CN1765392A - Chinese compound formulation for nourishing blood, regulating menstruation, stopping bleeding to prevent abortion and preparation method thereof - Google Patents
Chinese compound formulation for nourishing blood, regulating menstruation, stopping bleeding to prevent abortion and preparation method thereof Download PDFInfo
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- CN1765392A CN1765392A CN 200510097959 CN200510097959A CN1765392A CN 1765392 A CN1765392 A CN 1765392A CN 200510097959 CN200510097959 CN 200510097959 CN 200510097959 A CN200510097959 A CN 200510097959A CN 1765392 A CN1765392 A CN 1765392A
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Abstract
Disclosed is a Chinese compound formulation for nourishing blood, regulating menstruation, stopping bleeding to prevent abortion and preparation method, which is prepared from prepared rehmannia root, Ligusticum wallichii, root of herbaceous peony, Chinese mugwort leafmulberry leaf, Chinese angelica root, licorice root and donkey-hide gelatin, and can be made into preparations with the forms of electuary, granule, tablet or capsule.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of tonifying blood and regulating menstruation, the compound Chinese medicinal preparation of arresting bleeding and miscarriage prevention is used for the treatment of diseases such as severe loss of blood, shallow complexion, menoxenia, cold and pain in the lower abdomen, vaginal bleeding during pregnancy fetal movement, also can be used for the anal fistula hematochezia.The present invention has also announced the preparation method of this pharmaceutical preparation.
Background technology:
Severe loss of blood is the comparatively common symptom of gynecological, is more common in diseases such as metrorrhagia, vaginal bleeding during pregnancy fetal movement.Metrorrhagia is the health that the women in serious threat, in treatment, though method is more, but need take medicine for a long time mostly.Use some simple hemorrhage perhaps can temporarily make the state of an illness controlled, and in case discontinue medication very easily recurrence.
During the vaginal bleeding during pregnancy fetal movement, vagina has hemorrhage, and part patient's bleeding dripping urine endlessly is arranged, and causes severe loss of blood, very easily causes miscarriage.According to statistics, pregnant early stage hemorrhage rate accounts for about 11%, and this badly influences China perinatal stage mother and baby mortality rate.Therefore, improving the perinatal care level, realize the target of prenatal and postnatal care, improve the health of the people, will be an important problem.
Summary of the invention:
The invention provides a kind of tonifying blood and regulating menstruation, the compound Chinese medicinal preparation of arresting bleeding and miscarriage prevention is used for the treatment of diseases such as severe loss of blood, shallow complexion, menoxenia, cold and pain in the lower abdomen, vaginal bleeding during pregnancy fetal movement, also can be used for the anal fistula hematochezia, and good curative effect is arranged.
Compound Chinese medicinal preparation of the present invention is made by Radix Rehmanniae Preparata, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Folium Artemisiae Argyi, Radix Angelicae Sinensis, Radix Glycyrrhizae, Colla Corii Asini, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Angelicae Sinensis in the side, be common name side's SIWU TANG of treatment gynaecopathia, have the effect of nourshing blood and promoting blood circulation, Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, dispersing cold for relieving pain is arranged, and the effect of warming the meridian for stopping bleeding is used for few abdomen cold type of pain, the metrorrhagia warp is many, diseases such as gestation hemorrhage; Colla Corii Asini is gynecological's key medicine, and the effect of tonifying blood and arresting bleeding is arranged, and is used for blood deficiency and yellow complexion, the diseases such as metrorrhagia, vaginal bleeding during pregnancy of having blood in stool.All medicines are harmonious, and have and have tonifying blood and regulating menstruation, the effect of arresting bleeding and miscarriage prevention.
Compound Chinese medicinal preparation of the present invention, per 1000 dosage units, make by the raw material of Chinese medicine of following weight parts:
92 parts of 46 portions of Radix Paeoniae Albas of 115 parts of Rhizoma Chuanxiongs of Radix Rehmanniae Preparata
46 parts in 69 portions of Radix Glycyrrhizaes of 46 parts of Radix Angelicae Sinensis of Folium Artemisiae Argyi
69 parts in Colla Corii Asini
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000g etc.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Pharmaceutically active substance in the pharmaceutical preparation of the present invention, its shared percentage by weight in preparation can be 0.1～99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every of tablet, and capsular every capsules.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, pill, powder, oral liquid, syrup, unguentum, sublimed preparation, drop pill, patch, slow releasing preparation, controlled release preparation.
Pharmaceutical preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent, inclusion agents and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises crospolyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant, for example magnesium stearate, Macrogol 4000, polyethylene glycol 6000, Pulvis Talci, micropowder silica gel.
In case of necessity,, need to add suitable correctives, for example aspartame, flavoring orange essence, Herba Menthae essence, orange flavor essence etc. in order to improve taste of medicine.
The present invention also provides the preparation method of pharmaceutical preparation of the present invention, and preferred manufacturing procedure can be passed through following steps:
(1) takes by weighing medical material by the prescription weight proportion;
(2) get Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong and extract volatile oil, medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decoct with water three times, and 3 hours for the first time, for the second time, respectively 2 hours for the third time.Collecting decoction left standstill 24 hours, filtered, and filtrate is concentrated into the extractum that relative density is 1.05-1.10 (50 ℃).
(3) Colla Corii Asini melts by heat or pulverizes the back and mix with extractum, adds volatile oil, obtains active constituents of medicine;
(4) will obtain active constituents of medicine, and make preparation after the medicine acceptable carrier mixes.
The preparation that above step makes can be any pharmaceutical dosage form, preferably soft extract, granule, tablet, capsule.
Following data is in order to illustrate the beneficial effect of medicine of the present invention:
Medicine of the present invention has been used for for many years clinical, treatment metrorrhagia, vaginal bleeding during pregnancy, vaginal bleeding due to excessive movement of fetus, and other gynecological bleeding diseases have better curative effect.
Treat all types of gynecological bleeding disease 169 examples, comprise metrorrhagia 56 examples, vaginal bleeding during pregnancy fetal movement 48 examples, vaginal bleeding after drug abortion 65 examples.After the treatment, the metrorrhagia patient has 35 examples to stop the back vaginal hemorrhage of taking medicine, menstrual cycle after the drug withdrawal, count produce effects more than 3 months through measuring normally to reach, vagina went out stopped bleeding after obvious effective rate 59.3%, 19 example was taken medicine, but had after the drug withdrawal repeatedly, this medicine is hemorrhage then to be stopped taking, count effectively, effective percentage 32.2%, total effective rate are 91.5%; Among the 48 routine vaginal bleeding during pregnancy fetal movement patients, 35 example recoveries from illness are arranged, and the vaginal hemorrhage amount stops transference cure after the medication, B ultrasonic shows the early pregnancy live embryo, obvious effective rate 72.9%, effective 11 examples, vaginal bleeding volume reduces after patient's medication, symptom has clear improvement, B ultrasonic shows the early pregnancy live embryo, and effective percentage 22.9%, total effective rate are 95.8%.Among the 65 routine vaginal bleeding after drug abortion patients, treatment is organized 34 examples and is given medicine of the present invention,, every day 2 times, serve on 7～10 days; Matched group 31 examples, single intramuscular injection oxytocin 20U, average vaginal hemorrhage natural law is (8 ± 3.17) sky behind the drug induced abortion of treatment group as a result, is (14+6.29) sky than matched group, and the treatment group bleeding time obviously shortens, and two groups have significant difference (P＜005); Treatment group vaginal hemorrhage amount also obviously reduces than matched group, and two groups have highly significant difference (P＜0.001).
The specific embodiment:
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1:
The preparation method of soft extract of the present invention:
Prescription:
Radix Rehmanniae Preparata 115g Rhizoma Chuanxiong 46g Radix Paeoniae Alba 92g
Folium Artemisiae Argyi 46g Radix Angelicae Sinensis 69g Radix Glycyrrhizae 46g
Colla Corii Asini 69g
Sucrose 269g brown sugar 269g rice wine 45g
Make 1000g altogether
Method for making:
(1) get Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong and extract volatile oil, medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decoct with water three times, and 3 hours for the first time, for the second time, respectively 2 hours for the third time.Collecting decoction left standstill 24 hours, filtered, and filtrate is concentrated into the extractum that relative density is 1.05-1.10 (50 ℃).
(2) get sucrose, brown sugar is dissolved in and makes syrup in the suitable quantity of water, Colla Corii Asini is added the water heat fused to add respectively in the above-mentioned clear paste, heating stirs evenly, continue to be concentrated into the clear paste that relative density is 1.28-1.29 (50 ℃), put cold rnning and go into volatile oil and rice wine 45g, add water to 1000g, mixing promptly gets the 1000g soft extracts.
Embodiment 2:
The preparation method of tablet of the present invention:
Prescription:
Radix Rehmanniae Preparata 575g Rhizoma Chuanxiong 230g Radix Paeoniae Alba 460g
Folium Artemisiae Argyi 230g Radix Angelicae Sinensis 345g Radix Glycyrrhizae 230g
Colla Corii Asini 345g
Beta-schardinger dextrin-25g
95% ethanol is an amount of
Make 1000 altogether
Method for making:
Get Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong and extract volatile oil, medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decoct with water three times, and 3 hours for the first time, for the second time, respectively 2 hours for the third time.Collecting decoction left standstill 24 hours, filtered, and filtrate concentrates the thick paste drying under reduced pressure, pulverized, and got fine powder; Get Radix Angelicae Sinensis, Folium Artemisiae Argyi, volatile oil that Rhizoma Chuanxiong extracts, add beta-schardinger dextrin-, 40 ℃ of enclose 3 hours, cold preservation is spent the night, and filters, 40 ℃ of drying under reduced pressure are pulverized, fine powder is standby; Other gets Colla Corii Asini, is ground into fine powder.Get above fine powder mix homogeneously, 95% ethanol is granulated in right amount, drying, and tabletting is promptly.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Radix Rehmanniae Preparata 115g Rhizoma Chuanxiong 46g Radix Paeoniae Alba 92g
Folium Artemisiae Argyi 46g Radix Angelicae Sinensis 69g Radix Glycyrrhizae 46g
Colla Corii Asini 69g
Beta-schardinger dextrin-5g
Sucrose 800g dextrin 30g
95% ethanol is an amount of
Make 1000g altogether
Method for making:
Get Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong and extract volatile oil, medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decoct with water three times, and 3 hours for the first time, for the second time, respectively 2 hours for the third time.Collecting decoction left standstill 24 hours, filtered, and filtrate concentrates the thick paste drying under reduced pressure, pulverized, and got fine powder; Get Radix Angelicae Sinensis, Folium Artemisiae Argyi, volatile oil that Rhizoma Chuanxiong extracts, add beta-schardinger dextrin-, 40 ℃ of enclose 3 hours, cold preservation is spent the night, and filters, 40 ℃ of drying under reduced pressure are pulverized, fine powder is standby; Other gets Colla Corii Asini, is ground into fine powder.Get above fine powder mix homogeneously, 95% ethanol is granulated in right amount, drying, and tabletting is promptly.
Embodiment 4:
The preparation method of capsule of the present invention:
Prescription:
Radix Rehmanniae Preparata 335g Rhizoma Chuanxiong 138g Radix Paeoniae Alba 276g
Folium Artemisiae Argyi 138g Radix Angelicae Sinensis 207g Radix Glycyrrhizae 138g
Colla Corii Asini 207g
Beta-schardinger dextrin-18g
Magnesium stearate 6g
Make 1000 altogether
Method for making:
Get Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong and extract volatile oil, medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decoct with water three times, and 3 hours for the first time, for the second time, respectively 2 hours for the third time.Collecting decoction left standstill 24 hours, filtered, and filtrate concentrates the thick paste drying under reduced pressure, pulverized, and got fine powder; Get Radix Angelicae Sinensis, Folium Artemisiae Argyi, volatile oil that Rhizoma Chuanxiong extracts, add beta-schardinger dextrin-, 40 ℃ of enclose 3 hours, cold preservation is spent the night, and filters, 40 ℃ of drying under reduced pressure are pulverized, fine powder is standby; Other gets Colla Corii Asini, is ground into fine powder.Get above fine powder and add magnesium stearate, mix homogeneously, the dress capsule is promptly.
Claims (8)
1. tonifying blood and regulating menstruation, the compound Chinese medicinal preparation of arresting bleeding and miscarriage prevention is characterized in that, per 1000 dosage units are made by the raw material of Chinese medicine of following weight parts:
92 parts of 46 portions of Radix Paeoniae Albas of 115 parts of Rhizoma Chuanxiongs of Radix Rehmanniae Preparata
46 parts in 69 portions of Radix Glycyrrhizaes of 46 parts of Radix Angelicae Sinensis of Folium Artemisiae Argyi.
69 parts in Colla Corii Asini
2. the compound Chinese medicinal preparation of claim 1 wherein also comprises the medicine acceptable carrier.
3. the compound Chinese medicinal preparation of claim 1 is characterized in that, is soft extract, granule, tablet, capsule.
4. claim 2 Chinese medicine acceptable carrier is characterized in that, comprise in binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and the wetting agent any or several.
5. the described filler of claim 4 is characterized in that, can be selected from: any in starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, mannitol, calcium hydrogen phosphate and the calcium sulfate or several; Described disintegrating agent is characterized in that, can be selected from: crospolyvinylpyrrolidone and/or starch derivatives; Described lubricant is characterized in that, can be selected from: any in magnesium stearate, Macrogol 4000, polyethylene glycol 6000, Pulvis Talci, the micropowder silica gel or several; Described correctives is characterized in that, can be selected from: any in aspartame, flavoring orange essence, Herba Menthae essence, the orange flavor essence or several.
6. the described starch derivatives of claim 5 is characterized in that, is sodium starch glycollate.
7. the preparation method of the compound Chinese medicinal preparation of claim 3 is characterized in that, the process following steps:
(1) takes by weighing medical material by the prescription weight proportion;
(2) get Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong and extract volatile oil, medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decoct with water three times, and 3 hours for the first time, for the second time, respectively 2 hours for the third time.Collecting decoction left standstill 24 hours, filtered, and filtrate is concentrated into the extractum that relative density is 1.05-1.10 (50 ℃).
(3) Colla Corii Asini melts by heat or pulverizes the back and mix with extractum, adds volatile oil, obtains active constituents of medicine;
(4) will obtain active constituents of medicine, and make preparation after the medicine acceptable carrier mixes.
8. the preparation method of claim 7 is characterized in that, the preparation that uses this method to make is soft extract, granule, tablet, capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510097959 CN1765392A (en) | 2005-09-02 | 2005-09-02 | Chinese compound formulation for nourishing blood, regulating menstruation, stopping bleeding to prevent abortion and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510097959 CN1765392A (en) | 2005-09-02 | 2005-09-02 | Chinese compound formulation for nourishing blood, regulating menstruation, stopping bleeding to prevent abortion and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526322A (en) * | 2010-12-15 | 2012-07-04 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of novel integrated Jiaoai decoction dosage form |
| CN102552517A (en) * | 2011-12-28 | 2012-07-11 | 武汉哈瑞医药有限公司 | Gynecological sugar-free gynaecopathia treating particle and preparation method thereof |
| CN102772388A (en) * | 2012-08-17 | 2012-11-14 | 四川百利药业有限责任公司 | Method for preparing flupirtine maleate capsule |
| CN102919661A (en) * | 2012-10-26 | 2013-02-13 | 广西崇左市湘桂糖业有限公司 | Wormwood and brown sugar health-care product and production method thereof |
| CN103751747A (en) * | 2014-01-16 | 2014-04-30 | 曲洪翠 | Traditional Chinese medicine for treating vaginal bleeding after medical abortion |
| CN104997922A (en) * | 2015-08-05 | 2015-10-28 | 南京中医药大学 | Refined traditional Chinese medicine composition extract with hemostasis and miscarriage prevention effect and application thereof |
| CN105816621A (en) * | 2016-03-29 | 2016-08-03 | 广州暨南生物医药研究开发基地有限公司 | Folium artemisiae argyi-containing traditional Chinese medicine composition for treating vaginal bleeding |
| CN108175802A (en) * | 2018-01-30 | 2018-06-19 | 重庆芸峰药业有限公司 | A kind of FUKANGBAO KOUFUYE and preparation method thereof |
| CN108272981A (en) * | 2018-03-14 | 2018-07-13 | 江西地康药业有限公司 | Fukangbao koufuye |
-
2005
- 2005-09-02 CN CN 200510097959 patent/CN1765392A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526322A (en) * | 2010-12-15 | 2012-07-04 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of novel integrated Jiaoai decoction dosage form |
| CN102552517A (en) * | 2011-12-28 | 2012-07-11 | 武汉哈瑞医药有限公司 | Gynecological sugar-free gynaecopathia treating particle and preparation method thereof |
| CN102772388A (en) * | 2012-08-17 | 2012-11-14 | 四川百利药业有限责任公司 | Method for preparing flupirtine maleate capsule |
| CN102772388B (en) * | 2012-08-17 | 2014-09-03 | 四川百利药业有限责任公司 | Method for preparing flupirtine maleate capsule |
| CN102919661A (en) * | 2012-10-26 | 2013-02-13 | 广西崇左市湘桂糖业有限公司 | Wormwood and brown sugar health-care product and production method thereof |
| CN103751747A (en) * | 2014-01-16 | 2014-04-30 | 曲洪翠 | Traditional Chinese medicine for treating vaginal bleeding after medical abortion |
| CN104997922A (en) * | 2015-08-05 | 2015-10-28 | 南京中医药大学 | Refined traditional Chinese medicine composition extract with hemostasis and miscarriage prevention effect and application thereof |
| CN104997922B (en) * | 2015-08-05 | 2017-11-21 | 南京中医药大学 | The refined extract of Chinese medicine composition with arresting bleeding and miscarriage prevention effect and its application |
| CN105816621A (en) * | 2016-03-29 | 2016-08-03 | 广州暨南生物医药研究开发基地有限公司 | Folium artemisiae argyi-containing traditional Chinese medicine composition for treating vaginal bleeding |
| CN108175802A (en) * | 2018-01-30 | 2018-06-19 | 重庆芸峰药业有限公司 | A kind of FUKANGBAO KOUFUYE and preparation method thereof |
| CN108272981A (en) * | 2018-03-14 | 2018-07-13 | 江西地康药业有限公司 | Fukangbao koufuye |
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