CN102525862B - Mosquito repellent gel containing sedum sarmentosum and mint oil and preparation method thereof - Google Patents

Abstract

The invention relates to a mosquito-repelling gel with sage mint oil and a preparation method thereof, belonging to the field of pharmacy. The invention combines the detoxification, detumescence, antibacterial and anthelmintic effects of the weeping grass and the cooling, antipruritic and pain relieving effects of peppermint oil, and provides a gel preparation and a production technology for its preparation method. The method comprises the technical steps of preparing the filtered juice of the weeping grass, mixing, preparing the substrate, adjusting the pH, sterilizing and making a finished product. Moreover, the preparation has the effects of repelling mosquitoes, relieving itching, and antibacterial, and at the same time has the advantages of being natural, safe, harmless, convenient to carry, fast to absorb, and stable and long-lasting drug effect. Reached the purpose of expanding its clinical application again.

Description

A kind of anti-mosquito gel with peppermint oil and preparation method thereof

technical field

The invention relates to a method for preparing a mosquito repellent by using sage chinensis and peppermint oil, and belongs to the field of pharmacy.

Background technique

Mosquitoes are one of the four pests and also carriers of viruses. With the development of society and the continuous improvement of human living standards, people's awareness of health and self-protection awareness is also increasing, and various mosquito repellent products have emerged one after another. At present, there are many mosquito repellent products on the market, mainly concentrated in disc mosquito coils, mosquito coils, aerosol mosquito killers, toilet water, mosquito repellent cream, mosquito repellent, heating mosquito coils, etc. Most of these mosquito repellent products rely on pesticides or chemical ingredients to achieve the mosquito repellent effect, and only a few use natural and harmless ingredients to repel mosquitoes. And this part product is mostly liquid, solid again, and liquid mosquito repellent is inconvenient to carry and is subject to the influence of external factors such as temperature pressure, and solid mosquito repellent needs to ignite and use inconvenience, so both have certain weak point.

Sedum sarmentosum Bunge. Sedum sarmentosum Bunge is a perennial herb of the Sedum family. It is cool in nature and sweet in taste. Fresh or dried whole herb is used as medicine. It is a commonly used herbal medicine for treating sores and snake bites. Punched freshly, applied or applied externally with its juice, has the effects of detoxification, swelling, and antibacterial. Peppermint oil has cooling, antipruritic and analgesic effects, and it has a good synergistic effect of repelling mosquitoes and relieving itching when used in combination with Herba chinensis.

Gel is a commonly used traditional Chinese medicine form. It is lubricated and comfortable to apply, has excellent coupling effect with the skin, is easy to clean, absorbs quickly, is convenient to use, and has stable properties. In the present invention, the oils of sage and peppermint are prepared into a gel, and the preparation has the effects of repelling mosquitoes, relieving itching, and antibacterial, and has the advantages of being natural, safe, harmless, easy to carry, fast to absorb, and stable and long-lasting drug effect. It not only improves the utilization rate of medicinal material resources, meets medical needs, but also achieves the purpose of expanding its clinical application.

Contents of the invention

The invention combines the detoxification, detumescence, antibacterial and anthelmintic effects of weeping grass and the cooling, antipruritic and pain relieving effects of peppermint oil, and provides a gel preparation and a preparation method thereof. The technical problem to be solved by the present invention is to design a set of technological process, and select suitable auxiliary materials to make the peppermint oil gel with mosquito repelling, antipruritic and antibacterial effects. Aiming at the technical problem to be solved, the present invention is realized through the following technical solutions.

The gel agent of the present invention is prepared from weeping grass, peppermint oil and suitable auxiliary materials.

A mosquito repellent gel of sage mint oil, prepared from the following raw materials in parts by weight:

Weeping pot grass 400-1200 copies;

Peppermint oil 50-150 parts;

Carbomer 940 5-15 parts;

Distilled water 500-1500 parts;

Glycerin 5-15 parts;

Propylene glycol 5-10 parts;

Ethylparaben 5-15 parts;

pH regulator triethanolamine is used to adjust the pH in an appropriate amount.

A kind of preparation method of weeping grass peppermint oil mosquito repellent gel is carried out according to the following steps:

1. Preparing the filtered juice of C. chinensis: take 400-1200 parts of C. spp. with plump and fresh green leaves in July and August, after cleaning, drying, pounding the juice and filtering to obtain 100-300 parts of C. spp. juice for later use;

2. Mixing: add 50-150 parts of peppermint oil to the prepared weeping grass juice, mix well and set aside;

3. Preparation of matrix: Soak 5-15 parts of Carbomer 940 in 500-1500 parts of distilled water, add 5-15 parts of glycerin and grind evenly, then add 5-10 parts of propylene glycol, stir again and place it for a period of time until the matrix is moist. up completely;

4. Adjust the pH value: add the previously prepared peppermint oil mixture, add the pH regulator triethanolamine, stir well, and control the pH value to 5-7;

5. Finished product: Finally, mix all the solutions and add 5-15 parts of ethylparaben, mix well, fully stir, and sterilize to obtain a transparent gel, which is packaged to make a finished product.

The invention has obvious mosquito repelling effect, and has the advantages of being natural, safe, harmless, convenient to carry, quick to absorb, and stable and long-lasting drug effect.

Detailed ways

Further illustrate the technical process of the present invention below by specific embodiment:

Example 1

1. Preparing the filtered juice of C. chinensis: take 400 g of fresh and green Cedarsia spp. in July and August, after cleaning, drying, and pounding the juice to obtain 100 g of C. syringa juice for later use;

2. Mixing: add 150 g of peppermint oil to the prepared weeding grass juice, mix well and set aside;

3. Prepare the matrix: Soak 5 g of Carbomer 940 in 500 ml of distilled water, add 15 g of glycerin and grind it evenly, then add 10 g of propylene glycol, stir again and let it stand for a period of time until the matrix is completely moistened;

4. Adjust the pH value: add the previously prepared peppermint oil mixture, add the pH regulator triethanolamine, stir well to control the pH value to 5;

5. Finished product: Finally, mix all the solutions and add 5 g of ethylparaben, mix well, stir thoroughly, and sterilize to obtain a transparent gel, which is packaged to make a finished product.

Example 2

1. Preparing the filtered juice of C. chinensis: take 800 g of fresh and green Cedarsia spp. in July and August, after cleaning, drying, and pounding the juice to obtain 200 g of C. spp. juice for later use;

2. Mixing: Add 100 g of peppermint oil into the prepared weeding grass juice, mix well and set aside;

3. Prepare the matrix: Soak 10 g of Carbomer 940 in 1000 ml of distilled water, add 10 g of glycerin and grind it evenly, then add 5 g of propylene glycol, stir again and let it stand for a period of time until the matrix is completely moistened;

4. Adjust the pH: add the previously prepared peppermint oil mixture, add the pH regulator triethanolamine, stir well to control the pH value to 6;

5. Finished product: Finally, mix all the solutions and add 10 g of ethylparaben, mix well, stir thoroughly, and sterilize to obtain a transparent gel, which is packaged to make a finished product.

Example 3

1. Preparing the filtered juice of C. chinensis: take 1200 g of fresh and green C. sylvestris in July and August, after cleaning, drying, and pounding the juice to obtain 300 g of C. syringa juice for later use;

2. Mixing: Add 50 g of peppermint oil into the prepared sage juice, mix well and set aside;

3. Prepare the matrix: Soak 15 g of Carbomer 940 in 1500 ml of distilled water, add 5 g of glycerin and grind it evenly, then add 7.5 g of propylene glycol, stir again and let it stand for a period of time until the matrix is completely moistened;

4. Adjust the pH: add the previously prepared peppermint oil mixture, add the pH regulator triethanolamine, stir well to control the pH value to 7;

5. Finished product: Finally, mix all the solutions and add 15 g of ethylparaben, mix well, stir thoroughly, and sterilize to obtain a transparent gel, which is packaged to make a finished product.

Experiment 1 Mosquito repellent effect of weeping grass peppermint oil mosquito repellent gel

Use the method in GB/17322.10-1988 to test the mosquito repellent effect.

Mosquito attack power test: put 300 mosquitoes in a mosquito cage whose length×width×height are 40cm×30cm×30cm respectively. The experimenter’s arm exposes 4cm×4cm skin area, and the rest is covered. Put your arm into the mosquito cage and place it for 2 minutes, and record the number of mosquitoes that come to land. Those with more than 30 are qualified for the attack power. The tester and the mosquitoes in this cage can be used for the avoidance test.

Approach-to-avoidance test: choose qualified experimenters, and expose 4cm×4cm skin area on each of their arms as mentioned above, one of which is set as a blank control, without any smearing, and the exposed part of the other arm is treated with 1.5mg Apply mosquito repellent gel evenly at a dose of / cm2. After smearing for 2 hours, put your arm into the mosquito cage with qualified attack power for 2 minutes, observe whether there are mosquitoes coming to suck blood, and then test once every hour, as long as there are mosquitoes coming to suck blood, it is judged that the repellent is invalid, and record the repellent The effective protection time (h). A recipe is repeated 10 times.

Effective protection rate (%) = [(average number of stings in the control group - average number of stings in the experimental group)/average number of stings in the control group] × 100

Experimental results show that the effective protection rate of the mosquito repellent gel of the present invention is greater than 85%, and the average mosquito repellent effect is 10 h. It shows that the mosquito repellent gel provided by the invention has a very good mosquito repellent effect.

Claims (2)

1. A mosquito-repelling gel of Herba Peppermint Oil, characterized in that it is prepared from the raw materials of the following parts by weight: Weeping pot grass 400-1200 copies; Peppermint oil 50-150 parts; Carbomer 940 5-15 parts; Distilled water 500-1500 parts; Glycerin 5-15 parts; Propylene glycol 5-10 parts; Ethylparaben 5-15 parts; pH regulator triethanolamine is used to adjust the pH in an appropriate amount. 2. the preparation method of a kind of Herba Peppermint Oil Mosquito Repellent Gel as claimed in claim 1 is characterized in that carrying out according to the following steps: (1) Preparation of weeding grass filter juice: Take 400-1200 parts of weeding grass with plump and fresh green leaves in July and August, wash, dry, and pound the juice to obtain 100-300 parts of weeding grass juice for later use ; (2) Mixing: add 50-150 parts of peppermint oil to the prepared weeping grass juice, mix well and set aside; (3) Preparation of matrix: Soak 5-15 parts of Carbomer 940 in 500-1500 parts of distilled water, add 5-15 parts of glycerin, after grinding evenly, add 5-10 parts of propylene glycol, stir again and place it for a period of time until The matrix is fully moistened; (4) Adjust the pH value: add the previously prepared peppermint oil mixture, add the pH regulator triethanolamine, stir well, and control the pH value to 5-7; (5) Finished product: Finally, add 5-15 parts of ethylparaben to the mixed solution obtained in step (4), mix well, fully stir, and sterilize to obtain a transparent gel, which is packaged to make a finished product.