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CN102343019B - Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof - Google Patents

Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof Download PDF

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CN102343019B
CN102343019B CN2011103125630A CN201110312563A CN102343019B CN 102343019 B CN102343019 B CN 102343019B CN 2011103125630 A CN2011103125630 A CN 2011103125630A CN 201110312563 A CN201110312563 A CN 201110312563A CN 102343019 B CN102343019 B CN 102343019B
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孙丰卿
成林
于春阳
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Nantong San Intellectual Property Service Co ltd
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孙丰卿
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Abstract

The invention relates to a Chinese medicinal composition for treating amenorrhea and a preparation method of a preparation thereof. The Chinese medicinal composition comprises the following raw materials in parts by weight: 5-15 parts of ground beetle, 15-25 parts of red paeony root, 15-25 parts of Chinese angelica, 5-15 parts of szechuan lovage rhizome, 10-20 parts of safflower, 15-25 parts of nutgrass galingale rhizome, 10-20 parts of trogopterus dung, 5-15 parts of green tangerine peel, 15-25 parts of prepared rehmannia rhizome, 5-15 parts of peach kernel, 25-35 parts of motherwort herb and 15-25 parts of medicinal cyathula root. The invention further provides a preparation method of a decoction, paste, capsules, tablets, granules, water pills, honeyed pills or enteric coated tablets of the traditional Chinese medicine. The Chinese medicinal composition is applied internally and externally, has the effects of treating both principal and secondary aspects of a disease, can be used for inducing treatment of endometrial thickening during menstruation and facilitating falling of a thickened endometrium, has good curative effects on amenorrhea and hypomenorrhea, has low raw material price, and has the characteristics of small dosage, quick response and small side effect.

