CN1940153A - Chitose graft alginate fibre, its production and use - Google Patents

Abstract

The invention discloses a chitosan grafted seaweed fiber and its preparation method and application, wherein the method is to dissolve an appropriate amount of chitosan in a glacial acetic acid solution with a mass percentage of 1% to 2% to obtain a mass percentage of 2% ～6% chitosan solution; then prepare 2%～5% calcium chloride solution by mass percentage; The proportion of the mixture is fully mixed, as a coagulation bath, the sodium alginate solution with a mass percentage of 3% to 5% is then formed into fibers in the coagulation bath, and the chitosan-grafted seaweed fiber is obtained after stretching and drying. The fiber stretching rate is 10% to 30%. Because the surface of this fiber is coated with a certain amount of chitosan, it has good hygroscopicity and antibacterial properties, and is non-toxic, harmless, high in safety and biodegradable, and has good applications in the fields of medicine and environmental protection. Prospect, especially suitable for making gauze for wound dressing.

Description

Chitosan grafted seaweed fiber and its preparation method and application

technical field

The invention relates to a chitosan grafted seaweed fiber which can be used for making non-woven fabrics and textiles, and a preparation method and application thereof.

Background technique

Sodium alginate is a polysaccharide carbohydrate extracted from brown algae kelp or sargassum, which is a polysaccharide composed of β-D-mannuronic acid and α-L-guluronic acid. Using a solution containing Ca ²⁺ as a coagulation bath, sodium alginate can be made into fibers by wet spinning. When the dressing made of fiber is in contact with the wound, the Ca ²⁺ in the fiber can conduct ion exchange with Na ⁺ in the wound secretion of the human body to form a wet gel at the wound. However, if the gel is not removed in time, it can absorb a large number of bacteria, leading to wound infection, which also limits the wide application of seaweed fiber to a certain extent. Chitosan widely exists in animal shells such as shrimps, crabs, pupae, and insects, as well as in the cell walls of fungi and algae. It is the most basic and important derivative of chitin. It has good affinity with biological tissues and can It is degraded and absorbed by the tissue fluid in the human body, and has excellent properties such as biodegradability, antibacterial, antiseptic, hemostasis and promotion of wound healing.

Contents of the invention

One of the tasks of the present invention is to provide a chitosan-grafted seaweed fiber with ideal comprehensive properties, which has excellent mechanical properties and antibacterial properties.

The second task of the present invention is to provide a method for preparing chitosan-grafted seaweed fiber.

The third task of the present invention is to provide the purposes of chitosan grafted seaweed fiber.

For realizing task one of the present invention, its technical solution is:

The invention relates to chitosan grafted seaweed fiber, in which macromolecules of chitosan are grafted with macromolecules of sodium alginate.

The chitosan-grafted seaweed fiber has a chitosan coating layer on the surface of the single fiber.

For realizing task two of the present invention, its technical solution is:

A preparation method of chitosan-grafted seaweed fiber, which comprises taking sodium alginate aqueous solution and chitosan solution, performing ion cross-linking between the two to obtain chitosan-grafted sodium alginate, and making fibers by wet spinning .

Above-mentioned preparation method, it has the following specific steps:

(1) Dissolving an appropriate amount of sodium alginate in water to prepare a sodium alginate solution with a mass percentage of 3% to 5%;

(2) Dissolving an appropriate amount of chitosan in a glacial acetic acid solution with a mass percentage of 1% to 2% to prepare a chitosan solution with a mass percentage of 2% to 6%;

(3) Dissolving an appropriate amount of calcium chloride in water to prepare a calcium chloride solution with a mass percentage of 2% to 5%;

(4) two kinds of solutions prepared by step (2) and step (3) are fully mixed in the ratio of 25% to 75% according to the volume percentage of chitosan solution in the mixed solution to prepare a coagulation bath;

(5) After the sodium alginate solution prepared in step (1) is filtered and degassed under reduced pressure, chitosan is prepared by wet spinning in a sufficient amount of coagulation bath prepared in step (4) at room temperature The grafted seaweed fiber has a fiber elongation rate of 10% to 30%.

The water used for the above-mentioned preparation of sodium alginate solution, chitosan solution and calcium chloride solution is preferably distilled water.

For realizing task three of the present invention, its technical solution is:

A chitosan-grafted seaweed fiber is used to prepare non-woven fabrics as wound dressings or textiles.

Chitosan grafted seaweed fiber in the present invention not only has the advantages of sodium alginate and chitosan, but also has better mechanical properties of the fiber due to the crosslinking between the two, and because the surface of the fiber is covered with a certain Chitosan, therefore has good hygroscopicity and antibacterial properties, non-toxic, harmless, high safety and biodegradability, its raw material sources are abundant, and it has good application prospects in the fields of medicine and environmental protection, especially suitable Manufacture of gauze for wound dressings.

Description of drawings

Fig. 1 is a schematic diagram of chitosan grafted sodium alginate cross-linked structure.

Figure 2 is a schematic cross-sectional view of chitosan-grafted sodium alginate fibers.

Detailed ways

In the present invention, since the sodium alginate aqueous solution and the chitosan solution have opposite electrical charges, the ionic cross-linking between the two can be used to prepare chitosan-grafted sodium alginate, that is, in its fiber molecules, Chitosan macromolecule grafted sodium alginate macromolecule. Among the prepared chitosan-grafted seaweed fibers, it is preferred that the single fiber surface layer is a finished fiber product with a chitosan coating layer, as shown in Fig. 1 and Fig. 2 .

