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DE69229480D1 - Verfahren zur herstellung hochreiner eicosapentaensäure oder ester davon - Google Patents

Verfahren zur herstellung hochreiner eicosapentaensäure oder ester davon

Info

Publication number
DE69229480D1
DE69229480D1 DE69229480T DE69229480T DE69229480D1 DE 69229480 D1 DE69229480 D1 DE 69229480D1 DE 69229480 T DE69229480 T DE 69229480T DE 69229480 T DE69229480 T DE 69229480T DE 69229480 D1 DE69229480 D1 DE 69229480D1
Authority
DE
Germany
Prior art keywords
ester
acid
eicosapentic
high purity
producing high
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69229480T
Other languages
English (en)
Other versions
DE69229480T2 (de
Inventor
Kiyomi Furihata
Kazuhiko Hata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissui Corp
Original Assignee
Nippon Suisan Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Suisan Kaisha Ltd filed Critical Nippon Suisan Kaisha Ltd
Publication of DE69229480D1 publication Critical patent/DE69229480D1/de
Application granted granted Critical
Publication of DE69229480T2 publication Critical patent/DE69229480T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining
    • C11C1/10—Refining by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/10—Refining fats or fatty oils by adsorption
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/12—Refining fats or fatty oils by distillation
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
DE69229480T 1991-10-28 1992-10-28 Verfahren zur herstellung hochreiner eicosapentaensäure oder ester davon Expired - Lifetime DE69229480T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28168691A JP3400466B2 (ja) 1991-10-28 1991-10-28 高純度エイコサペンタエン酸またはそのエステルの製造方法
PCT/JP1992/001393 WO1993009210A1 (en) 1991-10-28 1992-10-28 Process for producing high-purity eicosapentaenoic acid or ester thereof

Publications (2)

Publication Number Publication Date
DE69229480D1 true DE69229480D1 (de) 1999-07-29
DE69229480T2 DE69229480T2 (de) 2000-02-17

Family

ID=17642575

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229480T Expired - Lifetime DE69229480T2 (de) 1991-10-28 1992-10-28 Verfahren zur herstellung hochreiner eicosapentaensäure oder ester davon

Country Status (11)

Country Link
US (1) US5840944A (de)
EP (1) EP0610506B1 (de)
JP (1) JP3400466B2 (de)
AT (1) ATE181567T1 (de)
AU (1) AU664866B2 (de)
CA (1) CA2122345C (de)
DE (1) DE69229480T2 (de)
DK (1) DK0610506T3 (de)
ES (1) ES2132133T3 (de)
NO (1) NO302038B1 (de)
WO (1) WO1993009210A1 (de)

