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DE69931929D1 - Peptidantagonisten von zonulin und methoden zu deren verwendung - Google Patents

Peptidantagonisten von zonulin und methoden zu deren verwendung

Info

Publication number
DE69931929D1
DE69931929D1 DE69931929T DE69931929T DE69931929D1 DE 69931929 D1 DE69931929 D1 DE 69931929D1 DE 69931929 T DE69931929 T DE 69931929T DE 69931929 T DE69931929 T DE 69931929T DE 69931929 D1 DE69931929 D1 DE 69931929D1
Authority
DE
Germany
Prior art keywords
zonulin
methods
peptidantagonists
peptide antagonists
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69931929T
Other languages
English (en)
Other versions
DE69931929T2 (de
Inventor
Alessio Fasano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland Baltimore
University of Maryland College Park
Original Assignee
University of Maryland Baltimore
University of Maryland College Park
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Maryland Baltimore, University of Maryland College Park filed Critical University of Maryland Baltimore
Publication of DE69931929D1 publication Critical patent/DE69931929D1/de
Application granted granted Critical
Publication of DE69931929T2 publication Critical patent/DE69931929T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69931929T 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung Expired - Lifetime DE69931929T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US127815 1998-08-03
US09/127,815 US6458925B1 (en) 1998-08-03 1998-08-03 Peptide antagonists of zonulin and methods for use of the same
PCT/US1999/016683 WO2000007609A1 (en) 1998-08-03 1999-07-28 Peptide antagonists of zonulin and methods for use of the same

Publications (2)

Publication Number Publication Date
DE69931929D1 true DE69931929D1 (de) 2006-07-27
DE69931929T2 DE69931929T2 (de) 2007-02-08

Family

ID=22432094

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69942753T Expired - Lifetime DE69942753D1 (de) 1998-08-03 1999-07-28 Peptidantagonist von Zonulin und dessen Verwendung
DE69931929T Expired - Lifetime DE69931929T2 (de) 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69942753T Expired - Lifetime DE69942753D1 (de) 1998-08-03 1999-07-28 Peptidantagonist von Zonulin und dessen Verwendung

Country Status (19)

Country Link
US (10) US6458925B1 (de)
EP (2) EP1698345B1 (de)
JP (1) JP4822585B2 (de)
KR (1) KR100610389B1 (de)
CN (2) CN100348266C (de)
AT (2) ATE480252T1 (de)
AU (1) AU745507B2 (de)
CA (1) CA2338005C (de)
DE (2) DE69942753D1 (de)
DK (1) DK1102596T3 (de)
ES (1) ES2267282T3 (de)
HK (1) HK1082210A1 (de)
HU (1) HU228079B1 (de)
IL (2) IL141082A0 (de)
NO (1) NO326552B1 (de)
NZ (1) NZ509579A (de)
RU (1) RU2214267C2 (de)
WO (1) WO2000007609A1 (de)
ZA (1) ZA200100829B (de)

