[go: up one dir, main page]

ATE480252T1 - Peptidantagonist von zonulin und dessen verwendung - Google Patents

Peptidantagonist von zonulin und dessen verwendung

Info

Publication number
ATE480252T1
ATE480252T1 AT06006483T AT06006483T ATE480252T1 AT E480252 T1 ATE480252 T1 AT E480252T1 AT 06006483 T AT06006483 T AT 06006483T AT 06006483 T AT06006483 T AT 06006483T AT E480252 T1 ATE480252 T1 AT E480252T1
Authority
AT
Austria
Prior art keywords
zonulin
peptide antagonist
peptide antagonists
peptide
methods
Prior art date
Application number
AT06006483T
Other languages
English (en)
Inventor
Alessio Fasano
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Application granted granted Critical
Publication of ATE480252T1 publication Critical patent/ATE480252T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4705Regulators; Modulating activity stimulating, promoting or activating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716Muscle proteins, e.g. myosin, actin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT06006483T 1998-08-03 1999-07-28 Peptidantagonist von zonulin und dessen verwendung ATE480252T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/127,815 US6458925B1 (en) 1998-08-03 1998-08-03 Peptide antagonists of zonulin and methods for use of the same

Publications (1)

Publication Number Publication Date
ATE480252T1 true ATE480252T1 (de) 2010-09-15

Family

ID=22432094

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99940809T ATE329606T1 (de) 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung
AT06006483T ATE480252T1 (de) 1998-08-03 1999-07-28 Peptidantagonist von zonulin und dessen verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99940809T ATE329606T1 (de) 1998-08-03 1999-07-28 Peptidantagonisten von zonulin und methoden zu deren verwendung

Country Status (19)