Description

A kind of preparation method that is used for the treatment of Chinese medicine composition and the preparation thereof of amenorrhea
Technical field
The present invention relates to a kind of preparation method that is used for the treatment of Chinese medicine composition and the preparation thereof of amenorrhea, belong to tcm field.
Background technology
Amenorrhea is a kind of common sympton of gynaecopathia, is not single disease.The reason of amenorrhea has: uterine amenorrhea--congenital vaginal and (or) defectus uteri or dysplasia all can cause primary amenorrhea.Excessive dilatation and curettage or serious infection such as tuberculosis etc. cause inner film injury or adhesion, and time of nursing is long makes atrophy of endometrium etc., all can cause the supervention amenorrhea.Ovarian amenorrhea--the amenorrhea that causes because of oophoropathy.Secondary amenorrhea can be because of after premature ovarian failure, excision, radiotherapy and the manlike tumor of ovary etc.The pituitary amenorrhea--occur in prepuberal pituitary tumor and can cause primary amenorrhea.Hypothalamic amenorrhea--hypothalamus is controlled by the central nervous system, and excessively psychentonia, worry, fear, living environment change, and all can cause central nervous system and hypothalamus functional disorder, amenorrhea occurs.Young woman particularly.Ovarian function is still unsound, more is prone to disorderly phenomenon.Chang Shouxian shows that amenorrhea appears in ovulation function extremely.Other are as severe malnutrition, and particularly nervous anorexia, wasting diseases, serious anemia etc., all can affect the synthesis secretion of hypothalamus gonadotropin releasing hormone (GnRH), and cause amenorrhea.The long-term taking some drugs as: reserpine, chlorpromazine, miltown and contraceptive etc. also can cause amenorrhea.Also can affect menstruation during the dysfunctions such as the abnormal adrenal gland of other endocrine gland, thyroid and pancreas.
Traditional Chinese medical science amenorrhea reason can be divided into two kinds of void, realities clinically.How not enough by natural endowment deficiency syndrome are deficiency of the liver and kindey,, and contain at the kidney qi end, and deficiency of liver-blood is few, and punching is appointed and do not filled, living menses of being difficult and cause amenorrhea; Also because of voluminous exhaustion due to sexual indulgence, or the kidney usually involved in chronic disease, cause the kidney essense deficiency of liver-blood, punching is appointed all empty, the blood underflow of uterus and cause amenorrhea.Deficient qi and blood: taste are unstrong, and the change source is not enough, or improper diet and overtiredness, be worried excessively, and damage heart spleen; Or serious disease, prolonged illness, lose blood, or suckling is excessively of a specified duration, causes the nutrient blood loss, and a blood deficiency is appointed in punching, and depletion of bloodization is given birth to and is caused amenorrhea.The element body deficiency of YIN, or lose blood the moon thanks to, or prolonged illness, heat formation from yin deficiency is burnt and is sought the moon, and the sea of blood dries up and sends out is amenorrhea.The qi depression to blood stasis internal injury caused by excess of seven emotions, depressed stasis, or when producing menstrual period, just open the blood chamber, wound wind and cold or internal injury raw food, the blood vessels stasis of blood is stagnant; Or pathogenic heat are bright cloudy, and punching appoints the stasis of blood stagnant, and vessels of the uterus intercepts, and causes through water not all right.Stagnation of phlegm-damp, the spleen sun loses warm, the wet expectorant that gathers into, the retardance punching is appointed, and vessels of the uterus is jammed and not all right through water.
There is no at present the medicine of special method and specially good effect for the treatment of amenorrhea, the treatment such as amenorrhea is general alone western medicine in the past, multiplex hormone medicine artificial cycle but side effect is large, curative effect is not good enough.In recent years, the Chinese traditional treatment amenorrhea had obtained very great achievement, outstanding clinical efficacy and the mechanism of action that is comparatively systematically to have studied Chinese medicine, and use the Chinese medicine primary disease and have no side effect and obtained satisfied effect.
Summary of the invention
The problem to be solved in the present invention is for above deficiency, and a kind of preparation method that is used for the treatment of Chinese medicine composition and the preparation thereof of amenorrhea is provided.
Technical scheme of the present invention is:
A kind of Chinese medicine composition that is used for the treatment of amenorrhea, made by the raw material of following weight portion:
Eupolyphaga Seu Steleophaga 5-15 part, Radix Paeoniae Rubra 15-25 part, Radix Angelicae Sinensis 15-25 part, Rhizoma Chuanxiong 5-15 part, Flos Carthami 10-20 part, Rhizoma Cyperi 15-25 part, Oletum Trogopterori 10-20 part, Pericarpium Citri Reticulatae Viride 5-15 part, Radix Rehmanniae Preparata 15-25 part, Semen Persicae 5-15 part Herba Leonuri 25-35 part and Radix Cyathulae 15-25 part.
Further preferred as technique scheme, described Chinese medicine composition is made by the raw material of following weight portion:
20 parts of 10 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts, Flos Carthami, 20 parts of Rhizoma Cyperis, 15 parts of Oletum Trogopteroris, 10 parts, Pericarpium Citri Reticulatae Viride, 20 parts, Radix Rehmanniae Preparata, 10 parts, Semen Persicae, 30 parts of Herba Leonuris and Radix Cyathulaes.
Described Chinese medicine composition pharmaceutical dosage form is: water decoction, unguentum, capsule, tablet, granule, watered pill, honey pill agent or enteric coated tablet.
According to the present invention, a kind of preparation method of Chinese medicinal composition preparation of amenorrhea for the treatment of comprises the following steps:
A, proportionally get each composition of raw material and mix, decoct with water 30 minutes water decoction.
B, Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Cyperi, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Radix Rehmanniae Preparata, Semen Persicae, Herba Leonuri and Radix Cyathulae are pulverized respectively, mix, add 5-6 and doubly measure 75% alcohol reflux 1-2 hour of volume, filter, get filtrate, filtering residue repeats to reflux 2-3 time, merging filtrate; Reclaim ethanol;
