CS242888B2 - Method of diamminoplatinous complexes production - Google Patents

Method of diamminoplatinous complexes production Download PDF

Info

Publication number: CS242888B2
Authority: CS; Czechoslovakia
Prior art keywords: formula; water; cis; wide; complexes
Prior art date: 1982-10-21

Application number

CS837752A

Other languages

Czech (cs)

English (en)

Other versions

CS775283A2 (en

Inventor

Francois Verbeek

Jan Berg

Eric J Bulten

Original Assignee

Tno

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-21

Filing date

1983-10-21

Publication date

1986-05-15

1983-10-21 Application filed by Tno filed Critical Tno

1985-08-15 Publication of CS775283A2 publication Critical patent/CS775283A2/cs

1986-05-15 Publication of CS242888B2 publication Critical patent/CS242888B2/cs

Links

238000000034 method Methods 0.000 title claims description 23
238000004519 manufacturing process Methods 0.000 title description 7
150000001875 compounds Chemical class 0.000 claims description 28
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 18
229910052799 carbon Inorganic materials 0.000 claims description 15
229910001961 silver nitrate Inorganic materials 0.000 claims description 9
-1 cyclohexyl ethyl group Chemical group 0.000 claims description 7
159000000000 sodium salts Chemical class 0.000 claims description 7
UMWYYMCOBYVEPY-UHFFFAOYSA-N azanide;platinum(2+) Chemical class [NH2-].[NH2-].[Pt+2] UMWYYMCOBYVEPY-UHFFFAOYSA-N 0.000 claims description 5
OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
UKFXDFUAPNAMPJ-UHFFFAOYSA-N ethylmalonic acid Chemical compound CCC(C(O)=O)C(O)=O UKFXDFUAPNAMPJ-UHFFFAOYSA-N 0.000 claims description 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
125000004122 cyclic group Chemical group 0.000 claims 2
QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical group OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
229940089960 chloroacetate Drugs 0.000 claims 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 25
208000032839 leukemia Diseases 0.000 description 23
206010028980 Neoplasm Diseases 0.000 description 16
229910052739 hydrogen Inorganic materials 0.000 description 16
239000000203 mixture Substances 0.000 description 14
229910052697 platinum Inorganic materials 0.000 description 14
239000000243 solution Substances 0.000 description 14
238000004458 analytical method Methods 0.000 description 13
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
201000011510 cancer Diseases 0.000 description 12
229910052757 nitrogen Inorganic materials 0.000 description 11
238000002360 preparation method Methods 0.000 description 9
210000003734 kidney Anatomy 0.000 description 8
201000007197 atypical autism Diseases 0.000 description 7
208000029560 autism spectrum disease Diseases 0.000 description 7
239000000706 filtrate Substances 0.000 description 7
239000002244 precipitate Substances 0.000 description 7
238000001407 pulse-discharge detection Methods 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
231100000417 nephrotoxicity Toxicity 0.000 description 6
231100000331 toxic Toxicity 0.000 description 6
230000002588 toxic effect Effects 0.000 description 6
229910021607 Silver chloride Inorganic materials 0.000 description 5
238000000354 decomposition reaction Methods 0.000 description 5
239000012153 distilled water Substances 0.000 description 5
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 5
238000003756 stirring Methods 0.000 description 5
208000028018 Lymphocytic leukaemia Diseases 0.000 description 4
125000003963 dichloro group Chemical group Cl* 0.000 description 4
230000000694 effects Effects 0.000 description 4
ROBFUDYVXSDBQM-UHFFFAOYSA-N hydroxymalonic acid Chemical compound OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 description 4