Country Link
US (10) US6458925B1 (de)
EP (2) EP1102596B1 (de)
JP (1) JP4822585B2 (de)
KR (1) KR100610389B1 (de)
CN (2) CN1217697C (de)
AT (2) ATE329606T1 (de)
AU (1) AU745507B2 (de)
CA (1) CA2338005C (de)
DE (2) DE69942753D1 (de)
DK (1) DK1102596T3 (de)
ES (1) ES2267282T3 (de)
HK (1) HK1082210A1 (de)
HU (1) HU228079B1 (de)
IL (2) IL141082A0 (de)
NO (1) NO326552B1 (de)
NZ (1) NZ509579A (de)
RU (1) RU2214267C2 (de)
WO (1) WO2000007609A1 (de)
ZA (1) ZA200100829B (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
WO2001089551A1 (en) * 2000-05-19 2001-11-29 University Of Maryland, Baltimore Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes
EP1485074A2 (de) 2002-03-15 2004-12-15 Rytek Zusammensetzungen zur behandlung von magendarm funktionellen störungen
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
BRPI0412430A (pt) * 2003-07-15 2006-09-05 Univ Maryland polipeptìdeo agonista do receptor de zot e zonulina
US7067385B2 (en) * 2003-09-04 2006-06-27 Micron Technology, Inc. Support for vertically oriented capacitors during the formation of a semiconductor device
US7125781B2 (en) * 2003-09-04 2006-10-24 Micron Technology, Inc. Methods of forming capacitor devices
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
US7387939B2 (en) * 2004-07-19 2008-06-17 Micron Technology, Inc. Methods of forming semiconductor structures and capacitor devices
US7439152B2 (en) * 2004-08-27 2008-10-21 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7202127B2 (en) * 2004-08-27 2007-04-10 Micron Technology, Inc. Methods of forming a plurality of capacitors
US20060046055A1 (en) 2004-08-30 2006-03-02 Nan Ya Plastics Corporation Superfine fiber containing grey dope dyed component and the fabric made of the same
US7547945B2 (en) 2004-09-01 2009-06-16 Micron Technology, Inc. Transistor devices, transistor structures and semiconductor constructions
US7320911B2 (en) * 2004-12-06 2008-01-22 Micron Technology, Inc. Methods of forming pluralities of capacitors
FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
TW200637573A (en) * 2005-01-14 2006-11-01 Univ Maryland Peptide for delivery of mucosal vaccines
US7557015B2 (en) 2005-03-18 2009-07-07 Micron Technology, Inc. Methods of forming pluralities of capacitors
GB2425654B (en) * 2005-04-29 2010-03-17 Seiko Epson Corp A method of fabricating a heterojunction of organic semiconducting polymers
EP1722466A1 (de) * 2005-05-13 2006-11-15 STMicroelectronics S.r.l. Verfahren und entsprechende Schaltung zur Erzeugung einer Steuergleichspannung eines Synchrongleichrichters
US7544563B2 (en) * 2005-05-18 2009-06-09 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7517753B2 (en) * 2005-05-18 2009-04-14 Micron Technology, Inc. Methods of forming pluralities of capacitors
AR057058A1 (es) * 2005-06-09 2007-11-14 Alba Therapeutics Corp Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas
US7282401B2 (en) 2005-07-08 2007-10-16 Micron Technology, Inc. Method and apparatus for a self-aligned recessed access device (RAD) transistor gate
US7199005B2 (en) * 2005-08-02 2007-04-03 Micron Technology, Inc. Methods of forming pluralities of capacitors
US7867851B2 (en) 2005-08-30 2011-01-11 Micron Technology, Inc. Methods of forming field effect transistors on substrates
US7700441B2 (en) 2006-02-02 2010-04-20 Micron Technology, Inc. Methods of forming field effect transistors, methods of forming field effect transistor gates, methods of forming integrated circuitry comprising a transistor gate array and circuitry peripheral to the gate array, and methods of forming integrated circuitry comprising a transistor gate array including first gates and second grounded isolation gates
EP1993357B1 (de) 2006-02-09 2014-01-22 Alba Therapeutics Corporation Formulierungen für tight-junction-effektor
US7557013B2 (en) 2006-04-10 2009-07-07 Micron Technology, Inc. Methods of forming a plurality of capacitors
US7602001B2 (en) 2006-07-17 2009-10-13 Micron Technology, Inc. Capacitorless one transistor DRAM cell, integrated circuitry comprising an array of capacitorless one transistor DRAM cells, and method of forming lines of capacitorless one transistor DRAM cells
US7772632B2 (en) 2006-08-21 2010-08-10 Micron Technology, Inc. Memory arrays and methods of fabricating memory arrays
US7589995B2 (en) 2006-09-07 2009-09-15 Micron Technology, Inc. One-transistor memory cell with bias gate
US20090069247A1 (en) * 2006-10-06 2009-03-12 Blake Paterson Use of tight junction antagonists to treat inflammatory bowel disease
US7902081B2 (en) 2006-10-11 2011-03-08 Micron Technology, Inc. Methods of etching polysilicon and methods of forming pluralities of capacitors
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
WO2008073627A2 (en) 2006-11-03 2008-06-19 Alba Therapeutics Corporation Method of diagnosing and treating asthma
US7785962B2 (en) 2007-02-26 2010-08-31 Micron Technology, Inc. Methods of forming a plurality of capacitors
US8728491B2 (en) * 2007-05-07 2014-05-20 Alba Therapeutics Corporation Transcutaneous delivery of therapeutic agents
WO2008150981A2 (en) * 2007-05-30 2008-12-11 Alba Therapeutics Corporation Novel short peptides that inhibit the opening of mammalian tight junctions
