATE23800T1 (de)	1986-12-15	Roentgen-sichtbarmachungsmittel.
BE886452A (fr)	1981-06-02	Compositions durcissables par l'oxygene, catalysees par des composes metal-carbonyle
AR242594A1 (es)	1993-04-30	Una composicion de goma no curada, procedimiento para su obtencion; vulcanizados y neumaticos preparados a partir de dicha composicion.
GB8508153D0 (en)	1985-05-01	Compounds & compositions
DE3464598D1 (en)	1987-08-13	Acetylene derivatives having an enzyme-inhibiting activity, their preparation and their use as medicines
IT1148192B (it)	1986-11-26	Composizioni flemmatizzate contenenti composti suscettibili di esplosione
IT8321385A1 (it)	1984-12-01	Composizioni farmaceutiche contenenti ferro

Legal Events

Date	Code	Title	Description
2002-04-04	8364	No opposition during term of opposition
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2011-06-16	8328	Change in the person/name/address of the agent	Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN