AR036119A1 - 6-l-fluorodopa rotulado con 18 f, procesos para su preparacion por fluoracion lectrofila en fase solida, un kit radiofarmaceutico, un cartucho para kit radiofarmaceutico para la preparacion de 18f-fdopa, y un metodo para obtener una imagen pet de diagnostico. - Google Patents
6-l-fluorodopa rotulado con 18 f, procesos para su preparacion por fluoracion lectrofila en fase solida, un kit radiofarmaceutico, un cartucho para kit radiofarmaceutico para la preparacion de 18f-fdopa, y un metodo para obtener una imagen pet de diagnostico.Info
- Publication number
- AR036119A1 AR036119A1 ARP020102432A ARP020102432A AR036119A1 AR 036119 A1 AR036119 A1 AR 036119A1 AR P020102432 A ARP020102432 A AR P020102432A AR P020102432 A ARP020102432 A AR P020102432A AR 036119 A1 AR036119 A1 AR 036119A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- fdopa
- formula
- pet
- radiopharmaceutical kit
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000012217 radiopharmaceutical Substances 0.000 title abstract 4
- 229940121896 radiopharmaceutical Drugs 0.000 title abstract 4
- 230000002799 radiopharmaceutical effect Effects 0.000 title abstract 4
- 239000007790 solid phase Substances 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000008030 elimination Effects 0.000 abstract 2
- 238000003379 elimination reaction Methods 0.000 abstract 2
- 238000003682 fluorination reaction Methods 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- PAXWQORCRCBOCU-LURJTMIESA-N 6-fluoro-L-dopa Chemical compound OC(=O)[C@@H](N)CC1=CC(O)=C(O)C=C1F PAXWQORCRCBOCU-LURJTMIESA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 239000000700 radioactive tracer Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se refiere al proceso para obtener compuestos de 6-L, 18F-fluorodopa de fórmula (1) y compuesto de fórmula (1). También se reivindica un proceso para la fabricación de un trazador rotulado con 18F de fórmula (2) para utilizar en PET; un kit radiofarmacéutico para la preparación de 18F-FDOPA para utilizar PET; un cartucho para un kit radiofarmacéutico para la preparación de 18F-FDOPA para utilizar en PET; definido anteriormente y un método para obtener una imagen de PET de diagnóstico. Reivindicación 1: Un proceso para la producción de 6-L-18F-fluorodopa (18F-FDOPA) el cual comprende tratamiento de un precursor de FDOPA unido a un soporte sólido de fórmula (1): en donde R1 y R2 independientemente son seleccionados entre alquilo C1-6; P1, P2, P3 y P4 son cada uno independientemente hidrógeno o un grupo protector; con una fuente de 18F, adecuadamente 18F2, 18F-CH3CCOF o 18F-OF2; para dar el trazador rotulado de fórmula (2): en donde P1, P2 P3 y P4 son cada uno independientemente hidrógeno o un grupo protector; optativamente seguido por: (i) eliminación de agente de fluoración en exceso y iones 18F producidos en la generación del agente de fluoración o en la reacción; y/o (ii) eliminación de cualquier grupo protector; y/o (iii) eliminación de disolvente orgánico; y/o (iv) formulación de un compuesto resultante de fórmula (2) como una solución acuosa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0115929.2A GB0115929D0 (en) | 2001-06-29 | 2001-06-29 | Solid-phase electrophilic fluorination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036119A1 true AR036119A1 (es) | 2004-08-11 |
Family
ID=9917610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102432A AR036119A1 (es) | 2001-06-29 | 2002-06-28 | 6-l-fluorodopa rotulado con 18 f, procesos para su preparacion por fluoracion lectrofila en fase solida, un kit radiofarmaceutico, un cartucho para kit radiofarmaceutico para la preparacion de 18f-fdopa, y un metodo para obtener una imagen pet de diagnostico. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7115249B2 (es) |
| EP (1) | EP1399401B1 (es) |
| JP (1) | JP4541696B2 (es) |
| AR (1) | AR036119A1 (es) |
| AT (1) | ATE337283T1 (es) |
| AU (1) | AU2002319387A1 (es) |
| DE (1) | DE60214171T2 (es) |
| ES (1) | ES2272741T3 (es) |
| GB (1) | GB0115929D0 (es) |
| WO (1) | WO2003002489A2 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| GB0206117D0 (en) * | 2002-03-15 | 2002-04-24 | Imaging Res Solutions Ltd | Use of microfabricated devices |
| GB0223249D0 (en) * | 2002-10-08 | 2002-11-13 | Amersham Plc | Improved imaging agents |
| GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
| EP1624901B1 (en) | 2003-05-02 | 2012-07-25 | The University Of Western Ontario | Prosthetic groups attached to stannylated polymers for the synthesis of radiopharmaceuticals |
| GB0317920D0 (en) * | 2003-07-31 | 2003-09-03 | Amersham Plc | Solid-phase synthesis |