208000003747 lymphoid leukemia Diseases 0.000 description 4
150000003057 platinum Chemical class 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
MWOHVKZEEZUNHJ-UHFFFAOYSA-N C1CCC(CC1)C(C(=O)O)C(=O)OCN Chemical compound C1CCC(CC1)C(C(=O)O)C(=O)OCN MWOHVKZEEZUNHJ-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000003814 drug Substances 0.000 description 2
125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 2
ARCGXLSVLAOJQL-UHFFFAOYSA-N trimellitic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C(C(O)=O)=C1 ARCGXLSVLAOJQL-UHFFFAOYSA-N 0.000 description 2
JKFYKCYQEWQPTM-UHFFFAOYSA-N 2-azaniumyl-2-(4-fluorophenyl)acetate Chemical compound OC(=O)C(N)C1=CC=C(F)C=C1 JKFYKCYQEWQPTM-UHFFFAOYSA-N 0.000 description 1
DDRVFRXYTKAZHH-UHFFFAOYSA-N 2-carboxyoxycarbonylbenzoic acid Chemical compound OC(=O)OC(=O)C1=CC=CC=C1C(O)=O DDRVFRXYTKAZHH-UHFFFAOYSA-N 0.000 description 1
238000011740 C57BL/6 mouse Methods 0.000 description 1
206010059024 Gastrointestinal toxicity Diseases 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
101150030170 Paat gene Proteins 0.000 description 1
241000700159 Rattus Species 0.000 description 1
206010062237 Renal impairment Diseases 0.000 description 1
229910021612 Silver iodide Inorganic materials 0.000 description 1
XZAHJRZBUWYCBM-UHFFFAOYSA-N [1-(aminomethyl)cyclohexyl]methanamine Chemical compound NCC1(CN)CCCCC1 XZAHJRZBUWYCBM-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
229940045985 antineoplastic platinum compound Drugs 0.000 description 1
125000003710 aryl alkyl group Chemical group 0.000 description 1
238000003556 assay Methods 0.000 description 1
NFVYWMHUQMVNRG-UHFFFAOYSA-N azanide;platinum(4+) Chemical class [NH2-].[NH2-].[Pt+4] NFVYWMHUQMVNRG-UHFFFAOYSA-N 0.000 description 1
FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 1
239000013256 coordination polymer Substances 0.000 description 1
CCQPAEQGAVNNIA-UHFFFAOYSA-L cyclobutane-1,1-dicarboxylate(2-) Chemical compound [O-]C(=O)C1(C([O-])=O)CCC1 CCQPAEQGAVNNIA-UHFFFAOYSA-L 0.000 description 1
CCQPAEQGAVNNIA-UHFFFAOYSA-N cyclobutane-1,1-dicarboxylic acid Chemical compound OC(=O)C1(C(O)=O)CCC1 CCQPAEQGAVNNIA-UHFFFAOYSA-N 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
229940127089 cytotoxic agent Drugs 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 1
IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000012173 estrus Effects 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000012530 fluid Substances 0.000 description 1
231100000414 gastrointestinal toxicity Toxicity 0.000 description 1
231100000086 high toxicity Toxicity 0.000 description 1
238000010562 histological examination Methods 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002386 leaching Methods 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
230000036651 mood Effects 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
230000008520 organization Effects 0.000 description 1
150000003891 oxalate salts Chemical group 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
150000003058 platinum compounds Chemical class 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000000047 product Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000012216 screening Methods 0.000 description 1
229940045105 silver iodide Drugs 0.000 description 1
HWEXKRHYVOGVDA-UHFFFAOYSA-M sodium;3-trimethylsilylpropane-1-sulfonate Chemical compound [Na+].C[Si](C)(C)CCCS([O-])(=O)=O HWEXKRHYVOGVDA-UHFFFAOYSA-M 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CS837752A 1982-10-21 1983-10-21 Method of diamminoplatinous complexes production CS242888B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8204067A NL8204067A (nl)	1982-10-21	1982-10-21	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.

