CN102397521A - Traditional Chinese medicine plaster for preventing and treating angina pectoris and preparation method thereof - Google Patents
Traditional Chinese medicine plaster for preventing and treating angina pectoris and preparation method thereof Download PDFInfo
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Abstract
A Chinese medicinal patch for preventing and treating angina pectoris comprises rhizoma Ligustici Chuanxiong, Saviae Miltiorrhizae radix, Mentholum, Moschus, storax, lignum Santali albi, fructus Foeniculi, Olibanum, Myrrha, rhizoma Cyperi, rhizoma corydalis, Borneolum Syntheticum and rhizoma Zingiberis recens juice. The matrix comprises gelatin, sodium carboxymethylcellulose, polyvinylpyrrolidone K30, sodium polyacrylate, kaolin, glycerol, azone and polyethylene glycol 400. The preparation method comprises the following steps: pulverizing rhizoma Ligustici Chuanxiong, Saviae Miltiorrhizae radix, rhizoma Cyperi, rhizoma corydalis and fructus Foeniculi into coarse powder, percolating after moistening with ethanol in a percolating tube, collecting percolate and making into extract, and mixing with fine powder of Olibanum, Myrrha, Mentholum, storax, lignum Santali albi, Moschus, Borneolum Syntheticum and rhizoma Zingiberis recens juice. Dissolving azone in glycerol to obtain glycerol mixture, soaking gelatin, CMC-Na, PVPK30, and PANA in water, heating in water bath to swell, adding glycerol mixture and PEG400, mixing, adding kaolin, mixing, adding the obtained medicinal preparation, grinding, spreading on backing material, drying, and packaging. The plaster can prevent and treat angina pectoris and has no toxic side effect. The preparation method is favorable for full play of the medicine.
Description
Technical field
The invention belongs to Chinese medicine plaster field, the Chinese medicine plaster of particularly a kind of prevention and alleviation angina pectoris attacks.
Background technology
Angina pectoris is a coronary insufficiency, and temporary transient ischemia that cardiac muscle is rapid and anoxia are caused to be the clinical syndrome of main performance with ictal chest pain or chest discomfort.Pathogenesis is owing to conflict between blood supply coronarius and the myocardium need blood, and it is caused that coronary artery blood flow can not satisfy the needs of myocardial metabolism.Therefore, any method that can improve coronary blood supply is the allevating angina pectoris symptom effectively, and also can reduce anginal outbreak through prophylactic treatment.Wherein, the external treatment of the traditional Chinese medical science is exactly a kind of approach safely and effectively, and because it passes through skin absorbs, persistent is having more advantage aspect the prevention angina pectoris attacks.This plaster just is based on meridional point theory and inventor's clinical experience for many years of the traditional Chinese medical science, and combines modern pharmacology and medicament achievement in research and a kind of Chinese medicine externally used paste of inventing.
The inventor is engaged in nearly 30 years of the clinical position of cardiovascular disease; Diagnosis and treatment countless patient with angina pectoris, constantly explore in practice and also sum up the treatment experience, find on the basis of oral drugs, to cooperate external treatment of Chinese medicine; Through the percutaneous drug delivery approach; Can play Chinese medicine, the effect of attenuation synergistic, especially evident in efficacy aspect the prevention angina pectoris attacks.Through clinical trial repeatedly, the inventor is the principles of formulating prescriptions with " promoting blood circulation and stopping pain, warm Tongxinluo, causing resuscitation with aromatic drugs " finally, has confirmed we.
