DE60319128D1 - Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere - Google Patents
Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymereInfo
- Publication number
- DE60319128D1 DE60319128D1 DE60319128T DE60319128T DE60319128D1 DE 60319128 D1 DE60319128 D1 DE 60319128D1 DE 60319128 T DE60319128 T DE 60319128T DE 60319128 T DE60319128 T DE 60319128T DE 60319128 D1 DE60319128 D1 DE 60319128D1
- Authority
- DE
- Germany
- Prior art keywords
- block copolymers
- ortho esters
- ketenacetales
- dioxide
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920001710 Polyorthoester Polymers 0.000 title abstract 3
- 229920001400 block copolymer Polymers 0.000 title abstract 3
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- -1 poly(ortho esters) Polymers 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 239000002198 insoluble material Substances 0.000 abstract 1
- 150000002560 ketene acetals Chemical class 0.000 abstract 1
- 239000000693 micelle Substances 0.000 abstract 1
- 230000000399 orthopedic effect Effects 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
- C08G2/18—Copolymerisation of aldehydes or ketones
- C08G2/24—Copolymerisation of aldehydes or ketones with acetals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
- C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
- C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US298151 | 2002-11-15 | ||
| US10/298,151 US7045589B2 (en) | 2002-11-15 | 2002-11-15 | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
| PCT/US2003/036616 WO2004046328A2 (en) | 2002-11-15 | 2003-11-13 | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60319128D1 true DE60319128D1 (de) | 2008-03-27 |
| DE60319128T2 DE60319128T2 (de) | 2009-02-05 |
Family
ID=32297370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60319128T Expired - Fee Related DE60319128T2 (de) | 2002-11-15 | 2003-11-13 | Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7045589B2 (de) |
| EP (1) | EP1569664B1 (de) |
| JP (1) | JP2006506514A (de) |
| KR (1) | KR20050075414A (de) |
| CN (1) | CN1726043A (de) |
| AT (1) | ATE385801T1 (de) |
| AU (1) | AU2003295563B2 (de) |
| CA (1) | CA2506241A1 (de) |
| DE (1) | DE60319128T2 (de) |
| ES (1) | ES2299746T3 (de) |
| WO (1) | WO2004046328A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| GB0329654D0 (en) * | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| US7350479B2 (en) * | 2004-09-10 | 2008-04-01 | United States Of America As Represented By The Secretary Of The Army | System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp |
| AU2006230247A1 (en) * | 2005-03-31 | 2006-10-05 | A.P. Pharma, Inc. | PEG-polyacetal and PEG-polyacetal-POE graft copolymers and pharmaceutical compositions |
| US20070264338A1 (en) * | 2006-05-12 | 2007-11-15 | Shah Devang T | Base-stabilized polyorthoester formulations |
| US20070264339A1 (en) * | 2006-05-12 | 2007-11-15 | Ap Pharma, Inc. | Base-stabilized polyorthoester formulations |
| US20070281870A1 (en) * | 2006-06-02 | 2007-12-06 | Halliburton Energy Services, Inc. | Stimuli-degradable gels |
| US7306040B1 (en) * | 2006-06-02 | 2007-12-11 | Halliburton Energy Services, Inc. | Stimuli-degradable gels |
| EP2044142A2 (de) * | 2006-06-29 | 2009-04-08 | Medtronic, Inc. | Poly(orthoester)polymere sowie herstellungs- und verwendungsverfahren dafür |