C, the filtrate of above-mentioned steps b is condensed into the thick extractum of relative density 1.21~1.25 (80 ℃ record), gets unguentum.
D, the filtrate of above-mentioned steps b is concentrated into the thick paste shape, gets thick paste, add appropriate sucrose and dextrin, granulation, drying is made 1000 parts (sugar-containing types), obtains granule.
E, the filtrate of above-mentioned steps b is concentrated into the thick paste shape, the shift-in baking oven is dried to moisture lower than 5% for 50-70 ℃, takes out, and pulverizes and sieves to 100 orders, obtains drug powder, adds adjuvant by prior art, makes capsule or enteric coated tablet.
F, proportionally get each composition of raw material and mix, pulverize, cross 80~100 mesh sieves, get medicated powder.Medicated powder after sieving is general for piller with cold boiled water or Sucus Zingberis, cold drying, quality inspection, packing namely gets watered pill.
G, separately get sucrose 90g, add water 45ml and refined honey 90g, mix, refine when being about 1.38 (70 ℃ record) to relative density, filter, with the medicated powder 200g mixing of above-mentioned steps f, pill piece, rub the ball bar with the hands, the pill grain, the heavy 9g of every ball namely gets honey pill agent.
Preferably, the method for concentration of step c is: take 50 parts, brown sugar, add water and 0.1% tartaric acid of brown sugar amount 1/2, heating is tempered, and constantly stirs, and endures when being golden yellow, continues to be concentrated into relative density 1.21~1.25 (80 ℃ record), and get final product.
The method for concentration of steps d is directly concentrated not with brown sugar, and gained thick paste relative density 0.8~1.0 (80 ℃ record) gets final product.
In above raw material,
The Pericarpium Citri Reticulatae Viride function with cure mainly soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.Be used for distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
The Flos Carthami function with cure mainly promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia, the abdominal mass mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Paeoniae Rubra contains paeoniflorin, energy promoting blood circulation to restore menstrual flow, cool the blood dissipate blood stasis, heat-clearing and toxic substances removing.Cure mainly the diseases such as amenorrhea due to stagnation of blood, herpes simplex toxic swelling, postnatal blood stasis, heat in blood epistaxis, warm malicious macule.
The Rhizoma Chuanxiong activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Eupolyphaga Seu Steleophaga effect removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Be used for the muscle fracture wound, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.
The effect of Rhizoma Cyperi the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.
Oletum Trogopterori function promoting blood circulation to remove blood stasis, the parch to black hemostasis.Be used for trusted subordinate's congestion and have a pain, dysmenorrhea, the blood stasis amenorrhea, puerperal abdominalgia with blood stasis.
Radix Rehmanniae Preparata has the nourishing yin effect of enriching blood, and can be used for blood deficiency and yellow complexion, and is dizzy, palpitation and insomnia, and menoxenia, the diseases such as metrorrhagia also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst.
Radix Cyathulae is dispeled the wind, and dampness removing stimulates the menstrual flow, and invigorates blood circulation.The dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea , mass in the abdomen.Be used for the amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
The Semen Persicae blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for amenorrhea, dysmenorrhea , WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Sweet flat, the bitter in the mouth of Semen Persicae enters lung, liver, large intestine channel; Blood stasis removing and clots absorbing is arranged, moisturize the effect of laxation; Control amenorrhea, dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, traumatic injury, dryness of the intestine constipation.
The Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Be used for menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Its basic pathogenesis of amenorrhea is deficiency of the liver and kindey: deficient qi and blood: deficiency of YIN blood is dry: qi depression to blood stasis stagnation of phlegm-damp, vessels of the uterus are jammed and are not all right through water.Menstruation is appointed relevant with punching, the married woman is take blood as main, the Liver Channel disorder of QI and blood is the main pathogenesis that causes primary disease, therefore the present invention first appoints benefiting blood and regulating blood circulation with Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Paeoniae Rubra invigorating the liver and kidney Gu Chong, the Herba Leonuri promoting blood flow to regulate menstruation is key medicine Flos Carthami, the Semen Persicae blood circulation promoting and blood stasis dispelling of regulating menstruation, is key medicine Rhizoma Cyperi, the Oletum Trogopterori Pericarpium Citri Reticulatae Viride depressed liver-energy dispersing and QI regulating of promoting blood circulation to restore menstrual flow removing blood stasis repercussive, menstruction regulating and pain relieving, Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood remove blood stasis and the fresh blood life; Radix Cyathulae restores menstrual flow and invigorates blood circulation, and priming is descending.
The present invention adopts above technical scheme, compared with prior art, has the following advantages: monarch of the present invention, minister, help, make and respectively execute its effect, have a medication few, and instant effect, side effect is little, can reach inside and outside and execute, the purpose of giving consideration to both the incidental and fundamental.Can bring out menstruation and remove endometrial thickness and impel it to come off, rather good to the symptom curative effect of amenorrhea and hypomenorrhea, and the prices of raw and semifnished materials are cheap, and simple to operate, therapeutic effect is good, is worthy of popularization.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1: a kind of Chinese medicine composition that is used for the treatment of amenorrhea, raw-material weight part is: 20 parts of 10 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts, Flos Carthami, 20 parts of Rhizoma Cyperis, 15 parts of Oletum Trogopteroris, 10 parts, Pericarpium Citri Reticulatae Viride, 20 parts, Radix Rehmanniae Preparata, 10 parts of Herba Leonuris 30 of Semen Persicae and Radix Cyathulaes.
Embodiment 2: a kind of Chinese medicine composition that is used for the treatment of amenorrhea, raw-material weight part is: 15 parts of 5 parts of Eupolyphaga Seu Steleophagas, 15 parts of Radix Paeoniae Rubra, 15 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Chuanxiongs, 10 parts, Flos Carthami, 15 parts of Rhizoma Cyperis, 10 parts of Oletum Trogopteroris, 5 parts, Pericarpium Citri Reticulatae Viride, 15 parts, Radix Rehmanniae Preparata, 5 parts of Herba Leonuris 25 of Semen Persicae and Radix Cyathulaes.
Embodiment 3: a kind of Chinese medicine composition that is used for the treatment of amenorrhea, raw-material weight part is: 25 parts of 15 parts of Eupolyphaga Seu Steleophagas, 25 parts of Radix Paeoniae Rubra, 25 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 20 parts, Flos Carthami, 25 parts of Rhizoma Cyperis, 20 parts of Oletum Trogopteroris, 15 parts, Pericarpium Citri Reticulatae Viride, 25 parts, Radix Rehmanniae Preparata, 15 parts of Herba Leonuris 35 of Semen Persicae and Radix Cyathulaes.
Embodiment 4: the medicine of above embodiment 1-3 is prepared into different dosage forms according to following steps: unguentum, granule, capsule, enteric coated tablet, watered pill, honey pill agent.
A, proportionally get each composition of raw material;
B, Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Cyperi, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Radix Rehmanniae Preparata, Semen Persicae, Herba Leonuri and Radix Cyathulae are pulverized successively, mix, add 5-6 and doubly measure 75% alcohol reflux 1-2 hour of volume, filter, get filtrate, filtering residue repeats to reflux 2-3 time, merging filtrate; Reclaim ethanol;
C, above-mentioned steps b filtrate are condensed into the thick extractum of relative density 1.21~1.25 (80 ℃ record), method is: take 50 parts, brown sugar, join in described filtrate, add the water of brown sugar weight 1/2 and 0.1% tartaric acid, heating is tempered, and constantly stirs, and endures when being golden yellow, continue to be concentrated into the relative density of regulation, namely get unguentum.
D, above-mentioned steps b filtrate are condensed into and are concentrated into the thick paste shape, and relative density 1.0 (80 ℃ record) adds appropriate sucrose and dextrin by prior art, makes the granule of 1000 weight portions (sugar-containing type), and drying obtains granule.
C, above-mentioned steps b filtrate are condensed into and are concentrated into the thick paste shape, and the shift-in baking oven is dried to moisture lower than 5% for 50-70 ℃, takes out, and pulverizes and sieves to 100 orders, gets drug powder, adds adjuvant by prior art, makes capsule or enteric coated tablet.
D, proportionally get each composition of raw material, mix, pulverize, cross 80~100 mesh sieves, get medicated powder.Medicated powder after sieving is general for piller with cold boiled water or Sucus Zingberis, cold drying, quality inspection, packing namely gets watered pill.
E, separately get sucrose 90g, add water 45ml and refined honey 90g, mix, refine when being about 1.38 (70 ℃ of mensuration) to relative density, filter, with the medicated powder 200g mixing of steps d, pill piece, rub the ball bar with the hands, the pill grain, the heavy 9g of every ball namely gets honey pill agent.
Contrast test: criterion of therapeutical effect; Curative effect determinate standard according to treatment amenorrhea in " new Chinese medicine guideline of clinical investigations ".Clinical recovery: in drug withdrawal 2 cycles, patient's menstrual cycle, through amount, normally reach clinical symptom disappearance through color, through matter, menstrual period.Produce effects; A drug withdrawal 2-3 cycle occasionally has irregular menses 1-2 time, and clinical symptoms is clearly better.Take a turn for the better: 3 of drug withdrawals are more than the cycle, occasionally amenorrhea are arranged or through medication and damp person, clinical symptoms partly takes a turn for the better.Invalid: as make moderate progress through the medication clinical symptoms, and menstruation not to be to the person.
Choose 400 routine amenorrhea patients, choose at random 300 examples as treatment group, other 100 examples as a control group, wherein 300 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3, the 100 routine patients that each treatment group treatment is chosen at random, treatment group 1 uses the unguentum of the embodiment of the present invention 1 preparation to treat, treatment group 2 uses the unguentum of the embodiment of the present invention 2 preparations to treat, treatment group 3 uses the unguentum that carries out of the embodiment of the present invention 3 preparations to treat, each 20ml, be a course for the treatment of at twice, 3 month every day.Nonjoinder other treatment method during treatment.Three menstrual cycle are estimated four groups of clinical efficacies after end the course for the treatment of.
The patient of matched group adopts elder generation with progestogen (Progesterone), continues and sets up artificial cycle with female-progestogen (diethylstilbestrol) sequential therapy, and three menstrual cycle were 1 course for the treatment of.
Therapeutic outcome such as following table:
Figure BDA0000098819750000041
Can find out from above tables of data, treatment group 1 nonresponder has 10 examples, accounts for 10%.Produce effects 11 examples account for 11%.12 examples that take a turn for the better account for 12%, cure 67 examples, account for 67%, total effective rate 90%, cure rate 67%.The matched group nonresponder has 15 examples, accounts for 15%.Produce effects 17 examples account for 17%.24 examples that take a turn for the better account for 24%, cure 54 examples, account for 54%, and are total effective 85%, cure rate 54%.Treatment group effective percentage cure rate is apparently higher than matched group, and the cure rate effective percentage for the treatment of group 1 is higher than all the other treatment groups 2 and treatment group 3, and treatment group 1 prescription is the most effective in sum.