| DE10346228B4 (de) * | 2003-09-25 | 2009-04-09 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Herstellung von [18F]fluormarkierten aromatischen L-Aminosäuren |
| GB0410448D0 (en) * | 2004-05-11 | 2004-06-16 | Hammersmith Imanet Ltd | Purification methods |
| GB0524851D0 (en) * | 2005-12-06 | 2006-01-11 | Ge Healthcare Ltd | Radiolabelling method using polymers |
| GB0524987D0 (en) | 2005-12-08 | 2006-01-18 | Ge Healthcare Ltd | Novel imaging agents for fibrosis |
| US7641860B2 (en) | 2006-06-01 | 2010-01-05 | Nanotek, Llc | Modular and reconfigurable multi-stage microreactor cartridge apparatus |
| US7998418B1 (en) | 2006-06-01 | 2011-08-16 | Nanotek, Llc | Evaporator and concentrator in reactor and loading system |
| US8142636B2 (en) | 2006-06-09 | 2012-03-27 | Ge Healthcare Limited | Electrochemically desorbing or adsorbing cryptate [18F] fluoride complexes |
| US7854902B2 (en) | 2006-08-23 | 2010-12-21 | Nanotek, Llc | Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same |
| WO2008023780A1 (fr) | 2006-08-25 | 2008-02-28 | Gifu University | Procédé de méthylation rapide, coffret pour préparer un traceur pet et procédé de fabrication d'un traceur pet |
| GB0625523D0 (en) | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
| WO2008118808A1 (en) | 2007-03-23 | 2008-10-02 | Advion Bioscience, Inc. | Liquid chromatography-mass spectrometry |
| US8686158B2 (en) * | 2008-06-05 | 2014-04-01 | President And Fellows Of Harvard College | High-valent palladium fluoride complexes and uses thereof |
| CA2742869A1 (en) | 2008-11-20 | 2010-05-27 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| GB0904715D0 (en) | 2009-03-19 | 2009-05-06 | Ge Healthcare Ltd | Aryloxyanilide derivataives |
| GB0905328D0 (en) | 2009-03-27 | 2009-05-13 | Ge Healthcare Ltd | Indole derivatives |
| JP5237880B2 (ja) * | 2009-04-30 | 2013-07-17 | Ｊｆｅテクノス株式会社 | マイクロチップを用いたｐｅｔ用標識化合物の製造方法及び装置 |
| GB0921967D0 (en) | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel Aryloxyanilide Derivatives |
| GB201016038D0 (en) | 2010-09-24 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method |
| GB201016411D0 (en) | 2010-09-30 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method for cancer |
| EP2697204B1 (en) | 2011-04-12 | 2017-03-08 | President and Fellows of Harvard College | Fluorination of organic compounds |
| US9101895B2 (en) | 2011-04-15 | 2015-08-11 | General Electric Company | System for mixing and dispersing microbubble pharmaceuticals |
| US9273083B2 (en) | 2012-09-26 | 2016-03-01 | President And Fellows Of Harvard College | Nickel fluorinating complexes and uses thereof |
| WO2015058047A2 (en) | 2013-10-18 | 2015-04-23 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| KR101850479B1 (ko) * | 2015-07-22 | 2018-05-30 | (주)듀켐바이오 | [18F]플루오로-도파의 중성 pH 안정화 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR70669B (es) * | 1979-10-22 | 1982-12-06 | Merck & Co Inc | |
| US5393908A (en) | 1992-06-25 | 1995-02-28 | Satyamurthy; Nagichettiar | Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[18 F]fluoro-L-dopa |
| JP3165775B2 (ja) | 1994-08-31 | 2001-05-14 | 日本鋼管株式会社 | フッ素放射性同位元素標識ｌ−ドーパの製造方法 |
| DE19949237B4 (de) * | 1999-10-13 | 2004-07-29 | Abx Advanced Biochemical Compounds Biomedizinische Forschungsreagenzien Gmbh | Vorstufenverbindung für Radiodiagnostika und Verfahren zu ihrer Herstellung |
| GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
-
2001
- 2001-06-29 GB GBGB0115929.2A patent/GB0115929D0/en not_active Ceased
-
2002
- 2002-06-18 US US10/482,542 patent/US7115249B2/en not_active Expired - Fee Related
- 2002-06-18 DE DE60214171T patent/DE60214171T2/de not_active Expired - Lifetime
- 2002-06-18 JP JP2003508675A patent/JP4541696B2/ja not_active Expired - Fee Related
- 2002-06-18 AU AU2002319387A patent/AU2002319387A1/en not_active Abandoned
- 2002-06-18 EP EP02748972A patent/EP1399401B1/en not_active Expired - Lifetime
- 2002-06-18 ES ES02748972T patent/ES2272741T3/es not_active Expired - Lifetime
- 2002-06-18 AT AT02748972T patent/ATE337283T1/de not_active IP Right Cessation
- 2002-06-18 WO PCT/GB2002/002529 patent/WO2003002489A2/en active IP Right Grant
- 2002-06-28 AR ARP020102432A patent/AR036119A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60214171T2 (de) | 2007-07-12 |
| AU2002319387A1 (en) | 2003-03-03 |
| JP4541696B2 (ja) | 2010-09-08 |
| WO2003002489A2 (en) | 2003-01-09 |
| EP1399401A2 (en) | 2004-03-24 |
| WO2003002489A3 (en) | 2003-04-24 |
| JP2005502617A (ja) | 2005-01-27 |
| DE60214171D1 (de) | 2006-10-05 |
| US7115249B2 (en) | 2006-10-03 |
| GB0115929D0 (en) | 2001-08-22 |
| EP1399401B1 (en) | 2006-08-23 |
| ATE337283T1 (de) | 2006-09-15 |
| US20040186312A1 (en) | 2004-09-23 |
| ES2272741T3 (es) | 2007-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |