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CY1106039T1 - Υδατοδιασπαρσιμες ενκαψουλωμενες στepολες - Google Patents

Υδατοδιασπαρσιμες ενκαψουλωμενες στepολες

Info

Publication number
CY1106039T1
CY1106039T1 CY20071100231T CY071100231T CY1106039T1 CY 1106039 T1 CY1106039 T1 CY 1106039T1 CY 20071100231 T CY20071100231 T CY 20071100231T CY 071100231 T CY071100231 T CY 071100231T CY 1106039 T1 CY1106039 T1 CY 1106039T1
Authority
CY
Cyprus
Prior art keywords
staples
water dispersible
water
encapsulated
sterol
Prior art date
Application number
CY20071100231T
Other languages
English (en)
Inventor
Nicolas Auriou
Original Assignee
Forbes Medi-Tech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forbes Medi-Tech Inc. filed Critical Forbes Medi-Tech Inc.
Publication of CY1106039T1 publication Critical patent/CY1106039T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)

Abstract

Εδώ περιγράφεται μια μέθοδος για την παραγωγή μιας υδατοδιασπάρσιμης σκόνης η οποία περιέχει μία ή περισσότερες στερόλες. Αυτή η μέθοδος περιλαμβάνει τη δημιουργία μικκυλίων που περιέχουν στερόλη και επιφανειοδραστικό εντός ενός υδατικού μέσου, και την επικάλυψη αυτών των μικκυλίων με ένα μίγμα αμύλου και τροποποιημένου αμύλου σε ένα στάδιο ξήρανσης. Η ξηραμένη σκόνη μπορεί προσφόρως να προστεθεί σε εδώδιμα ή πόσιμα σκευάσματα με βάση το ύδωρ, καθιστώντας έτσι δυνατή τη χορήγηση της στερόλης η οποία μειώνει τη χοληστερόλη σε συνδυασμό με μια δίαιτα περιορισμού των λιπών.
CY20071100231T 2000-09-01 2007-02-20 Υδατοδιασπαρσιμες ενκαψουλωμενες στepολες CY1106039T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0021498.1A GB0021498D0 (en) 2000-09-01 2000-09-01 New formulation
PCT/EP2001/010044 WO2002017892A2 (en) 2000-09-01 2001-08-30 Water-dispersible encapsulated sterols

Publications (1)

Publication Number Publication Date
CY1106039T1 true CY1106039T1 (el) 2011-04-06

Family

ID=9898673

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100231T CY1106039T1 (el) 2000-09-01 2007-02-20 Υδατοδιασπαρσιμες ενκαψουλωμενες στepολες

Country Status (17)

