CN103751747A - Traditional Chinese medicine for treating vaginal bleeding after medical abortion - Google Patents
Traditional Chinese medicine for treating vaginal bleeding after medical abortion Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine for treating vaginal bleeding after medical abortion. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 9-15 parts of Panax ginseng, 20-28 parts of Angelica sinensis, 6-12 parts of Ligusticum chuanxiong, 3-9 parts of Semen Persicae, 2-4 parts of dried ginger, 2-4 parts of processed radix glycyrrhizae, 20-28 parts of Agrimonia pilosa, 20-28 parts of lotus rhizome node, 9-15 parts of Hibiscus rosa-sinensis flower, 7-13 parts of Radix Rubiac Cordifoliae, 6-12 parts of Fineleaf Schizonepeta Herb, 7-13 parts of Paeonia suffruticosa bark, 7-13 parts of ass-hide glue, 2-4 parts of Squama manitis, 3-9 parts of parched Vaccaria segetalis, 3-9 parts of Radix Arnebiae, 3-9 parts of Scrophularia ningpoensis, and 2-4 parts of Panax notoginseng powder. According to clinical trial results, the cure rate is 82.0% and the total effective rate is 98.0% in the observation group of the traditional Chinese medicine provided by the invention, which are both significantly higher than the cure rate (62.5%) and the total effective rate (81.3%) in the control group, with significant difference (P<0.05), the vaginal bleeding period is short, and proportion of the complete curettage of uterine cavity is low.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine of medicine colporrhagia due to abortion disease.
Background technology
Drug induced abortion is the remedial measure after contraceptive failure, is the method for current the most frequently used termination of pregnancy.Mifepristone Plus Misoprostol alcohol sheet termination of early pregnancy success rate can reach more than 90%, is current the most frequently used drug induced abortion mode clinically.But exist clinically drug induced abortion postoperative cause hemorrhage many, the defect that the bleeding time is long.This and medicine flow postoperative bad because of uterine contraction, and decidua tissue is discharged not good enough, and blood-stasis internal-depression is relevant.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine of medicine colporrhagia due to abortion disease.
The present invention realizes by following technical scheme:
A Chinese medicine for medicine colporrhagia due to abortion disease, it is to be made by the raw material of Chinese medicine of following weight portion proportioning:
Radix Ginseng 9-15 part, Radix Angelicae Sinensis 20-28 part, Rhizoma Chuanxiong 6-12 part, Semen Persicae 3-9 part, Rhizoma Zingiberis 2-4 part, Radix Glycyrrhizae Preparata 2-4 part, Herba Agrimoniae 20-28 part, Nodus Nelumbinis Rhizomatis 20-28 part, Flos Hibisci Rosae-Sinensis 9-15 part, Radix Rubiae 7-13 part, Herba Schizonepetae charcoal 6-12 part, Cortex Moutan 7-13 part, Colla Corii Asini 7-13 part, Squama Manis 2-4 part, Semen Vaccariae (parched) 3-9 part, Radix Arnebiae (Radix Lithospermi) 3-9 part, Radix Scrophulariae 3-9 part, Radix Notoginseng powder 2-4 part.
Preferably, the Chinese medicine of above-mentioned medicine colporrhagia due to abortion disease, it is to be made by the raw material of Chinese medicine of following weight portion proportioning:
Radix Ginseng 11-13 part, Radix Angelicae Sinensis 22-26 part, Rhizoma Chuanxiong 8-10 part, Semen Persicae 5-7 part, Rhizoma Zingiberis 2.5-3.5 part, Radix Glycyrrhizae Preparata 2.5-3.5 part, Herba Agrimoniae 22-26 part, Nodus Nelumbinis Rhizomatis 22-26 part, Flos Hibisci Rosae-Sinensis 11-13 part, Radix Rubiae 9-11 part, Herba Schizonepetae charcoal 8-10 part, Cortex Moutan 9-11 part, Colla Corii Asini 9-11 part, Squama Manis 2.5-3.5 part, Semen Vaccariae (parched) 5-7 part, Radix Arnebiae (Radix Lithospermi) 5-7 part, Radix Scrophulariae 5-7 part, Radix Notoginseng powder 2.5-3.5 part.
Preferred, the Chinese medicine of above-mentioned medicine colporrhagia due to abortion disease, is characterized in that, it is to be made by the raw material of Chinese medicine of following weight portion proportioning:
12 parts of Radix Ginsengs, 24 parts of Radix Angelicae Sinensis, 9 parts of Rhizoma Chuanxiongs, 6 parts, Semen Persicae, 3 parts of Rhizoma Zingiberiss, 3 parts of Radix Glycyrrhizae Preparatas, 24 parts of Herba Agrimoniaes, 24 parts of Nodus Nelumbinis Rhizomatis, 12 parts of Flos Hibisci Rosae-Sinensis, 10 parts of Radix Rubiae, 9 parts of Herba Schizonepetae charcoals, 10 parts of Cortex Moutans, 10 parts, Colla Corii Asini, 3 parts of Squama Maniss, 6 parts of Semen Vaccariae (parched)s, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Radix Scrophulariaes, 3 parts of Radix Notoginseng powder.
The Chinese medicine of upper medicine colporrhagia due to abortion disease, the dosage form of this Chinese medicine is decoction.
The preparation method of the Chinese medicine of above-mentioned medicine colporrhagia due to abortion disease, step is as follows:
According to above-mentioned weight portion proportioning, take raw material of Chinese medicine, by the Radix Ginseng taking, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae is put into drug-decocting appliance in the lump, again to the drinking water that adds injection volume 3-5 doubly to measure in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use again slow fire instead and decoct 15～20 minutes and stop, elimination medicinal residues, get decoction, again the Colla Corii Asini taking is added to molten in decoction, add Radix Notoginseng powder to stir and get final product.
Chinese medicine of the present invention has benefiting qi and nourishing blood, nourishing YIN and clearing away heat, and the effect of blood stasis dispersing and fresh blood promoting, for commotio retinae colporrhagia disease.
The instructions of taking of decoction of the present invention is as follows:
Every day twice, each serving with 600～800 milliliters; The upper and lower noon respectively once, takes medicine after the meal for two hours; Decoction being taken warmly.
Taboo item: fried sticky, the solid hard cold for the treatment of, period in a medicine taboo edible oil, food nondigestible and excitatory.
By clinical experience for many years, applicant thinks that vaginal bleeding after drug abortion disease is deficiency of both QI and YIN, can not astringency inducing blood due to, treatment is upper should be with the main assistant of QI invigorating nourishing YIN and benefiting blood to stop blooding as method.
In the Chinese medicine of medicine colporrhagia due to abortion disease of the present invention, reuse ginseng and Chinese angelica root strongly invigorating QI and blood, astringency inducing dai channel; Rhizoma Chuanxiong, Semen Persicae, Squama Manis, Semen Vaccariae (parched) blood circulation promoting and blood stasis dispelling, for promoting the intrauterine lochia of commotio retinae to discharge, so that blood stasis dispersing and fresh blood promoting; Rhizoma Zingiberis, Herba Schizonepetae charcoal, the hemostasis of Radix Glycyrrhizae Preparata temperature palace; Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), the hemostasis of Radix Scrophulariae nourishing YIN and clearing away heat; Colla Corii Asini hemostasis is enriched blood; Radix Notoginseng hemostasis is invigorated blood circulation.All medicines share, and play altogether benefiting qi and nourishing blood, nourishing YIN and clearing away heat, the effect of blood stasis dispersing and fresh blood promoting.Chinese medicine of the present invention, both can medicine colporrhagia post-abortion, can also promote intrauterine lochia to discharge simultaneously, accelerated the recovery of commotio retinae women's body constitution.
Decoction of the present invention preparation easily, taking convenience, evident in efficacy, effectively hemorrhage after prevention of miscarriage, infection etc., promote that post-abortion, physical function recovered, to improving women of child-bearing age's healthy reproduction, carrying out of family planning work of propelling has very important effect.Clinical test results shows, observation group's cure rate 82.0% of application Chinese medicine of the present invention, total effective rate 98.0%; All apparently higher than the cure rate 62.5% of matched group, total effective rate 81.3%, difference has significance (P < 0.05), and the vaginal hemorrhage time is short, and clearing heat in the pericardium rate is low.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Radix Ginseng 12g, Radix Angelicae Sinensis 24g, Rhizoma Chuanxiong 9g, Semen Persicae 6g, Rhizoma Zingiberis 3g, Radix Glycyrrhizae Preparata 3g, Herba Agrimoniae 24g, Nodus Nelumbinis Rhizomatis 24g, Flos Hibisci Rosae-Sinensis 12g, Radix Rubiae 10g, Herba Schizonepetae charcoal 9g, Cortex Moutan 10g, Colla Corii Asini 10g, Squama Manis 3g, Semen Vaccariae (parched) 6g, Radix Arnebiae (Radix Lithospermi) 6g, Radix Scrophulariae 6g, Radix Notoginseng powder 3g.