Claims (2)

1. Chinese medicine composition that is used for the treatment of amenorrhea, it is characterized in that: described medicine is made by the raw material of following weight portion: Eupolyphaga Seu Steleophaga 5-15 part, Radix Paeoniae Rubra 15-25 part, Radix Angelicae Sinensis 15-25 part, Rhizoma Chuanxiong 5-15 part, Flos Carthami 10-20 part, Rhizoma Cyperi 15-25 part, Oletum Trogopterori 10-20 part, Pericarpium Citri Reticulatae Viride 5-15 part, Radix Rehmanniae Preparata 15-25 part, Semen Persicae 5-15 part, Herba Leonuri 25-35 part and Radix Cyathulae 15-25 part.
2. the Chinese medicine composition that is used for the treatment of amenorrhea as claimed in claim 1, it is characterized in that: described raw-material weight part is as follows: 20 parts of 10 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts, Flos Carthami, 20 parts of Rhizoma Cyperis, 15 parts of Oletum Trogopteroris, 10 parts, Pericarpium Citri Reticulatae Viride, 20 parts, Radix Rehmanniae Preparata, 10 parts, Semen Persicae, 30 parts of Herba Leonuris and Radix Cyathulaes.
3. the Chinese medicine composition that is used for the treatment of amenorrhea as claimed in claim 1 or 2, it is characterized in that: described medicine is made following dosage forms: water decoction, unguentum, capsule, tablet, granule, watered pill or honey pill agent.
CN2011103125630A 2011-10-14 2011-10-14 Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof Active CN102343019B (en)

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CN102920813B (en) * 2012-11-06 2014-01-15 李艳 Chinese medicinal formula for treating amenorrhea after subcutaneous embedding
CN104666792A (en) * 2015-02-01 2015-06-03 胡文杰 Traditional Chinese medicine composition for treating endometrial hyperplasia caused by cold coagulation and blood stasis
CN104721316A (en) * 2015-04-15 2015-06-24 刘卓韬 Traditional Chinese medicine composition and acupuncture point combined application for treating amenorrhea

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Assignee: Jiangsu Yichuang Packaging Materials Co.,Ltd.

