CN1813912A - Ointment for treating coronary disease and its production process - Google Patents

Abstract

The present invention discloses a Guanxin adhesive plaster and its production process. It is made up by using the Chinese medicinal materials of salvia root, ligusticum root, Chinese angelica root, carthamus flower, myrrh, clove, frankincense, dalbergia wood, camphor, xylene musk, menthanol, diphenhydramine hydrochloride, borneol and medical carrier rubber plaster matrix through a certain preparation process. Besides, said invention also provides the concrete steps of said preparation process.

Description

A kind of ointment for treating coronary disease and production technology thereof

One, affiliated technical field

The present invention relates to a kind of ointment for treating coronary disease and production technology thereof.

Two, background technology

Coronary heart disease, angina pectoris are the diseases occurred frequently in clinical, and the sickness rate of this disease is the trend that increases year by year, and its serious harm human healthy.What existing ointment for treating coronary disease adopted is natural rubber substrate, be referred to as rubber-emplastrum, when producing, the agitator tank of use cleans difficulty, can't guarantee that every batch is all cleared out a gathering place, so health is difficult for up to standard, and clean and to use 120# gasoline just can clean up, and use 120# gasoline to clean, must be ready to fire-fighting equipment again, its equipment complexity, contaminated environment again.Use the rubber-emplastrum of natural rubber substrate, its substrate and medicine are difficult for mix homogeneously, and the sizing material loss is big, and yield rate is low, the complexity of clearing out a gathering place, and gluing speed is slow, makes cream, to be coated with the cream equipment volume big, complexity, complex process, its paste containing amount is low, and drug loading is few, weak curative effect.In use, small number of patients also has skin allergy and stimulates phenomenon: mainly comprise (1) stripping reaction: when skin is taken rubber plaster off, because the physics wound can cause erythema, and slight edema; The adhesion of rubber plaster is bigger, more easily causes this inflammation.(2) anaphylaxis: compositions such as trace protein that contains in the natural rubber and Colophonium easily cause skin allergy, anaphylactoid lesion tissue of rubber plaster and contact dermatitis are similar, occur after being reflected at a few hours of applying ointment or plaster, reach summit in 24～72 hours, reaction is persistence, after rubber plaster was peeled off, inflammation still can continue, and scope surmounts former application site.Though this kind anaphylaxis is rare, in case take place, bigger to the influence of human body.(3) irritant reaction: the scytitis that this type causes is maximum, and irritant reaction generally can be divided into two kinds: after 1. rubber plaster was applied ointment or plaster, the outermost horny layer of skin surface made antiperspirant mouth obturation then very easily because of irriate causes hyperkeratosis, hindered the drainage of perspiration.2. because after rubber plaster applies ointment or plaster, skin antiperspirant mouth is blocked, perspiration is detained, and causes the skin dipping softening, makes whiteness of skin, deliquescing, simultaneously also make the tissue of skin become good culture medium with suitable humiture, microorganisms such as antibacterial and fungus are bred easily at this skin surface, and its product causes pessimal stimulation to skin, and the pH value of skin surface is descended, further promote the breeding of antibacterial again, caused antiperspirant pipe and follicular infection and eczema.Also have machinery and chemical stimulation, mechanical stimulus is owing to application hard rubber plaster causes that this stimulation is temporary transient on the skin in the wrong frequently stretching; Chemical stimulation is to cause owing to the chemical irritant in goo or the ground diffuses into skin histology.In a word, adopt the ointment for treating coronary disease of natural rubber substrate, very big to people's skin influence, cause some not use.

Three, summary of the invention

The present invention solves the above-mentioned problems in the prior art exactly, and a kind of no allergy and irritant reaction are provided, and paste containing amount is big, eutherapeutic ointment for treating coronary disease and preparation technology thereof.

For addressing the above problem, technical solution of the present invention is: a kind of ointment for treating coronary disease, it is become by following material preparation: each component content is in weight ratio, Radix Salviae Miltiorrhizae 100-105g, Rhizoma Chuanxiong 100-105g, Radix Angelicae Sinensis 100-105g, Flos Carthami 50-52.5g, Myrrha 37.5-39.4g, Flos Caryophylli 37.5-39.4g, Olibanum 37.5-39.4g, Lignum Dalbergiae Odoriferae 37.5-39.4g, Camphora 25-26.3g, musk xylene 12.5-13.1g, Mentholum 25-26.3g, diphhydramine hydrochloride 5-5.3g, Borneolum Syntheticum 50-52.5g and Medical carrier gel ointment substrate 3705-3891.6g.

The production technology of above-mentioned described ointment for treating coronary disease is: the preparation of (1) fluid extract: after Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Myrrha, Flos Caryophylli, Olibanum and the Lignum Dalbergiae Odoriferae of above-mentioned amount is ground into coarse powder, put it in 90% the ethanol, flood after at least 48 hours, speed diafiltration with per minute 120-170ml, ooze out fully to effective ingredient, collect filtrate, decompression filtrate recycling ethanol, be concentrated into temperature 60 ℃ the time with reclaiming filtrate behind the ethanol, relative density is about 1.20 fluid extract; (2) above-mentioned described amount Medical carrier gel ointment substrate is put in the material-compound tank, after being heated to thawing, Camphora, Mentholum, Borneolum Syntheticum, diphhydramine hydrochloride and musk xylene with fluid extract, above-mentioned described amount adds in the material-compound tank again, stir, make coating, with coating after at least 80 mesh sieves filter, coating, cut, the lid lining cuts off promptly.

Coronary heart disease, anginal basic pathology mechanism are stagnation of heart-blood, so this disease of treatment should be fundamentum with the blood circulation promoting and blood stasis dispelling.The present invention forms by having blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, the sensible medicine that reaches effect, and Radix Angelicae Sinensis, Flos Carthami blood circulation promoting and blood stasis dispelling and blood nourish heart; Olibanum, the analgesic therapy of Lignum Dalbergiae Odoriferae dissipating blood stasis, sending down the abnormal ascending QIization is turbid; Radix Salviae Miltiorrhizae is apt to nourishing blood and promoting blood circulation; Rhizoma Chuanxiong is the gas medicine in the blood, confirms through modern pharmacological research, and said medicine has coronary artery dilating increases coronary blood flow, adjusts microcirculation, improves the effect of myocardial ischemia.Musk xylene, Borneolum Syntheticum, Herba Menthae, Camphora fragrant odour Zhang Lie are good at walking to scurry, and can declare smooth mechanism of qi, reach blood vessels thoroughly and can open all keys, are medicine for external use advantages of good skin penetrating agent again; Adopt the Medical carrier gel ointment of no acute general toxic reaction to make substrate, its stimulation index is 0, the sensitization rate is 0%, it is stable that substrate also has physical property, no migration, separation and catabiosis all have good blending with various medicines, and substrate and drug ratios can reach 1: 1, be natural rubber substrate 4-5 doubly, paste containing amount is generally 0.8-30g/100cm ²The present invention had both overcome rubber-emplastrum and has easily produced skin allergy and stimulate phenomenon, had overcome the shortcoming that black plaster easily pollutes again, and it has inherited big, the eutherapeutic advantage of black plaster content of dispersion.In process of production, its advantage is: (1) no solvent, no dust, do not use steam, and pollution-free, production safety, energy-saving and environmental protection; (2) production technology is simple, and the production cycle just for one day can be continuously produced; (3) substrate and medicament mixed are even, are beneficial to product is analysed scientifically and illustrated; No sizing material loss, the yield rate height; It is thoroughly simple to clear out a gathering place, each operation GMP compatible; (4) gluing speed is fast, can reach per minute more than 10 meters; (5) system cream, to be coated with the cream equipment volume little, the automaticity height, two people can operate.The active ingredient of plaster medicine of the present invention can promptly discharge osmotic absorption in local organization, treating selected SHANZHONG acupoint is " sea of gas " in the human body, Hsinshu (acupoint), ke shu through gas all lie in heart diaphragm, RUGEN acupoint is positioned at ambition portion, can make the efficacy of a drug sick institute that goes directly so this medicine is executed at above-mentioned acupuncture point to control, the medicine cave is share, and gives full play to rouse oneself the breast sun, thirsty logical heart arteries and veins, blood circulation promoting and blood stasis dispelling, the effect of promoting the circulation of QI to relieve pain, thus in clinical, received the curative effect of satisfaction.

Four, the specific embodiment

1, the ointment for treating coronary disease of present embodiment is made by following raw material: Radix Salviae Miltiorrhizae 100g, Rhizoma Chuanxiong 100g, Radix Angelicae Sinensis 100g, Flos Carthami 50g, Myrrha 37.5g, Flos Caryophylli 37.5-39g, Olibanum 37.5g, Lignum Dalbergiae Odoriferae 37.5g, Camphora 25g, musk xylene 12.5g, Mentholum 25g, diphhydramine hydrochloride 5g, Borneolum Syntheticum 50g and Medical carrier gel ointment substrate 3705g.(1) Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Myrrha, Flos Caryophylli, Olibanum and the Lignum Dalbergiae Odoriferae of above-mentioned amount is ground into coarse powder after, put it in 90% the ethanol, flood after at least 48 hours, speed diafiltration with per minute 150ml, ooze out fully to effective ingredient, collect filtrate, decompression filtrate recycling ethanol, be concentrated into temperature 60 ℃ the time with reclaiming filtrate behind the ethanol, relative density is about 1.20 fluid extract.(2) above-mentioned described amount Medical carrier gel ointment substrate is put in the material-compound tank, after being heated to thawing, Camphora, Mentholum, Borneolum Syntheticum, diphhydramine hydrochloride and musk xylene with fluid extract, above-mentioned described amount adds in the material-compound tank again, stir, make coating, after at least 80 mesh sieves filters, sampling, after semi-finished product inspection is qualified, standby.(3) coating process: 1. front truck heats up: glue spreader front truck temperature is set at: 75 ℃ of scrapers, and 50 ℃ of bottom rollers, 70 ℃ of paddles, preceding 30 minutes of gluing is opened heating system; 2. connect cloth: what will connect draws cloth below pedal, by paddle, scraper, chill roll, Distribution roller etc., links to each other with back car Scroll at last; 3. gluing: from couveuse, take out the good sizing material of baking, be placed on front truck paddle and scraper junction; 4. gluing: adjust scraper and bottom roller spacing, open the cooling system device, start glue spreader, the speed of a motor vehicle is set at 5 meters/minute; (4) cut: glue-coated volume is cut into rouleau; (5) disconnected cutting: with the compound lid lining form of part machine part; (6) bag in: the pack of inspection sheet is sealed.

2, the ointment for treating coronary disease of present embodiment is made by following raw material: Radix Salviae Miltiorrhizae 105g, Rhizoma Chuanxiong 105g, Radix Angelicae Sinensis 105g, Flos Carthami 52.5g, Myrrha 39.4g, Flos Caryophylli 39.4g, Olibanum 39.4g, Lignum Dalbergiae Odoriferae 39.4g, Camphora 26.3g, musk xylene 13.1g, Mentholum 26.3g, diphhydramine hydrochloride 5.3g, Borneolum Syntheticum 52.5g and Medical carrier gel ointment substrate 3891.6g.Its production technology is with embodiment 1.

3, the ointment for treating coronary disease of present embodiment is made by following raw material: Radix Salviae Miltiorrhizae 102g, Rhizoma Chuanxiong 101g, Radix Angelicae Sinensis 104g, Flos Carthami 51g, Myrrha 38g, Flos Caryophylli 38g, Olibanum 38g, Lignum Dalbergiae Odoriferae 38g, Camphora 25.5g, musk xylene 12.8g, Mentholum 25.5g, diphhydramine hydrochloride 5.15g, Borneolum Syntheticum 51g and Medical carrier gel ointment substrate 3800g.Its production technology is with embodiment 1.

