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KR900002771A - 지방산 조성물 - Google Patents

지방산 조성물 Download PDF

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Publication number
KR900002771A
KR900002771A KR1019890011456A KR890011456A KR900002771A KR 900002771 A KR900002771 A KR 900002771A KR 1019890011456 A KR1019890011456 A KR 1019890011456A KR 890011456 A KR890011456 A KR 890011456A KR 900002771 A KR900002771 A KR 900002771A
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South Korea
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weight
fatty acid
long chain
acid
composition
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KR1019890011456A
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KR0126286B1 (ko
Inventor
브레이빅 하랄드
보레트젠 베른트
헬카스 달 크너트
에이너 크로칸 한스
에이취.버나 카아레
Original Assignee
아르네 선드네스
노르스크 히드로 아.세
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

내용 없음

Description

지방산 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 적어도 80중량%의 오메가-3-지방산을 포함하며, 상기 지방산중의 (all-Z)-5,8,11,14,17-에이코사펜타에노산(EPA) C20 : 5 및 (all-Z)-4,7,10,13,16,19-도코사에 노산(DHA) C22 : 6이 1 : 2 내지 2 : 1의 상대적 함량으로 존재하고 또한 적어도 75중량%의 총지방산을 구성하는 것을 특징으로 하는 조성물.
  2. 제 1 항에 있어서, 존재하는 다른 장쇄 지방산이 (all-Z C21 : 5)-6,9,12,15,18-헨에이코사펜타에노산, 및/또는 (all-Z C22 : 5)-7,10,13,16,19-에이코사헥사에노산 및/또는 (all-Z C18 : 4)-6,9,12,15-옥사데카테트라에노산인 것을 특징으로 하는 조성물.
  3. 제 1 항 또는 제 2 항에 있어서, 상기 장쇄 오메가-3 지방산의 전체 농도가 적어도 90중량%이고, 지방산의 EPA 및 DHA가 적어도 85중량%의 총 지방산을 구성하고, EPA : DHA의 상대적 함량비가 1 : 1 내지 2 : 1 구체적으로 약 3 : 2이며, 다른 장쇄 오메가 -3 C20,C21 및 C22산이 적어도 4.5중량%의 농도로 존재하는 것을 특징으로 하는 조성물.
  4. 제 1 항에 있어서, 상기 장쇄 오메가-3 지방산의 전체 농도가 적어도 95중량%이고, 상기 EPA 및 DHA가 적어도 90중량%의 총 지방산을 구성하고, 다른 장쇄 C20,C21 및 C22산이 적어도 4.5중량%의 농도로 존재하는 것을 특징으로 하는 조성물.
  5. 제 1 항에 또는 제 2 항에 있어서, 상기 장쇄 오메가-3 지방산의 전체 농도가 적어도 85중량%이고, 상기 EPA 및 DHA가 적어도 80중량%의 농도로 존재하고, 다른 장쇄 C20,C21 및 C22산이 적어도 4.5중량%의 농도로 존재하는 것을 특징으로 하는 조성물.
  6. 제 4 항 또는 제 5 항에 있어서, 상기 EPA 및 DHA가 1 : 1 내지 2 : 1의 상대적 함량으로 존재하는 것을 특징으로 하는 조성물.
  7. 제 1 항에 있어서, 상기 지방산이 약학적 허용염 형태로 존재하는 것을 특징으로 하는 조성물.
  8. 제 1 항에 있어서, 상기 지방산이 유도체 형태로 존재하는 것을 특징으로 하는 조성물.
  9. 제 8 항에 있어서, 상기 유도체가 에스테르 구체적으로, 알킬 에스테르인 것을 특징으로 하는 조성물.
  10. 제 9 항에 있어서, 상기 지방산이 에틸 에스테르 형태로 존재하는 것을 특징으로 하는 조성물.
  11. 상기 항중 어느 한 항에 있어서, 심장 혈관계 질환에 대한 다수의 위험인자들의 치료 및 예방을 위한 조성물.
  12. 임의의 단계에서 해양원료를 트렌스 에스테르화 단계, 우레아 분별을 경유하는 농축단계, 분자 증류 및/또는 초임계 유체 추출 단계 또는 크로마토그라피 단계를 수반시켜, 이로 인해 오메가-3 C20 : 5 및 C22 : 6산의 에스테르로 주로 구성되는 주요 유분은 분리되어 총 함량이 적어도 80중량%의 장쇄 오메가-3 지방산 에스테르를 산출하고, 상기 우레아 분별 및 분자 증류는 오메가-3산의 산화 및 이성체화를 피하기 위해 완만한 조건하에서 실시되는 것을 특징으로 하는 제 1 항 내지 제10항중 어느 한 항에 기재된 지방산 조성물의 제조방법.
  13. 심장 혈관계 질환에 대한 다수 위험인자의 치료 또는 예방을 위한 약학 제제의 제조에 (all-Z)-5,8,11,14,17-에이코사펜타에노산(EPA) C20 : 5 및 (all-Z)-4,7,10,13,16,19-도코사헥사에노산(DHA) C22 : 6이 1 : 2 내지 2 : 1의 상대적 함량으로 존재하고, 적어도 75중량%의 총 장쇄 지방산을 구성하는 80중량%의 장쇄 오메가-3 지방산 또는 염 또는 그 유도체를 함유하는 해양 오일 농출물의 사용방법.
  14. 약학적 허용 담체와 혼합한 제 1 항 내지 제10항의 조성물을 투여하는 것을 포함하는 심장 혈관계 질환에 대한 다수 위험 인자의 치료 또는 예방법.
  15. 약학적 허용 담체 또는 희석제를 적어도 80중량%의 장쇄 오메가-3 지방산 또는 염 또는 그 유도체를 함유하는 해양 오일 농축물에 첨가시키는 것을 포함하며, 상기 (all-Z)-5,8,11,14,17-에이코사펜타에노산(EPA) C20 : 5 및 (all-Z)-4,7,10,13,16,19-토코사헥사에노산(DHA) C22 : 6은 1 : 2 내지 2 : 1의 상대적 함량으로 존재하며, 적어도 75중량%의 총 지방산을 구성하는 심장 혈관계 질환에 대한 다수 위험 인자의 치료 또는 예방에 대한 약학적 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890011456A 1988-08-11 1989-08-11 지방산 조성물 KR0126286B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888819110A GB8819110D0 (en) 1988-08-11 1988-08-11 Antihypertensive drug & method for production
GB8819110.1 1988-08-11