Theory of Chinese medical science thinks that the people is an organic whole, through channel system with the vital organs of the human body, the face nine orifices, five body constituents, the extremity bones of the body collectively is related to together, and they are connected each other on physiology, mutual restriction influences each other on the pathology.Meridians are passages of operation QI and blood in the human body, are the internal organs direct bearing, and the direct bearing internal organs are carried and acted on to medicine by the transmitting effect of meridians with effective ingredient, regulates human-body viscera function, and this also becomes the theoretical basis of " sick outside interior person can take from ".Acupuncture points on the human body be viscera QI of channels and collaterals infusion in the privileged sites of body surface, promptly be the reflecting point of disease.Acupuncture points on the human body both can have been treated place position disease, can follow again through and control, simultaneously, have dual regulation.The inventor has chosen the XINYU acupoint of bladder meridian, the Neiguan acupoint of pericardium meridian, the SHANZHONG acupoint of conception vessel and the tsusanli acupoint conduct of the stomach channel of foot-Yang-ming and has sticked the position; Through inside and outside with up and down, the whole adjunct acupuncture points method of taking into account with the part; Make medicine act on heart arteries and veins, play the effect of invigorating the spleen and replenishing QI, dredge the meridian passage through meridians.Can be during application according to patient's situation, point selection treatment based on syndrome differentiation on basis, above-mentioned basic acupuncture point.This plaster can be avoided the first pass effect of liver through the administration of skin particular acupoint, and the absorption of medicine is not influenced by gastrointestinal factors, and is easy to use, and interruption of the administration reduces drug resistance at any time, has reduced toxicity.But because the speed limit barrier action of keratodermatitis, the transdermal characteristic of most drug is very poor, and behind the transdermal administration, infiltration rate and infiltration capacity do not reach the treatment requirement.So, seek suitable method and improve the permeability of skin, improve the transdermal amount of medicine and just become key., numerous dosage forms find that cataplasma has been avoided above-mentioned shortcoming after being compared.Cataplasma is to adopt macromolecular material to make substrate, has the drug capacity height, dosage is accurate, and transdermal characteristic, applicating property, moisture retention are good, pasting comfortable, pollution clothes not, characteristics such as no sensitization and zest.Therefore, the inventor has processed analgesic ointment cream with this angina pectoris plaster.
Summary of the invention
An object of the present invention is to provide the anginal Chinese medicine plaster of a kind of control, another object of the present invention provides a kind of method for preparing of preventing and treating anginal Chinese medicine plaster.This plaster has good preventing angina pectoris attacks and the effectively effect of allevating angina pectoris symptom, and the manufacture method of this plaster is reasonable, helps medicine and plays one's part to the full.
The technical scheme that adopts is:
The anginal Chinese medicine plaster of a kind of control comprises: medicine, substrate, mount backing material and adherent layer.
If drug main is prepared from Rhizoma Chuanxiong 45-55g, Radix Salviae Miltiorrhizae 45-55g, Mentholum 15-25g, Moschus 0.5-1.5g, Styrax 20-30g, Lignum Santali Albi 7-8g, Fructus Foeniculi 15-25g, Borneolum Syntheticum 10-20g, Olibanum (processed) (wick system) 20-30g, Myrrha (processed) (wick system) 20-30g, Rhizoma Cyperi 20-30g, Rhizoma Corydalis 20-30g and Rhizoma Zingiberis Recens juice 5-15g.Rhizoma Zingiberis Recens juice is the fresh ginger filtration gained of directly squeezing the juice.
Substrate is prepared from gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone.The mass ratio of gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone is: 3: 4: 3: 3.5: 4: 20:10: 2.Be applied to after medicine and substrate are mixed and mount on the backing material, mounting the backing material is the known material of mounting.Cover known adherent layer encapsulation then.
A kind of method for preparing of preventing and treating anginal Chinese medicine plaster comprises following process steps: 1, the preparation of medicine:
1., get Rhizoma Chuanxiong 45-55g, Radix Salviae Miltiorrhizae 45-55 g, Rhizoma Cyperi 20-30g, Rhizoma Corydalis 20-30g and Fructus Foeniculi 15-25g, be broken into coarse powder, cross 10 mesh sieves; Place in the percolator, add 65% ethanol, amount of ethanol is 70% of a medical material amount; Behind the moistening 48h, press 3ml/min speed percolation, when oozing dropping liquid color volume extremely shallow or percolate and be equivalent to heavy 10 times of crude drug with 65% ethanol; Collect percolate and adopt the vacuum concentration pot reduction vaporization to process extractum, subsequent use.Above-mentioned percent is mass percent.
2., get Olibanum (processed) (wick system) 20-30g, Myrrha (processed) (wick system) 20-30g, Mentholum 15-25g, Styrax 20-30g and Lignum Santali Albi 7-8g; Be broken into fine powder; Cross 180 mesh sieves; After adding Moschus 0.5-1.5g, Borneolum Syntheticum 10-20g and Rhizoma Zingiberis Recens juice 5-15g mix homogeneously, add the extractum mix homogeneously that 1. step is processed, it is subsequent use promptly to get medicine.
2, the preparation of substrate:
By mass ratio be:
Gelatin: sodium carboxymethyl cellulose (CMC-Na): polyvinylpyrrolidone K30 (PVPK30): sodium polyacrylate (PANa): Kaolin: glycerol: PEG400 (PEG400): azone=3: 4: 3: 3.5: 4: 20:10: 2 proportioning is got material, and is subsequent use.
Azone is dissolved in the glycerol, and it is subsequent use to process the glycerol mixed liquor.Getting gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone K30, sodium polyacrylate adds suitable quantity of water and soaks; In 70 ℃ of water-baths, heat swelling; After treating that temperature is reduced to room temperature; Add mix homogeneously in the swelling liquid to the glycerol mixed liquor of processing, PEG400, add the Kaolin mixing again, process substrate.
3, be that the 1:3 agitation grinding is even with medicine and substrate according to mass ratio, evenly coat on the material of mounting, every 10g, the vacuum constant temperature drying baker is dry, covers known adherent layer, and encapsulation promptly gets.
The described material of mounting can be non-woven fabrics, and described adherent layer can be polyethylene film.
The side separates:
Rhizoma Chuanxiong:Hot temperature is fragrant dry, walks and does not keep, can go diffusing, the up top, mountain peak that reaches; Go into blood system again, the descending sea of blood that reaches.The blood circulation promoting and blood stasis dispelling action range, the various diseases of suitable stagnation of blood stasis.
Radix Salviae Miltiorrhizae:Hardship is slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Herba Menthae:Suffering, cold.Effect: dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.
Moschus:Acrid in the mouth, warm in nature.GUIXIN, liver, spleen channel.Fragrant strongly scurry diffusingly, can rise and to fall, have the refreshment of having one's ideas straightened out, blood circulation promoting and dispersing pathogen accumulation, the effect of alleviating pain and detumescence.
Styrax:Suffering, temperature.GUIXIN warp, spleen channel.Effect: open and steal, ward off dirty, pain relieving.
Lignum Santali Albi:Suffering, temperature.Return spleen, stomach, the heart, lung meridian.Row heart warming middle-JIAO, the appetizing pain relieving has the nerve of pacifying, auxiliary deep in thought, the effect with all worries set aside of refreshing oneself.
Fructus Foeniculi:Warm in nature, acrid in the mouth.Return liver,kidney,spleen, stomach warp.Effect: warming the liver kidney, warming the stomach gas, diffusing plug knot, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.
Borneolum Syntheticum:Arduous, cold.Go into the heart, lung meridian.Effect: logical all keys, the stagnated fire of loosing goes nebula to make eye bright, reducing swelling and alleviating pain.
Olibanum:The property hot, bitter, warm.Go into the heart, liver, spleen channel.These article suffering is loose and is walked to scurry, and bitter in the mouth is removed heat by catharsis, and has both gone into blood system, goes into edema caused by disorder of QI again, the stagnation of QI in the ability promoting the circulation of blood, and blood-activating analgetic, internal energy a surname is led to the internal organs QI and blood, and external enwergy reaches meridians thoroughly, can be used for the card bitterly of all qi depressions to blood stasis.
Myrrha:Hardship, suffering, flat.Effect: the blood blood stasis removing that looses, subduing swelling and relieving pain." Records of Tradition Chinese and Western Medicine in Combination ": " Olibanum, Myrrha, two medicines and usefulness are for declaring the key medicine of logical internal organs, circulation meridians, so all pain of all heart stomach flank limbs joints all can be controlled it ".
Rhizoma Cyperi:Acrid in the mouth, sweet, little hardship, property is flat.Return liver, tri-jiao channel.The fragrant row of gas looses, and can rise and can fall, and has the resolving depression of regulating the flow of vital energy, the menstruction regulating and pain relieving effect.
Rhizoma Corydalis:Warm in nature, acrid in the mouth is bitter.Go into the heart, spleen, liver, lung meridian.Be the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, be world-famous for the effect of pain relieving especially.Li Shizhen (1518-1593 A.D.) is concluded Rhizoma Corydalis in Compendium of Material Medica have " invigorating blood circulation promoting the circulation of QI, pain relieving, diuresis " four large effects, and praise highly Rhizoma Corydalis " stagnation of QI in the ability promoting the circulation of blood, stasis in the gas is so specially control all up and down all over the body pains ".
Rhizoma Zingiberis Recens:Hot, tepor.Return lung, spleen, stomach warp.Effect: relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough.
All medicines share, and play the effect of " promoting blood circulation and stopping pain, warm Tongxinluo, causing resuscitation with aromatic drugs " altogether.Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae are longer than blood circulation promoting and blood stasis dispelling and are monarch; Herba Menthae, Moschus, Styrax, Lignum Santali Albi, Fructus Foeniculi, the refreshment of Borneolum Syntheticum causing resuscitation with aromatic drugs, dredging the meridian is a ministerial drug; Olibanum (processed) (wick system), Myrrha (processed) (wick system) be promoting blood circulation and stopping pain relatively, and Rhizoma Cyperi, Rhizoma Corydalis are longer than the merit that pain relieving has blood circulation promoting regulates qi concurrently and are adjuvant drug altogether with Olibanum, Myrrha, assistant principal drug assistance vital energy regualting and blood circulation-promoting, the merit of enhancing pain relieving; The Sucus Zingberis coordinating the actions of various ingredients in a prescription is a messenger drug, and it is capable that Rhizoma Zingiberis Recens is hot, temperature can strengthen full square tube, the power of dispersing.
Modern pharmacological research:
Rhizoma Chuanxiong: contain alkaloid, like ligustrazine, perlolyrine etc.; Contain volatile oil, like pentadecanoic acid ethyl ester, ethyl palmitate etc.; Contain lactone compound, like butylphthalide, butylidenephthalide etc.; Contain organic acid, like ferulic acid, sedanoic acid, folic acid etc.; Also contain phthalide analog compound 4-hydroxyl-3-butylphthalide and phthalide derivant, like cnidium lactone, chuanxingol etc. and two phthalide derivant.Pharmacological action: ligustrazine has the effect that increases coronary flow, and ability blood pressure lowering simultaneously also has cardiotonic.
Radix Salviae Miltiorrhizae:The master contains fat-soluble Diterpenes composition and water miscible phenolic acid composition, also contains flavonoid, triterpenes, other compositions such as sterol.Pharmacological action: the ability coronary artery dilator, increase coronary flow, improve myocardial ischemia, infraction and cardiac function, regulate the rhythm of the heart, and can expand peripheral blood vessel, microcirculation improvement; Can improve body's hypoxia tolerance; Anticoagulation is arranged, promote fibrinolytic, suppress platelet aggregation, suppress thrombotic effect; The ability blood fat reducing suppresses coronary atherosclerosis and forms.
Herba Menthae:Stem, leaf contain volatile oil, and Herba Menthae fragrance is arranged, and acrid in the mouth is peppery refrigerant, and the main l-menthol (Mentholum) that contains is about 77%～87% in the oil, l-menthone about 10%.Pharmacological action: Herba Menthae preparation topical application can make Mucocutaneous Cold receptor produce sense of cold reflection, causes mucocutaneous vasoconstriction; Oleum menthae can slowly infiltrate through in the skin, and external can be anaesthetized teleneuron, has refrigerant, antiinflammatory, pain relieving and itching-relieving action; Herba Menthae and effective ingredient thereof all have spasmolysis.
MentholumSystem by in the leaf of Herba Menthae and the stem extract, white crystal has another name called menthol, Mentholum.
Moschus:The main muscone that contains, content is about 0.9%～3%, is colourless liquid, the distinctive fragrance of tool Moschus, and contain muscopyridine and 11 kinds of androstane derivative classes.Pharmacological action: stimulating central nervous system and the effect of reviving are arranged, can excitedly breathe, cardioacceleration, the rising blood pressure has cardiotonic.
Styrax:Contain volatile oil, contain oleanonic acid, 3-Epioleanolic Acid again.Pharmacological action: antiplatelet aggregation, the main component of Styrax antiplatelet aggregation are the cis cinnamic acids, and the obvious decreased heart rate of ability, reduce myocardial oxygen consumption.
Lignum Santali Albi:Contain volatile oil, its main constituent is α and β-santalene, wingceltis terpene, wingceltis terpene ketone, α-wingceltis terpene alcohol, sandatone, santalic acid, teresantalic acid.Relaxation effect is excellent, can pacify nervous and anxiety.
Fructus Foeniculi:Contain volatile oil, be mainly compositions such as methoxybenzene, fenchone, estragole, anisaldehyde.Smooth muscle there is relexation.
Borneolum Syntheticum:These article are the crystallization that from the resin of Borneolum Syntheticum and volatile oil, obtains, and are to be close to pure dextro Borneolum Syntheticum, contain multiple ter penoids.Tangible analgesia and sedation are arranged; CBSF is gone up, and decreased heart rate reduces myocardial oxygen consumption, helps the control of coronary spasm, and can alleviate the myocardial damage that ischemia causes.
Olibanum:Resinous 60%～70%, natural gum 27%～35%, volatile oil 3%～8%.Pharmacological action: significant analgesic activity is arranged.
Myrrha:Resinous 25%～35%, natural gum 57%～65%, volatile oil 2.5%～9%.Pharmacological action: the oleo-resins part has the effect that reduces cholesterolemia content.
Rhizoma Cyperi:Be mainly Rhizoma Cyperi alkene, cyperol, isocyperol etc. in the volatile oil, also contain triterpenes, flavonoid and alkaloid etc.Pharmacological action: the aqueous solution of Rhizoma Cyperi total alkaloids, glycoside, flavonoid and phenolic compound has heart tonifying and decreased heart rate effect, and tangible hypotensive effect is arranged.In addition, has the effect that improves the threshold of pain.
Rhizoma Corydalis:Contain multiple alkaloid: d-corydaline, dl-Tetrahydropalmatine, protopine, l-Tetrahydrocoptisine, d1-Tetrahydrocoptisine, coptisine etc.Pharmacological action: corydaline, Tetrahydropalmatine have analgesic activity, and Tetrahydropalmatine analgesia index is higher.
Rhizoma Zingiberis Recens:Contain pungent and fragrance ingredient.Piquancy component is the (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone in a kind of armaticity stearopten.Pharmacological action: normal person's chewing Rhizoma Zingiberis Recens 1g, can make the systolic pressure 11.2mm mercury column that on average raises, diastolic pressure rising 14mm mercury column does not then make significant difference to pulse frequency.Alcoholic extract has excitation to vasomotor center and respiratory center, and heart is also had direct excitation.
Acupoint selection
Hsinshu (acupoint):Through belonging to: bladder meridian.Acupoint selection: generally can adopt and just sit or front lying position, the acupuncture point is positioned under the fifth dorsal vertebra spinous process, about the other two finger beam places (or about about 1.5 cun) that open.Cure mainly heart channel and blood circulation diseases.
Interior closing:Pericardium meridian is returned in the cave, is the herbal classic luo-connecting point, is again one of the eight confluent acupoints connecting the eight extra channels, leads in Yin Link Channel, Yin Link Vessel.Be positioned at the bracket inboard, between palmaris longus tendon and the flexor carpi radialis muscle tendon, 2 cun places on the rasceta.Cure mainly the pathological changes that herbal classic is become estranged through sick stomach function regulating, the heart, percardium illness and with feelings will, the mechanism of qi retardance is relevant.
Danzhong:Being the confluent acupoint of conception vessel, spleen meridian, kidney meridian, small intestine meridian, SAN JIAO meridian of Hand-SHAO YANG warp, also is pectoral qi party part.Be positioned at the mid point of chest two nipple lines, flat the 4th intercostal place.Have functions such as the chest stuffiness relieving is regulated the flow of vital energy, promoting blood circulation to remove obstruction in the collateral, lung heat clearing Zhichuan, happy ambition.Huangdi's Internal Classics is thought " gas can Danzhong ", that is to say the mechanism of qi of Danzhong scalable human body whole body.In addition, it has the effect that stops pathogen, a surname's healthy energy.Modern study is found: SHANZHONG acupoint is positioned at the position of human thymocyte, and the cellular immunization that can participate in body is movable; This cave can influence the neural adjusting maincenter of cardiovascular, promotes redistributing of systemic blood, improves coronary blood flow.
Tsu san li:Being one of main acupuncture point of the stomach channel of foot-Yang-ming, is the big cave of a strong body and mind.Be positioned at four horizontal fingers, tibia edge under the outer Xiyan.During " three li " are meant and manage upward, manage, under the reason, it has the function of function of spleen and stomach regulating, invigorating the spleen and replenishing QI, dredge the meridian passage, dispelling wind removing dampness, strengthening vital QI to eliminate pathogenic factors.In blood circulation, can improve cardiac function, regulate the rhythm of the heart.
Applying method:Get bilateral Hsinshu (acupoint), Nei Guan, tsu san li and SHANZHONG acupoint, every day, pasted in every cave one, sticked 2-4 hour.Can be during application according to patient's situation, point selection treatment based on syndrome differentiation on basis, above-mentioned basic acupuncture point.
Clinical treatment observation:
120 routine instability mode heart strand patients are carried out clinical observation, be divided into treatment group and matched group at random, wherein 60 examples are organized in treatment, male's 34 examples, women's 26 examples, mean age (65.77 ± 8.37); Matched group 60 examples, male's 32 examples, women's 28 examples, mean age (65.96 ± 7.69).The treatment group is given the angina pectoris conventional therapy and added the angina pectoris plaster, and conventional therapy comprises: 1. western medicine: antithrombotic, coronary dilating reduces myocardial oxygen consumption.2. treatment by Chinese herbs: SHENGMAI ZHUSHEYE 60ml and SHUXUENING ZHUSHEYE 20ml day once quiet notes.Angina pectoris plaster point-application is got bilateral Hsinshu (acupoint), Nei Guan, tsu san li and SHANZHONG acupoint, and every day, pasted in every cave one, sticked 2-4 hour, totally 2 weeks; Matched group gives conventional therapy merely.But two groups of patients equal sublingual administration nitroglycerine tablets when angina pectoris attacks.Two groups of patients write down angina pectoris symptom, nitroglycerin consumption equal every day, and the difference recording ecg changes before treating, when treating one week of back and treatment end.Simultaneously, two groups of patients all check safety indexes such as blood, routine urinalysis and Liver and kidney merit before and after treatment.
Treatment back angina pectoris symptom relatively
| Group | The example number | Produce effects (n) | Effectively (n) | Invalid (n) | Increase the weight of (n) | Total effective rate |
| The treatment group | 60 | 42 | 16 | 2 | 0 | 96.67% |
| Matched group | 60 | 35 | 19 | 6 | 0 | 90.00% |
Treatment back nitroglycerin stops lapse rate relatively
| Group | The example number | Drug withdrawal (n) | Subtract medicine (n) | Constant (n) | Stop lapse rate |
| The treatment group | 60 | 15 | 22 | 23 | 61.67% |
| Matched group | 60 | 9 | 16 | 35 | 41.67% |
Treatment back electrocardiogram relatively
| Group | The example number | Produce effects (n) | Effectively (n) | Invalid (n) | Increase the weight of (n) | Total effective rate |
| The treatment group | 60 | 13 | 11 | 36 | 0 | 40.00% |
| Matched group | 60 | 10 | 8 | 42 | 0 | 30.00% |
The result shows: stop aspect treatment groups such as lapse rate, electrocardiogram improvement and all be superior to matched group at angina pectoris symptom improvement, nitroglycerin.Two groups of blood, routine urinalysis and Liver and kidney merits before and after the treatment do not find to have unusual person.Angina pectoris plaster determined curative effect, safe in utilization clinically is described.
Its advantage is:
This plaster can be prevented and treated angina pectoris, good effect, and short treating period, safe in utilization, toxic and side effects is few.The manufacture method of this plaster is reasonable, helps medicine and plays one's part to the full.
The specific embodiment
Embodiment 1
The anginal Chinese medicine plaster of a kind of control comprises: medicine, substrate, mount backing material and adherent layer.
If drug main is prepared from Rhizoma Chuanxiong 50g, Radix Salviae Miltiorrhizae 50 g, Mentholum 20g, Moschus 1g, Styrax 25g, Lignum Santali Albi 7.5g, Fructus Foeniculi 20g, Borneolum Syntheticum 15g, Olibanum (processed) (wick system) 25g, Myrrha (processed) (wick system) 25g, Rhizoma Cyperi 25g, Rhizoma Corydalis 25g and Rhizoma Zingiberis Recens juice 10g.Rhizoma Zingiberis Recens juice is the fresh ginger filtration gained of directly squeezing the juice.
Substrate is prepared from gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone.The mass ratio of gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone is: 3: 4: 3: 3.5: 4: 20:10: 2.
Be applied to after medicine and substrate are mixed and mount on the backing material, mounting the backing material is non-woven fabrics.Cover the polyethylene film encapsulation then.
Embodiment 2
The anginal Chinese medicine plaster of a kind of control comprises: medicine, substrate, mount backing material and adherent layer.
If drug main is prepared from Rhizoma Chuanxiong 45g, Radix Salviae Miltiorrhizae 45 g, Mentholum 15g, Moschus 0.5g, Styrax 20g, Lignum Santali Albi 7g, Fructus Foeniculi 15g, Borneolum Syntheticum 10g, Olibanum (processed) (wick system) 20g, Myrrha (processed) (wick system) 20g, Rhizoma Cyperi 20g, Rhizoma Corydalis 20g and Rhizoma Zingiberis Recens juice 5g.Rhizoma Zingiberis Recens juice is the fresh ginger filtration gained of directly squeezing the juice.
