[go: up one dir, main page]

BR9706960A - Polìmeros com estado fìsico e condição de bioerosão controlados - Google Patents

Polìmeros com estado fìsico e condição de bioerosão controlados

Info

Publication number
BR9706960A
BR9706960A BR9706960-4A BR9706960A BR9706960A BR 9706960 A BR9706960 A BR 9706960A BR 9706960 A BR9706960 A BR 9706960A BR 9706960 A BR9706960 A BR 9706960A
Authority
BR
Brazil
Prior art keywords
esters
bioerosion
condition
polymers
physical state
Prior art date
Application number
BR9706960-4A
Other languages
English (en)
Inventor
Jorge Heller
Steve Y Ng
Original Assignee
Advanced Polymer Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Polymer Systems Inc filed Critical Advanced Polymer Systems Inc
Publication of BR9706960A publication Critical patent/BR9706960A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Patente de Invenção: <B.''POLìMEROS COM ESTADO FìSICO E CONDIçãO DE BIOEROSãO CONTROLADOS''<D>. A presente invenção refere-se a polímeros utilizáveis como implantes ortopédicos ou veículos para a liberação sustentada de agentes farmacêuticos, cosméticos e de agricultura. Os polímeros são preparados de uma tal maneira que a velocidade e o grau nos quais eles são hidrolisados podem ser controlados sem a adição de um ácido exógeno. Esta verificação reside na incorporação de ésteres de ácidos (- hidróxi de cadeia curta tais como os copolímeros dos ésteres do ácido glicólico, ácido láctico ou do ácido glicólico-co--láctico dentro da cadeia do polímero, e na variação da quantidade desses ésteres, com relação ao polímero como um todo.
BR9706960-4A 1996-01-05 1997-01-03 Polìmeros com estado fìsico e condição de bioerosão controlados BR9706960A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58364996A 1996-01-05 1996-01-05
US58358596A 1996-01-05 1996-01-05
PCT/US1997/000144 WO1997025366A1 (en) 1996-01-05 1997-01-03 Polymers with controlled physical state and bioerodibility

Publications (1)

Publication Number Publication Date
BR9706960A true BR9706960A (pt) 1999-12-28

Family

ID=27078846

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9706960-4A BR9706960A (pt) 1996-01-05 1997-01-03 Polìmeros com estado fìsico e condição de bioerosão controlados

Country Status (11)

Country Link
EP (1) EP0869986B1 (pt)
JP (1) JP4015194B2 (pt)
AT (1) ATE197310T1 (pt)
AU (1) AU1527097A (pt)
BR (1) BR9706960A (pt)
CA (1) CA2242631C (pt)
DE (1) DE69703430T2 (pt)
ES (1) ES2153648T3 (pt)
GR (1) GR3034753T3 (pt)
PT (1) PT869986E (pt)
WO (1) WO1997025366A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
DE60131177T2 (de) 2000-09-06 2008-08-07 AP Pharma, Inc., Redwood Abbaubare polyacetal-polymere
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
EP2044142A2 (en) 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
CN114886899B (zh) * 2014-04-21 2024-02-13 赫伦治疗有限公司 长效聚合物输送系统

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003510A1 (en) * 1989-08-28 1991-03-21 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5047464A (en) * 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers

Also Published As

Publication number Publication date
JP4015194B2 (ja) 2007-11-28
AU1527097A (en) 1997-08-01
GR3034753T3 (en) 2001-02-28
DE69703430D1 (de) 2000-12-07
WO1997025366A1 (en) 1997-07-17
ATE197310T1 (de) 2000-11-15
EP0869986A1 (en) 1998-10-14
CA2242631C (en) 2008-09-09
CA2242631A1 (en) 1997-07-17
JP2000512322A (ja) 2000-09-19
DE69703430T2 (de) 2001-05-03
ES2153648T3 (es) 2001-03-01
PT869986E (pt) 2001-04-30
EP0869986B1 (en) 2000-11-02

Similar Documents

Publication Publication Date Title
WO1997013502A3 (en) Prolonged release of gm-csf
SE9504495D0 (sv) Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat
IE882727L (en) Sustained release pharmaceutical compositions
BR9706960A (pt) Polìmeros com estado fìsico e condição de bioerosão controlados
DK0981381T3 (da) Polyhydroxyalkanoater ti anvendelser in vivo
WO2006036202A3 (en) Stabilized biodegradable neurotoxin implants
BR9916053A (pt) Composições contendo um peptìdio e um ácido glicólico poliláctico, adequadas para preparação de implantes subcutâneos com perìodo de liberação prolongado
WO2003007782A3 (en) Biodegradable injectable implants and related methods of manufacture and use
BR9808933A (pt) Composição sob forma de microcápsulas ou de implantes, processo de preparação de uma substância hidrossolúvel, substância ativa, acetato de triptorelina, acetato de lanreotìdeo, ou acetato de octreotìdeo, e rna de filamento duplo
AU1278000A (en) Particles based on polyamino-acid(s) and methods for preparing same
PL311633A1 (en) Biologically active and/or oriented conjugates of dendrimers
CA2411277A1 (en) Neurotoxin implant
PT839525E (pt) Preparacao de libertacao prolongada
EP2292672A3 (en) Biocompatible polymers and co-polymers comprising amino acids in the side chain
IL115138A0 (en) Implantable polymer-containing molded articles for the administration of active substances to plants and processes for the preparation thereof
WO2005033181A3 (fr) Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
Francis et al. Synthesis, structure, and properties of biopolymers (natural and synthetic)
WO2007051923A3 (fr) Acides polyglutamiques fonctionnalises par des derives de l&#39;histidine et des groupements hydrophobes et leurs applications notamment therapeutiques
DE60138552D1 (de) Peptide mit integrinbindungsmotiv und behandlungsmethoden für muskelkrankheiten
WO2004022000A3 (en) Antibiotic microspheres for treatment of infections and osteomyelitis
Indalkar et al. A comprehensive review on biodegradable polymers
US5576418A (en) Resorbable biocompatible copolymers and their use
IL128329A (en) Pharmaceutical composition of hedgehog proteins and use thereof
Ben Abdeladhim et al. Polyhydroxyalkanoates: Medical Applications and Potential for Use in Dentistry. Materials 2024, 17, 5415
Seidel et al. Degradation of oligo (lactone) branches linked to poly (methacrylate) networks

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/01/1997, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: AP PHARMA, INC. (US)

Free format text: ALTERADO DE: ADVANCED POLYMER SYSTEMS, INC.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]