| EP2042538A1 (de) * | 2007-09-18 | 2009-04-01 | Nirvana's Tree House | Amphiphile Copolymere und Zusammensetzungen mit solchen Polymeren |
| US8475823B2 (en) * | 2008-04-18 | 2013-07-02 | Medtronic, Inc. | Baclofen formulation in a polyorthoester carrier |
| US8956642B2 (en) * | 2008-04-18 | 2015-02-17 | Medtronic, Inc. | Bupivacaine formulation in a polyorthoester carrier |
| EP2326304A2 (de) | 2008-07-17 | 2011-06-01 | Merial Limited | Verfahren zur verbesserung der stabilität von polyorthoestern und ihren formulierungen |
| EP2370064A4 (de) * | 2008-12-11 | 2012-09-19 | A P Pharma Inc | Verfahren zur erhöhung der stabilität von polyorthoestern und ihren formulierungen |
| WO2013142152A1 (en) * | 2012-03-23 | 2013-09-26 | Regents Of The University Of Minnesota | Semi-solid delivery systems |
| US9592227B2 (en) * | 2013-03-15 | 2017-03-14 | Heron Therapeutics, Inc. | Compositions of a polyorthoester and an aprotic solvent |
| KR102063027B1 (ko) | 2013-10-31 | 2020-01-07 | (주)아모레퍼시픽 | 캡슐화된 향기를 포함하는 조성물 |
| JP6232280B2 (ja) * | 2013-12-25 | 2017-11-15 | 株式会社ダイセル | 含酸素飽和ヘテロ環を有する重合体及びその製造方法 |
| CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 |
| CN113980254A (zh) * | 2020-07-10 | 2022-01-28 | 南京泛太化工医药研究所 | 一种具有酸敏感降解、温敏性质的系列聚合物及其载药组合物 |
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| US138474A (en) * | 1873-05-06 | Improvement in wave-powers | ||
| US168336A (en) * | 1875-10-05 | Improvement in horseshoe-machines | ||
| US176844A (en) * | 1876-05-02 | Improvement in beer-taps | ||
| US37300A (en) * | 1863-01-06 | Improvement in window-blind fastenings | ||
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-
2002
- 2002-11-15 US US10/298,151 patent/US7045589B2/en not_active Expired - Fee Related
-
2003
- 2003-11-13 AT AT03786759T patent/ATE385801T1/de not_active IP Right Cessation
- 2003-11-13 DE DE60319128T patent/DE60319128T2/de not_active Expired - Fee Related
- 2003-11-13 EP EP03786759A patent/EP1569664B1/de not_active Expired - Lifetime
- 2003-11-13 CA CA002506241A patent/CA2506241A1/en not_active Abandoned
- 2003-11-13 JP JP2004553783A patent/JP2006506514A/ja active Pending
- 2003-11-13 AU AU2003295563A patent/AU2003295563B2/en not_active Expired - Fee Related
- 2003-11-13 CN CNA2003801063135A patent/CN1726043A/zh active Pending
- 2003-11-13 WO PCT/US2003/036616 patent/WO2004046328A2/en active IP Right Grant
- 2003-11-13 KR KR1020057008690A patent/KR20050075414A/ko not_active Application Discontinuation
- 2003-11-13 ES ES03786759T patent/ES2299746T3/es not_active Expired - Lifetime
-
2006
- 2006-03-08 US US11/371,959 patent/US7163694B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003295563B2 (en) | 2009-01-08 |
| KR20050075414A (ko) | 2005-07-20 |
| US20040096506A1 (en) | 2004-05-20 |
| US20060155101A1 (en) | 2006-07-13 |
| AU2003295563A1 (en) | 2004-06-15 |
| CA2506241A1 (en) | 2004-06-03 |
| US7045589B2 (en) | 2006-05-16 |
| DE60319128T2 (de) | 2009-02-05 |
| EP1569664A4 (de) | 2006-11-02 |
| EP1569664B1 (de) | 2008-02-13 |
| ES2299746T3 (es) | 2008-06-01 |
| WO2004046328A3 (en) | 2004-08-26 |
| ATE385801T1 (de) | 2008-03-15 |
| JP2006506514A (ja) | 2006-02-23 |
| EP1569664A2 (de) | 2005-09-07 |
| US7163694B2 (en) | 2007-01-16 |
| WO2004046328A2 (en) | 2004-06-03 |
| CN1726043A (zh) | 2006-01-25 |
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