Embodiment 1: get 30g sodium alginate and be dissolved in 970mL distilled water and obtain the sodium alginate solution of 3% (mass percentage); Get an appropriate amount of chitosan, be dissolved in the acetic acid solution of 1% (mass percentage) to obtain 2% (mass percentage) percentage) chitosan solution; prepare 5% calcium chloride solution. After the sodium alginate solution is filtered and defoamed under reduced pressure, chitosan is prepared by wet spinning in a coagulation bath composed of a mixture of chitosan solution and calcium chloride solution with a volume ratio of 3:1 at room temperature. Sugar grafted seaweed fiber, the fiber stretch rate can reach 30%. And it can be further used as fiber raw material to make non-woven gauze for wound dressing.

Embodiment 2: get 40g sodium alginate and be dissolved in 960mL distilled water and obtain 4% (mass percentage) sodium alginate solution; Take appropriate amount of chitosan, dissolve in the acetic acid solution of 1.5% (mass percentage) to obtain 4% shell Polysaccharide solution; prepare 4% calcium chloride solution. After the sodium alginate solution is filtered and defoamed under reduced pressure, chitosan is prepared by wet spinning in a coagulation bath composed of a mixture of chitosan solution and calcium chloride solution with a volume ratio of 2:1 at room temperature. Sugar grafted seaweed fiber, the fiber stretch rate can reach 20%. And it can be further used as fiber raw material to make non-woven gauze for wound dressing.

Embodiment 3: get 50g sodium alginate and be dissolved in 950mL distilled water and obtain the sodium alginate solution of 5% (mass percentage); Get an appropriate amount of chitosan, be dissolved in the acetic acid solution of 2% (mass percentage) to obtain 6% (mass percentage) percentage) chitosan solution; prepare 2% (mass percentage) calcium chloride solution. After the sodium alginate solution is filtered and defoamed under reduced pressure, chitosan is prepared by wet spinning in a coagulation bath composed of a mixture of chitosan solution and calcium chloride solution with a volume ratio of 1:1 at room temperature. Sugar grafted seaweed fiber, the fiber stretch rate can reach 10%. And it can be further used as fiber raw material to make non-woven gauze for wound dressing.

Embodiment 4: get 50g sodium alginate and be dissolved in 950mL distilled water and obtain the sodium alginate solution of 5% (mass percentage); Get an appropriate amount of chitosan, be dissolved in the acetic acid solution of 2% (mass percentage) to obtain 6% (mass percentage) percentage) chitosan solution; prepare 2% (mass percentage) calcium chloride solution. After the sodium alginate solution is filtered and defoamed under reduced pressure, chitosan is prepared by wet spinning in a coagulation bath composed of a mixture of chitosan solution and calcium chloride solution with a volume ratio of 1:3 at room temperature. Sugar grafted seaweed fiber, the fiber stretch rate can reach 10%. And it can be further used as fiber raw material to make non-woven gauze for wound dressing.

The product obtained in Examples 1, 2, 3 (or 4) is tested for mechanical properties and antibacterial properties, and the test results are shown in the table below.

Mechanical Properties of Chitosan Grafted Seaweed Fiber Dry Tensile StrengthcN/dtex Dry elongation at break% Wet tensile strengthcN/dtex Wet elongation at break% Example 1 Example 2 Example 3 1.932.112.04 22.3420.5821.77 2.562.782.69 56.4462.3660.91

Antibacterial properties of chitosan-grafted seaweed fiber Staphylococcus aureus Escherichia coli Bacteriostatic Bactericidal Bacteriostatic Bactericidal Example 1 Example 2 Example 3 2.89333.25273.0139 0.25840.40000.3782 2.65123.00242.9278 0.20140.36910.3235

It can be seen from the above data that the chitosan-grafted seaweed fiber has good mechanical properties and antibacterial properties.

The cross-section of the prepared chitosan-grafted sodium alginate fiber is shown in Fig. 2, wherein 1 is the chitosan coating layer, and 2 is the sodium alginate fiber core.

Claims (6)

1, a kind of chitose graft alginate fibre is characterised in that: in its fiber molecule, and the big molecule of the big molecule grafting of shitosan sodium alginate.

2, chitose graft alginate fibre according to claim 1 is characterized in that: its filament top layer is the shitosan clad.

3, a kind of preparation method of chitose graft alginate fibre is characterized in that: take sodium alginate aqueous solution and chitosan solution, carry out ionomer between the two and obtain the chitosan graft sodium alginate, and make fiber with wet spinning.

4, the preparation method of chitose graft alginate fibre according to claim 3, it has following concrete steps:

(1) be 3%～5% sodium alginate soln with the water-soluble mass percent of producing of an amount of sodium alginate;

(2) an amount of shitosan being dissolved in mass percent is in 1%～2% the glacial acetic acid solution, produces mass percent and be 2%～6% chitosan solution;

(3) be 2%～5% calcium chloride solution with an amount of calcium chloride mass percent of producing soluble in water;

(4) two kinds of solution that step (2) and step (3) are produced are that 25%～75% ratio is fully mixed in chitosan solution shared percent by volume in mixed solution, produce coagulating bath;

(5) sodium alginate soln that step (1) is produced after filtration, behind the vacuum deaerator, in the coagulating bath that the step (4) of capacity is produced, produce chitose graft alginate fibre with wet spinning process in room temperature, its tensile fiber rate is 10%～30%.

5, the preparation method of chitose graft alginate fibre according to claim 4 is characterized in that: described preparation sodium alginate soln, chitosan solution and the used water of calcium chloride solution are preferably distilled water.

6, a kind of chitose graft alginate fibre, it is used to prepare nonwoven fabric as wound dressing.

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