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US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
AU2001249067A1 (en) * 2000-05-19 2001-12-03 University Of Maryland, Baltimore Method of use of peptide antagonists of zonulin to prevent or delay the onset ofdiabetes
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
AU2003244690A1 (en) 2002-03-15 2003-09-29 Rytek Compositions for treating digestive functional pathologies
CN1852919A (zh) * 2003-07-15 2006-10-25 马里兰州巴尔的摩大学 Zot和连蛋白受体的激动剂多肽
US7067385B2 (en) 2003-09-04 2006-06-27 Micron Technology, Inc. Support for vertically oriented capacitors during the formation of a semiconductor device
US7125781B2 (en) * 2003-09-04 2006-10-24 Micron Technology, Inc. Methods of forming capacitor devices
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
US7387939B2 (en) * 2004-07-19 2008-06-17 Micron Technology, Inc. Methods of forming semiconductor structures and capacitor devices
US7202127B2 (en) * 2004-08-27 2007-04-10 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7439152B2 (en) * 2004-08-27 2008-10-21 Micron Technology, Inc. Methods of forming a plurality of capacitors
US20060046055A1 (en) 2004-08-30 2006-03-02 Nan Ya Plastics Corporation Superfine fiber containing grey dope dyed component and the fabric made of the same
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US7320911B2 (en) 2004-12-06 2008-01-22 Micron Technology, Inc. Methods of forming pluralities of capacitors
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AR053661A1 (es) * 2005-01-14 2007-05-16 Univ Maryland Peptido para entregar vacunas via mucosas
US7557015B2 (en) * 2005-03-18 2009-07-07 Micron Technology, Inc. Methods of forming pluralities of capacitors
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US7517753B2 (en) * 2005-05-18 2009-04-14 Micron Technology, Inc. Methods of forming pluralities of capacitors
US7544563B2 (en) * 2005-05-18 2009-06-09 Micron Technology, Inc. Methods of forming a plurality of capacitors
TW200716159A (en) * 2005-06-09 2007-05-01 Univ Maryland Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells
US7282401B2 (en) 2005-07-08 2007-10-16 Micron Technology, Inc. Method and apparatus for a self-aligned recessed access device (RAD) transistor gate
US7199005B2 (en) * 2005-08-02 2007-04-03 Micron Technology, Inc. Methods of forming pluralities of capacitors
US7867851B2 (en) 2005-08-30 2011-01-11 Micron Technology, Inc. Methods of forming field effect transistors on substrates
US7700441B2 (en) 2006-02-02 2010-04-20 Micron Technology, Inc. Methods of forming field effect transistors, methods of forming field effect transistor gates, methods of forming integrated circuitry comprising a transistor gate array and circuitry peripheral to the gate array, and methods of forming integrated circuitry comprising a transistor gate array including first gates and second grounded isolation gates
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US7557013B2 (en) 2006-04-10 2009-07-07 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7602001B2 (en) * 2006-07-17 2009-10-13 Micron Technology, Inc. Capacitorless one transistor DRAM cell, integrated circuitry comprising an array of capacitorless one transistor DRAM cells, and method of forming lines of capacitorless one transistor DRAM cells
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WO2008043107A2 (en) * 2006-10-06 2008-04-10 Alba Therapeutics Corporation Use of tight junction antagonists to treat inflammatory bowel disease
US7902081B2 (en) 2006-10-11 2011-03-08 Micron Technology, Inc. Methods of etching polysilicon and methods of forming pluralities of capacitors
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
WO2008073627A2 (en) 2006-11-03 2008-06-19 Alba Therapeutics Corporation Method of diagnosing and treating asthma
US7785962B2 (en) 2007-02-26 2010-08-31 Micron Technology, Inc. Methods of forming a plurality of capacitors
US8728491B2 (en) * 2007-05-07 2014-05-20 Alba Therapeutics Corporation Transcutaneous delivery of therapeutic agents
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Also Published As

Publication number Publication date
ATE329606T1 (de) 2006-07-15
CN1313772A (zh) 2001-09-19
KR100610389B1 (ko) 2006-08-09
DK1102596T3 (da) 2006-10-09
AU745507B2 (en) 2002-03-21
EP1102596B1 (de) 2006-06-14
KR20010072245A (ko) 2001-07-31
ES2267282T3 (es) 2007-03-01
CN1679915A (zh) 2005-10-12
DE69931929T2 (de) 2007-02-08
US20080051349A1 (en) 2008-02-28
NO20010567D0 (no) 2001-02-02
CA2338005C (en) 2012-05-29
US20140128328A1 (en) 2014-05-08
US7531504B2 (en) 2009-05-12
CN1217697C (zh) 2005-09-07
US6936689B2 (en) 2005-08-30
ZA200100829B (en) 2002-06-26
EP1698345B1 (de) 2010-09-08
US6458925B1 (en) 2002-10-01
US7582603B2 (en) 2009-09-01
US6670448B2 (en) 2003-12-30
US20130190247A1 (en) 2013-07-25
IL141082A (en) 2012-09-24
RU2214267C2 (ru) 2003-10-20
EP1102596A4 (de) 2002-08-14
HUP0103321A2 (hu) 2001-12-28
NO326552B1 (no) 2009-01-05
CA2338005A1 (en) 2000-02-17
NZ509579A (en) 2003-07-25
HUP0103321A3 (en) 2006-01-30
CN100348266C (zh) 2007-11-14
US20090082279A1 (en) 2009-03-26
NO20010567L (no) 2001-04-02
US20060276399A1 (en) 2006-12-07
IL141082A0 (en) 2002-02-10
JP2002524393A (ja) 2002-08-06
US20110183923A1 (en) 2011-07-28
HU228079B1 (en) 2012-10-29
JP4822585B2 (ja) 2011-11-24
HK1082210A1 (en) 2006-06-02
DE69942753D1 (de) 2010-10-21
EP1698345A2 (de) 2006-09-06
WO2000007609A1 (en) 2000-02-17
ATE480252T1 (de) 2010-09-15
US7189696B2 (en) 2007-03-13
EP1102596A1 (de) 2001-05-30
US20040082512A1 (en) 2004-04-29
AU5459099A (en) 2000-02-28
US20020115825A1 (en) 2002-08-22
EP1698345A3 (de) 2006-09-13
US20050209161A1 (en) 2005-09-22

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