Country Link
EP (2) EP1315482B1 (el)
JP (1) JP2004507492A (el)
AT (1) ATE345783T1 (el)
AU (1) AU2002213868A1 (el)
BR (1) BR0113621A (el)
CA (1) CA2419249A1 (el)
CY (1) CY1106039T1 (el)
DE (1) DE60124738T2 (el)
DK (1) DK1315482T3 (el)
ES (1) ES2277952T3 (el)
GB (1) GB0021498D0 (el)
HU (1) HUP0300878A3 (el)
MX (1) MXPA03001831A (el)
PL (1) PL359704A1 (el)
PT (1) PT1315482E (el)
WO (1) WO2002017892A2 (el)
ZA (1) ZA200301097B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673383B2 (en) * 2001-03-26 2004-01-06 Unilever Patent Holdings Bv Method for improving the performance of a food product
US6773733B2 (en) 2001-03-26 2004-08-10 Loders Croklaan Usa Llc Structured particulate systems
US20030003131A1 (en) * 2001-06-22 2003-01-02 Matthew Dyer Method for manufacture of free-flowing powder containing water-dispersible sterols
US20060147523A1 (en) 2002-10-16 2006-07-06 Alan Fergusson Composition for the regulation of the human immune system and the prevention and treatment of diseases thereof
DE10253111A1 (de) * 2002-11-13 2004-05-27 Basf Ag Pulverförmige Phytosterol-Formulierungen
CA2536283A1 (en) * 2003-08-20 2005-03-03 Ajinomoto Co., Inc. Pharmaceutical preparations having an improved solubility
WO2005032277A1 (en) * 2003-09-22 2005-04-14 Degussa Health & Nutrition Americas, Inc. Incorporation of phytosterols into flavorings
US20070154557A1 (en) * 2004-01-30 2007-07-05 Veldhuizen Yvonne S J Particulate comprising phytosterols and food compositions comprising said creamer
US20050233002A1 (en) * 2004-04-15 2005-10-20 Trubiano Paolo C Encapsulation of oxygen sensitive agents
DE602004002763T2 (de) * 2004-06-04 2007-08-16 The Procter & Gamble Company, Cincinnati Verkapselte Partikel
US20060034934A1 (en) * 2004-08-13 2006-02-16 Deguise Matthew L Agglomeration of sterol particles
EP1788896B1 (en) * 2004-09-02 2014-03-05 Givaudan Nederland Services B.V. Heat stable flavouring compositions
JP4915717B2 (ja) * 2004-09-09 2012-04-11 花王株式会社 肥満予防・改善剤
WO2006095798A1 (ja) * 2005-03-09 2006-09-14 Sunstar Inc. フィトステロールを含んだリポソームを含有する抗癌用経口組成物、該リポソームによる癌の予防又は治療
US8309156B2 (en) 2005-12-20 2012-11-13 Pharmachem Laboratories, Inc. Compositions comprising one or more phytosterols and/or phytostanols, or derivatives thereof, and high HLB emulsifiers
CA2673010A1 (en) * 2005-12-20 2007-06-28 Forbes Medi-Tech Inc. Compositions comprising one or more phytosterols and/or phytostanols, or derivatives thereof, and high hlb emulsifiers
JP4989956B2 (ja) * 2006-12-11 2012-08-01 松谷化学工業株式会社 粉末化植物ステロールエステル製剤、その製造方法及びこれを含む飲食品
WO2009071285A1 (en) * 2007-12-05 2009-06-11 Dsm Ip Assets B.V. Pulverous formulation of a fat-soluble active ingredient
CN101888786A (zh) * 2007-12-05 2010-11-17 帝斯曼知识产权资产管理有限公司 脂溶性活性成分的粉状制剂
EP2067410A1 (en) 2007-12-07 2009-06-10 Cognis IP Management GmbH Water-dispersable sterol containing dispersion
EP2397160A1 (en) * 2009-02-13 2011-12-21 Nisshin Kasei Co., Ltd. Hard capsule
ES2374780A1 (es) * 2009-12-30 2012-02-22 José Javier Villa Cervera Procedimiento de fabricación de agua de beber, agua mineral, agua medicinal o similar, caracterizada porque incluye esteroles vegetales-fitoesteroles. la bebida contiene de 0.1 a 3 g litro de esteroles vegetales.
EP2658638B1 (en) 2010-12-28 2014-09-03 Unilever N.V. Method for production of an emulsion
US20120282368A1 (en) * 2011-05-03 2012-11-08 Brandeis University Amphiphilic sterol/fat-based particles
JP6092579B2 (ja) * 2012-11-07 2017-03-08 理研ビタミン株式会社 粉末状植物ステロール組成物およびその製造方法
CN104822276A (zh) * 2012-11-07 2015-08-05 理研维他命股份有限公司 粉末状植物甾醇组合物及其制造方法
JP6092580B2 (ja) * 2012-11-07 2017-03-08 理研ビタミン株式会社 粉末状植物ステロール組成物およびその製造方法
FR3069757B1 (fr) * 2017-08-07 2021-07-23 Innovi Production Composition a base de sterols
US11779019B2 (en) 2017-08-07 2023-10-10 Elicit Plant Composition made from polyol(s) and sterol(s) for use in the agricultural field
US20220312762A1 (en) * 2019-09-06 2022-10-06 The Texas A&M University System Use of encapsulated sterols to modify growth of crops, control, agricultural pests and as non-toxic pre-emergent herbicides
CA3233786A1 (en) 2021-10-08 2023-04-13 Aymeric MOLIN Phytosterol-based agricultural composition and their use.
CN115969036B (zh) * 2023-01-10 2024-05-07 丰益油脂科技有限公司 植物甾醇颗粒物及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3881005A (en) * 1973-08-13 1975-04-29 Lilly Co Eli Pharmaceutical dispersible powder of sitosterols and a method for the preparation thereof
JPS62186936A (ja) * 1986-02-13 1987-08-15 Asahi Denka Kogyo Kk ステリン乳化乃至可溶化組成物
US5405615A (en) 1991-09-17 1995-04-11 Micro Vesicular Systems, Inc. Sucrose distearate lipid vesicles
WO1999018977A1 (en) 1997-10-16 1999-04-22 Medical Isotopes Inc. Readily absorbable phytosterol glycosides to treat hypercholesterolemia
IN185730B (el) * 1998-02-19 2001-04-14 Mcneil Ppc Inc

Also Published As

Publication number Publication date
HUP0300878A2 (hu) 2003-09-29
PT1315482E (pt) 2007-02-28
GB0021498D0 (en) 2000-10-18
BR0113621A (pt) 2003-07-22
WO2002017892A2 (en) 2002-03-07
AU2002213868A1 (en) 2002-03-13
EP1315482A2 (en) 2003-06-04
ES2277952T3 (es) 2007-08-01
DE60124738T2 (de) 2007-09-13
EP1315482B1 (en) 2006-11-22
ZA200301097B (en) 2004-04-21
MXPA03001831A (es) 2003-06-04
HUP0300878A3 (en) 2008-03-28
PL359704A1 (en) 2004-09-06
DE60124738D1 (de) 2007-01-04
JP2004507492A (ja) 2004-03-11
WO2002017892A3 (en) 2002-05-16
CA2419249A1 (en) 2002-03-07
DK1315482T3 (da) 2007-04-02
EP1749520A1 (en) 2007-02-07
ATE345783T1 (de) 2006-12-15

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