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DE69133405D1 - Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression - Google Patents

Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression

Info

Publication number
DE69133405D1
DE69133405D1 DE69133405T DE69133405T DE69133405D1 DE 69133405 D1 DE69133405 D1 DE 69133405D1 DE 69133405 T DE69133405 T DE 69133405T DE 69133405 T DE69133405 T DE 69133405T DE 69133405 D1 DE69133405 D1 DE 69133405D1
Authority
DE
Germany
Prior art keywords
reactive
oligonucleotid
derivatives
detecting
gene expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133405T
Other languages
English (en)
Other versions
DE69133405T2 (de
Inventor
Dan Cook
J Ecker
John Guinosso
Leobardo Acevedo
Mamoto Kawasaki
Kandasamy Ramasamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of DE69133405D1 publication Critical patent/DE69133405D1/de
Application granted granted Critical
Publication of DE69133405T2 publication Critical patent/DE69133405T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12Y113/11—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11012—Linoleate 13S-lipoxygenase (1.13.11.12)
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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DE69133405T 1990-01-11 1991-01-11 Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression Expired - Lifetime DE69133405T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46335890A 1990-01-11 1990-01-11
US463358 1990-01-11
US56697790A 1990-08-13 1990-08-13
US566977 1990-08-13
PCT/US1991/000243 WO1991010671A1 (en) 1990-01-11 1991-01-11 Compositions and methods for detecting and modulating rna activity and gene expression

Publications (2)

Publication Number Publication Date
DE69133405D1 true DE69133405D1 (de) 2004-08-19
DE69133405T2 DE69133405T2 (de) 2005-07-07

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DE69133405T Expired - Lifetime DE69133405T2 (de) 1990-01-11 1991-01-11 Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression

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Country Link
EP (2) EP1418179A3 (de)
JP (1) JP2580091B2 (de)
KR (1) KR927003044A (de)
AT (1) ATE271064T1 (de)
AU (1) AU651569B2 (de)
BR (1) BR9105935A (de)
CA (1) CA2073500C (de)
DE (1) DE69133405T2 (de)
FI (1) FI923176A (de)
HU (1) HUT63170A (de)
NO (1) NO922718L (de)
WO (1) WO1991010671A1 (de)

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CA2073500C (en) 2008-03-25
HUT63170A (en) 1993-07-28
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NO922718D0 (no) 1992-07-09
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JPH05502031A (ja) 1993-04-15
CA2073500A1 (en) 1991-07-12
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NO922718L (no) 1992-09-09
FI923176A0 (fi) 1992-07-09
ATE271064T1 (de) 2004-07-15
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EP1418179A2 (de) 2004-05-12
FI923176A (fi) 1992-07-09
AU7179891A (en) 1991-08-05
BR9105935A (pt) 1992-11-17

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