DE60218199D1 - Humane wachstumshormone freisetzende hormonanaloge, deren herstellung und verwendung - Google Patents
Humane wachstumshormone freisetzende hormonanaloge, deren herstellung und verwendungInfo
- Publication number
- DE60218199D1 DE60218199D1 DE60218199T DE60218199T DE60218199D1 DE 60218199 D1 DE60218199 D1 DE 60218199D1 DE 60218199 T DE60218199 T DE 60218199T DE 60218199 T DE60218199 T DE 60218199T DE 60218199 D1 DE60218199 D1 DE 60218199D1
- Authority
- DE
- Germany
- Prior art keywords
- harg
- gab
- gap
- leu
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000825742 Homo sapiens Somatoliberin Proteins 0.000 title 1
- 102000045304 human GHRH Human genes 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 abstract 1
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 101710142969 Somatoliberin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000007515 enzymatic degradation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- -1 t-butyloxycarbonyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL35046301 | 2001-10-31 | ||
| PL350463A PL195917B1 (pl) | 2001-10-31 | 2001-10-31 | Nowe peptydy - analogi ludzkiego hormonu uwalniającego hormon wzrostu |
| PCT/PL2002/000080 WO2003037928A2 (en) | 2001-10-31 | 2002-10-30 | Analogs of human growth hormone-releasing hormone, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60218199D1 true DE60218199D1 (de) | 2007-03-29 |
| DE60218199T2 DE60218199T2 (de) | 2007-11-22 |
Family
ID=20079564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60218199T Expired - Lifetime DE60218199T2 (de) | 2001-10-31 | 2002-10-30 | Humane wachstumshormone freisetzende hormonanaloge, deren herstellung und verwendung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7928063B2 (de) |
| EP (1) | EP1442059B1 (de) |
| JP (1) | JP4401170B2 (de) |
| AT (1) | ATE353917T1 (de) |
| AU (1) | AU2002351536A1 (de) |
| CA (1) | CA2465667C (de) |
| DE (1) | DE60218199T2 (de) |
| EA (1) | EA007841B1 (de) |
| ES (1) | ES2282494T3 (de) |
| HU (1) | HU229220B1 (de) |
| PL (1) | PL195917B1 (de) |
| SI (1) | SI1442059T1 (de) |
| UA (1) | UA79440C2 (de) |
| WO (1) | WO2003037928A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05002991A (es) * | 2002-09-18 | 2005-10-05 | Univ Montreal Ct Hospitalier Chum | Analogos de ghrh. |
| US8980249B2 (en) | 2010-06-03 | 2015-03-17 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| US20130261058A1 (en) * | 2010-09-16 | 2013-10-03 | University Of Miami | Acceleration of wound healing by growth hormone releasing hormone and its agonists |
| EP2640400A4 (de) * | 2010-11-19 | 2016-01-20 | Sirna Therapeutics Inc | (poly)amidpolymere für die verabreichung von oligonukleotiden |
| CN108929375A (zh) * | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| EP2935317B1 (de) | 2012-12-21 | 2019-03-27 | University of Miami | Ghrh-agonisten zur inselzelltransplantation und -funktion und zur behandlung von diabetes |
| EP2934565B1 (de) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh-agonisten zur behandlung von ischämischen erkrankungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5416073A (en) * | 1983-08-10 | 1995-05-16 | The Adminstrators Of The Tulane Educational Fund | Growth hormone-releasing peptides and method of treating animals, therewith |
| US5792747A (en) * | 1995-01-24 | 1998-08-11 | The Administrators Of The Tulane Educational Fund | Highly potent agonists of growth hormone releasing hormone |
| US6072075A (en) * | 1997-05-22 | 2000-06-06 | The Regents Of The University Of California | Guanidinylation reagents |
-
2001
- 2001-10-31 PL PL350463A patent/PL195917B1/pl unknown
-
2002
- 2002-10-30 JP JP2003540209A patent/JP4401170B2/ja not_active Expired - Fee Related
