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DE60214171D1 - Elektrophile fluorierung mit einer festphase - Google Patents

Elektrophile fluorierung mit einer festphase

Info

Publication number
DE60214171D1
DE60214171D1 DE60214171T DE60214171T DE60214171D1 DE 60214171 D1 DE60214171 D1 DE 60214171D1 DE 60214171 T DE60214171 T DE 60214171T DE 60214171 T DE60214171 T DE 60214171T DE 60214171 D1 DE60214171 D1 DE 60214171D1
Authority
DE
Germany
Prior art keywords
fluoration
electrophilic
solid phase
solid
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60214171T
Other languages
English (en)
Other versions
DE60214171T2 (de
Inventor
Sajinder Luthra
Frank Brady
John Wadsworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Hammersmith Imanet Ltd
Original Assignee
GE Healthcare Ltd
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd, Hammersmith Imanet Ltd filed Critical GE Healthcare Ltd
Application granted granted Critical
Publication of DE60214171D1 publication Critical patent/DE60214171D1/de
Publication of DE60214171T2 publication Critical patent/DE60214171T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60214171T 2001-06-29 2002-06-18 Elektrophile fluorierung mit einer festphase Expired - Lifetime DE60214171T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0115929 2001-06-29
GBGB0115929.2A GB0115929D0 (en) 2001-06-29 2001-06-29 Solid-phase electrophilic fluorination
PCT/GB2002/002529 WO2003002489A2 (en) 2001-06-29 2002-06-18 Solid-phase electrophilic fluorination

Publications (2)

Publication Number Publication Date
DE60214171D1 true DE60214171D1 (de) 2006-10-05
DE60214171T2 DE60214171T2 (de) 2007-07-12

Family

ID=9917610

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60214171T Expired - Lifetime DE60214171T2 (de) 2001-06-29 2002-06-18 Elektrophile fluorierung mit einer festphase

Country Status (10)

Country Link
US (1) US7115249B2 (de)
EP (1) EP1399401B1 (de)
JP (1) JP4541696B2 (de)
AR (1) AR036119A1 (de)
AT (1) ATE337283T1 (de)
AU (1) AU2002319387A1 (de)
DE (1) DE60214171T2 (de)
ES (1) ES2272741T3 (de)
GB (1) GB0115929D0 (de)
WO (1) WO2003002489A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0206117D0 (en) * 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
GB0223249D0 (en) * 2002-10-08 2002-11-13 Amersham Plc Improved imaging agents
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
EP1624901B1 (de) 2003-05-02 2012-07-25 The University Of Western Ontario Prothesengruppen gebunden an stannylierten polymeren für die synthese von radiopharmazeutika
GB0317920D0 (en) * 2003-07-31 2003-09-03 Amersham Plc Solid-phase synthesis
DE10346228B4 (de) * 2003-09-25 2009-04-09 Eberhard-Karls-Universität Tübingen Universitätsklinikum Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren
GB0410448D0 (en) * 2004-05-11 2004-06-16 Hammersmith Imanet Ltd Purification methods
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US8142636B2 (en) 2006-06-09 2012-03-27 Ge Healthcare Limited Electrochemically desorbing or adsorbing cryptate [18F] fluoride complexes
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
WO2008023780A1 (fr) 2006-08-25 2008-02-28 Gifu University Procédé de méthylation rapide, coffret pour préparer un traceur pet et procédé de fabrication d'un traceur pet
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
WO2008118808A1 (en) 2007-03-23 2008-10-02 Advion Bioscience, Inc. Liquid chromatography-mass spectrometry
US8686158B2 (en) * 2008-06-05 2014-04-01 President And Fellows Of Harvard College High-valent palladium fluoride complexes and uses thereof
CA2742869A1 (en) 2008-11-20 2010-05-27 President And Fellows Of Harvard College Fluorination of organic compounds
GB0904715D0 (en) 2009-03-19 2009-05-06 Ge Healthcare Ltd Aryloxyanilide derivataives
GB0905328D0 (en) 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
JP5237880B2 (ja) * 2009-04-30 2013-07-17 Ｊｆｅテクノス株式会社 マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置
GB0921967D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel Aryloxyanilide Derivatives
GB201016038D0 (en) 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
EP2697204B1 (de) 2011-04-12 2017-03-08 President and Fellows of Harvard College Fluorierung organischer verbindungen
US9101895B2 (en) 2011-04-15 2015-08-11 General Electric Company System for mixing and dispersing microbubble pharmaceuticals
US9273083B2 (en) 2012-09-26 2016-03-01 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
WO2015058047A2 (en) 2013-10-18 2015-04-23 President And Fellows Of Harvard College Fluorination of organic compounds
KR101850479B1 (ko) * 2015-07-22 2018-05-30 (주)듀켐바이오 [18F]플루오로-도파의 중성 pH 안정화 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR70669B (de) * 1979-10-22 1982-12-06 Merck & Co Inc
US5393908A (en) 1992-06-25 1995-02-28 Satyamurthy; Nagichettiar Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[18 F]fluoro-L-dopa
JP3165775B2 (ja) 1994-08-31 2001-05-14 日本鋼管株式会社 フッ素放射性同位元素標識ｌ−ドーパの製造方法
DE19949237B4 (de) * 1999-10-13 2004-07-29 Abx Advanced Biochemical Compounds Biomedizinische Forschungsreagenzien Gmbh Vorstufenverbindung für Radiodiagnostika und Verfahren zu ihrer Herstellung
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination

Also Published As

Publication number Publication date
DE60214171T2 (de) 2007-07-12
AR036119A1 (es) 2004-08-11
AU2002319387A1 (en) 2003-03-03
JP4541696B2 (ja) 2010-09-08
WO2003002489A2 (en) 2003-01-09
EP1399401A2 (de) 2004-03-24
WO2003002489A3 (en) 2003-04-24
JP2005502617A (ja) 2005-01-27
US7115249B2 (en) 2006-10-03
GB0115929D0 (en) 2001-08-22
EP1399401B1 (de) 2006-08-23
ATE337283T1 (de) 2006-09-15
US20040186312A1 (en) 2004-09-23
ES2272741T3 (es) 2007-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB