CN101804110B - Traditional Chinese medicine preparation for thrombosis and blood lipid - Google Patents
Traditional Chinese medicine preparation for thrombosis and blood lipid Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for purifying blood, which comprises the following components: hawthorn, Astragalus root, leech, cortex moutan, safflower, hemlock parsley, suberect spatholobus stem, vinegar-radix paeoniae alba, angelica, trogopterus dung, salviae miltiorrhizae, propolis, calendula officinalis root, ginkgo leaf and gynostemma pentaphylla. The traditional Chinese medicine composite has the obvious effect of reducing blood lipid, can promote the decomposition of blood lipid, reduces blood viscosity, and resists atherosclerosis; the traditional Chinese medicine composite has the obvious effects of anticoagulation and anti-thrombosis, can inhibit the aggregation of thrombocyte, improves the activity of plasmin, and promotes fibrinolysis; the traditional Chinese medicine composite has favorable effects of heart strengthening, decompression and arrhythmia resistance, can slow heart rate, dilates coronary artery and blood vessel of brain, increases blood flow, lightens myocardial ischemic injury degree, lowers myocardial oxygen consumption, has obvious prevention effect on ischemic cerebrovascular diseases, can dilate peripheral vessel, reduces vascular resistance and promotes blood circulation; and the traditional Chinese medicine composite can promote the generation of haemoglobin and erythrocyte.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation that purifies the blood.
Background technology
The blood in human body in liquid measure approximately is 7～8% of a body weight, and the physiology of each organ of human body and pathological change tend to cause that blood constituent changes, and whether the quality of blood quality often also is related to a people healthy.Along with the quickening of urbanization rhythm, increasing people suffers from various affluenza, as hypertension, and hyperlipidemia, diabetes and cardiovascular and cerebrovascular disease or the like, this becomes the main killer that human especially old people subtracts the longevity, has influence on people's quality of life greatly.The pathological changes basis of cardiovascular and cerebrovascular disease is an atherosclerosis, and it is narrow that atherosclerotic speckle forms limitation, causes blood vessel obstruction in various degree, and it is unobstructed to influence blood flow, causes body corresponding organ ischemia, and dysfunction takes place.Coronary atherosclerosis causes cardiac blood supply deficiency, myocardial ischemia-anoxemia, and coronary heart disease, angina pectoris take place, even myocardial infarction; Cerebral arteriosclerosis causes cerebral blood supply insufficiency, and apoplexy takes place; The blood vessel blockage severe patient then can cause lifelong disability or death.Therefore, the control cardiovascular and cerebrovascular disease should be started with from atherosclerosis.It is reported that forming atherosclerotic basic reason is hyperlipidemia, hyperlipidemia increases blood viscosity, and blood flow is slack-off, is deposited on the arterial blood tube wall easily and to make it stenosis narrow, causes thrombosis even artery-clogging, quickens atherosclerosis and forms.Therefore, the key of control cardiovascular and cerebrovascular disease is how to clean blood, improves blood quality, and this is the blood fat reducing sticking basic place that disappears.
Modern medicine science and technology has had a lot of method treatment cardiovascular and cerebrovascular diseases, as blood vessel dilating, thrombolytic, dilute blood etc., these means are relief of symptoms fast, but shortcoming is not improve the essence of blood and blood vessel from the morbidity root, blood fat situation high and hyperlipidemia does not change, the blood dirt is not thoroughly removed, and blood vessel still is hardening state, and cardiovascular and cerebrovascular disease may develop and break out at any time.At present, blood fat reducing and Antiatherosclerosis medicine are more, differ from one another, but also have certain deficiency simultaneously, and be higher as price, and the patient is difficult to accept; Specific aim is not strong, and therapeutic effect is undesirable etc.
Press for a kind of lipid composition that can effectively be in harmonious proportion now clinically, purify the blood, improve blood quality, can alleviate the toxic and side effects of medicine again, further realize removing the lipid components of atheromatous plaque, recover tremulous pulse inner wall smooth and elasticity, guarantee unobstructed blood vessel, remove free radical, all many-sided cardiovascular and cerebrovascular diseases that solves such as enhancing human body immunity function, hyperlipidemia, hypertension, the fundamental issue in the source of diabetes etc., and can be heavy dose of and the taking of long period, for delaying and a kind of new blood fat reducing of providing of cardiovascular and cerebrovascular vessel incident, the Chinese medicine that purifies the blood being provided.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine preparation that purifies the blood is provided, satisfy the lipid composition that effectively to be in harmonious proportion of needs clinically, purify the blood, improve blood quality, can alleviate the toxic and side effects of medicine again, further realize removing the lipid components of atheromatous plaque, recover tremulous pulse inner wall smooth and elasticity, guarantee unobstructed blood vessel, remove free radical, all many-sided cardiovascular and cerebrovascular diseases that solves such as enhancing human body immunity function, hyperlipidemia, hypertension, the fundamental issue in the source of diabetes etc.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation that purifies the blood, comprise following medical material component: Fructus Crataegi, the Radix Astragali, Hirudo, Cortex Moutan, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Paeoniae Alba (processed with vinegar), Radix Angelicae Sinensis, Oletum Trogopterori, Radix Salviae Miltiorrhizae, propolis, "root of Potmarigold Calendul", Folium Ginkgo and Herb Gynostemmae Pentaphylli; Percentage by weight between them can be preferably: 1～7 part of Fructus Crataegi, 1～7 part of the Radix Astragali, 1～5 part of Hirudo, 1～7 part of Cortex Moutan, 1～7 part on Flos Carthami, 1～7 part of Rhizoma Chuanxiong, 1～7 part of Caulis Spatholobi, 1～7 part of Radix Paeoniae Alba (processed with vinegar), 1～7 part of Radix Angelicae Sinensis, 1～5 part of Oletum Trogopterori, 1～7 part of Radix Salviae Miltiorrhizae, 1～7 part of propolis, 1～7 part of "root of Potmarigold Calendul", 1～6 part of Folium Ginkgo, 1～7 part of Herb Gynostemmae Pentaphylli.
The dosage form of the described Chinese medicine preparation that purifies the blood can for: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, drop or patch.
The described Chinese medicine preparation that purifies the blood, when its dosage form was honey pill agent, preparation process preferably included following steps:
A. described medical material component is removed propolis and Hirudo and add the water logging bubble;
B. with soaked medical material component heated and boiled, filter;
C. the filtrate heating is concentrated into pasty state, puts into baking oven, the oven dry postcooling is milled into fine powder and sieves;
D. Hirudo and propolis are pulverized, the fine powder blending honey that obtains with the c step is twisted into slice.
The preparation method of the honey pill agent of the described Chinese medicine preparation that purifies the blood, in the b step:
Described soaked medical material component heated and boiled 30～45 minutes can be filtered filtrate for later use;
Filtering residue adds water and heats for the second time, boils 30～45 minutes, filters filtrate for later use;
Filtering residue adds water again, and heated and boiled is 30～45 minutes for the third time, filters filtrate for later use;
Three filtrates are combined.
In the described c step: the heating of the filtrate after merging can be concentrated into pasty state, put into 60 ℃～85 ℃ oven dry of baking oven postcooling, and sieve after grinding into fine powder.
In the described d step: Hirudo and propolis directly can be put into pulverizer and be pulverized, after the fine powder blending honey that obtains with the c step stirs then, be twisted into slice together; Can be ball wax seal packing with 5g～8g.
The described Chinese medicine preparation that purifies the blood, its dosage form can also be capsule, preparation method preferably includes:
A. Hirudo is put into the ethanol heating and refluxing extraction;
B. get residue medical material component among the above-mentioned side again except that propolis, add the water heating and refluxing extraction;
C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol also concentrates sucking filtration absorption, obtains component medicated powder;
D. propolis is directly put into pulverizer and pulverized, the component medicated powder that obtains in sterilization back and the c step mixes, and incapsulates and is made as capsule.
Among the described step a, Hirudo can be put into 10 times of amount ethanol, heating and refluxing extraction 30 minutes～45 minutes is extracted active ingredient, and extracting solution is left standstill.
Among the described step b, residue medical material component can be put into 10 times of water gagings except that propolis, heating and refluxing extraction 3 times each 30 minutes～45 minutes, leaves standstill 3 extracting solution merging.
Among the described step c, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.8g crude drug/mL is behind the sucking filtration, when the relative density of filtrate is about 20 ℃ 1.07; Above-mentioned filtrate is the macroporous adsorptive resins absorption of 10L through volume; With the deionized water or the distilled water eluting of 10 times of resin column volumes, 5 times of resin column volume of ethanol of reuse eluting is collected ethanol elution, removes alcohol solvent, obtains component medicated powder after the absorption.
Ratio of weight and number between the described component is preferably: 2～3 parts of Fructus Crataegis, 2～3 parts of the Radixs Astragali, 3～5 parts of Hirudos, 2～3 parts of Cortex Moutans, 2～3 parts on Flos Carthami, 2～3 parts of Rhizoma Chuanxiongs, 2～3 parts of Caulis Spatholobis, 2～3 parts of Radix Paeoniae Alba (processed with vinegar), 2～3 parts of Radix Angelicae Sinensis, 3～5 parts of Oletum Trogopteroris, 1～2 part of Radix Salviae Miltiorrhizae, 1～2 part of propolis, 1～2 part of "root of Potmarigold Calendul", 4～6 parts of Folium Ginkgos, 1～2 part of Herb Gynostemmae Pentaphylli.
Ratio of weight and number between the described component can also be preferably: 1～2 part of Fructus Crataegi, 1～2 part of the Radix Astragali, 1～2 part of Hirudo, 1～2 part of Cortex Moutan, 1～2 part on Flos Carthami, 1～2 part of Rhizoma Chuanxiong, 1～2 part of Caulis Spatholobi, 1～2 part of Radix Paeoniae Alba (processed with vinegar), 1～2 part of Radix Angelicae Sinensis, 1～2 part of Oletum Trogopterori, 1～2 part of Radix Salviae Miltiorrhizae, 1～2 part of propolis, 1～2 part of "root of Potmarigold Calendul", 1～2 part of Folium Ginkgo, 1～2 part of Herb Gynostemmae Pentaphylli.
Chinese medicine preparation of the present invention has tangible effect for reducing blood fat, can promote blood fat to decompose blood viscosity lowering, atherosclerosis; Have significant anticoagulant and anti-thrombosis function, the energy anticoagulant improves plasmin activity, promotes fibrinolysis; Have good heart tonifying, blood pressure lowering and anti-arrhythmia effect, the energy decreased heart rate, coronary artery dilator and cerebrovascular, blood flow increasing alleviates the myocardial ischemic injury degree, reduces myocardial oxygen consumption, courageous and upright cerebrovascular there is remarkable preventive effect, and can expand peripheral blood vessel, reduce vascular resistance, blood circulation promoting; Contain rich in protein, vitamin and trace element, but human body immunity improving power also can promote hemoglobin and erythrocytic generation.Chyle fat albumen, cholesterol, triglyceride and low density lipoprotein, LDL etc. during the present invention can effectively purify the blood; And economical and practical, preparation method is simple, can obtain good economic benefit.The Chinese medicine of blood fat reducing of the present invention and efficacy enhancing and toxicity reducing effect mainly has following remarkable function and outstanding substantive distinguishing features:
1, have and suppress the effect of the synthetic accent fat of cholesterol, promptly have purify the blood, the source transfers the fat effect: as can blood fat reducing, triglyceride reducing, cholesterol reducing, fall LDL-C, fall VLDL-C, fall blood viscosity; Rising HDL-C, rising ApoA-1/ApoB ratio.
2, reparation and maintenance vascular endothelial function make the blood vessel rejuvenation: can suppress the propagation of blood vessel endothelium smooth muscle cell and migration, inflammation-inhibiting, stable and remove atherosclerotic plaque composition in the blood vessel, promote angiogenesis, repair vascular endothelial injury, improve the cardiac-cerebral ischemia state.
3, have the strengthening the spleen and nourishing the stomach of protecting the liver effect: the present invention is little to the intestines and stomach stimulation, makes patient also can be used as the auxiliary treatment in the cardiovascular and cerebrovascular diseases that is caused by hyperlipemia and atherosclerosis with the taking of heavy dose of and long period.
4, the raw materials used pure natural medical material that is of the present invention, not only can not produce toxic and side effects to vitals such as gastrointestinal tract, heart and brain, Liver and kidney, its effective ingredient can also nutrition and the histiocyte of moist internal organs, be highly advantageous to and improve cardiovascular and cerebrovascular vessel patient's immunologic function, the enhancing body resistance, do not rebound after the healing, can clear up maintenance timely blood vessel.
The specific embodiment
From modern medicine study, Chinese medicine composition of the present invention has tangible effect for reducing blood fat, can promote blood fat to decompose blood viscosity lowering, atherosclerosis; Have significant anticoagulant and anti-thrombosis function, the energy anticoagulant improves plasmin activity, promotes fibrinolysis; Have good heart tonifying, blood pressure lowering and anti-arrhythmia effect, the energy decreased heart rate, coronary artery dilator and cerebrovascular, blood flow increasing alleviates the myocardial ischemic injury degree, reduces myocardial oxygen consumption, ischemic cerebrovascular there is remarkable preventive effect, and can expand peripheral blood vessel, reduce vascular resistance, blood circulation promoting; Contain rich in protein, vitamin and trace element, but human body immunity improving power also can promote hemoglobin and erythrocytic generation.Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi and the Radix Astragali all are blood circulation promoting and blood stasis dispelling in the side, the good medicine of benefiting qi and nourishing blood; The Fructus Crataegi blood fat reducing, blood viscosity lowering, antagonism sclerosis of blood vessels; The Radix Paeoniae Alba (processed with vinegar) sterilization of having one's ideas straightened out of inducing sweat, the activation blood vessel; The Radix Salviae Miltiorrhizae blood stasis dispelling circulation of qi promoting of unstinging; Basic medicine as blood circulation promoting and blood stasis dispelling; The Oletum Trogopterori blood rearing interpolating kidney is the medical material of strongly invigorating primordial QI; "root of Potmarigold Calendul", Herb Gynostemmae Pentaphylli and propolis have effects such as resisting fatigue, anti-hypoxia, immunomodulating, blood fat reducing, blood sugar lowering; Contain a large amount of protein and several amino acids in the Hirudo, it has the effect of thromboembolism preventing thrombolytic; Cortex Moutan clearing away heat and cooling blood, Folium Ginkgo extract effectively the blood fat reducing level, can obviously reduce triglyceride and low density lipoprotein, LDL amount in the serum, improve the lipid metabolism under the moving atherosis state; All medicines share and can promote blood fat to decompose blood viscosity lowering, atherosclerosis; Have significant anticoagulant and anti-thrombosis function, the energy anticoagulant improves plasmin activity, promotes fibrinolysis; Have good heart tonifying, blood pressure lowering and anti-arrhythmia effect.
Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Caulis Spatholobi property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration to be that the treatment blood stasis is not loose the good medicine that nourishing blood silt is invigorated blood circulation.
Flos Carthami is warm in nature, acrid in the mouth.Cure mainly the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or blood expands in vexed, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.All friendship as the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred." medicine justice ": Flos Carthami, kind tonneau passages through which vital energy circulates is gas medicine in the blood, can rush down and can mend, and wonderful justice is respectively arranged.If how with three, four money, then too hot warm, blood is wandered away.With Lignum Sappan removing blood stasis blood, to close Cortex Cinnamomi and stimulate the menstrual flow and close, assistant is returned, Chinese herbaceous peony is controlled all over or the pricking caused by the stagnation of QI and blood of breast abdomen, and this its row is led and is invigorated blood circulation also.If use seven, eight fens less, with dispersing liver-energy, helping the sea of blood, the void of enriching blood greatly, this its transfer smooth and and blood also; If end with two, three minutes, go into the heart to join painstaking effort, dismiss heart channel pathogenic fire, make the blood mediation, this its nourishing and hemopoietic are also; The justice of component number, meagre.
Rhizoma Chuanxiong: warm in nature, acrid in the mouth; Return liver, gallbladder, pericardium channel; Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping; Cure mainly menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Modern pharmacological research shows: Rhizoma Chuanxiong mainly contains multiple alkaloids such as ligustrazine, phenolic substances such as ferulic acid, multiple volatile oil such as ligustilide, cnidium lactone; Rhizoma Chuanxiong extract has coronary artery dilating, and coronary blood flow increasing reduces myocardial oxygen consumption, and microcirculation improvement reduces surface activity of blood platelet, effects such as anticoagulant; Ligustrazine can resist thrombosis, and ischemic cerebrovascular is had remarkable preventive effect; Water decoction has calmness, hypotensive effect to the animal nervus centralis; Can strengthen uterine contraction, heavy dose then transfers inhibition to; Ferulic acid can improve gamma Globulin and the lymphocytic immunization of T; Various pathogenic bacterium and virus there is inhibitory action.
Radix Paeoniae Alba (processed with vinegar) is gone into liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.
The Radix Salviae Miltiorrhizae hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.
Fructus Crataegi contains multivitamin, Crataegolic acid, tartaric acid, citric acid, malic acid etc., also contains mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, phosphorus, ferrum, and contained lipolytic enzyme can promote the digestion of fat food.Promote functions such as gastric secretion and increase gastric enzyme element.The traditional Chinese medical science thinks that Fructus Crataegi has effects such as removing food stagnancyization stagnates, convergence dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.Contain ingredients such as mountain terpenoid and pyrite class in the Fructus Crataegi, have significant blood vessel dilating and hypotensive effect, the function that strengthens cardiac muscle, arrhythmia, blood lipid regulation and cholesterol level is arranged, Fructus Crataegi has the effect of activating blood circulation to dissipate blood stasis, help to remove local congestion state, traumatic injury is had auxiliary curative effect; The generation of free radical can be blocked and reduce to flavonoid that Fructus Crataegi is contained and materials such as vitamin C, carotene, and the immunity of energy enhancing body has anti-aging, anticancer effect; Having in the Fructus Crataegi relievings asthma reduces phlegm, suppresses antibacterial, the treatment abdominal pain diarrhea composition.
Folium Ginkgo: this product has astringing the lung, relievings asthma, blood circulation promoting and blood stasis dispelling, analgesic effect.Be used for the cough due to deficiency of the lung; Coronary heart disease, angina pectoris, the treatment of hyperlipemia.Mainly contain multiple active component such as flavonoid, terpenoid, phenols, alkaloids, polyprene, polysaccharide with pharmacological action.Folium Ginkgo extract has pharmacologically active widely, 1. discharges the endogenous relaxation factor by stimulating endothelial cell, and the tremulous pulse that the antagonism epinephrine causes shrinks, and suppresses hypertensin conversion enzyme activity and blood vessel dilating.Resist myocardial ischemia and damage, reach antioxidation with ischemia again.2. improve hemorheological property, the blood viscosity that slows down advance the speed, reduce the maximum viscosity of blood.Bilobalide has strong antagonism platelet activating factor, antiplatelet to adhere to and the thrombosis effect.3. Folium Ginkgo extract effectively the blood fat reducing level, can obviously reduce triglyceride and low density lipoprotein, LDL amount in the serum, improve the lipid metabolism under the moving atherosis state.Can adopt traditional water boiling and extraction technology.
Herb Gynostemmae Pentaphylli: this product extract has effects such as resisting fatigue, anti-hypoxia, immunomodulating, blood fat reducing, blood sugar lowering.Mainly contain saponins, flavonoid, sweet foline, saccharide and several amino acids and vitamins composition.Modern pharmacological research shows, Herb Gynostemmae Pentaphylli total glycosides has effects such as antitumor, blood fat reducing, atherosclerosis, inhibition obesity and fat-reducing, anti-heart ischemia and antiulcer, adjusting body's immunity, its main active is a saponins, the suitable water boiling and extraction technology that adopts.
Propolis: the effect that this product has anti-inflammation, regulates immunity, antioxidation, acceleration organization healing.Modern pharmacology experiment shows: propolis has antibiotic property, antifungal, antiviral, antiinflammatory, protects the liver, antioxidation, anticancer etc.The chemical constituent of propolis may be because the difference of the plant secretion thing of Apis collecting region causes the propolis composition to differ greatly.Up to the present, from all kinds of propolis, identify nearly 300 kinds of chemical constituents, mainly comprised 71 kinds of flavone compounds such as galangin, pinocembrin, chrysin, Tectona grandis L. F. Yang Su, acacetin; 59 kinds of aromatic acids such as cinnamic acid, caffeic acid, ferulic acid and aromatic esters compounds; 24 kinds of phenols, alcohols and multiple other compounds such as cinnamyl alcohol, benzyl alcohol, acetaminol, esculetin, scopoleine.Propolis is fit to directly pulverize be used as medicine, and need be through not extracting.
The Radix Astragali is based on tonify deficiency, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.
Oletum Trogopterori is the feces of Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards (cold number bird), flying squirrel or other nearly edge animal.Oletum Trogopterori is sweet in flavor and warm in property, and is nontoxic, goes into Liver Channel, has the mediation blood vessels, the effect of eliminating stasis to stop pain; It is gynecological's key medicine.Cure mainly stasis, amenorrhea, stomachache; Diseases such as breast side of body twinge tumbling and swelling and snake bite and insect sting.It is logical that the Oletum Trogopterori hardship is let out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly." " the stasis passages through which vital energy circulates, gas must not be gone, and attacks cards such as thorn pain, must use in institute so " Bencao Jingshu " calls it." " detailed outline " carry: Oletum Trogopterori, liver channel of foot-Jueyin medicine also, abnormal smells from the patient is all thick, the yin aspect of yin is so go into blood system.Liver master blood so medicine can be controlled disorders of blood, looses blood and blood and ends all pains.End and remove malaria dysentery, removing food stagnancy reduces phlegm, and treats the infantile malnutrition parasite killing, controls arthralgia due to stagnation of blood, all diseases of blood eye, all belongs to Liver Channel also.
Cortex Moutan is cold in nature, bitter in the mouth, suffering.Has clearing away heat and cooling blood, blood circulation promoting competent silt.Be used for maculae caused by violent heat pathogen, carbuncle sore tumefacting virus.Compendium of Material Medica is carried: " control the blood fire second of the three ten-day periods of the hot season, heat clearing away and restlessness relieving." this medicine contains Paeonia suffruticosa acid, Paeonia suffruticosa acid glycoside, paeonolide, paeoniflorin, volatile oil and plant sterol etc., paeonol and glucoside composition all have antiinflammatory action.Paeonol has central inhibitory actions such as calmness, cooling, analgesic, analgesia, spasmolytic.
Record in the ancient medical book and utilize Hirudo to treat multiple disease, call its " main by stagnant blood, blood stasis, month close, the removing blood stasis removing food stagnancy is poly-... ".Cure its eliminating pathogenic factor for supporting vital QI of holy Zhang Zhongjing, hirudin is the most effective known natural anticoagulant, and its effect is better than heparin, has anticoagulation, thrombolytic effect, i.e. the said function of promoting blood circulation to disperse blood clots of the traditional Chinese medical science.Therefore, handling such as the deteriorated blood shock, atherosclerosis, cerebral infarction, cardiovascular diseases, hypertension, ophthalmology and the multiple disease aspect that lacks antithrombase demonstrate huge superiority and wide prospect.Function cures mainly diseases such as menstruation apolipsis, lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas." herbal classic " carries it: " main by closing stagnant blood, blood stasis, the moon, the removing blood stasis abdominal mass is gathered, loss of fecundity, dredging water passages." disease of Hirudo treatment " blood stasis ", " water knot ", shown the curative effect that it is unique.Later age, Zhang Xichun praised this medicine: " deposit blood stasis and do not hinder fresh blood, the elite of pure lines water generates, and is at all harmless in edema caused by disorder of QI, and blood stasis is silently in invisible, and true good medicine also ".Contain a large amount of protein and several amino acids in the Hirudo, it has the effect of thromboembolism preventing thrombolytic, if through heating extraction its drug effect is descended, so select directly to pulverize to be used as medicine.
The "root of Potmarigold Calendul" promoting blood circulation to remove blood stasis; Promoting the circulation of QI to relieve pain.Calendula officinalis is rich in multivitamin, especially vitamin A and vitamin C; Almost each position can eat; Its petal has the function of beauty treatment, and flower contains carotenoid, lycopene, violaxanthin, rubixanthin, volatile oil, resin, lymphatic temperament, malic acid etc.Root contains amaroid, mountain gold east glycol; Seed contains glyceride, ceryl alcohol and alkaloid.Putting into can be so that hair color be thin out in the shampoo.The Calendula officinalis nature and flavor are light flat, and flower, leaf have antiinflammatory, antibacterial action.Root energy promoting flow of QI and blood, but removing heat from blood, hemostasis spent.The Europe outer various inflammation that are used for skin, mucosa among the people also can various inflammation of orally taken for curing and ulcer.Fresh flowers can be placed in the salad and eat.
The preparation method of Chinese medicine pill agent of the present invention is:
Get Fructus Crataegi 1000g, Radix Astragali 1000g, Cortex Moutan 1000g, Flos Carthami 1000g, Rhizoma Chuanxiong 1000g, Caulis Spatholobi 1000g, Radix Paeoniae Alba (processed with vinegar) 1000g, Radix Angelicae Sinensis 1000g, Oletum Trogopterori 500g, Radix Salviae Miltiorrhizae 1000g, "root of Potmarigold Calendul" 1000g, Folium Ginkgo 600g and Herb Gynostemmae Pentaphylli 1000g, soak;
With described soaked medical material component heated and boiled 30～45 minutes, filter filtrate for later use;
Filtering residue adds water and heats for the second time, boils 30～45 minutes, filters filtrate for later use;
Filtering residue adds water again, and heated and boiled is 30～45 minutes for the third time, filters filtrate for later use;
Three filtrates are combined.
Filtrate heating after merging is concentrated into pasty state, puts into 60 ℃～85 ℃ oven dry of baking oven postcooling, and sieve after grinding into fine powder.
Again Hirudo 500g and propolis 1000g are directly put into pulverizer and pulverize, after the fine powder blending honey that obtains of above-mentioned steps stirs then, be twisted into slice together; With 8g is ball wax seal packing.
The preparation method of Chinese medicine preparation capsule of the present invention comprises:
Hirudo 500g is put into 10 times of amount ethanol, and heating and refluxing extraction 30 minutes～45 minutes is extracted active ingredient, extracting solution is left standstill put into the ethanol heating and refluxing extraction;
Get residue medical material component among the above-mentioned side again except that propolis, get Fructus Crataegi 1000g, Radix Astragali 1000g, Cortex Moutan 1000g, Flos Carthami 1000g, Rhizoma Chuanxiong 1000g, Caulis Spatholobi 1000g, Radix Paeoniae Alba (processed with vinegar) 1000g, Radix Angelicae Sinensis 1000g, Oletum Trogopterori 500g, Radix Salviae Miltiorrhizae 1000g, "root of Potmarigold Calendul" 1000g, Folium Ginkgo 600g and Herb Gynostemmae Pentaphylli 1000g, put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes～45 minutes, 3 extracting solution merging are left standstill.
Above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol and to be concentrated into liquor strength be 0.8g crude drug/mL is behind the sucking filtration, when the relative density of filtrate is about 20 ℃ 1.07; Above-mentioned filtrate is the macroporous adsorptive resins absorption of 10L through volume; With the deionized water or the distilled water eluting of 10 times of resin column volumes, 5 times of resin column volume of ethanol of reuse eluting is collected ethanol elution, removes alcohol solvent, obtains component medicated powder after the absorption; Propolis 1000g is directly put into pulverizer pulverize, the component medicated powder that obtains in sterilization back and the above-mentioned steps mixes, and incapsulates and is made as capsule.
Chinese medicine preparation medicament contg of the present invention is accurate, and good stability absorbs soon good effect.Membrane is thin and soft, and dissolving is fast, prove effective rapidly, and blood circulation promoting and blood stasis dispelling, nourishing blood and promoting blood circulation, treating both the principal and secondary aspects of a disease improves immunity of human body itself, but chyle fat albumen, cholesterol, triglyceride and low density lipoprotein, LDL etc. in the present invention's elimination blood plasma; And economical and practical, manufacture method is simple, can obtain good economic benefit.
The pharmacological effect experiment:
(1) irritant test:
A. rabbit eye irritant test: getting eye health does not have 3 of the rabbit of wound, and this product 0.1g is applied in the branch hole conjunctival sac, gently sleeps eyelid 5-10 second every day 1 time, logotype 7 days then; Splash into the blank substrate of volume in the eye conjunctival sac of opposite side and do negative control.After the last administration, used the nose fiberscopy to observe that nose is shed tears and irritant reaction such as photophobia in 6,12,24,48,72 hours.Result of the test: cornea, iris and the conjunctiva of the whole rabbit eyes of test group and matched group are all no abnormal.
B. nasal mucosa irritant test: get 3 of healthy rabbits, this product 0.1g is applied in the side nasal cavity, every day 1 time, logotype 7 days; Do negative control with blank substrate in the opposite side nasal cavity with volume.After the last administration, used nose fiberendoscopy observation bronchia mucosal to have or not irritant reaction such as hyperemia, edema in 6,12,24,48,72 hours.Result of the test: untoward reaction such as edema, hyperemia all do not appear in the whole rabbit bronchia mucosals of test group and matched group.
(2) hypersensitive test:
Get 18 of healthy albino guinea-pigs, body weight 250-300g, the male and female dual-purpose is rejected the both sides dorsal body setae before the test, and every side 3 * 3cm is divided into test group, blank group (substrate) and positive controls at random.Positive controls is with 2, the 4-dinitrochlorobenzene, and sensitization 1% concentration excites and uses 0.1% concentration.Get this product 0.1g and be applied to unhairing district, back, the next day 1 time, totally 3 times.Contact back 14 days in last, smear this product 0.1g, observe at once after removing medicine behind the 6h at back the same area, and in 24,48,72h observes and has or not anaphylaxis.Blank group and positive controls are used to excite with method and are contacted and observe.Result of the test: the positive controls animal skin localized erythema and slight edema promptly occur in sensitization after 1 hour, symptoms of allergic increased the weight of in 24 hours, and there is scleroma to form, the sensitization rate is 100%, any symptoms of allergic does not all appear in test group and blank treated animal skin, and the sensitization rate is 0%.
(3) long term toxicity test:
Select the SD rat for use, give variable concentrations (18.0,6.0, the Chinese medicine preparation of the present invention of 2.0g crude drug/kg), irritate stomach every day once, continuous 90 days, respectively organized 1/2 animal (male and female half and half) extremely that lives in 24 hours after the last administration, all the other 1/2 animals continuation observation, 2 all backs are extremely alive.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days and carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and index inspections such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, all no abnormal variation of outward appearance sign, behavioral activity, food-intake and body weight gain; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, do not have significant difference between group; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal is not seen change after 2 weeks yet.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days does not have obvious influence to rat, no clear and definite toxicity target organ and sensitive indicator, the retardance toxic reaction is not seen in the convalescent period observation yet, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.
Chinese medicine of the present invention is through 6 months long-term toxicity test for animals result of gastric infusion: the SD rat is divided into three groups, and 30 every group, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group) are wherein given normal saline through irritating stomach for first group; Give Chinese medicinal capsule agent of the present invention through irritating stomach for second group, dosage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is given the dosage of lovastatin through the filling stomach is 0.5mg, 5.0m g and 50.0mg/kg.d.During administration, the indexs such as clinical manifestation, hematology, blood biochemistry, organ coefficient and histopathology of observing respectively after each treated animal administration are carried out the evaluation of drug toxicity.Result of study: main toxic reaction shows lovastatin 50mg/kg.d and 5.0mg group, shows after the administration that reaction and symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step have appearred in the SD rat, total food ration with lose weight; Blood test shows that total white blood cells increases to some extent, erythrocyte sum, content of hemoglobin and platelet count obviously descend (P all＜0.05); Blood biochemistry checking shows that ALT, AST, ALP and CK raise 1～8 times (P all＜0.05), and creatinine and blood urea nitrogen raise (P all＜0.05) to some extent, but do not cause animal dead; Histopathological analysis result shows that lovastatin 50mg/kg.d group has occurred and Liver and kidney pathological change like the physiognomy.And similar reaction does not all appear in three dosage groups of capsule 0.25g, the 2.5g of normal saline group and Chinese medicine preparation of the present invention and 12.5g/kg.d and lovastatin 0.5mg/kg.d dosage group during whole administration, at the convalescent period viewing duration, the symptom that each treated animal of reaction the occurs recovery normal condition that fades away.As seen the capsule of Chinese medicine preparation of the present invention not only can reduce the toxic and side effects of lovastatin, and can make the clinical non-toxic of lovastatin increase to 5～25 times (P all＜0.01).
Pharmacodynamic experiment (is contrast with the HUATUO ZAIZAO WAN)
1.1 influence to cerebrovascular permeability
48 of rat, be divided into operative control group at random, the cerebral ischemic model group, HUATUO ZAIZAO WAN 8g/kg group, honey pill agent 12g/kg of the present invention, 6g/kg, three dosage groups of 3g/kg, administration during 1hr before experiment preceding 9 days and art, the blue 50mg/kg of anesthesia back tongue intravenous injection ivens, ligation rat bilateral common carotid arteries causes the incomplete ischemia model of acute experiment after 5 minutes, not ligation of matched group, behind the ligation 3hr, get brain and be soaked in the formamide solution, incubation 72hr in 45 ℃ of calorstats, get soak and carry out colorimetric with 7230 spectrophotometers, calculate the blue content of ivens in the brain according to standard curve,, the results are shown in Table 1 with microgram/gram expression.
Table 1 honey pill agent of the present invention is to the influence of cerebrovascular permeability (X ± S)
| Group and dosage | Number of animals | The blue content (μ g/g) of ivens |
| The normal control group | 8 | 4.53±1.11 |
| Cerebral ischemic model | 8 | 6.03±1.32△△ |
| HUATUO ZAIZAO WAN 8g/kg | 8 | 5.27±1.12 |
| Honey pill agent 12g/kg of the present invention | 8 | 4.61±0.94 |
| Honey pill agent 6g/kg of the present invention | 8 | 4.63±0.88 |
| Honey pill agent 3g/kg of the present invention | 8 | 4.58±1.68 |
Compare △ △ P＜0.01 with operative control group
Compare with the cerebral ischemic model group
*P＜0.05
The result shows that honey pill agent 12g/kg of the present invention and 6g/kg group all can obviously lower cerebrovascular permeability, and the blue seepage discharge of cerebral tissue ivens significantly is lower than matched group (p＜0.05), and the 3g/kg group also has the trend that reduces cerebrovascular permeability.
2.1 to the thrombotic influence of rat neck artery-vein blood flow coronary artery bypass grafting
Male rat, about body weight 200g, random packet, press table 3 dosed administration, the experiment undertaken by literature method, animal with 50mg/kg pentobarbital sodium intraperitoneal injection of anesthesia after, it is fixing to face upward the position, separate left external jugular vein and right side common carotid artery, elder generation inserts right carotid with the other end after being full of the heparin-saline solution 0.1ml/mg of 50 μ g/ml by one of left external jugular vein insertion, cause the bypass of neck artery-vein, behind gastric infusion 40 minutes, behind the open blood flow 15min in Herba Clinopodii, take out silk thread rapidly, with Shanghai paper inhale remove excessive moisture after torsion balance weigh, gross weight deducts silk thread and heavily is wet weight of thrombus, and the experiment that hockets of administration group and matched group the results are shown in Table 2.
Table 2 honey pill agent of the present invention is to the thrombotic influence of rat neck artery-vein blood flow coronary artery bypass grafting
| Group and dosage | Number of animals | Wet weight of thrombus (X ± Smg) | Suppression ratio |
| Matched group | 10 | 123.9±47.46 | 28.5％ |
| HUATUO ZAIZAO WAN 8g/kg | 7 | 81.3±30.29 | 31.6％ |
| Honey pill agent 12g/kg of the present invention | 7 | 67.5±14.68 | 42.6％ |
| Honey pill agent 6g/kg of the present invention | 7 | 78.1±34.14 | 34.5％ |
| Honey pill agent 3g/kg of the present invention | 7 | 78.9±32.49 | 36.5％ |
Compare with matched group
*P＜0.05
The result shows that each administration group and matched group more all can make wet weight of thrombus alleviate, and honey pill agent 6g/kg group wherein of the present invention compares with matched group, and the P value has significant difference (P＜0.05).
2.2 to the thrombotic influence of rats in vitro
Rat about 37 body weight 200g is divided into contrast at random, positive controls and honey pill agent of the present invention are big, in, small dose group, successive administration 10 days, last administration 40 minutes, animal with pentobarbital sodium 50mg/kg intraperitoneal injection of anesthesia after, in the vinyon ring with silication, put on formation of XSN-R type external thrombus and the platelet adhesion double-purpose instrument and measure with 74 ° of angles, take off behind the speed rotation 10min of 17r/min and measure wet weight of thrombus (blotting the back with filter paper measures) and thrombosis dry weight (65 ℃ of baking 20min) respectively, each dosage group of honey pill agent of the present invention as a result all makes wet weight of thrombus alleviate, and 6g/kg and 3g/kg group can make the thrombosis dry weight alleviate (P＜0.05) and see Table 3.
The influence that table 3 honey pill agent of the present invention forms rats in vitro thrombosis
| Group and dosage | Number of animals | Wet weight of thrombus (mg) (X ± S) | The thrombosis dry weight |
| Matched group | 8 | 114.88±42.80 | 73.75±39.87 |
| HUATUO ZAIZAO WAN 8g/kg | 8 | 85.88±33.79 | 50.47±32.67 |
| Honey pill agent 12g/kg of the present invention | 7 | 77.12±22.58 | 41.6±15.08 |
| Honey pill agent 6g/kg of the present invention | 7 | 63.52±18.10 | 30.93±11.61 * |
| Honey pill agent 3g/kg of the present invention | 7 | 73.57±25.33 | 38.27±13.38 * |
*P＜0.05
*P＜0.01 and matched group relatively, in rat artery-thrombotic experiment of venous blood flow coronary artery bypass grafting, wet weight of thrombus that large, medium and small three dosage groups of honey pill agent of the present invention and matched group form and model control group more all have and alleviate.Honey pill agent 6g/kg group of the present invention compares P＜0.05 with model control group; In rats in vitro thrombosis process, each administration group of honey pill agent of the present invention all makes wet weight of thrombus than matched group notable difference (P＜0.05) more also be arranged.
3, to normal and the influence of blood stasis rat platelet aggregation
3.1 influence to normal rat platelet aggregation
Get 35 of body weight 150-200g rat, with keeping the score be 5 groups by dosed administration shown in the table 5 10 days, 1hr after the last administration, abdominal aortic blood, 3.8% sodium citrate anticoagulant, separate platelet rich plasma (PRP) and platelet poor plasma (PPP), the results are shown in Table 4 to measure platelet 3min maximum agglutination rate (ADP with 1mM is a derivant) with SPA-4 type platelet aggregation.
Table 4 honey pill agent of the present invention is to the influence of normal rat platelet aggregation (X ± S)
| Group and dosage | Number of animals | 3 minutes maximum agglutination rate (%) |
| The normal control group | 7 | 72.1±18.3 |
| HUATUO ZAIZAO WAN 8g/kg | 7 | 46.5±33.4 |
| Honey pill agent 12g/kg of the present invention | 7 | 47.9±16.87 * |
| Honey pill agent 6g/kg of the present invention | 7 | 50.3±23.17 |
| Honey pill agent 3g/kg of the present invention | 7 | 42.9±24.68 * |
*Compare with matched group P＜0.05
The result shows that each group of administration all has certain inhibitory action to normal rat platelet aggregation, and wherein administration heavy dose and small dose group and matched group relatively act on obviously (P＜0.05).
3.2 influence to the blood stasis rat platelet aggregation
43 rats are divided into 6 groups at random, press table 5 dosed administration, successive administration 8 days, all the other each treated animals are only pressed literature method subcutaneous injection 0.1% epinephrine 0.1ml/ except that first group, after stimulation causes " blood stasis " state with frozen water, continue administration 2 days, administration is 10 days altogether, 1hr puts to death animal and gets blood system from PRP and PPP mensuration platelet aggregation after the last administration, the results are shown in Table 5.
Table 5 honey pill agent of the present invention is to the influence of blood stasis rat platelet aggregation (X ± S)
| Group and dosage | Number of animals | 3 minutes maximum agglutination rate (%) |
| Matched group | 8 | 64.7±1.11 |
| The blood stasis model group | 7 | 81.5±8.7△△ |
| HUATUO ZAIZAO WAN 8g/kg | 7 | 63.6±10.7 ** |
| Honey pill agent 12g/kg of the present invention | 7 | 67.8±8.7 * |
| Honey pill agent 6g/kg of the present invention | 7 | 68.7±13.5 |
| Honey pill agent 3g/kg of the present invention | 7 | 64.9±8.1 *** |
Compare △ △ P＜0.01 with the normal control group
Compare with the blood stasis model group
*P＜0.05
Compare with the blood stasis model group
* *P＜0.001
By table 5 result as can be known, large and small dosage group of HUATUO ZAIZAO WAN and honey pill agent of the present invention and blood stasis model group more all have the effect of anticoagulant.To normal rat and because of the subcutaneous injection 0.1% epinephrine later rat administration honey pill agent of the present invention of blood stasis state that stimulation causes with frozen water, measure hematoblastic aggregation, each group and matched group and model control group more all have inhibitory action in various degree as a result, and wherein HUATUO ZAIZAO WAN and honey pill agent 12g of the present invention and 3g/kg group and matched group relatively have the effect of obvious suppression platelet aggregation.
Clinical experiment:
The result of the clinical trial of Chinese medicine of the present invention: test objective: observe the clinical efficacy that the over-65s gerontal patient takes Chinese medicine preparation of the present invention and lovastatin tablet treatment coronary heart disease merging hyperlipidemia patient respectively, inquire into the characteristics and the corresponding atherosclerosis firsts and seconds preventive measure of lipid lowering therapy.Method: 150 routine over-65s are suffered from coronary heart disease merging hyperlipidemia patient be divided into capsule treatment group 4.0g/d of the present invention and lovastatin treatment group 20mg/d at random; Treating for 10 weeks or measuring the Blood Lipid level that it treats front and back more than 10 weeks respectively; Each group is divided into two groups according to degree of danger again, and promptly dangerous group and atheromatosis or diabetic groups are observed its therapeutic effect.The result: cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level before and after the lovastatin treatment group treatment have obvious decline (P＜0.05), and the HDL-C level raises to some extent, but diversity not significantly (P＞0.05); Cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level before and after the capsule treatment group treatment of the present invention all have very obviously decline (P＜0.01), and the HDL-C level has obvious rising (P＜0.05).Total compliance rate is 77.06% in 150 examples, wherein dangerous group compliance rate is 88.01%, atheromatosis or diabetic groups compliance rate are 54.02%, the lovastatin treatment is for atherosclerosis or diabetics blood fat reducing in secondary prevention relatively difficulty up to standard, and total blood fat compliance rate of capsule treatment group of the present invention is 68.81%, apparently higher than 36.61% (P＜0.05) of lovastatin group;
Conclusion: capsule of the present invention and lovastatin all have better curative effect for reducing senile hyperlipidemia, treatment atherosclerosis and diabetes, but the clinical efficacy of capsule treatment group of the present invention will obviously be better than lovastatin treatment group, illustrate that the Chinese medicine ingredients in the capsule of the present invention has certain potentiation, Attenuation for statins, proved that also the present invention can be used as the first-selected kind of blood fat reducing treatment up to standard for atherosclerosis or diabetics in the secondary prevention process simultaneously.
Claims (9)
1. the Chinese medicine preparation of antithrombotic and blood fat reducing, it is characterized in that its raw medicinal material is: Fructus Crataegi, the Radix Astragali, Hirudo, Cortex Moutan, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Paeoniae Alba (processed with vinegar), Radix Angelicae Sinensis, Oletum Trogopterori, Radix Salviae Miltiorrhizae, propolis, "root of Potmarigold Calendul", Folium Ginkgo and Herb Gynostemmae Pentaphylli; Ratio of weight and number between them is: 1～7 part of Fructus Crataegi, 1～7 part of the Radix Astragali, 1～5 part of Hirudo, 1～7 part of Cortex Moutan, 1～7 part on Flos Carthami, 1～7 part of Rhizoma Chuanxiong, 1～7 part of Caulis Spatholobi, 1～7 part of Radix Paeoniae Alba (processed with vinegar), 1～7 part of Radix Angelicae Sinensis, 1～5 part of Oletum Trogopterori, 1～7 part of Radix Salviae Miltiorrhizae, 1～7 part of propolis, 1～7 part of "root of Potmarigold Calendul", 1～6 part of Folium Ginkgo, 1～7 part of Herb Gynostemmae Pentaphylli.
2. according to the Chinese medicine preparation of described antithrombotic of claim 1 and blood fat reducing, it is characterized in that described Chinese medicine preparation dosage form is a honey pill agent, its preparation process comprises:
A. described component is removed propolis and Hirudo and add the water logging bubble;
B. with soaked component heated and boiled, filter;
C. the filtrate heating is concentrated into pasty state, puts into baking oven, the oven dry postcooling is milled into fine powder and sieves;
D. Hirudo and propolis are pulverized, the fine powder blending honey that obtains with the c step is twisted into slice.
3. according to the Chinese medicine preparation of described antithrombotic of claim 2 and blood fat reducing, it is characterized in that, in the described b step:
With described soaked component heated and boiled 30～45 minutes, filter filtrate for later use;
Filtering residue adds water and heats for the second time, boils 30～45 minutes, filters filtrate for later use;
Filtering residue adds water again, and heated and boiled is 30～45 minutes for the third time, filters filtrate for later use;
Three filtrates are combined.
4. according to the Chinese medicine preparation of described antithrombotic of claim 2 and blood fat reducing, it is characterized in that in the described c step: the filtrate heating after will merging is concentrated into pasty state, puts into 60 ℃～85 ℃ oven dry of baking oven postcooling, and sieves after grinding into fine powder.
5. according to the Chinese medicine preparation of described antithrombotic of claim 2 and blood fat reducing, it is characterized in that, in the described d step: Hirudo and propolis are directly put into pulverizer pulverize, after the fine powder blending honey that obtains with the c step stirs then, be twisted into slice together; With 5g～8g is ball wax seal packing.
6. according to the Chinese medicine preparation of described antithrombotic of claim 1 and blood fat reducing, it is characterized in that the dosage form of described Chinese medicine preparation is a capsule, its preparation method comprises:
A. Hirudo is put into the ethanol heating and refluxing extraction;
B. get residue component in the described component again except that propolis, add the water heating and refluxing extraction;
C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol also concentrates sucking filtration absorption, obtains component medicated powder;
D. propolis is directly put into pulverizer and pulverized, the component medicated powder that obtains in sterilization back and the c step mixes, and incapsulates and is made as capsule.
7. according to the Chinese medicine preparation of described antithrombotic of claim 6 and blood fat reducing, it is characterized in that among the described step a, Hirudo is put into the ethanol of 10 times of amounts of its weight, heating and refluxing extraction 30 minutes～45 minutes is extracted active ingredient, and extracting solution is left standstill; Among the described step b, the residue component in the described component is put into the water of 10 times of amounts of its weight except that propolis, and heating and refluxing extraction 3 times each 30 minutes～45 minutes, leaves standstill 3 extracting solution merging; Among the described step c, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.8g crude drug/mL is behind the sucking filtration, when making the relative density of filtrate be 20 ℃ 1.07; Above-mentioned filtrate is the macroporous adsorptive resins absorption of 10L through volume; With the deionized water or the distilled water eluting of 10 times of resin column volumes, 5 times of resin column volume of ethanol of reuse eluting is collected ethanol elution, removes alcohol solvent, obtains component medicated powder after the absorption.
8. according to the Chinese medicine preparation of described antithrombotic of claim 1 and blood fat reducing, it is characterized in that the ratio of weight and number between the described component is: 2～3 parts of Fructus Crataegis, 2～3 parts of the Radixs Astragali, 3～5 parts of Hirudos, 2～3 parts of Cortex Moutans, 2～3 parts on Flos Carthami, 2～3 parts of Rhizoma Chuanxiongs, 2～3 parts of Caulis Spatholobis, 2～3 parts of Radix Paeoniae Alba (processed with vinegar), 2～3 parts of Radix Angelicae Sinensis, 3～5 parts of Oletum Trogopteroris, 1～2 part of Radix Salviae Miltiorrhizae, 1～2 part of propolis, 1～2 part of "root of Potmarigold Calendul", 4～6 parts of Folium Ginkgos, 1～2 part of Herb Gynostemmae Pentaphylli.
9. according to the Chinese medicine preparation of described antithrombotic of claim 1 and blood fat reducing, it is characterized in that the ratio of weight and number between the described component is: 1～2 part of Fructus Crataegi, 1～2 part of the Radix Astragali, 1～2 part of Hirudo, 1～2 part of Cortex Moutan, 1～2 part on Flos Carthami, 1～2 part of Rhizoma Chuanxiong, 1～2 part of Caulis Spatholobi, 1～2 part of Radix Paeoniae Alba (processed with vinegar), 1～2 part of Radix Angelicae Sinensis, 1～2 part of Oletum Trogopterori, 1～2 part of Radix Salviae Miltiorrhizae, 1～2 part of propolis, 1～2 part of "root of Potmarigold Calendul", 1～2 part of Folium Ginkgo, 1～2 part of Herb Gynostemmae Pentaphylli.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101621222A CN101804110B (en) | 2010-05-05 | 2010-05-05 | Traditional Chinese medicine preparation for thrombosis and blood lipid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101621222A CN101804110B (en) | 2010-05-05 | 2010-05-05 | Traditional Chinese medicine preparation for thrombosis and blood lipid |
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| Publication Number | Publication Date |
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| CN101804110A CN101804110A (en) | 2010-08-18 |
| CN101804110B true CN101804110B (en) | 2011-07-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101621222A Expired - Fee Related CN101804110B (en) | 2010-05-05 | 2010-05-05 | Traditional Chinese medicine preparation for thrombosis and blood lipid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103251737A (en) * | 2012-05-18 | 2013-08-21 | 乔德京 | Yindan capsule |
| CN103071063B (en) * | 2013-02-27 | 2014-01-08 | 崔合芳 | Traditional Chinese medicinal composition for treating hyperlipidemia and preparation method thereof |
| CN103784545B (en) * | 2014-02-13 | 2015-09-16 | 徐艳艳 | A kind of Chinese medicine composition improving blood viscosity and preparation method thereof |
| CN104771601B (en) * | 2015-04-14 | 2018-06-19 | 张坤镛 | A kind of combination agent for improving blood viscosity and hematoblastic aggregation |
| CN112931240B (en) * | 2021-01-26 | 2022-05-06 | 薄彧坤 | Trogopterus dung collecting and purifying device for drug analysis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101229312A (en) * | 2007-01-23 | 2008-07-30 | 凌泰祥 | Medicine compounds capable of regulating hypertension, hyperlipemia and angina |
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