US7923373B2 (en) 2007-06-04 2011-04-12 Micron Technology, Inc. Pitch multiplication using self-assembling materials
WO2008154493A2 (en) * 2007-06-07 2008-12-18 Alba Therapeutics Corporation Novel peptides that inhibit the opening of mammalian tight junctions
WO2008154350A2 (en) * 2007-06-08 2008-12-18 Alba Therapeutics Corporation Use of tight junction agonists to suppress immune responses
WO2009006246A1 (en) * 2007-06-29 2009-01-08 Alea Therapeutics Corp. Use of tight junction antagonists in the treatment of acute long injury and acute respiratory distress syndrome
WO2009015382A2 (en) 2007-07-26 2009-01-29 Alba Therapeutics Corporation Novel peptides that enhance tight junction permeability
US7682924B2 (en) 2007-08-13 2010-03-23 Micron Technology, Inc. Methods of forming a plurality of capacitors
WO2009052489A2 (en) * 2007-10-19 2009-04-23 Alba Therapeutics Corporation Novel inhibitors of mammalian tight junction opening
EP2062909A1 (de) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Herstellung von Peptiden und Reinigungsverfahren
US9051349B2 (en) 2007-11-21 2015-06-09 Alba Therapeutics Corporation Larazotide acetate compositions
WO2009110947A2 (en) * 2007-12-19 2009-09-11 Alba Therapeutics Corporation Compositions and methods for inhibiting cytokine production
US8388851B2 (en) 2008-01-08 2013-03-05 Micron Technology, Inc. Capacitor forming methods
US8274777B2 (en) 2008-04-08 2012-09-25 Micron Technology, Inc. High aspect ratio openings
US8957032B2 (en) 2008-05-06 2015-02-17 Alba Therapeutics Corporation Inhibition of gliadin peptides
US7759193B2 (en) 2008-07-09 2010-07-20 Micron Technology, Inc. Methods of forming a plurality of capacitors
AU2010259213A1 (en) * 2009-06-10 2012-01-19 University Of Maryland, Baltimore EGFR and PAR2 regulation of intestinal permeability
US8518788B2 (en) 2010-08-11 2013-08-27 Micron Technology, Inc. Methods of forming a plurality of capacitors
US9076680B2 (en) 2011-10-18 2015-07-07 Micron Technology, Inc. Integrated circuitry, methods of forming capacitors, and methods of forming integrated circuitry comprising an array of capacitors and circuitry peripheral to the array
US8946043B2 (en) 2011-12-21 2015-02-03 Micron Technology, Inc. Methods of forming capacitors
LT3677252T (lt) 2012-03-19 2023-10-10 Cidara Therapeutics, Inc. Dozavimo režimas, skirtas echinokandino klasės junginiams
US8652926B1 (en) 2012-07-26 2014-02-18 Micron Technology, Inc. Methods of forming capacitors
EP3896082A1 (de) * 2013-11-05 2021-10-20 Bio-Rad Laboratories, Inc. Monoklonaler prä-haptoglobin-2-antikörper und verwendungen davon
EP3125870A4 (de) * 2014-04-04 2017-12-13 Alba Therapeutics Corporation Verfahren zur behandlung von zöliakie mit larazotid
JP2020507626A (ja) 2017-02-10 2020-03-12 イノベイト バイオファーマシューティカルズ インコーポレイテッド 腸上皮の透過性と関連する疾患を治療する組成物及び方法
US11608359B2 (en) 2018-02-23 2023-03-21 9 Meters Biopharma, Inc. Compounds and methods for treating tight junction permeabtility
EP4326304A1 (de) 2021-04-19 2024-02-28 Ebris S.r.l. Zonulinantagonisten zur behandlung des multisystem-entzündlichen syndroms bei kindern (mis-c) und erwachsenen (mis-a)
CN118873629B (zh) * 2024-09-27 2024-12-10 北京大学口腔医学院 醋酸拉唑肽在制备促进成骨药物中的用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US667048A (en) * 1900-07-06 1901-01-29 Edson F Whitman Torpedo-projectile.
US2419898A (en) 1943-12-10 1947-04-29 Int Harvester Co Shelled corn saver for husking devices
US5395750A (en) * 1992-02-28 1995-03-07 Hoffmann-La Roche Inc. Methods for producing proteins which bind to predetermined antigens
AU5896394A (en) * 1992-11-10 1994-06-08 Washington University Pars planitis specific polypeptides
AU5615594A (en) * 1992-11-13 1994-06-08 Cancer Research Fund Of Contra Costa Polypeptides with specificity for neoplasias, kit, and diagnostic, vaccination, and therapeutic methods
AU6396494A (en) * 1992-11-16 1994-06-08 Cancer Research Fund Of Contra Costa Peptides and anti-sense peptides with broad neoplastic specificity
JP2996864B2 (ja) * 1994-03-30 2000-01-11 寳酒造株式会社 抗体可変領域dna
US5665389A (en) 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes
CO4600637A1 (es) * 1996-03-15 1998-05-08 Corixa Corp Compuestos para inmunoterapia e inmunodiagnosis del cancer de prostata
US5912323A (en) * 1997-02-20 1999-06-15 University Of Maryland, Baltimore Zonula occludens toxin receptors
US5945510A (en) * 1997-05-21 1999-08-31 University Of Maryland, Baltimore Substantially pure zonulin, a physiological modulator of mammalian tight junctions
US6506577B1 (en) * 1998-03-19 2003-01-14 The Regents Of The University Of California Synthesis and crosslinking of catechol containing copolypeptides
US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
ES2239480T3 (es) * 1998-09-14 2005-09-16 University Of Maryland, Baltimore Metodo in vitro de utilizacion de zot o zonulina para inhibir la proliferacion de linfocitos especifica de antigeno.
WO2001089551A1 (en) * 2000-05-19 2001-11-29 University Of Maryland, Baltimore Method of use of peptide antagonists of zonulin to prevent or delay the onset of diabetes
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease

Also Published As

Publication number Publication date
JP2002524393A (ja) 2002-08-06
US20140128328A1 (en) 2014-05-08
EP1698345A3 (de) 2006-09-13
US7582603B2 (en) 2009-09-01
US20060276399A1 (en) 2006-12-07
WO2000007609A1 (en) 2000-02-17
US7189696B2 (en) 2007-03-13
IL141082A (en) 2012-09-24
NO20010567D0 (no) 2001-02-02
CN1217697C (zh) 2005-09-07
AU5459099A (en) 2000-02-28
EP1698345A2 (de) 2006-09-06
DE69931929D1 (de) 2006-07-27
IL141082A0 (en) 2002-02-10
ES2267282T3 (es) 2007-03-01
NO20010567L (no) 2001-04-02
US6936689B2 (en) 2005-08-30
CN1313772A (zh) 2001-09-19
US6670448B2 (en) 2003-12-30
US20050209161A1 (en) 2005-09-22
US20110183923A1 (en) 2011-07-28
HK1082210A1 (en) 2006-06-02
US20090082279A1 (en) 2009-03-26
KR20010072245A (ko) 2001-07-31
CA2338005C (en) 2012-05-29
NO326552B1 (no) 2009-01-05
DE69931929T2 (de) 2007-02-08
NZ509579A (en) 2003-07-25
CN1679915A (zh) 2005-10-12
US6458925B1 (en) 2002-10-01
HUP0103321A3 (en) 2006-01-30
US7531504B2 (en) 2009-05-12
ATE329606T1 (de) 2006-07-15
HU228079B1 (en) 2012-10-29
HUP0103321A2 (hu) 2001-12-28
RU2214267C2 (ru) 2003-10-20
EP1102596A4 (de) 2002-08-14
US20020115825A1 (en) 2002-08-22
CN100348266C (zh) 2007-11-14
DE69942753D1 (de) 2010-10-21
US20040082512A1 (en) 2004-04-29
EP1102596B1 (de) 2006-06-14
KR100610389B1 (ko) 2006-08-09
CA2338005A1 (en) 2000-02-17
US20080051349A1 (en) 2008-02-28
AU745507B2 (en) 2002-03-21
DK1102596T3 (da) 2006-10-09
EP1102596A1 (de) 2001-05-30
US20130190247A1 (en) 2013-07-25
EP1698345B1 (de) 2010-09-08
ZA200100829B (en) 2002-06-26
JP4822585B2 (ja) 2011-11-24

Similar Documents

Publication Publication Date Title
ATE480252T1 (de) Peptidantagonist von zonulin und dessen verwendung
DE69940063D1 (de) Biphenylsulfonamide als zweifach aktive rezeptor antagonisten von angiotensin und endothelin
TR199801255T2 (xx) Vitronektin resept�r antagonistleri.
EA200101177A1 (ru) Производные индола в качестве антагонистов прогестерона
DE69616480D1 (de) Piperidinderivate als neurokininantagonisten
ES2147729T3 (es) Dominios de la region extracelular de polipeptidos receptores de factor de crecimiento derivado de plaquetas humano.
TR200101398T2 (tr) Pirolidin türevleri-CCR-3 reseptörü antagonistleri.
TR199801594A2 (xx) CCR-3 resept�r antagonistleri.
TR200101155T2 (tr) 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
DK1129186T3 (da) Et faktor VIII-polypeptid med faktor VIII:C-aktivitet
TR200002896T2 (tr) Kalsilitik Bileşimler
TR200100462T2 (tr) Muskarinik agonistleri ve antagonistleri
MX9801890A (es) Nuevos compuestos antagonistas selectivos del receptor nk3 humano, procedimiento para su obtencion y composiciones farmaceuticas que los contienen.
EA200201138A1 (ru) Пептид, модулирующий рецептор тромбопоэтина
CO5460266A1 (es) Novedosos analogos de la somatostatina
AU1667500A (en) N-(2-phenyl-4-piperidinybutyl)-5,6,7,8-tetrahydro-1-naphthal necarboxamides and their use as neurokinin 1 (nk1) and/or neurokinin 2 (nk2) receptor antagonists
EA200000198A1 (ru) 2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов
ATE279923T1 (de) Urotensin-ii rezeptorantagonisten
MX9603045A (es) Antagonistas de los receptores endoteliales.
TR199800152T1 (xx) Endotelin Resept�r Antagonistleri
DE69526738D1 (de) Endothelin-rezeptor-antagonisten
TR200101030T2 (tr) İnsanlara özgü NK3 reseptörlerinin seçici antagonistleri olarak üreidopiperidin türevleri
TR200100354T2 (tr) NK-2 Antagonist hareketine sahip monosiklik bileşimler ve oluşumlar.
DE69921300D1 (de) Phthalimido arylpiperazinen als alpha 1a rezeptor antagonisten nützlich zur behandlung von gutartigen prostatahyperplasia
RU93046495A (ru) Гетероциклические соединения, промежуточные соединения, способ получения и фармацевтическая композиция

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties