DD299428A5 - Neue 2-oxo-4-methylen-8-aza-spiro[4,5]dekan-derivate und verfahren zu ihrer herstellung - Google Patents

Neue 2-oxo-4-methylen-8-aza-spiro[4,5]dekan-derivate und verfahren zu ihrer herstellung Download PDF

Info

Publication number: DD299428A5
Authority: DD; German Democratic Republic
Prior art keywords: general formula; oxo; methylene; meaning; spiro
Prior art date: 1989-08-10

Application number

DD90343354A

Other languages

German (de)

English (en)

Inventor

Edit Toth

Jozsef Toerley

Sandor Goeroeg

Laszlo Szporny

Bela Kiss

Eva Palosi

Dora Groo

Istvan Laszlovszky

Erzsebet Lapis

Ferenc Auth

Laszlo Gaal

Original Assignee

��@��@��@��@��Kk��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1990-08-09

Publication date

1992-04-16

1990-08-09 Application filed by ��@��@��@��@��Kk�� filed Critical ��@��@��@��@��Kk��

1992-04-16 Publication of DD299428A5 publication Critical patent/DD299428A5/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

DD90343354A 1989-08-10 1990-08-09 Neue 2-oxo-4-methylen-8-aza-spiro[4,5]dekan-derivate und verfahren zu ihrer herstellung DD299428A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU894094A HU204276B (en)	1989-08-10	1989-08-10	Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
DD299428A5 true DD299428A5 (de)	1992-04-16

Family

ID=10966866

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DD90343354A DD299428A5 (de)	1989-08-10	1990-08-09	Neue 2-oxo-4-methylen-8-aza-spiro[4,5]dekan-derivate und verfahren zu ihrer herstellung
DD90343359A DD299431A5 (de)	1989-08-10	1990-08-09	Neue 2-oxo-3,8-diaza-spiro[4,5]dekan-derivate und verfahren zur herstellung dieser verbindungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DD90343359A DD299431A5 (de)	1989-08-10	1990-08-09	Neue 2-oxo-3,8-diaza-spiro[4,5]dekan-derivate und verfahren zur herstellung dieser verbindungen

Country Status (26)

Country	Link
US (2)	US5132309A (sh)
EP (2)	EP0412821B1 (sh)
JP (2)	JPH0383985A (sh)
KR (2)	KR940000830B1 (sh)
CN (1)	CN1025031C (sh)
AT (2)	ATE113951T1 (sh)
AU (2)	AU621771B2 (sh)
CA (2)	CA2023015A1 (sh)
DD (2)	DD299428A5 (sh)
DE (2)	DE69014008T2 (sh)
DK (1)	DK0413516T3 (sh)
ES (2)	ES2063923T3 (sh)
FI (1)	FI93456C (sh)
HK (1)	HK118295A (sh)
HU (2)	HU204276B (sh)
IE (1)	IE902885A1 (sh)
IL (2)	IL95324A (sh)
IN (1)	IN170979B (sh)
IS (1)	IS3612A7 (sh)
MY (1)	MY107240A (sh)
NO (1)	NO903511L (sh)
NZ (2)	NZ234843A (sh)
PL (2)	PL164662B1 (sh)
SG (1)	SG59864G (sh)
YU (2)	YU150489A (sh)
ZA (3)	ZA906300B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4985437A (en) *	1986-12-17	1991-01-15	Glaxo Group Limited	Medicaments
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
US5852029A (en) *	1990-04-10	1998-12-22	Israel Institute For Biological Research	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
EP0492020A1 (en) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9206989D0 (en) *	1992-03-31	1992-05-13	Glaxo Group Ltd	Chemical compounds
US5756743A (en) *	1996-04-10	1998-05-26	Hoechst Marion Roussel Inc.	Spiro cyclopent b!indole-piperidines!
US6100256A (en) *	1996-12-02	2000-08-08	Merck Sharp & Dohme Ltd.	Use of NK-1 receptors antagonists for treating schizophrenic disorders
SE9604786D0 (sv)	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
US6974825B1 (en)	1996-12-20	2005-12-13	Astrazeneca Canada Inc.	Compounds with analgesic effect
SE9904675D0 (sv)	1999-12-20	1999-12-20	Astra Pharma Inc	Novel compounds
SE0101771D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101770D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101773D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101769D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
KR20030087248A (ko) *	2002-05-08	2003-11-14	(주)씨엔아이	온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
CN102459278A (zh) *	2009-06-16	2012-05-16	默沙东公司	取代的-1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮
GB201416352D0 (en) *	2014-09-16	2014-10-29	Shire Internat Gmbh	Spirocyclic derivatives
GB201416346D0 (en) *	2014-09-16	2014-10-29	Shire Internat Gmbh	Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL127065C (sh) *	1964-04-22
CH601304A5 (sh) *	1974-02-12	1978-07-14	Buskine Sa
BE790675A (fr) *	1971-10-29	1973-04-27	Science Union & Cie	Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) *	1987-05-22	1989-06-30	Adir	Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204530B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost

1989
- 1989-07-27 YU YU150489A patent/YU150489A/sh unknown
- 1989-08-10 HU HU894094A patent/HU204276B/hu not_active IP Right Cessation
- 1989-08-10 HU HU903233A patent/HU206677B/hu not_active IP Right Cessation
1990
- 1990-08-08 KR KR1019900012169A patent/KR940000830B1/ko not_active IP Right Cessation
- 1990-08-08 KR KR1019900012168A patent/KR940002826B1/ko not_active IP Right Cessation
- 1990-08-09 DD DD90343354A patent/DD299428A5/de not_active IP Right Cessation
- 1990-08-09 IN IN687/CAL/90A patent/IN170979B/en unknown
- 1990-08-09 IE IE288590A patent/IE902885A1/en unknown
- 1990-08-09 NZ NZ234843A patent/NZ234843A/en unknown
- 1990-08-09 CA CA002023015A patent/CA2023015A1/en not_active Abandoned
- 1990-08-09 AU AU60803/90A patent/AU621771B2/en not_active Ceased
- 1990-08-09 DE DE69014008T patent/DE69014008T2/de not_active Expired - Fee Related
- 1990-08-09 ZA ZA906300A patent/ZA906300B/xx unknown
- 1990-08-09 JP JP2209363A patent/JPH0383985A/ja active Pending
- 1990-08-09 ZA ZA906304A patent/ZA906304B/xx unknown
- 1990-08-09 ES ES90308779T patent/ES2063923T3/es not_active Expired - Lifetime
- 1990-08-09 NO NO90903511A patent/NO903511L/no unknown
- 1990-08-09 IS IS3612A patent/IS3612A7/is unknown
- 1990-08-09 DD DD90343359A patent/DD299431A5/de not_active IP Right Cessation
- 1990-08-09 AU AU60804/90A patent/AU621238B2/en not_active Ceased
- 1990-08-09 CA CA002023018A patent/CA2023018C/en not_active Expired - Fee Related
- 1990-08-09 IL IL9532490A patent/IL95324A/en not_active IP Right Cessation
- 1990-08-09 SG SG1995903969A patent/SG59864G/en unknown
- 1990-08-09 ES ES90308783T patent/ES2052179T3/es not_active Expired - Lifetime
- 1990-08-09 AT AT90308779T patent/ATE113951T1/de not_active IP Right Cessation
- 1990-08-09 AT AT9090308783T patent/ATE104671T1/de not_active IP Right Cessation
- 1990-08-09 EP EP90308779A patent/EP0412821B1/en not_active Expired - Lifetime
- 1990-08-09 DK DK90308783.1T patent/DK0413516T3/da active
- 1990-08-09 JP JP2209362A patent/JPH0381277A/ja active Pending
- 1990-08-09 NZ NZ234846A patent/NZ234846A/en unknown
- 1990-08-09 YU YU154090A patent/YU154090A/sh unknown
- 1990-08-09 DE DE69008275T patent/DE69008275T2/de not_active Expired - Fee Related
- 1990-08-09 IL IL9532590A patent/IL95325A/en not_active IP Right Cessation
- 1990-08-09 ZA ZA906299A patent/ZA906299B/xx unknown
- 1990-08-09 EP EP90308783A patent/EP0413516B1/en not_active Expired - Lifetime
- 1990-08-10 CN CN90106974A patent/CN1025031C/zh not_active Expired - Fee Related
- 1990-08-10 US US07/566,279 patent/US5132309A/en not_active Expired - Fee Related
- 1990-08-10 PL PL90291648A patent/PL164662B1/pl unknown
- 1990-08-10 MY MYPI90001343A patent/MY107240A/en unknown
- 1990-08-10 PL PL90286443A patent/PL163899B1/pl unknown
- 1990-08-10 US US07/566,278 patent/US5132303A/en not_active Expired - Fee Related
- 1990-08-10 FI FI903974A patent/FI93456C/fi not_active IP Right Cessation
1995
- 1995-07-20 HK HK118295A patent/HK118295A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ234846A (en)	1992-03-26
JPH0381277A (ja)	1991-04-05
CA2023018C (en)	1995-11-28
KR940002826B1 (ko)	1994-04-04
ES2052179T3 (es)	1994-07-01
IL95325A0 (en)	1991-06-30
EP0412821A2 (en)	1991-02-13
CN1049349A (zh)	1991-02-20
IN170979B (sh)	1992-06-27
HU206677B (en)	1992-12-28
AU621238B2 (en)	1992-03-05
AU621771B2 (en)	1992-03-19
NO903511L (no)	1991-02-11
EP0413516B1 (en)	1994-04-20
NO903511D0 (no)	1990-08-09
DK0413516T3 (da)	1994-05-24
PL291648A1 (en)	1992-06-01
JPH0383985A (ja)	1991-04-09
PL164662B1 (pl)	1994-09-30
AU6080390A (en)	1991-02-14
AU6080490A (en)	1991-02-14
ES2063923T3 (es)	1995-01-16
KR940000830B1 (ko)	1994-02-02
DE69008275D1 (de)	1994-05-26
IL95324A0 (en)	1991-06-30
ATE113951T1 (de)	1994-11-15
HUT55785A (en)	1991-06-28
ZA906304B (en)	1991-06-26
ZA906299B (en)	1991-06-26
IL95324A (en)	1994-02-27
IL95325A (en)	1994-06-24
FI903974A0 (fi)	1990-08-10
YU150489A (sh)	1992-12-21
FI93456C (fi)	1995-04-10
HK118295A (en)	1995-07-28
EP0412821A3 (en)	1991-11-27
ATE104671T1 (de)	1994-05-15
EP0412821B1 (en)	1994-11-09
CA2023015A1 (en)	1991-02-11
DE69008275T2 (de)	1994-08-04
CN1025031C (zh)	1994-06-15
ZA906300B (en)	1991-05-29
IS3612A7 (is)	1991-02-11
HU204276B (en)	1991-12-30
IE902885A1 (en)	1991-02-27
CA2023018A1 (en)	1991-02-11
MY107240A (en)	1995-10-31
PL163899B1 (pl)	1994-05-31
EP0413516A3 (en)	1991-11-27
PL286443A1 (en)	1992-01-13
DD299431A5 (de)	1992-04-16
US5132303A (en)	1992-07-21
EP0413516A2 (en)	1991-02-20
HUT59375A (en)	1992-05-28
YU154090A (sh)	1992-12-21
US5132309A (en)	1992-07-21
NZ234843A (en)	1992-03-26
KR910004631A (ko)	1991-03-29
HU903233D0 (en)	1990-10-28
KR910004630A (ko)	1991-03-29
DE69014008T2 (de)	1995-03-23
FI93456B (fi)	1994-12-30
DE69014008D1 (de)	1994-12-15
SG59864G (en)	1995-09-01

