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DE69815316D1 - Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist - Google Patents

Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist

Info

Publication number
DE69815316D1
DE69815316D1 DE69815316T DE69815316T DE69815316D1 DE 69815316 D1 DE69815316 D1 DE 69815316D1 DE 69815316 T DE69815316 T DE 69815316T DE 69815316 T DE69815316 T DE 69815316T DE 69815316 D1 DE69815316 D1 DE 69815316D1
Authority
DE
Germany
Prior art keywords
fungicide
tablets
polymer
core coated
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69815316T
Other languages
English (en)
Other versions
DE69815316T2 (de
Inventor
Petrus Vandecruys
Conde Florent De
Marie Gilis
Jozef Peeters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69815316D1 publication Critical patent/DE69815316D1/de
Application granted granted Critical
Publication of DE69815316T2 publication Critical patent/DE69815316T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69815316T 1997-03-26 1998-03-18 Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist Expired - Lifetime DE69815316T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
EP97200914 1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en) 1997-03-26 1998-03-18 Pellets having a core coated with an antifungal and a polymer

Publications (2)

Publication Number Publication Date
DE69815316D1 true DE69815316D1 (de) 2003-07-10
DE69815316T2 DE69815316T2 (de) 2004-04-29

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69815316T Expired - Lifetime DE69815316T2 (de) 1997-03-26 1998-03-18 Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist

Country Status (31)

Country Link
EP (1) EP0969821B1 (de)
JP (1) JP3608800B2 (de)
KR (1) KR100520936B1 (de)
CN (1) CN1206984C (de)
AP (1) AP1227A (de)
AT (1) ATE241969T1 (de)
AU (1) AU734248B2 (de)
BG (1) BG64434B1 (de)
BR (1) BR9806174A (de)
CA (1) CA2269501C (de)
CY (1) CY2384B1 (de)
CZ (1) CZ295502B6 (de)
DE (1) DE69815316T2 (de)
DK (1) DK0969821T3 (de)
EE (1) EE03904B1 (de)
ES (1) ES2201485T3 (de)
HK (1) HK1022840A1 (de)
HU (1) HU224217B1 (de)
ID (1) ID21477A (de)
IL (1) IL129575A (de)
NO (1) NO325102B1 (de)
NZ (1) NZ335364A (de)
OA (1) OA11162A (de)
PL (1) PL190566B1 (de)
PT (1) PT969821E (de)
RU (1) RU2218153C2 (de)
SI (1) SI0969821T1 (de)
SK (1) SK284813B6 (de)
TR (1) TR199900990T2 (de)
UA (1) UA60318C2 (de)
WO (1) WO1998042318A1 (de)

