[go: up one dir, main page]

DE2456959A1 - 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen - Google Patents

4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen

Info

Publication number
DE2456959A1
DE2456959A1 DE19742456959 DE2456959A DE2456959A1 DE 2456959 A1 DE2456959 A1 DE 2456959A1 DE 19742456959 DE19742456959 DE 19742456959 DE 2456959 A DE2456959 A DE 2456959A DE 2456959 A1 DE2456959 A1 DE 2456959A1
Authority
DE
Germany
Prior art keywords
acid
desmethyl
vitamin
cis
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19742456959
Other languages
German (de)
English (en)
Inventor
Wolfgang Dr Blechschmidt
Enno Prof Dr Christophers
Horst Dr Koenig
Rolf Dr Kretzschmar
Joachim Dr Paust
Herbert Dr Scholz
Walter-Wielant Dr Wiersdorff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to DE19742456959 priority Critical patent/DE2456959A1/de
Priority to SE7513080A priority patent/SE413139B/sv
Priority to BE162142A priority patent/BE835902A/xx
Priority to CH1559775A priority patent/CH619211A5/de
Priority to FR7536850A priority patent/FR2293193A1/fr
Priority to GB49370/75A priority patent/GB1526410A/en
Priority to ZA00757545A priority patent/ZA757545B/xx
Publication of DE2456959A1 publication Critical patent/DE2456959A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19742456959 1974-12-03 1974-12-03 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen Withdrawn DE2456959A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19742456959 DE2456959A1 (de) 1974-12-03 1974-12-03 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen
SE7513080A SE413139B (sv) 1974-12-03 1975-11-20 Forfarande for framstellning av 11-cis-13-desmetyl-vitamin-a-syra
BE162142A BE835902A (fr) 1974-12-03 1975-11-25 L'acide 4 - (e) - et 4 - (z) - 7 - methyl - 9 - (2,6,6 - trimethyl -1- cyclohexene -1- yle) - nona - 2,4,6,8 - tetraenecarboxylique et ses derives, leurpreparation et leur utilisation dans des compositions pharmaceutiques
CH1559775A CH619211A5 (en) 1974-12-03 1975-12-01 Process for the preparation of 11-cis-13-desmethyl vitamin A acid and all-trans-13-desmethyl vitamin A acid and their derivatives
FR7536850A FR2293193A1 (fr) 1974-12-03 1975-12-02 Acides 4-(e)- et 4-(z)-7-methyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl) -nona-2,4,6,8-tetraene-carboxyliques, leurs derives et leurs applications therapeutiques
GB49370/75A GB1526410A (en) 1974-12-03 1975-12-02 4-(e)-and 4-(z)-7-methyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8-tetraenecarboxylic acid their derivatives and preparations containing same
ZA00757545A ZA757545B (en) 1974-12-03 1975-12-02 4-(e)- and 4-(z)-7-methyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8-tetraenecarboxylic acid, their derivatives and preparations containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742456959 DE2456959A1 (de) 1974-12-03 1974-12-03 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen

Publications (1)

Publication Number Publication Date
DE2456959A1 true DE2456959A1 (de) 1976-06-16

Family

ID=5932289

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742456959 Withdrawn DE2456959A1 (de) 1974-12-03 1974-12-03 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen

Country Status (7)

Country Link
BE (1) BE835902A (xx)
CH (1) CH619211A5 (xx)
DE (1) DE2456959A1 (xx)
FR (1) FR2293193A1 (xx)
GB (1) GB1526410A (xx)
SE (1) SE413139B (xx)
ZA (1) ZA757545B (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321662A1 (de) * 1982-06-24 1983-12-29 F. Hoffmann-La Roche & Co AG, 4002 Basel Polyenverbindungen
US4539154A (en) * 1983-06-15 1985-09-03 Hoffmann-La Roche Inc. Polyene compounds
US4743400A (en) * 1986-09-22 1988-05-10 Mcneilab, Inc. Process for preparing retinoyl chlorides

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2843811A1 (de) * 1978-10-07 1980-04-24 Basf Ag Retinsaeure- und 7,8-dehydro-retinsaeure-n-(carboxy)-phenylamide
DE3177177D1 (de) * 1981-02-17 1990-06-13 Gail S Bazzano Die verwendung von retinoiden und ihren derivaten zum erhoehen des wachstumsgrades von menschlichen haaren und zum erhoehen des wachstumsgrades des pelzes bei bestimmten pelztieren.
WO1983002558A1 (en) * 1981-11-09 1983-08-04 Gail Sansone Bazzano The use of retinoids and minoxidil (2,4,-diamino-6-piperidino-pyrimidine-3-oxide) to increase the rate of growth of human scalp hair and to treat certain types of alopecias
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5962731A (en) * 1992-04-22 1999-10-05 Ligand Pharmaceuticals Incorporated Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
DK0678087T3 (da) * 1993-01-11 1999-09-27 Ligand Pharm Inc Forbindelser med selektiv aktivitet til retinoid-X-receptorer og metoder til modulering af processer medieret af retinoid-X
JPH09509403A (ja) * 1993-12-15 1997-09-22 エイボン プロダクツ インコーポレイテッド 新規なレチノイド共役体化合物及び皮膚老化を処置するための方法
US20040242704A1 (en) 2003-03-14 2004-12-02 University Of Washington, Techtransfer - Invention Licensing Stabilized mutant opsin proteins
US7566808B2 (en) 2004-02-17 2009-07-28 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
CN1988898B (zh) 2004-06-18 2012-12-26 华盛顿大学 用于治疗视觉障碍的视黄醛衍生物及其使用方法
JP6022746B2 (ja) 2008-02-11 2016-11-09 ユニヴァーシティ オブ ワシントン 加齢関連性網膜機能不全の治療及び予防方法
RU2546005C2 (ru) 2009-09-15 2015-04-10 Кью Эл Ти ИНК. Фармацевтические составы, содержащие 9-цис-ретиниловые сложные эфиры в липидном наполнителе
CA2796991A1 (en) 2010-04-19 2011-10-27 Qlt Inc. Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
EP2819667B8 (en) 2012-03-01 2020-03-04 Retinagenix Therapeutics, Inc. Retinal derivatives for use in improving visual function

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321662A1 (de) * 1982-06-24 1983-12-29 F. Hoffmann-La Roche & Co AG, 4002 Basel Polyenverbindungen
FR2529201A1 (fr) * 1982-06-24 1983-12-30 Hoffmann La Roche Composes polyethyleniques, procede pour leur preparation et leurs utilisations therapeutiques, notamment en tant qu'agents antitumeurs
US4539154A (en) * 1983-06-15 1985-09-03 Hoffmann-La Roche Inc. Polyene compounds
US4743400A (en) * 1986-09-22 1988-05-10 Mcneilab, Inc. Process for preparing retinoyl chlorides

Also Published As

Publication number Publication date
CH619211A5 (en) 1980-09-15
FR2293193B1 (xx) 1979-09-21
GB1526410A (en) 1978-09-27
SE7513080L (sv) 1976-06-04
BE835902A (fr) 1976-05-25
ZA757545B (en) 1976-12-29
SE413139B (sv) 1980-04-21
FR2293193A1 (fr) 1976-07-02

Similar Documents

Publication Publication Date Title
DE2456959A1 (de) 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen
DE2434911C2 (de) Phenyläthylamin-Derivate und pharmazeutische Zusammensetzungen
DD143902A5 (de) Verfahren zur herstellung von aminderivaten von glyzerin und propandiolen
AT368125B (de) Verfahren zur herstellung von neuen 9-aminoalkyl- fluorenen und von deren salzen
CH633249A5 (de) Verfahren zur herstellung von neuen polyprenylderivaten.
DE69200311T2 (de) Acylaminophenolderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
EP0056956B1 (de) Neue Indanyl-Derivate, ihre Herstellung und Verwendung
DE3030462A1 (de) Polyprenylcarbonsaeureamide, verfahren zu deren herstellung sowie diese verbindung enthaltende arzneimittel
DE2504045A1 (de) 16,17 dihydro-apovincaminsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0009777B1 (de) Retinsäure- und 7,8-Dehydro-retinsäure-N-(carboxy)-phenyl-amide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DD211548A1 (de) Verfahren zur herstellung neuartiger alkan- und alkenderivate
CH385196A (de) Verfahren zur Herstellung analeptisch wirksamer N-substituierter Aminonorcamphanderivate
EP0009776B1 (de) N-Monohydroxypropylamide, N-Dihydroxypropylamide und deren Acetonoide der all-E- und 13-Z-Retinsäure, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE3002545A1 (de) 5-amino-tetrazol-derivate von retinsaeuren, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
DE2462967C2 (de) Derivate des 3-Amino-5-methyl-2-phenyl-pyrrols, deren Salze und diese enthaltende pharmazeutische Zubereitung
CH649758A5 (de) 1,1,2-triphenyl-propan- und -propen-derivate, verfahren zur herstellung derselben und diese verbindungen enthaltende pharmazeutische praeparate.
AT256816B (de) Verfahren zur Herstellung von neuen substituierten 1-Phenyl-2-aminoalkanolen und deren Säureadditionssalzen
DD144764A5 (de) Verfahren zur herstellung von r-n-(2-phenyl-2-hydroxyethyl)-3-phenylpropylaminen
AT219020B (de) Verfahren zur Herstellung von neuen N-substituierten Amino-norcamphanderivaten sowie deren Säureadditionssalzen und quaternären Ammoniumverbindungen
DE3873720T2 (de) Nicotinoylpiperazin-derivate, verfahren zu ihrer herstellung und ihre verwendung in der therapie.
DD151447A1 (de) Verfahren zur herstellung von amidinen und deren salzen
AT216011B (de) Verfahren zur Herstellung von neuen Oxygruppen tragenden 1-bzw. 7-Aminoalkylxanthinderivaten
DE2500692C3 (de) Derivate des 4-Amidoalkylen-4'oxy diphenyle
AT336592B (de) Verfahren zur herstellung neuer 3-(4- biphenylyl)-buttersauren, deren estern, amiden und salzen
DE1618297C3 (de) Verfahren zur Herstellung von basischen Äthern

Legal Events

Date Code Title Description
8141 Disposal/no request for examination