According to above-mentioned weight portion proportioning, take raw material of Chinese medicine, by the Radix Ginseng taking, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae is put into drug-decocting appliance in the lump, again to the drinking water that adds 4 times of amounts of injection volume in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use again slow fire instead and decoct 20 minutes and stop, elimination medicinal residues, get decoction, again the Colla Corii Asini taking is added to molten in decoction, add Radix Notoginseng powder to stir and get final product.
Embodiment 2
Radix Ginseng 11g, Radix Angelicae Sinensis 26g, Rhizoma Chuanxiong 8g, Semen Persicae 7g, Rhizoma Zingiberis 2.5g, Radix Glycyrrhizae Preparata 3.5g, Herba Agrimoniae 22g, Nodus Nelumbinis Rhizomatis 26g, Flos Hibisci Rosae-Sinensis 11g, Radix Rubiae 11g, Herba Schizonepetae charcoal 8g, Cortex Moutan 11g, Colla Corii Asini 9g, Squama Manis 3.5g, Semen Vaccariae (parched) 5g, Radix Arnebiae (Radix Lithospermi) 7g, Radix Scrophulariae 5g, Radix Notoginseng powder 3.5g.
According to above-mentioned weight portion proportioning, take raw material of Chinese medicine, by the Radix Ginseng taking, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae is put into drug-decocting appliance in the lump, again to the drinking water that adds 3 times of amounts of injection volume in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use again slow fire instead and decoct 15 minutes and stop, elimination medicinal residues, get decoction, again the Colla Corii Asini taking is added to molten in decoction, add Radix Notoginseng powder to stir and get final product.
Embodiment 3
Radix Ginseng 13g, Radix Angelicae Sinensis 22g, Rhizoma Chuanxiong 10g, Semen Persicae 5g, Rhizoma Zingiberis 3.5g, Radix Glycyrrhizae Preparata 2.5g, Herba Agrimoniae 26g, Nodus Nelumbinis Rhizomatis 22g, Flos Hibisci Rosae-Sinensis 13g, Radix Rubiae 9g, Herba Schizonepetae charcoal 10g, Cortex Moutan 9g, Colla Corii Asini 11g, Squama Manis 2.5g, Semen Vaccariae (parched) 7g, Radix Arnebiae (Radix Lithospermi) 5g, Radix Scrophulariae 7g, Radix Notoginseng powder 2.5g.
According to above-mentioned weight portion proportioning, take raw material of Chinese medicine, by the Radix Ginseng taking, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae is put into drug-decocting appliance in the lump, again to the drinking water that adds 5 times of amounts of injection volume in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use again slow fire instead and decoct 20 minutes and stop, elimination medicinal residues, get decoction, again the Colla Corii Asini taking is added to molten in decoction, add Radix Notoginseng powder to stir and get final product.
Embodiment 4
Radix Ginseng 9g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 6g, Semen Persicae 3g, Rhizoma Zingiberis 2g, Radix Glycyrrhizae Preparata 2g, Herba Agrimoniae 20g, Nodus Nelumbinis Rhizomatis 20g, Flos Hibisci Rosae-Sinensis 9g, Radix Rubiae 7g, Herba Schizonepetae charcoal 6g, Cortex Moutan 7g, Colla Corii Asini 7g, Squama Manis 2g, Semen Vaccariae (parched) 3g, Radix Arnebiae (Radix Lithospermi) 3g, Radix Scrophulariae 3g, Radix Notoginseng powder 2g.
Preparation method is with embodiment 1.
Embodiment 5
Radix Ginseng 15g, Radix Angelicae Sinensis 28g, Rhizoma Chuanxiong 12g, Semen Persicae 9g, Rhizoma Zingiberis 4g, Radix Glycyrrhizae Preparata 4g, Herba Agrimoniae 28g, Nodus Nelumbinis Rhizomatis 28g, Flos Hibisci Rosae-Sinensis 15g, Radix Rubiae 13g, Herba Schizonepetae charcoal 12g, Cortex Moutan 13g, Colla Corii Asini 13g, Squama Manis 4g, Semen Vaccariae (parched) 9g, Radix Arnebiae (Radix Lithospermi) 9g, Radix Scrophulariae 9g, Radix Notoginseng powder 4g.
Preparation method is with embodiment 1.
The Chinese medicine of the embodiment of the present invention 1 has been carried out to clinical trial, and Details as Follows:
1 data and method
1.1 object of study
Carry out 196 examples of drug induced abortion, the healthy women of reproductive age of menolipsis 49d, age < 40 years old.Through gynecologial examination urinary chorionic gonadotropin (HCG).B ultrasonic turns out to be uterine pregnancy, without drug induced abortion contraindication, is divided into immediately observation group's 100 example and matched group 96 examples.
Every 25mg of 1.2 medicine mifepristones (Hualian Pharmaceutical Co., Ltd., Shanghai's production); every 200 μ g of Misoprostol alcohol sheet (Hualian Pharmaceutical Co., Ltd., Shanghai's production), the Chinese medicine of medicine colporrhagia due to abortion disease prepared by the embodiment of the present invention 1.
Take mifepristone 50mg 1.3 9 of administering mode women gestations treatments mornings on the same day, 9 of evenings takes mifepristone 25mg, 9 of the 2nd day mornings takes mifepristone 25mg, 9 of evenings takes mifepristone 50mg, 7 of the 3rd day mornings takes Misoprostol alcohol sheet 600 μ g.In 3d, before and after taking medicine, 2h on an empty stomach, advises patient to prohibit and take other drug during taking said medicine.The 3rd day mornings 8, Dian Lai hospital was observed, after pregnant capsule is discharged, matched group and observation group all give oxytocin 10U intramuscular injection, observation group's routine gives 5 doses, the Chinese medicine of medicine colporrhagia due to abortion disease prepared by inventive embodiments 1, every day, potion took 5d altogether, sooner or later take for twice every day, each 600-800ml.Matched group gives oral carbazochrome salicylate 5mg every day the inferior 5d that takes medicine altogether.
1.4 curative effect judging standards are cured: hemostasis in the 7d that takes medicine; Effective: the 14d that takes medicine hemostasis; Invalid: the hemorrhage 14d of exceeding or need the clearing heat in the pericardium after taking medicine.Cure and add effectively for effectively total.
2 results
2.1 observation of curative effect group cure rates 82.0%, total effective rate 98.0%; Matched group cure rate 62.5%, total effective rate 81.3%.Two groups of cure rates carry out X 2 test V
2=8.78, P < 0.05; Two groups of total effective rates carry out X 2 test V
2=7.66, P < 0.01, both differences all have significance.In Table 1.
Table 1 liang group curative effect of medication comparison
| Group | Number of cases | Cure (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Observation group | 100 | 82(80.0) | 15(15.0) | 2(3.0) | 98(98.0) |
| Matched group | 96 | 60(62.5) | 18(18.8) | 13(13.5) | 78(81.3) |
2.2 vaginal hemorrhage times and clearing heat in the pericardium rate take medicine 8d have no foetal sac discharge, or after foetal sac is got rid of, hemorrhage more, B ultrasonic confirms that embryo exists or has Slough film residual, carries out uterine curettage, if foetal sac is discharged, but after taking medicine 2 weeks, still have hemorrhagely on a small quantity, B ultrasonic confirms without Hemorrhage, according to clinical setting, continue to observe 1 week, take the circumstances into consideration to use hemorrhage.The observation group vaginal hemorrhage time is shorter than matched group, and difference has significance (P < 0.05); Observation group's clearing heat in the pericardium rate is lower than matched group, but no significant difference (P > 0.05).In Table 2.
Table 2 liang group vaginal hemorrhage time and clearing heat in the pericardium situation comparison
| Group | Number of cases | The vaginal hemorrhage time (d) | Clearing heat in the pericardium example (%) |
| Observation group | 100 | 8.02±2.15 | 2 |
| Matched group | 96 | 10.78±3.05 | 5 |
| T or V 2Value | ? | 4.21 | 0.68 |
| P value | ? | P＜0.05 | P＞0.05 |
Clinical test results shows, observation group's cure rate 82.0% of application Chinese medicine of the present invention, total effective rate 98.0%; All apparently higher than the cure rate 62.5% of matched group, total effective rate 81.3%, difference has significance (P < 0.05), and the vaginal hemorrhage time is short, and clearing heat in the pericardium rate is low.
Claims (5)
1. a Chinese medicine for medicine colporrhagia due to abortion disease, is characterized in that, it is to be made by the raw material of Chinese medicine of following weight portion proportioning:
Radix Ginseng 9-15 part, Radix Angelicae Sinensis 20-28 part, Rhizoma Chuanxiong 6-12 part, Semen Persicae 3-9 part, Rhizoma Zingiberis 2-4 part, Radix Glycyrrhizae Preparata 2-4 part, Herba Agrimoniae 20-28 part, Nodus Nelumbinis Rhizomatis 20-28 part, Flos Hibisci Rosae-Sinensis 9-15 part, Radix Rubiae 7-13 part, Herba Schizonepetae charcoal 6-12 part, Cortex Moutan 7-13 part, Colla Corii Asini 7-13 part, Squama Manis 2-4 part, Semen Vaccariae (parched) 3-9 part, Radix Arnebiae (Radix Lithospermi) 3-9 part, Radix Scrophulariae 3-9 part, Radix Notoginseng powder 2-4 part.
2. the Chinese medicine of medicine colporrhagia due to abortion disease according to claim 1, is characterized in that, it is to be made by the raw material of Chinese medicine of following weight portion proportioning:
Radix Ginseng 11-13 part, Radix Angelicae Sinensis 22-26 part, Rhizoma Chuanxiong 8-10 part, Semen Persicae 5-7 part, Rhizoma Zingiberis 2.5-3.5 part, Radix Glycyrrhizae Preparata 2.5-3.5 part, Herba Agrimoniae 22-26 part, Nodus Nelumbinis Rhizomatis 22-26 part, Flos Hibisci Rosae-Sinensis 11-13 part, Radix Rubiae 9-11 part, Herba Schizonepetae charcoal 8-10 part, Cortex Moutan 9-11 part, Colla Corii Asini 9-11 part, Squama Manis 2.5-3.5 part, Semen Vaccariae (parched) 5-7 part, Radix Arnebiae (Radix Lithospermi) 5-7 part, Radix Scrophulariae 5-7 part, Radix Notoginseng powder 2.5-3.5 part.
3. the Chinese medicine of medicine colporrhagia due to abortion disease according to claim 2, is characterized in that, it is to be made by the raw material of Chinese medicine of following weight portion proportioning:
12 parts of Radix Ginsengs, 24 parts of Radix Angelicae Sinensis, 9 parts of Rhizoma Chuanxiongs, 6 parts, Semen Persicae, 3 parts of Rhizoma Zingiberiss, 3 parts of Radix Glycyrrhizae Preparatas, 24 parts of Herba Agrimoniaes, 24 parts of Nodus Nelumbinis Rhizomatis, 12 parts of Flos Hibisci Rosae-Sinensis, 10 parts of Radix Rubiae, 9 parts of Herba Schizonepetae charcoals, 10 parts of Cortex Moutans, 10 parts, Colla Corii Asini, 3 parts of Squama Maniss, 6 parts of Semen Vaccariae (parched)s, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Radix Scrophulariaes, 3 parts of Radix Notoginseng powder.
4. according to the Chinese medicine of the medicine colporrhagia due to abortion disease described in claim 1 or 2 or 3, it is characterized in that, the dosage form of this Chinese medicine is decoction.
5. the preparation method of the Chinese medicine of the medicine colporrhagia due to abortion disease described in claim 1 or 2 or 3, step is as follows:
According to above-mentioned weight portion proportioning, take raw material of Chinese medicine, by the Radix Ginseng taking, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Nodus Nelumbinis Rhizomatis, Flos Hibisci Rosae-Sinensis, Radix Rubiae, Herba Schizonepetae charcoal, Cortex Moutan, Squama Manis, Semen Vaccariae (parched), Radix Arnebiae (Radix Lithospermi), Radix Scrophulariae is put into drug-decocting appliance in the lump, again to the drinking water that adds injection volume 3-5 doubly to measure in drug-decocting appliance, soak half an hour, make medicine fully moistening, fully fried in order to medicine juice, then boil with high heat and use again slow fire instead and decoct 15～20 minutes and stop, elimination medicinal residues, get decoction, again the Colla Corii Asini taking is added to molten in decoction, add Radix Notoginseng powder to stir and get final product.
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Address after: 250200 Shandong city of Ji'nan province Zhangqiu Mingshui Road No. 1281 Tang maternal and Child Health Hospital of Zhangqiu City Department of gynecology and obstetrics Patentee after: Qu Hongcui Address before: 250200 Shandong city of Ji'nan province Zhangqiu Mingshui Tang Road No. 1281 Zhangqiu young women health hospital of Obstetrics and Gynecology Patentee before: Qu Hongcui |
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