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DE69422526D1 - Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung - Google Patents

Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung

Info

Publication number
DE69422526D1
DE69422526D1 DE69422526T DE69422526T DE69422526D1 DE 69422526 D1 DE69422526 D1 DE 69422526D1 DE 69422526 T DE69422526 T DE 69422526T DE 69422526 T DE69422526 T DE 69422526T DE 69422526 D1 DE69422526 D1 DE 69422526D1
Authority
DE
Germany
Prior art keywords
polycyclic
stem
production
antiparasitic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69422526T
Other languages
English (en)
Other versions
DE69422526T2 (de
Inventor
W Dombrowski
G Endris
L Helms
D Hensens
G Ondeyka
A Ostlind
D Polishook
L Zink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69422526D1 publication Critical patent/DE69422526D1/de
Publication of DE69422526T2 publication Critical patent/DE69422526T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
DE69422526T 1993-11-01 1994-10-27 Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung Expired - Lifetime DE69422526T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/146,638 US5399582A (en) 1993-11-01 1993-11-01 Antiparasitic agents
PCT/US1994/012302 WO1995012599A1 (en) 1993-11-01 1994-10-27 Polycyclic antiparasitic agents, process and strain for their preparation and their use

Publications (2)

Publication Number Publication Date
DE69422526D1 true DE69422526D1 (de) 2000-02-10
DE69422526T2 DE69422526T2 (de) 2000-07-27

Family

ID=22518283

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69422526T Expired - Lifetime DE69422526T2 (de) 1993-11-01 1994-10-27 Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung

Country Status (24)

Country Link
US (2) US5399582A (de)
EP (1) EP0726902B1 (de)
JP (1) JP3557212B2 (de)
KR (1) KR100333017B1 (de)
CN (2) CN1046943C (de)
AT (1) ATE188476T1 (de)
AU (1) AU688405B2 (de)
CA (1) CA2174645C (de)
CZ (1) CZ286032B6 (de)
DE (1) DE69422526T2 (de)
DK (1) DK0726902T3 (de)
ES (1) ES2143558T3 (de)
FI (2) FI110871B (de)
GR (1) GR3032493T3 (de)
HU (1) HU221276B1 (de)
NO (1) NO315942B1 (de)
NZ (1) NZ275339A (de)
PL (1) PL178879B1 (de)
PT (1) PT726902E (de)
RU (1) RU2139874C1 (de)
SI (1) SI0726902T1 (de)
SK (1) SK281510B6 (de)
WO (1) WO1995012599A1 (de)
ZA (1) ZA948542B (de)

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US5541208A (en) * 1994-01-24 1996-07-30 Merck & Co., Inc. Indole diterpene alkaloid compounds
US5595991A (en) * 1995-03-20 1997-01-21 Merck & Co., Inc. Anthelmintic use of nodulisporic acid and analogs thereof
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US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
US5962499A (en) * 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US5834260A (en) * 1996-08-30 1998-11-10 Merck & Co., Inc. Antiparasitic agents
DK0931082T3 (da) * 1996-09-19 2003-04-22 Merck & Co Inc Nodulisporinsyrederivater
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ES2359973T3 (es) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
US6586452B1 (en) 2000-07-14 2003-07-01 Merck & Co., Inc. C1 to C4 side chain modified nodulisporic acid analogs
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US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US7759381B2 (en) 2006-07-05 2010-07-20 Aventis Agriculture 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
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WO2009080546A1 (en) 2007-12-21 2009-07-02 Basf Se The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals
ES2729854T3 (es) 2008-11-14 2019-11-06 Merial Inc Compuestos de ariloazol-2-ilcianoetilamino parasiticidas enriquecidos enantioméricamente
SG171751A1 (en) 2008-11-19 2011-07-28 Merial Ltd Compositions comprising an aryl pyrazole and/ or a formamidine methods and uses thereof
WO2010065852A1 (en) 2008-12-04 2010-06-10 Merial Limited Dimeric avermectin and milbemycin derivatives
NZ597929A (en) 2009-07-30 2013-09-27 Merial Ltd Insecticidal 4-amino-thieno[2,3-d]-pyrimidine compounds and methods of their use
ES2546100T3 (es) 2009-12-04 2015-09-18 Merial, Inc. Compuestos pesticidas bis-organosulfurados
NZ600845A (en) 2009-12-17 2014-08-29 Merial Ltd Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
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WO2011095581A1 (en) 2010-02-05 2011-08-11 Intervet International B.V. S piroindoline compounds for use as anthelminthi cs
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
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KR102066757B1 (ko) 2011-11-17 2020-01-15 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 아릴 피라졸 및 치환된 이미다졸을 함유하는 조성물, 그의 방법 및 용도
MX2014006317A (es) 2011-11-28 2014-06-23 Du Pont Derivados de n-(4-quinolinilmetil) sulfonamida y su uso como antihelminticos.
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Also Published As

Publication number Publication date
DE69422526T2 (de) 2000-07-27
AU8092994A (en) 1995-05-23
CZ286032B6 (cs) 1999-12-15
NO315942B1 (no) 2003-11-17
FI110871B (fi) 2003-04-15
CA2174645C (en) 2004-09-07
ZA948542B (en) 1995-06-27
HU221276B1 (en) 2002-09-28
PL178879B1 (pl) 2000-06-30
CN1046943C (zh) 1999-12-01
CN1236012A (zh) 1999-11-24
FI961839A0 (fi) 1996-04-30
US5614546A (en) 1997-03-25
GR3032493T3 (en) 2000-05-31
PL314190A1 (en) 1996-09-02
FI961839L (fi) 1996-04-30
ES2143558T3 (es) 2000-05-16
DK0726902T3 (da) 2000-05-01
NO961748L (no) 1996-07-01
KR960705828A (ko) 1996-11-08
FI112503B (fi) 2003-12-15
US5399582A (en) 1995-03-21
CN1137796A (zh) 1996-12-11
CA2174645A1 (en) 1995-05-11
SK53996A3 (en) 1997-03-05
AU688405B2 (en) 1998-03-12
ATE188476T1 (de) 2000-01-15
RU2139874C1 (ru) 1999-10-20
EP0726902A1 (de) 1996-08-21
HUT74959A (en) 1997-03-28
JPH09505567A (ja) 1997-06-03
SK281510B6 (sk) 2001-04-09
EP0726902B1 (de) 2000-01-05
CN1082543C (zh) 2002-04-10
KR100333017B1 (ko) 2002-09-27
NZ275339A (en) 1997-11-24
WO1995012599A1 (en) 1995-05-11
HU9601138D0 (en) 1996-06-28
JP3557212B2 (ja) 2004-08-25
NO961748D0 (no) 1996-04-30
CZ124996A3 (en) 1996-10-16
SI0726902T1 (en) 2000-04-30
PT726902E (pt) 2000-06-30
FI20012318L (fi) 2001-11-27

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