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KR100657642B1 (ko) 1996-10-11 2006-12-19 스카리스타 리미티드 에이코사펜타엔산 및/또는 스테아리돈산을 포함하여 이루어지는 오일
JP2872986B1 (ja) * 1998-01-21 1999-03-24 池田食研株式会社 高純度高度不飽和脂肪酸の低級アルコールエステル精製方法
GB9901809D0 (en) * 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
WO2000050547A1 (en) 1999-02-26 2000-08-31 Monsanto Company Process for separating a triglyceride comprising a docosahexaenoic acid residue from a mixture of triglycerides
ES2159257B1 (es) * 1999-11-19 2002-04-16 Kd Iqa S L Nuevo procedimiento de preparacion del ester etilico del acido eicosa pentaenoico.
EP1125914A1 (de) 2000-02-14 2001-08-22 Nisshin Flour Milling Co., Ltd. Verfahren zur Reinigung und Abtrennung von Eicosapentaencarbonsäure oder ihrer Ester
FR2833006A1 (fr) * 2001-11-30 2003-06-06 Cognis France Sa Procede de preparation d'ester methylique d'acide oleique industriel
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EP2046136A2 (de) * 2006-06-23 2009-04-15 The Procter and Gamble Company Konzentrierte geruchlose omega-3-fettsäuren
KR101357298B1 (ko) * 2008-06-20 2014-01-28 에이케이 앤 엠엔 바이오팜 주식회사 오메가-3계 고도불포화 지방산의 고순도 정제방법
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KR20140007973A (ko) 2009-02-10 2014-01-20 아마린 파마, 인크. 고중성지방혈증 치료 방법
AU2010241571B2 (en) 2009-04-29 2014-06-26 Amarin Pharmaceuticals Ireland Limited Stable pharmaceutical composition and methods of using same
SG175390A1 (en) 2009-04-29 2011-12-29 Amarin Corp Plc Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
PL3318255T3 (pl) 2009-06-15 2021-09-06 Amarin Pharmaceuticals Ireland Limited Kompozycje i sposoby leczenia udaru u pacjenta z jednoczesną terapią statyną
CA2775339C (en) 2009-09-23 2017-03-28 Amarin Corporation Plc Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
KR101801011B1 (ko) * 2009-12-30 2017-11-23 바스프 파마 (칼라니쉬) 리미티드 다중 불포화 지방산을 정제하기 위한 시뮬레이션된 이동상 크로마토그래피 분리 방법
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US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
EP2646013A4 (de) 2010-11-29 2014-03-26 Amarin Pharma Inc Zusammensetzung mit geringem aufstosseffekt und verfahren zur behandlung und/oder vorbeugung kardiovaskulärer erkrankungen bei einem patienten mit fischallergie/-überempfindlichkeit
US9119826B2 (en) 2011-02-16 2015-09-01 Pivotal Therapeutics, Inc. Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels
US8951514B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels
ES2395320B1 (es) 2011-07-14 2013-12-18 Soluciones Extractivas Alimentarias, S.L. Nuevo método para la reducción de contaminantes en grasas y aceites a partir de aceites y sus derivados.
CN102391112B (zh) * 2011-10-31 2014-06-04 赵永俊 一种工业化生产二十碳五烯酸乙酯的方法
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
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CN104797249A (zh) * 2012-09-28 2015-07-22 持田制药株式会社 用于减少新发糖尿病的组合物
US20150265566A1 (en) 2012-11-06 2015-09-24 Amarin Pharmaceuticals Ireland Limited Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy
US9629820B2 (en) 2012-12-24 2017-04-25 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US10123986B2 (en) 2012-12-24 2018-11-13 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
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US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
EP2801604B1 (de) 2013-05-07 2017-04-12 Groupe Novasep Chromatographisches Verfahren zur Herstellung von hochreinen, mehrfach ungesättigten Fettsäuren
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
EP3101138B1 (de) * 2013-12-04 2021-05-05 Nippon Suisan Kaisha, Ltd. Mikrobielles öl, verfahren zur herstellung von mikrobiellen ölen, konzentriertes mikrobielles öl und verfahren zur herstellung von konzentriertem mikrobiellem öl
EP2883860B1 (de) * 2013-12-11 2016-08-24 Novasep Process Chromatografisches Verfahren zur Herstellung von mehrfach ungesättigten Fettsäuren
EP3092218B1 (de) 2014-01-07 2022-03-09 Novasep Process Solutions Verfahren zur reinigung von aminosäuren
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
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HUE068083T2 (hu) * 2014-07-02 2024-12-28 Nissui Corp Eljárás tengeri termékbõl származó egyvegyértékû telítetlen zsírsavak vagy ezek alacsony-szénatomszámú alkohollal képzett észtereinek elõállítására
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CN108289470A (zh) * 2015-10-05 2018-07-17 帝斯曼知识产权资产管理有限公司 油组合物和制备方法
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US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
AU2019349563B2 (en) 2018-09-24 2023-06-08 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of cardiovascular events in a subject
CN109438220B (zh) * 2018-10-31 2021-04-13 苏州赛分科技有限公司 一种从鱼油中纯化epa的方法
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JPS57149400A (en) * 1981-03-12 1982-09-14 Kureha Chemical Ind Co Ltd Manufacture of high purity long chain highly unsaturated fatty acid ester
US4377526A (en) * 1981-05-15 1983-03-22 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid and its esters
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JPS60208940A (ja) * 1984-03-31 1985-10-21 Nippon Zeon Co Ltd 長鎮不飽和脂肪酸化合物の分離精製法
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JPH02268133A (ja) * 1989-04-10 1990-11-01 Nippon Suisan Kaisha Ltd エイコサペンタエン酸またはそのエステルの製造法
CA2043615C (en) * 1990-06-04 2001-08-14 Kazuhiko Hata Method of producing eicosapentaenoic acid or the ester derivative thereof
US5215630A (en) * 1991-06-04 1993-06-01 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid or the ester derivative thereof by fractional distillation

Also Published As

Publication number Publication date
NO941550L (de) 1994-06-27
ES2132133T3 (es) 1999-08-16
DE69229480T2 (de) 2000-02-17
WO1993009210A1 (en) 1993-05-13
EP0610506A4 (en) 1995-12-13
NO302038B1 (no) 1998-01-12
JPH05222392A (ja) 1993-08-31
EP0610506A1 (de) 1994-08-17
AU664866B2 (en) 1995-12-07
DK0610506T3 (da) 2000-01-24
ATE181567T1 (de) 1999-07-15
CA2122345C (en) 2004-03-09
NO941550D0 (de) 1994-04-27
AU2873992A (en) 1993-06-07
JP3400466B2 (ja) 2003-04-28
US5840944A (en) 1998-11-24
CA2122345A1 (en) 1993-05-13
EP0610506B1 (de) 1999-06-23

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