Publications (2)

Publication Number	Publication Date
CS775283A2 CS775283A2 (en)	1985-08-15
CS242888B2 true CS242888B2 (en)	1986-05-15

Family

ID=19840444

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS837752A CS242888B2 (en)	1982-10-21	1983-10-21	Method of diamminoplatinous complexes production

Country Status (28)

Country	Link
JP (1)	JPS5993091A (de)
KR (1)	KR910002536B1 (de)
AT (1)	AT390610B (de)
AU (1)	AU562964B2 (de)
BE (1)	BE898058A (de)
CA (1)	CA1229618A (de)
CH (1)	CH658244A5 (de)
CS (1)	CS242888B2 (de)
DD (1)	DD217522A5 (de)
DE (1)	DE3337333A1 (de)
DK (2)	DK483083A (de)
ES (1)	ES526670A0 (de)
FI (1)	FI76351C (de)
FR (1)	FR2534907B1 (de)
GB (1)	GB2128615B (de)
GR (1)	GR79652B (de)
HU (1)	HU188035B (de)
IE (1)	IE56124B1 (de)
IT (1)	IT1169858B (de)
LU (1)	LU85054A1 (de)
NL (1)	NL8204067A (de)
NO (1)	NO171276C (de)
NZ (1)	NZ206018A (de)
PH (1)	PH24077A (de)
PT (1)	PT77542B (de)
SE (1)	SE8305783L (de)
YU (1)	YU43554B (de)
ZA (1)	ZA837857B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4786725A (en) *	1982-06-28	1988-11-22	Engelhard Corporation	Solubilized platinum (II) complexes
US4661516A (en) *	1983-06-20	1987-04-28	Research Corporation	Diaminocyclohexane platinum complexes
US4758588A (en) *	1983-06-20	1988-07-19	Research Corporation Technologies	Diaminocyclohexane platinum complexes
EP0169645A1 (de) *	1984-06-27	1986-01-29	Johnson Matthey Public Limited Company	Platin-Koordinationsverbindungen
DE3432320A1 (de) *	1984-09-03	1986-03-13	Behringwerke Ag, 3550 Marburg	Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
HU193809B (en) *	1984-09-12	1987-12-28	Chugai Pharmaceutical Co Ltd	Process for producing new platinum complexes
US4737589A (en) *	1985-08-27	1988-04-12	Nippon Kayaku Kabushiki Kaisha	Platinum Complexes
US4760157A (en) *	1986-01-31	1988-07-26	American Cyanamid Company	(2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
US4880790A (en) *	1986-01-31	1989-11-14	American Cyanamid Company	(Gem-heterocyclodimethanamine-N,N')platinum complexes
DE3630497A1 (de) *	1986-09-08	1988-03-10	Behringwerke Ag	Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
ATE53217T1 (de) *	1986-10-03	1990-06-15	Asta Pharma Ag	Diamin-platin (ii)-komplexverbindungen mit einem hydroxylierten 2-phenyl-indolring.
JPS63203692A (ja) *	1987-02-19	1988-08-23	Nippon Kayaku Co Ltd	新規白金錯体
AT390065B (de) *	1987-10-08	1990-03-12	Behringwerke Ag	Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
NL8802149A (nl) *	1988-08-31	1990-03-16	Tno	Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
NL8802150A (nl) *	1988-08-31	1990-03-16	Tno	Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
CN102924528B (zh) *	2012-10-29	2015-04-15	东南大学	抗肿瘤二价铂配合物以及该配合物和其配体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4115418A (en) *	1976-09-02	1978-09-19	Government Of The United States Of America	1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
US4206226A (en) *	1977-08-29	1980-06-03	The United States Of America As Represented By The Department Of Health, Education And Welfare	Use of 4-carboxy-phthalato-(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof in alleviating L1210 murine leukemia
NL189358C (nl) *	1978-07-06	1993-03-16	Tno	Werkwijze voor het bereiden van een geneesmiddel voor de behandeling van kanker, alsmede een van een 1,3-alkaandiamine afgeleid platina-diamminecomplex.
NL7807334A (nl) *	1978-07-06	1980-01-08	Tno	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
US4322362A (en) *	1980-07-28	1982-03-30	Bristol-Myers Company	Salts of 2-hydroxymalonate platinum complexes
NZ197104A (en) *	1980-05-27	1984-05-31	Bristol Myers Co	Soluble ammonium and sodium salts of 2-hydroxymalonato platinum ii derivatives