- 2002-10-30 US US10/494,218 patent/US7928063B2/en not_active Expired - Fee Related
- 2002-10-30 HU HU0401589A patent/HU229220B1/hu not_active IP Right Cessation
- 2002-10-30 UA UA20040504092A patent/UA79440C2/uk unknown
- 2002-10-30 DE DE60218199T patent/DE60218199T2/de not_active Expired - Lifetime
- 2002-10-30 ES ES02786274T patent/ES2282494T3/es not_active Expired - Lifetime
- 2002-10-30 SI SI200230531T patent/SI1442059T1/sl unknown
- 2002-10-30 CA CA2465667A patent/CA2465667C/en not_active Expired - Fee Related
- 2002-10-30 EA EA200400603A patent/EA007841B1/ru not_active IP Right Cessation
- 2002-10-30 AU AU2002351536A patent/AU2002351536A1/en not_active Abandoned
- 2002-10-30 AT AT02786274T patent/ATE353917T1/de not_active IP Right Cessation
- 2002-10-30 EP EP02786274A patent/EP1442059B1/de not_active Expired - Lifetime
- 2002-10-30 WO PCT/PL2002/000080 patent/WO2003037928A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE60218199T2 (de) | 2007-11-22 |
| PL350463A1 (en) | 2003-05-05 |
| SI1442059T1 (sl) | 2007-08-31 |
| CA2465667C (en) | 2011-03-08 |
| HU229220B1 (hu) | 2013-09-30 |
| UA79440C2 (uk) | 2007-06-25 |
| ES2282494T3 (es) | 2007-10-16 |
| WO2003037928A2 (en) | 2003-05-08 |
| HUP0401589A3 (en) | 2005-11-28 |
| US7928063B2 (en) | 2011-04-19 |
| HUP0401589A2 (hu) | 2004-11-29 |
| PL195917B1 (pl) | 2007-11-30 |
| EP1442059B1 (de) | 2007-02-14 |
| EA007841B1 (ru) | 2007-02-27 |
| US20060172927A1 (en) | 2006-08-03 |
| EP1442059A2 (de) | 2004-08-04 |
| WO2003037928A3 (en) | 2004-03-04 |
| EA200400603A1 (ru) | 2006-06-30 |
| JP2005517633A (ja) | 2005-06-16 |
| JP4401170B2 (ja) | 2010-01-20 |
| ATE353917T1 (de) | 2007-03-15 |
| CA2465667A1 (en) | 2003-05-08 |
| AU2002351536A1 (en) | 2003-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3915125B2 (ja) | ニトロシル化神経ペプチド、その類似体、断片または誘導体より成る化合物とその使用法 | |
| CN113056475B (zh) | 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法 | |
| DK185486A (da) | Octapeptidderivater | |
| CY1107051T1 (el) | Αντι-διηθητικα και αντι-αγγειογενετικα θραυσματα ουροκινασης και η χρηση τους | |
| ATE321068T1 (de) | Alterungsschutztetrapeptid, dieses enthaltende pharmazeutische zusammensetzungen und seine verwendung | |
| NZ206401A (en) | Granulopoiesis inhibition factor analogue and pharmaceutical compositions | |
| HU216795B (hu) | Ciklopeptidek, eljárás előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása | |
| IE54494B1 (en) | Cyclic octapeptides and pharmaceutical preparations thereof, as well as processes for their manufacture, and their use | |
| JPH06503090A (ja) | ノナペプチドのボンベシン拮抗薬 | |
| DE60218199D1 (de) | Humane wachstumshormone freisetzende hormonanaloge, deren herstellung und verwendung | |
| US5387671A (en) | Hexa- and heptapeptide anaphylatoxin-receptor ligands | |
| NZ564694A (en) | Peptide vectors | |
| US5079231A (en) | Immunostimulating peptides, a process for their preparation and pharmaceutical compositions containing them | |
| KR100360975B1 (ko) | 위장운동자극활성을가지는폴리펩티드 | |
| EP3433259B1 (de) | Konjugate von tacrolimus, deren zusammensetzungen und deren verwendungen | |
| US3917581A (en) | Derivatives of somatostatin and process therefor | |
| AU718320B2 (en) | Peptide derivatives | |
| RU2008125167A (ru) | Терапевтическое средство для ускоренного заживления кожи, содержащее в качестве активного ингредиента дезацил-грелин и его производные | |
| JPH06509571A (ja) | タキキニン拮抗薬としての環状ヘキサペプチドの製法およびその薬学的化合物 | |
| US7399826B1 (en) | Peptide for promoting healing of fractures | |
| RU96123301A (ru) | НОВЫЕ ОПИОИДНЫЕ АНАЛОГИ ПЕПТИДОВ СО СМЕШАННЫМИ СВОЙСТВАМИ μ-АГОНИСТО/δ-АНТАГОНИСТОВ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R082 | Change of representative |
Ref document number: 1442059 Country of ref document: EP Representative=s name: BEATE KOENIG, 80539 MUENCHEN, DE |