Publication	Publication Date	Title
DD299428A5 (de)	1992-04-16	Neue 2-oxo-4-methylen-8-aza-spiro[4,5]dekan-derivate und verfahren zu ihrer herstellung
AT392276B (de)	1991-02-25	Verfahren zur herstellung von neuen tetrahydrocarbazol-derivaten
EP0546388B1 (de)	1996-03-27	Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems
DE3342164C2 (sh)	1989-03-02
DE29724281U1 (de)	2000-08-10	4-Phenylpiperidin-Verbindungen
DE2451932A1 (de)	1975-05-07	1-hydroxy-und 1-alkanoyloxy-3-alkyl-6, 6a,7,8,10,10a-hexahydro-9h-dibenzo eckige klammer auf b,d eckige klammer zu pyran-9one und verfahren zu ihrer herstellung
DE10153737A1 (de)	2003-05-28	Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
EP0550895B1 (de)	1997-07-16	4,13-Dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE69007905T2 (de)	1994-07-21	1-Oxa-2-oxo-8-azaspiro[4,5]decan-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen daraus.
DE60214138T2 (de)	2007-03-29	Isoxazolin-derivate als antidepressiva
DE69614407T2 (de)	2002-05-29	Pharmazeutische zusammensetzungen
DE69232484T2 (de)	2002-10-31	Hydroisochinolinderivate
DE69007900T2 (de)	1994-07-21	4,4-Disubstituierte Piperidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
DE3326724A1 (de)	1985-02-07	In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE2718455A1 (de)	1977-11-10	1,3-dihydro-heteroarylspiro eckige klammer auf isobenzofuran eckige klammer zu e
DE68905363T2 (de)	1993-08-05	Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
EP0717043B1 (de)	1999-11-10	Verwendung von 1,2-überbrückten 1,4-Dihydropyridinen als selektive Kaliumkanalmodulatoren
CH620685A5 (sh)	1980-12-15
DE2854727A1 (de)	1979-06-28	Polyfluorhydroxyisopropyl-substituierte bicyclische und tricyclische carbostyrile, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
CH634839A5 (de)	1983-02-28	Pyranochromonderivate und ihre verwendung in arzneimitteln zur behandlung von allergien.
DE60204046T2 (de)	2006-01-19	N-heterocyclylhydrazide als neurotrophe mittel
DE2530005C3 (de)	1978-09-28	6,11-Dihydrodibenzo [b,e] thiepin-Derivate und deren Salze, Verfahren zu ihrer Herstellung und diese Substanzen enthaltende pharmazeutische Zubereitungen
DE3520104A1 (de)	1985-12-12	Naphthoxazine, ihre herstellung und verwendung
DD299429A5 (de)	1992-04-16	Neue 1-oxa-2-oxo-8-aza-spiro[4,5]dekan-derivate und verfahren zur herstellung dieser verbindungen
DE69911995T2 (de)	2004-09-02	Benzisoxazole und phenone als alpha-2-antagonisten

Legal Events

Date	Code	Title	Description
1998-08-13	ENJ	Ceased due to non-payment of renewal fee