1982
- 1982-10-21 NL NL8204067A patent/NL8204067A/nl not_active Application Discontinuation
1983
- 1983-10-13 DE DE19833337333 patent/DE3337333A1/de not_active Ceased
- 1983-10-18 AU AU20275/83A patent/AU562964B2/en not_active Ceased
- 1983-10-19 CA CA000439308A patent/CA1229618A/en not_active Expired
- 1983-10-19 IT IT23359/83A patent/IT1169858B/it active
- 1983-10-20 YU YU2107/83A patent/YU43554B/xx unknown
- 1983-10-20 DK DK483083A patent/DK483083A/da not_active Application Discontinuation
- 1983-10-20 AT AT0373083A patent/AT390610B/de not_active IP Right Cessation
- 1983-10-20 IE IE2459/83A patent/IE56124B1/en not_active IP Right Cessation
- 1983-10-20 GR GR72754A patent/GR79652B/el unknown
- 1983-10-20 SE SE8305783A patent/SE8305783L/ not_active Application Discontinuation
- 1983-10-20 GB GB08328084A patent/GB2128615B/en not_active Expired
- 1983-10-20 DD DD83255826A patent/DD217522A5/de not_active IP Right Cessation
- 1983-10-20 NZ NZ206018A patent/NZ206018A/en unknown
- 1983-10-20 FR FR8316715A patent/FR2534907B1/fr not_active Expired
- 1983-10-20 PT PT77542A patent/PT77542B/pt unknown
- 1983-10-20 FI FI833842A patent/FI76351C/fi not_active IP Right Cessation
- 1983-10-20 LU LU85054A patent/LU85054A1/xx unknown
- 1983-10-20 CH CH5718/83A patent/CH658244A5/de not_active IP Right Cessation
- 1983-10-20 HU HU833623A patent/HU188035B/hu not_active IP Right Cessation
- 1983-10-20 NO NO833825A patent/NO171276C/no unknown
- 1983-10-21 JP JP58196286A patent/JPS5993091A/ja active Granted
- 1983-10-21 PH PH29726A patent/PH24077A/en unknown
- 1983-10-21 KR KR1019830004987A patent/KR910002536B1/ko not_active IP Right Cessation
- 1983-10-21 ES ES526670A patent/ES526670A0/es active Granted
- 1983-10-21 BE BE0/211755A patent/BE898058A/nl not_active IP Right Cessation
- 1983-10-21 CS CS837752A patent/CS242888B2/cs unknown
- 1983-10-21 ZA ZA837857A patent/ZA837857B/xx unknown
1992
- 1992-06-09 DK DK075592A patent/DK75592A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
FR2534907A1 (fr)	1984-04-27
IE832459L (en)	1984-04-21
IE56124B1 (en)	1991-04-24
GB8328084D0 (en)	1983-11-23
LU85054A1 (de)	1984-03-22
NL8204067A (nl)	1984-05-16
JPS5993091A (ja)	1984-05-29
NO171276C (no)	1993-02-17
DD217522A5 (de)	1985-01-16
AU562964B2 (en)	1987-06-25
GR79652B (de)	1984-10-31
FR2534907B1 (fr)	1988-08-19
SE8305783D0 (sv)	1983-10-20
DE3337333A1 (de)	1984-04-26
SE8305783L (sv)	1984-04-22
NZ206018A (en)	1986-02-21
ATA373083A (de)	1989-11-15
FI833842A0 (fi)	1983-10-20
FI833842A (fi)	1984-04-22
ES8406498A1 (es)	1984-07-01
PT77542A (en)	1983-11-01
IT1169858B (it)	1987-06-03
DK75592D0 (da)	1992-06-09
IT8323359A0 (it)	1983-10-19
HU188035B (en)	1986-03-28
PH24077A (en)	1990-03-05
FI76351B (fi)	1988-06-30
JPH0244479B2 (de)	1990-10-04
CA1229618A (en)	1987-11-24
KR840006492A (ko)	1984-11-30
KR910002536B1 (ko)	1991-04-23
FI76351C (fi)	1988-10-10
ZA837857B (en)	1984-06-27
ES526670A0 (es)	1984-07-01
CH658244A5 (de)	1986-10-31
YU43554B (en)	1989-08-31
PT77542B (en)	1986-02-12
YU210783A (en)	1986-08-31
NO171276B (no)	1992-11-09
AT390610B (de)	1990-06-11
DK483083D0 (da)	1983-10-20
NO833825L (no)	1984-04-24
CS775283A2 (en)	1985-08-15
DK75592A (da)	1992-06-09
DK483083A (da)	1984-04-22
AU2027583A (en)	1984-05-03
GB2128615A (en)	1984-05-02
GB2128615B (en)	1986-07-16
BE898058A (nl)	1984-04-24

Publication	Publication Date	Title
US4410544A (en)	1983-10-18	Platinum-diamine complexes, a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumor in mice
CS242888B2 (en)	1986-05-15	Method of diamminoplatinous complexes production
EP0001126B1 (de)	1982-08-18	Cis-Platin (II) Komplexe des 1,2-Diamino-cyclohexans und diese enthaltende pharmazeutisch Zubereitungen
JPS61171494A (ja)	1986-08-02	抗腫瘍性白金錯体
CS239911B2 (en)	1986-01-16	Processing of complexed diamino platinum
DE3023111C2 (de)	1988-09-22
NL8101026A (nl)	1982-10-01	Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
RU2140422C1 (ru)	1999-10-27	Трехплатиновые комплексы pt(ii), способ их получения
US4739087A (en)	1988-04-19	Antineoplastic platinum complexes
US20170050997A1 (en)	2017-02-23	Heterodinuclear platinum-ruthenium complexes, preparation thereof and therapeutic use thereof
WO2004099224A1 (de)	2004-11-18	Carboplatin-artige platin (ii)- komplexe
Hall et al.	1979	Unsymmetrical C-substituted ethylenediamine platinum coordination complexes: synthesis and activity against mouse leukemia L1210
NZ218072A (en)	1990-12-21	Phosphino-hydrocarbon-group viii metal complexes and pharmaceutical compositions
EP0174114A1 (de)	1986-03-12	Platinkomplexe von Ascorbinsäure und von analogen Verbindungen
JPS6176497A (ja)	1986-04-18	白金錯体
CS235311B2 (cs)	1985-05-15	Způsob výroby komplexního 2,2-disubstituovaného 1,3-alkandiaminu platnatého
NL8302115A (nl)	1985-01-02	Platina-diamine complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platina-diamine complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
DE10351021A1 (de)	2004-11-25	Carboplatin-artige Platin (II)-Komplexe
JPH0689011B2 (ja)	1994-11-09	新規抗がん性白金錯化合物及びその製造方法
JPS5988499A (ja)	1984-05-22	白金−ジアミン錯体
LU84365A1 (fr)	1983-04-13	Complexes de platine-diamine,procede d'obtention,application d'un tel complexe pour l'obtention d'un medicament pour le traitement du cancer et medicament ainsi obtenu