4, the ointment for treating coronary disease of present embodiment is made by following raw material: Radix Salviae Miltiorrhizae 104g, Rhizoma Chuanxiong 103g, Radix Angelicae Sinensis 103g, Flos Carthami 52g, Myrrha 39g, Flos Caryophylli 37g, Olibanum 37g, Lignum Dalbergiae Odoriferae 39g, Camphora 26g, musk xylene 13g, Mentholum 26g, diphhydramine hydrochloride 5.2g, Borneolum Syntheticum 52g and Medical carrier gel ointment substrate 3750g.Its production technology is with embodiment 1.

5, the ointment for treating coronary disease of present embodiment is made by following raw material: Radix Salviae Miltiorrhizae 103g, Rhizoma Chuanxiong 104g, Radix Angelicae Sinensis 103g, Flos Carthami 50.5g, Myrrha 38.8g, Flos Caryophylli 39g, Olibanum 39g, Lignum Dalbergiae Odoriferae 38.5g, Camphora 25.8g, musk xylene 12.7g, Mentholum 25.8g, diphhydramine hydrochloride 5.25g, Borneolum Syntheticum 51.5g and Medical carrier gel ointment substrate 3850g.Its production technology is with embodiment 1.

Claims (3)

1, a kind of ointment for treating coronary disease is characterized in that: it is become by following material preparation: each component content is in weight ratio, Radix Salviae Miltiorrhizae 100-105g, Rhizoma Chuanxiong 100-105g, Radix Angelicae Sinensis 100-105g, Flos Carthami 50-52.5g, Myrrha 37.5-39.4g, Flos Caryophylli 37.5-39.4g, Olibanum 37.5-39.4g, Lignum Dalbergiae Odoriferae 37.5-39.4g, Camphora 25-26.3g, musk xylene 12.5-13.1g, Mentholum 25-26.3g, diphhydramine hydrochloride 5-5.3g, Borneolum Syntheticum 50-52.5g and Medical carrier gel ointment substrate 3705-3891.6g.

2, the production technology of the described ointment for treating coronary disease of a kind of claim 1, it comprises step: the preparation of (1) fluid extract: after Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami, Myrrha, Flos Caryophylli, Olibanum and the Lignum Dalbergiae Odoriferae of described amount is ground into coarse powder, put it in 90% the ethanol, flood after at least 48 hours, speed diafiltration with per minute 120-170ml, ooze out fully to effective ingredient, collect filtrate, with decompression filtrate recycling ethanol, be concentrated into temperature 60 ℃ the time with reclaiming filtrate behind the ethanol, relative density is about 1.20 fluid extract; It is characterized in that: further comprising step (2) puts into described amount Medical carrier gel ointment substrate in the material-compound tank, after being heated to thawing, Camphora, Mentholum, Borneolum Syntheticum, diphhydramine hydrochloride and musk xylene with fluid extract, described amount adds in the material-compound tank again, stir, make coating, coating after at least 80 mesh sieves filter, is coated with.

3, the production technology of ointment for treating coronary disease according to claim 2, it is characterized in that: the coating process in the described step (2) is: 1. front truck heats up: glue spreader front truck temperature is set at: 75 ℃ of scrapers, 50 ℃ of bottom rollers, 70 ℃ of paddles, preceding 30 minutes of gluing is opened heating system; 2. connect cloth: what will connect draws cloth below pedal, by paddle, scraper, chill roll, Distribution roller etc., links to each other with back car Scroll at last; 3. gluing: from couveuse, take out the good sizing material of baking, be placed on front truck paddle and scraper junction; 4. gluing: adjust scraper and bottom roller spacing, open the cooling system device, start glue spreader, the speed of a motor vehicle is set at 5 meters/minute.