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ES2157731B1 (es) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
AU3900300A (en) 1999-03-24 2000-10-09 Fmc Corporation Improved aqueous solubility pharmaceutical formulations
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
SI1370543T1 (sl) 2001-02-14 2007-04-30 Tibotec Pharm Ltd Sirokospektralni 2-(substituirani-amino)-benzotiazol sulfonamidni inhibitorji HIV proteaze
PL367084A1 (en) 2001-04-09 2005-02-21 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
CA2444895C (en) 2001-05-11 2011-02-15 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
HUP0500164A3 (en) 2001-12-21 2009-03-30 Tibotec Pharm Ltd Heterocyclic substituted benzenesulfonamides as hiv protease inhibitors and pharmaceutical compositions containing them
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
EA010908B1 (ru) 2002-05-17 2008-12-30 Тиботек Фармасьютикалз Лтд. Ингибиторы вич-протеазы на основе замещённых бензизоксазолсульфонамидов широкого спектра действия
MXPA05001792A (es) 2002-08-14 2005-04-25 Tibotec Pharm Ltd Oxindolsulfonamida sustituida como inhibidores de proteasa de virus de inmunodeficiencia humana de amplio espectro.
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
SI1438960T2 (sl) * 2003-01-14 2013-04-30 Cimex Pharma Ag Sestavek itrakonazola, dispergiranega v hidrofilnem polimeru, z izboljšano biorazpoložljivostjo
SI1438961T2 (sl) * 2003-01-14 2014-12-31 Cimex Pharma Ag Bioekvivalenten sestavek itrakonazola, dispergiranega v hidrofilnem polimeru
EP1651192A1 (de) * 2003-08-06 2006-05-03 Nirmal Mulye Pharmazeutische zusammensetzung mit einem wasserlöslichen arzneimittel
SG145742A1 (en) 2003-09-11 2008-09-29 Tibotec Pharm Ltd Entry inhibitors of the hiv virus
EP1568369A1 (de) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
AU2005244121B2 (en) 2004-05-07 2012-01-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
US7615639B2 (en) 2004-05-17 2009-11-10 Tibotec Pharmaceuticals, Ltd. 1-pyridyl-benzofuro[3,2-b]pyridin-2(1H)-ones
BRPI0511173A (pt) 2004-05-17 2007-12-04 Tibotec Pharm Ltd 1-fenil-1,5-diidro-pirido-(3,2b)indol-2-onas substituìdas nas posições 6,7,8,9, de utilidade como agentes farmacêuticos antiinfecciosos
MXPA06013315A (es) 2004-05-17 2007-02-02 Tibotec Pharm Ltd 1,5-dihidro-pirido[3,2-b]indol-2-onas 4-sustituidas.
US7994187B2 (en) 2006-04-03 2011-08-09 Tibotec Pharmaceuticals Ltd. HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones
WO2008062440A2 (en) * 2006-09-04 2008-05-29 Panacea Biotec Limited Programmable buoyant delivery technology
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
WO2009070744A1 (en) 2007-11-28 2009-06-04 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome p450 2d6
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
US8313527B2 (en) 2007-11-05 2012-11-20 Allergan, Inc. Soft prosthesis shell texturing method
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US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
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US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
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US8679279B2 (en) 2010-11-16 2014-03-25 Allergan, Inc. Methods for creating foam-like texture
CN102100678B (zh) * 2011-02-18 2012-10-17 天津力生制药股份有限公司 伊曲康唑硫酸盐微丸及其制备方法
EP2962662A1 (de) 2012-12-13 2016-01-06 Allergan, Inc. Brustimplantats mit veränderlicher oberfläche
US10092392B2 (en) 2014-05-16 2018-10-09 Allergan, Inc. Textured breast implant and methods of making same
KR102600541B1 (ko) * 2016-01-20 2023-11-08 테라비다, 인코포레이티드 다한증을 치료하기 위한 방법 및 조성물
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DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
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Also Published As

Publication number Publication date
JP2001520663A (ja) 2001-10-30
EP0969821B1 (de) 2003-06-04
NO992114L (no) 1999-08-26
SK54499A3 (en) 2000-01-18
SI0969821T1 (en) 2003-10-31
ES2201485T3 (es) 2004-03-16
HUP0002056A3 (en) 2001-01-29
EE03904B1 (et) 2002-12-16
OA11162A (en) 2003-04-16
CN1206984C (zh) 2005-06-22
NO325102B1 (no) 2008-02-04
PT969821E (pt) 2003-10-31
KR100520936B1 (ko) 2005-10-17
CA2269501C (en) 2005-11-08
IL129575A0 (en) 2000-02-29
ID21477A (id) 1999-06-17
CZ295502B6 (cs) 2005-08-17
EE9900453A (et) 2000-04-17
HUP0002056A2 (hu) 2000-12-28
RU2218153C2 (ru) 2003-12-10
CZ139899A3 (cs) 1999-10-13
PL190566B1 (pl) 2005-12-30
ATE241969T1 (de) 2003-06-15
UA60318C2 (uk) 2003-10-15
NO992114D0 (no) 1999-04-30
AP9901516A0 (en) 1999-06-30
HU224217B1 (hu) 2005-06-28
AP1227A (en) 2003-11-24
CY2384B1 (en) 2004-06-04
BG103356A (en) 2000-03-31
CN1244796A (zh) 2000-02-16
HK1022840A1 (en) 2000-08-25
AU7210798A (en) 1998-10-20
EP0969821A1 (de) 2000-01-12
AU734248B2 (en) 2001-06-07
DK0969821T3 (da) 2003-09-15
IL129575A (en) 2004-06-20
NZ335364A (en) 2000-08-25
TR199900990T2 (xx) 1999-10-21
SK284813B6 (sk) 2005-12-01
DE69815316T2 (de) 2004-04-29
WO1998042318A1 (en) 1998-10-01
JP3608800B2 (ja) 2005-01-12
CA2269501A1 (en) 1998-10-01
PL335542A1 (en) 2000-04-25
KR20000052971A (ko) 2000-08-25
BG64434B1 (en) 2005-02-28
BR9806174A (pt) 1999-10-19

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Legal Events

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