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Contract record no.: X2023980048413

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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License type: Common License

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Assignee: Nantong Jingxuan Textile Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048319

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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Assignee: Nantong Huanlian Textile Technology Co.,Ltd.

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Contract record no.: X2023980048315

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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Assignee: Nantong Huase Space Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048606

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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Assignee: Nantong Anergu New Material Technology Co.,Ltd.

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Contract record no.: X2023980048605

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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Assignee: Nantong Laiou Electronic Technology Co.,Ltd.

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Contract record no.: X2023980048604

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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License type: Common License

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Assignee: Yitong Intelligent Control Technology (Nantong) Co.,Ltd.

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Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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Assignee: Nantong Ouchen Electronic Technology Co.,Ltd.

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Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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License type: Common License

Record date: 20231129

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Assignee: Nantong Laishang Electronic Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048601

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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License type: Common License

Record date: 20231129

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Assignee: Nantong Lingde Pharmaceutical Equipment Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048600

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Chujie Electronic Equipment Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048597

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Jiaerjie Labor Care Products Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048596

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: JIANGSU KANGFEITE POWER TECHNOLOGY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048594

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Tuoerpu Surveying and Mapping Information Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048583

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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License type: Common License

Record date: 20231128

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Assignee: Nantong TongZhou Jinfeng Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048582

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

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Assignee: Nantong Weiai Home Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048563

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

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Assignee: Nantong Qiju Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048556

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Juguang Trading Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048551

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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License type: Common License

Record date: 20231128

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Assignee: Nantong Chenghui Pharmacy Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048548

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

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License type: Common License

Record date: 20231128

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Assignee: Nantong Tongzhou Kangxintang Drugstore Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048542

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tuanpinhui E-commerce Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048537

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Koushun E-commerce Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048506

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tuoda Machinery Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048494

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Weizhi New Material Technology (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048487

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: NANTONG FEIHAI ELECTRONIC TECHNOLOGY CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048483

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Haoshi new material technology Nantong Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048475

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Steel Machinery Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048466

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: NANTONG YUQI METAL PRODUCTS Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048459

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: NANTONG KYLIN MACHINERY LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048456

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: NANTONG LILIAN MACHINE TOOL MANUFACTURING CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048450

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Yuma Electromechanical Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048446

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Dongdong Steel Structure Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048444

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Huaxin Price Evaluation Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048443

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Yaocheng mechanical equipment manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048440

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Xinxin Pharmaceutical Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048425

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

EE01 Entry into force of recordation of patent licensing contract
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Application publication date: 20120208

Assignee: Nantong Yijialai Woolen Knitting Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049377

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG BEITE PHARMACEUTICAL MACHINERY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049199

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG HAIGUO MACHINERY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049196

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Qiaojiang packaging materials Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049191

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Bairun Catering Management Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049185

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Nongchaoer Food Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048976

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Xingren Tank Farm of Nantong Xinhai Liquefied Gas Service Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048969

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG SHUANGHE FOOD Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048967

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Jiangsu guanan electromechanical Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048961

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Runyuan structural parts Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048952

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Jinbao Machinery Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048947

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Nantong Juntai motor vehicle testing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048942

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Honglei mechanical equipment (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048782

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: American Antelope Home Textile (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048774

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Nantong Ansheng Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048765

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231130

Application publication date: 20120208

Assignee: NANTONG YA TAI CANDLE ARTS & CRAFTS Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048764

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231130

Application publication date: 20120208

Assignee: Nantong Jianwei Metal Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048759

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: JIANGSU YATAI FITNESS CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048748

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

EE01 Entry into force of recordation of patent licensing contract
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: Nantong Zhili Machinery Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049698

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231205

OL01 Intention to license declared
OL01 Intention to license declared
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Application publication date: 20120208

Assignee: JIANGSU HAOHAN INFORMATION TECHNOLOGY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2024980003183

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20240322

EE01 Entry into force of recordation of patent licensing contract