Publications (2)

Publication Number Publication Date
KR900002771A true KR900002771A (ko) 1990-03-23
KR0126286B1 KR0126286B1 (ko) 1997-12-26

Family

ID=10641979

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Application Number Title Priority Date Filing Date
KR1019890011456A KR0126286B1 (ko) 1988-08-11 1989-08-11 지방산 조성물

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US (3) US5502077A (ko)
JP (1) JP2810916B2 (ko)
KR (1) KR0126286B1 (ko)
AT (1) AT398779B (ko)
AU (1) AU616784B2 (ko)
BE (1) BE1002547A5 (ko)
CA (1) CA1337548C (ko)
CH (1) CH680789A5 (ko)
DE (1) DE3926658C2 (ko)
DK (1) DK173371B1 (ko)
ES (1) ES2018384A6 (ko)
FI (1) FI893805L (ko)
FR (1) FR2635263A1 (ko)
GB (2) GB8819110D0 (ko)
GR (1) GR1000567B (ko)
HK (1) HK84196A (ko)
IE (1) IE64524B1 (ko)
IL (1) IL91275A (ko)
IT (1) IT1235879B (ko)
LU (1) LU87570A1 (ko)
NL (1) NL193459C (ko)
NZ (1) NZ230022A (ko)
SE (1) SE504742C2 (ko)
ZA (1) ZA895512B (ko)

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NL8902020A (nl) 1990-03-01
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IT8921521A0 (it) 1989-08-11
NZ230022A (en) 1990-10-26
DK173371B1 (da) 2000-09-04
CH680789A5 (ko) 1992-11-13
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FI893805L (fi) 1990-02-12
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DK392089A (da) 1990-02-12
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GB2221843A (en) 1990-02-21
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US5698594A (en) 1997-12-16
IL91275A (en) 1996-01-19
CA1337548C (en) 1995-11-14
AT398779B (de) 1995-01-25
SE8902701L (sv) 1990-02-12
JP2810916B2 (ja) 1998-10-15
DK392089D0 (da) 1989-08-10
ZA895512B (en) 1990-07-25
GB2221843B (en) 1992-12-02
AU616784B2 (en) 1991-11-07
BE1002547A5 (fr) 1991-03-19
NL193459B (nl) 1999-07-01
FI893805A0 (fi) 1989-08-11
SE8902701D0 (sv) 1989-08-09
IE64524B1 (en) 1995-08-09
US5656667A (en) 1997-08-12
AU3896789A (en) 1990-02-15
FR2635263A1 (en) 1990-02-16
NL193459C (nl) 1999-11-02
ATA191889A (de) 1994-06-15
KR0126286B1 (ko) 1997-12-26
SE504742C2 (sv) 1997-04-14
US5502077A (en) 1996-03-26
DE3926658C2 (de) 1998-10-15
IT1235879B (it) 1992-11-23
GR890100507A (en) 1990-08-22
GR1000567B (el) 1992-08-26

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