Substrate is prepared from gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone.The mass ratio of gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone is: 3: 4: 3: 3.5: 4: 20:10: 2.
Be applied to after medicine and substrate are mixed and mount on the backing material, mounting the backing material is that known Chinese medicine plaster is mounted the backing material.Cover known adherent layer encapsulation then.
Embodiment 3
The anginal Chinese medicine plaster of a kind of control comprises: medicine, substrate, mount backing material and adherent layer.
If drug main is prepared from Rhizoma Chuanxiong 55g, Radix Salviae Miltiorrhizae 55 g, Mentholum 25g, Moschus 1.5g, Styrax 30g, Lignum Santali Albi 8g, Fructus Foeniculi 25g, Borneolum Syntheticum 20g, Olibanum (processed) (wick system) 30g, Myrrha (processed) (wick system) 30g, Rhizoma Cyperi 30g, Rhizoma Corydalis 30g and Rhizoma Zingiberis Recens juice 15g.Rhizoma Zingiberis Recens juice is the fresh ginger filtration gained of directly squeezing the juice.
Substrate is prepared from gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone.The mass ratio of gelatin, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone K30 (PVPK30), sodium polyacrylate (PANa), Kaolin, glycerol, PEG400 (PEG400) and azone is: 3: 4: 3: 3.5: 4: 20:10: 2.
Be applied to after medicine and substrate are mixed and mount on the backing material, mounting the backing material is that known Chinese medicine plaster is mounted the backing material.Cover known adherent layer encapsulation then.
Embodiment 4
A kind of method for preparing of preventing and treating anginal Chinese medicine plaster comprises following process steps: 1, the preparation of medicine:
1., get Rhizoma Chuanxiong 45-55g, Radix Salviae Miltiorrhizae 45-55 g, Rhizoma Cyperi 20-30g, Rhizoma Corydalis 20-30g and Fructus Foeniculi 15-25g, be broken into coarse powder, cross 10 mesh sieves; Place in the percolator, add 65% ethanol, amount of ethanol is 70% of a medical material amount; Behind the moistening 48h, press 3ml/min speed percolation, when oozing dropping liquid color volume extremely shallow or percolate and be equivalent to heavy 10 times of crude drug with 65% ethanol; Collect percolate and adopt the vacuum concentration pot reduction vaporization to process extractum, subsequent use.Above-mentioned percent is mass percent.
2., get Olibanum (processed) (wick system) 20-30g, Myrrha (processed) (wick system) 20-30g, Mentholum 15-25g, Styrax 20-30g and Lignum Santali Albi 7-8g; Be broken into fine powder; Cross 180 mesh sieves; After adding Moschus 0.5-1.5g, Borneolum Syntheticum 10-20g and Rhizoma Zingiberis Recens juice 5-15g mix homogeneously, add the extractum mix homogeneously that 1. step is processed, it is subsequent use promptly to get medicine.
2, the preparation of substrate:
By mass ratio be:
Gelatin: sodium carboxymethyl cellulose (CMC-Na): polyvinylpyrrolidone K30 (PVPK30): sodium polyacrylate (PANa): Kaolin: glycerol: PEG400 (PEG400): azone=3: 4: 3: 3.5: 4: 20:10: 2 proportioning is got material, and is subsequent use.
Azone is dissolved in the glycerol, and it is subsequent use to process the glycerol mixed liquor.Getting gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone K30, sodium polyacrylate adds suitable quantity of water and soaks; In 70 ℃ of water-baths, heat swelling; After treating that temperature is reduced to room temperature; Add mix homogeneously in the swelling liquid to the glycerol mixed liquor of processing, PEG400, add the Kaolin mixing again, process substrate.
3, be that the 1:3 agitation grinding is even with medicine and substrate according to mass ratio, evenly coat on the non-woven fabrics, every 10g, the vacuum constant temperature drying baker is dry, covers polyethylene film, and encapsulation promptly gets.
Claims (2)
1. the anginal Chinese medicine plaster of control comprises: medicine, substrate, mount backing material and adherent layer, it is characterized in that: if drug main is prepared from Rhizoma Chuanxiong 45-55g, Radix Salviae Miltiorrhizae 45-55 g, Mentholum 15-25g, Moschus 0.5-1.5g, Styrax 20-30g, Lignum Santali Albi 7-8g, Fructus Foeniculi 15-25g, Borneolum Syntheticum 10-20g, Olibanum (processed) 20-30g, Myrrha (processed) 20-30g, Rhizoma Cyperi 20-30g, Rhizoma Corydalis 20-30g and Rhizoma Zingiberis Recens juice 5-15g; Rhizoma Zingiberis Recens juice is the fresh ginger filtration gained of directly squeezing the juice;
Substrate is prepared from gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone K30, sodium polyacrylate, Kaolin, glycerol, PEG400 and azone;
The mass ratio of gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone K30, sodium polyacrylate, Kaolin, glycerol, PEG400 and azone is: 3: 4: 3: 3.5: 4: 20:10: 2;
Be applied to after medicine and substrate are mixed and mount on the backing material, mounting the backing material is that known Chinese medicine plaster is mounted the backing material; Cover known adherent layer encapsulation then.
1), the preparation of medicine 2. the method for preparing of the anginal Chinese medicine plaster of control is characterized in that comprising following process steps::
1., get Rhizoma Chuanxiong 45-55g, Radix Salviae Miltiorrhizae 45-55 g, Rhizoma Corydalis 20-30g and Fructus Foeniculi 15-25g, be broken into coarse powder, cross 10 mesh sieves; Place in the percolator, add 65% ethanol, amount of ethanol is 70% of a medical material amount; Behind the moistening 48h, press 3ml/min speed percolation, when oozing dropping liquid color volume extremely shallow or percolate and be equivalent to heavy 10 times of crude drug with 65% ethanol; Collect percolate and adopt the vacuum concentration pot reduction vaporization to process extractum, subsequent use; Above-mentioned percent is mass percent;
2., get Olibanum (processed) 20-30g, Myrrha (processed) 20-30g, Rhizoma Cyperi 20-30g, Mentholum 15-25g, Styrax 20-30g and Lignum Santali Albi 7-8g; Be broken into fine powder; Cross 180 mesh sieves; After adding Moschus 0.5-1.5g, Borneolum Syntheticum 10-20g and Rhizoma Zingiberis Recens juice 5-15g mix homogeneously, add the extractum mix homogeneously that 1. step is processed, it is subsequent use promptly to get medicine;
2), the preparation of substrate:
By mass ratio be:
Gelatin: sodium carboxymethyl cellulose: polyvinylpyrrolidone K30: sodium polyacrylate: Kaolin: glycerol: PEG400: azone=3: 4: 3: 3.5: 4: 20:10: 2 proportioning is got material, and is subsequent use;
Azone is dissolved in the glycerol, and it is subsequent use to process the glycerol mixed liquor; Getting gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone K30, sodium polyacrylate adds suitable quantity of water and soaks; In 70 ℃ of water-baths, heat swelling; After treating that temperature is reduced to room temperature; Add mix homogeneously in the swelling liquid to the glycerol mixed liquor of processing, PEG400, add the Kaolin mixing again, process substrate;
3), be that the 1:3 agitation grinding is even with medicine and substrate according to mass ratio, evenly coat on the material of mounting, every 10g, the vacuum constant temperature drying baker is dry, covers known adherent layer, encapsulation promptly gets.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813912A (en) * | 2005-12-19 | 2006-08-09 | 李秀花 | Ointment for treating coronary disease and its production process |
| CN101698090A (en) * | 2009-11-19 | 2010-04-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composite for treating coma and heart syncope symptoms and preparation method thereof |
| CN101716330A (en) * | 2009-11-19 | 2010-06-02 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating angina disease and preparation method thereof |
| CN101745078A (en) * | 2009-11-18 | 2010-06-23 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating cardiac failure and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813912A (en) * | 2005-12-19 | 2006-08-09 | 李秀花 | Ointment for treating coronary disease and its production process |
| CN101745078A (en) * | 2009-11-18 | 2010-06-23 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating cardiac failure and preparation method thereof |
| CN101698090A (en) * | 2009-11-19 | 2010-04-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composite for treating coma and heart syncope symptoms and preparation method thereof |
| CN101716330A (en) * | 2009-11-19 | 2010-06-02 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating angina disease and preparation method thereof |
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Effective date of registration: 20200628 Address after: Beiling Street in Huanggu District of Shenyang City, Liaoning Province, No. 33 110032 Patentee after: FIRST AFFILIATED HOSPITAL OF LIAONING University OF TRADITIONAL CHINESE MEDICINE Address before: Beiling Street in Shenyang city of Liaoning province in 110032 Affiliated Hospital of Liaoning University of Traditional Chinese Medicine No. 33 Department of heart Patentee before: Wang Fengrong |
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