CN102552517A - Gynecological sugar-free gynaecopathia treating particle and preparation method thereof - Google Patents
Gynecological sugar-free gynaecopathia treating particle and preparation method thereof Download PDFInfo
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- CN102552517A CN102552517A CN201110448948XA CN201110448948A CN102552517A CN 102552517 A CN102552517 A CN 102552517A CN 201110448948X A CN201110448948X A CN 201110448948XA CN 201110448948 A CN201110448948 A CN 201110448948A CN 102552517 A CN102552517 A CN 102552517A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicinal sugar-free gynaecopathia treating particle for treating gynaecopathia and a preparation method thereof. The particle is prepared from the following raw and auxiliary materials in parts by weight: 115 parts of prepared rehmannia root, 46 parts of szechuan lovage rhizome, 93 parts of white paeony root, 46 parts of Chinese mugwort leaf, 69 parts of Chinese angelica, 46 parts of liquoric root, 69 parts of donkey-hide gelatin, and non-cane-sugar auxiliary materials consisting of 100-800 parts of a diluent, 0-100 parts of a wetting agent, 0-50 parts of a bonding agent and 0-10 parts of a flavoring agent. The preparation method comprises the following steps of: extracting volatile oil from Chinese angelica, Chinese mugwort leaf and szechuan lovage rhizome, adding water into decoction dregs, white paeony root, prepared rehmannia root and liquoric root for decocting twice for 3 hours in a first time and 2 hours in a second time, combining decoctions, standing for 18-24 hours, and filtering to obtain an extract; and smashing the donkey-hide gelatin, adding donkey-hide gelatin powder and non-cane-sugar auxiliary material powder into the extract, preparing into particles, drying and spraying volatile oil. The particle is a sugar-free preparation, and is suitable for people suffering from diabetes and other people with no sugar requirements; and the using amount of the auxiliary materials is lowered remarkably.
Description
Technical field
The invention belongs to the technical field of pharmaceuticals of treatment gynaecopathia, be specifically related to a kind of Chinese medicine Sugarless type FUKANG nourishing granules of treating gynaecopathia and preparation method thereof.
Background technology
Present dysmenorrhea; In the early stage pregnant drug induced abortion of being pregnent, artificial abortion, cuing open the palace, to produce the vaginal hemorrhage that causes be commonly encountered diseases, the frequently-occurring disease of young women, serious modern female, the physical and mental health that is endangering vast young women of perplexing; Doctor trained in Western medicine is many at present with treatment dysmenorrheas such as ibuprofen, treatment vaginal hemorrhage methylnaphthohydroquinone added with antibiotic commonly used; But all side effect is big, and therapeutic effect is unequal to obviously, unsuitable conventional the use.Motherland's medical science thinks that the women is this with blood; Women all one's life through, pregnant, produce, the physiological characteristics of breast is all relevant with blood; All are processes of blood trouble hematozemia; Women's warp, band, bitterly, to leak all diseases also relevant with blood, the precious prescription of FUKANG effectively embodied invigorates blood circulation and enriches blood, nourishing the liver with the kidney invigorating, treat and nurse one's health the characteristics that combine.The FUKANG treasured can tonifying blood and regulating menstruation, again can arresting bleeding and miscarriage prevention, can be widely used in severe loss of blood, shallow complexion, menoxenia, cold and pain in the lower abdomen, vaginal bleeding during pregnancy fetal movement, anal fistula hematochezia in clinical.
The FUKANG treasured comes from the Han dynasty and cures " golden plaque outline " rhizome of chuanxiong of holy Zhang Zhongjing and return Ass-hide Glue and Argyi Leaf Decoction; But existing 'Fukangbao ' all contains sugar; Very big clinical use limitation is arranged, especially for diabetes patient, obese patient and the Ms that likes to be beautiful who dislikes absorbing too much sugar significant limitation is arranged.
In addition, existing 'Fukangbao ' all contains sugar and sugar content is very high, needs to use a large amount of adjuvants, the resource of waste adjuvant.
Summary of the invention
The objective of the invention is in order to solve the problem of above-mentioned existence, and provide a kind of for any crowd's thing clinical use circumscribed Sugarless type FUKANG nourishing granules and method for preparing.
In order to realize this purpose; Gynecological provided by the invention Sugarless type FUKANG nourishing granules; The granule that it is processed by the supplementary material of following weight proportioning: 115 parts of Radix Rehmanniae Preparata, 46 parts of Rhizoma Chuanxiongs, 93 parts of the Radix Paeoniae Albas, 46 parts of Folium Artemisiae Argyis, 69 parts of Radix Angelicae Sinensis, 46 parts in Radix Glycyrrhizae, 69 parts in Colla Corii Asini, and by 100～800 parts of diluent, 0～100 part of wetting agent, 0～50 part of adhesive, 0～10 part of non-sucrose adjuvant of forming of correctives; Said diluent is a kind of adjuvant or the compositions of more than one adjuvants in dextrin, lactose, soluble starch, mannitol, the sorbitol; Said wetting agent is an ethanol; Said adhesive is a kind of adjuvant or the compositions of more than one adjuvants in starch slurry, methylcellulose, carboxymethyl cellulose, the hydroxypropyl cellulose; Said correctives is a kind of adjuvant or the compositions of more than one adjuvants in cyclamate, stevioside, aspartame, xylitol, Sorbitol, the acesulfame potassium.
Preferably, diluent described in the technique scheme is that dextrin, lactose, soluble starch are the compositions of adjuvant; Said wetting agent is that concentration is 75%～95% ethanol; Said adhesive is the compositions of starch slurry and carboxymethyl cellulose; Said correctives is the compositions of stevioside and aspartame.
The method for preparing of gynecological provided by the invention Sugarless type FUKANG nourishing granules may further comprise the steps:
1., Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong extract volatile oil;
2., will extract medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decocte with water secondary behind the volatile oil, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 18～24 hours, and filtered, filtrating is condensed into the extractum that relative density is 1.20～1.40 (30 ℃～60 ℃);
3., Colla Corii Asini is pulverized, in extractum, add Colla Corii Asini powder and non-sucrose adjuvant fine powder after pulverizing, process granule, drying sprays into volatile oil;
4., the granule mixing that makes, be distributed into bag.
Preferably, the step in the technique scheme 2. in, the relative density of concentrated extract is 1.25～1.35 (30 ℃～60 ℃).
Preferably, the step in the technique scheme 3. in, drying is under temperature is 60 ℃～90 ℃ condition, to carry out;
Preferably, the step in the technique scheme 3. in, contain moisture less than 6.0% behind the particle drying of processing.
Preferably, the step in the technique scheme 4. in, the net content of packing granule is 3～9 gram/bags or 3～9 gram/bottles.
Gynecological of the present invention Sugarless type FUKANG nourishing granules according to its component analysis, belongs to Chinese patent medicine, natural drug; Prescription reasonable recipe, science, no incompatibility, avirulence medical material, the high strong medical material of no flavour of a drug in the prescription; No eighteen imcompatible pairs, nineteen medicaments of mutual restraint, safe, prescription will invigorate blood circulation with enrich blood, nourishing the liver combines with conditioning with the kidney invigorating, treatment; Can tonifying blood and regulating menstruation, again can arresting bleeding and miscarriage prevention, and applicable to the diabetes patient and the vast Ms of liking to be beautiful who dislikes taking too many sugar; Significantly reduce supplementary product consumption, economize on resources.
Can be widely used in severe loss of blood, shallow complexion, menoxenia in clinical; Cold and pain in the lower abdomen, vaginal bleeding during pregnancy fetal movement, anal fistula hematochezia; Its pharmacological action: the Han dynasty is cured " golden plaque outline " rhizome of chuanxiong of holy Zhang Zhongjing and is returned Ass-hide Glue and Argyi Leaf Decoction, and rhizome of chuanxiong returns Ass-hide Glue and Argyi Leaf Decoction to add Colla Corii Asini, Folium Artemisiae Argyi, Radix Glycyrrhizae by SIWU TANG to form Colla Corii Asini nourishing blood hemostasis in the side; The Folium Artemisiae Argyi warming the meridian for stopping bleeding, it is antiabortive that the two share regulating menstruation, for controlling the key medicine that collapses leak-stopping; Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Alba nourshing blood and promoting blood circulation, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines share, and get final product nourishing blood and hemoslasis, and are again can regulating menstruation antiabortive.The modern pharmacology pharmacodynamic study shows that medicine of the present invention can obviously reduce metrorrhagia amount and persistent period behind the pregnant drug induced abortion of being pregnent of early metaphase, can promote decidua to strip off discharge, and can improve the menstruation compound tides behind the drug induced abortion.Can improve behind the cesarean section puerpera's body void symptom of losing blood, reduce the vaginal hemorrhage amount, improve hemoglobin content and RBC level, help improving puerpera's body constitution, enhancing human body immunity power.
The medicine that will make according to prescription of the present invention and method for preparing is used for severe loss of blood, shallow complexion, and menoxenia, cold and pain in the lower abdomen, the vaginal bleeding during pregnancy fetal movement, the clinical trial of anal fistula hematochezia disease, therapeutic effect is good:
1, the medicine that makes according to prescription of the present invention and method for preparing is used to treat the clinical trial of dysmenorrhea:
Drug therapy primary dysmenorrhea 45 examples that Suzhou City hospital uses prescription of the present invention and method for preparing to make, and compare with 41 examples of previous employing ibuprofen treatment: cured substance rate 66.7% of the present invention as a result, total effective rate 95.6%; Ibuprofen cure rate 48.87%, total effective rate 75.6%; Both differences have significance (P＜0.01), and it is better to show that the present invention treats the dysmenorrhea curative effect.
2, the medicine that makes according to prescription of the present invention and method for preparing is used to treat the clinical trial of colporrhagia due to abortion:
Henan Province hospital adopts Drug therapy oral drugs colporrhagia due to abortion 60 examples of the present invention, and clinical observation shows: the bleeding time obviously shortens, treatment recovery from illness 39 examples; Produce effects 11 examples, effective 5 examples, invalid 5 examples; Cure-remarkable-effectiveness rate is 83.3%, and total effective rate is 91.7%, and therapeutic effect is good.
Zhejiang Province healthcare hospital for women & children uses hemorrhage 40 examples of Drug therapy drug flow postpartum vaginal of invention, and clinical observation shows: Drug therapy drug flow postpartum vaginal of the present invention is hemorrhage, and the overall bleeding time obviously shortens; Treatment recovery from illness 18 examples, produce effects 15 examples, effective 5 examples; Invalid 2 examples; Cure-remarkable-effectiveness rate is 87.5%, and total effective rate is 95%, and therapeutic effect is good.
3, the medicine that makes according to prescription of the present invention and method for preparing is used for the clinical trial of vaginal bleeding during pregnancy fetal movement:
Chongqing City hospital has chosen 10 routine patients' vaginal bleeding during pregnancy fetal movement patient, and the patient is at pregnancy duration, and the soreness of waist is suffered from abdominal pain, or sagging distention in the smaller abdomen; Or, adopt clinical observation after the Drug therapy of the present invention with a small amount of colporrhagia person, and can not only stop blooding, alleviate clinical symptoms such as stomachache, the soreness of waist; Wherein treat recovery from illness 5 examples, produce effects 2 examples, effective 2 examples, invalid 1 example; Cure-remarkable-effectiveness rate is 70%, and total effective rate is 90%, and therapeutic effect is good.
The specific embodiment
Below in conjunction with embodiment the present invention is done further detailed description, be convenient to be well understood to the present invention, but they do not constitute qualification to the present invention.
Embodiment one:
Gynecological's Sugarless type FUKANG nourishing granules is prepared into by Radix Rehmanniae Preparata 115g, Rhizoma Chuanxiong 46g, Radix Paeoniae Alba 93g, Folium Artemisiae Argyi 46g, Radix Angelicae Sinensis 69g, Radix Glycyrrhizae 46g, Colla Corii Asini 69g, dextrin 200 grams, lactose 160 grams, dextrin 200 grams, lactose 160 grams, steviosin 0.3 gram.
The method for preparing that it is concrete: Radix Angelicae Sinensis 69g, Folium Artemisiae Argyi 93g, Rhizoma Chuanxiong 46g extracting in water volatile oil; Medicinal residues and Radix Paeoniae Alba 93g, Radix Rehmanniae Preparata 115g, Radix Glycyrrhizae 46g decocte with water twice, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 18 hours, and filtered, it is 1.20 extractum that filtrating is condensed in the time of 60 ℃ relative density.Colla Corii Asini 69g pulverizes, and adds the Colla Corii Asini powder pulverized and dextrin 200 grams, lactose 160 grams, steviosin 0.3 gram in the extractum, processes granule, and drying is put coldly, sprays into the volatile oil of said extracted, mixing, and being distributed into net content is 3 gram/bags, promptly gets.
Embodiment two:
Gynecological's Sugarless type FUKANG nourishing granules is to be prepared into by Radix Rehmanniae Preparata 115g, Rhizoma Chuanxiong 46g, Radix Paeoniae Alba 93g, Folium Artemisiae Argyi 46g, Radix Angelicae Sinensis 69g, Radix Glycyrrhizae 46g, Colla Corii Asini 69g, dextrin 200 grams, mannitol 200 grams, steviosin 0.3 gram.
The method for preparing that it is concrete: Radix Angelicae Sinensis 69g, Folium Artemisiae Argyi 93g, Rhizoma Chuanxiong 46g extracting in water volatile oil; Medicinal residues and Radix Paeoniae Alba 93g, Radix Rehmanniae Preparata 115g, Radix Glycyrrhizae 46g decocte with water twice, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 21 hours, and filtered, it is 1.35 extractum that filtrating is condensed in the time of 45 ℃ relative density.Colla Corii Asini 69g pulverizes, and adds the Colla Corii Asini powder pulverized and dextrin 200 grams, mannitol 200 grams, steviosin 0.3 gram in the extractum, processes granule, and drying is put coldly, sprays into the volatile oil of said extracted, mixing, and being distributed into net content is 6 gram/bags, promptly gets.
Embodiment three:
Gynecological's Sugarless type FUKANG nourishing granules is to be prepared into by Radix Rehmanniae Preparata 115g, Rhizoma Chuanxiong 46g, Radix Paeoniae Alba 93g, Folium Artemisiae Argyi 46g, Radix Angelicae Sinensis 69g, Radix Glycyrrhizae 46g, Colla Corii Asini 69g, dextrin 600 grams, aspartame 0.3 gram.
The method for preparing that it is concrete: Radix Angelicae Sinensis 69g, Folium Artemisiae Argyi 93g, Rhizoma Chuanxiong 46g extracting in water volatile oil; Medicinal residues and Radix Paeoniae Alba 93g, Radix Rehmanniae Preparata 115g, Radix Glycyrrhizae 46g decocte with water twice, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 18～24 hours, and filtered, it is 1.40 extractum that filtrating is condensed in the time of 60 ℃ relative density.Colla Corii Asini 69g pulverizes, and adds the Colla Corii Asini powder pulverized and dextrin 600 grams, aspartame 0.3 gram in the extractum, processes granule, and drying is put coldly, sprays into the volatile oil of said extracted, mixing, and being distributed into net content is 9 gram/bags, promptly gets.
Embodiment four:
Gynecological's Sugarless type FUKANG nourishing granules is to be prepared into by Radix Rehmanniae Preparata 115g, Rhizoma Chuanxiong 46g, Radix Paeoniae Alba 93g, Folium Artemisiae Argyi 46g, Radix Angelicae Sinensis 69g, Radix Glycyrrhizae 46g, Colla Corii Asini 69g, lactose 200 grams, mannitol 200 grams, saccharin sodium 0.3 gram.
The method for preparing that it is concrete: Radix Angelicae Sinensis 69g, Folium Artemisiae Argyi 93g, Rhizoma Chuanxiong 46g extracting in water volatile oil; Medicinal residues and Radix Paeoniae Alba 93g, Radix Rehmanniae Preparata 115g, Radix Glycyrrhizae 46g decocte with water twice, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 20 hours, and filtered, it is 1.25 extractum that filtrating is condensed into 40 ℃ of relative densities.Colla Corii Asini 69g pulverizes, and adds the Colla Corii Asini powder pulverized and lactose 200 grams, mannitol 200 grams, saccharin sodium 0.3 gram in the extractum, processes granule, and drying is put coldly, sprays into the volatile oil of said extracted, mixing, and being distributed into net content is 8 gram/bags, promptly gets.
Embodiment five:
Gynecological's Sugarless type FUKANG nourishing granules is to be prepared into by Radix Rehmanniae Preparata 115g, Rhizoma Chuanxiong 46g, Radix Paeoniae Alba 93g, Folium Artemisiae Argyi 46g, Radix Angelicae Sinensis 69g, Radix Glycyrrhizae 46g, Colla Corii Asini 69g, dextrin 200 grams, soluble starch 300 grams, mannitol 200 grams, xylitol 3 grams.
The method for preparing that it is concrete: Radix Angelicae Sinensis 69g, Folium Artemisiae Argyi 93g, Rhizoma Chuanxiong 46g extracting in water volatile oil; Medicinal residues and Radix Paeoniae Alba 93g, Radix Rehmanniae Preparata 115g, Radix Glycyrrhizae 46g decocte with water twice, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 18 hours, and filtered, it is 1.25 extractum that filtrating is condensed in the time of 50 ℃ relative density.Colla Corii Asini 69g pulverizes, and adds the Colla Corii Asini powder pulverized and dextrin 200 grams, soluble starch 300 grams, mannitol 200 grams, xylitol 3 grams in the extractum, processes granule, and drying is put coldly, sprays into the volatile oil of said extracted, mixing, and being distributed into net content is 9 gram/bags, promptly gets.
Embodiment six:
Gynecological's Sugarless type FUKANG nourishing granules is to be prepared into by Radix Rehmanniae Preparata 115g, Rhizoma Chuanxiong 46g, Radix Paeoniae Alba 93g, Folium Artemisiae Argyi 46g, Radix Angelicae Sinensis 69g, Radix Glycyrrhizae 46g, Colla Corii Asini 69g, soluble starch 200 grams, mannitol 200 grams, lactose 160 grams, Sorbitol 1.0 grams.
The method for preparing that it is concrete: Radix Angelicae Sinensis 69g, Folium Artemisiae Argyi 93g, Rhizoma Chuanxiong 46g extracting in water volatile oil; Medicinal residues and Radix Paeoniae Alba 93g, Radix Rehmanniae Preparata 115g, Radix Glycyrrhizae 46g decocte with water twice, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 19 hours, and filtered, it is 1.30 extractum that filtrating is condensed in the time of 55 ℃ relative density.Colla Corii Asini 69g pulverizes, and Colla Corii Asini powder that adding is pulverized in the extractum and soluble starch 200 grams, mannitol 200 grams, lactose 160 grams, Sorbitol 1.0 restrain, and process granule; Drying is put coldly, sprays into the volatile oil of said extracted; Mixing, being distributed into net content is 6 gram/bags, promptly gets.
The content of not doing in this description to describe in detail belongs to this area professional and technical personnel's known prior art.
Claims (7)
1. gynecological's Sugarless type FUKANG nourishing granules; It is characterized in that the granule that it is processed by the supplementary material of following weight proportioning: 115 parts of Radix Rehmanniae Preparata, 46 parts of Rhizoma Chuanxiongs, 93 parts of the Radix Paeoniae Albas, 46 parts of Folium Artemisiae Argyis, 69 parts of Radix Angelicae Sinensis, 46 parts in Radix Glycyrrhizae, 69 parts in Colla Corii Asini, and by 100～800 parts of diluent, 0～100 part of wetting agent, 0～50 part of adhesive, 0～10 part of non-sucrose adjuvant of forming of correctives; Said diluent is a kind of adjuvant or the compositions of more than one adjuvants in dextrin, lactose, soluble starch, mannitol, the sorbitol; Said wetting agent is an ethanol; Said adhesive is a kind of adjuvant or the compositions of more than one adjuvants in starch slurry, methylcellulose, carboxymethyl cellulose, the hydroxypropyl cellulose; Said correctives is a kind of adjuvant or the compositions of more than one adjuvants in cyclamate, stevioside, aspartame, xylitol, Sorbitol, the acesulfame potassium.
2. gynecological according to claim 1 Sugarless type FUKANG nourishing granules is characterized in that: said diluent is that dextrin, lactose, soluble starch are the compositions of adjuvant; Said wetting agent is that concentration is 75%～95% ethanol; Said adhesive is the compositions of starch slurry and carboxymethyl cellulose; Said correctives is the compositions of stevioside and aspartame.
3. the method for preparing of claim 1 or 2 said gynecological Sugarless type FUKANG nourishing granules is characterized in that may further comprise the steps:
1., Radix Angelicae Sinensis, Folium Artemisiae Argyi, Rhizoma Chuanxiong extract volatile oil;
2., will extract medicinal residues and the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae decocte with water secondary behind the volatile oil, 3 hours for the first time, 2 hours for the second time; Collecting decoction; Left standstill 18～24 hours, and filtered, filtrating is condensed into the extractum that relative density is 1.20～1.40 (30 ℃～60 ℃);
3., Colla Corii Asini is pulverized, in extractum, add Colla Corii Asini powder and non-sucrose adjuvant fine powder after pulverizing, process granule, drying sprays into volatile oil;
4., the granule mixing that makes, be distributed into bag.
4. according to the method for preparing of the said gynecological of claim 3 Sugarless type FUKANG nourishing granules, it is characterized in that, step 2. in, the relative density of concentrated extract is 1.25～1.35 (30 ℃～60 ℃).
5. according to the method for preparing of the said gynecological of claim 3 Sugarless type FUKANG nourishing granules, it is characterized in that, step 3. in, drying is under temperature is 60 ℃～90 ℃ condition, to carry out.
6. according to the method for preparing of the said gynecological of claim 3 Sugarless type FUKANG nourishing granules, it is characterized in that, step 3. in, contain moisture less than 6.0% behind the particle drying of processing.
7. according to the method for preparing of the said gynecological of claim 3 Sugarless type FUKANG nourishing granules, it is characterized in that, step 4. in, the net content of packing granule is 3～9 gram/bags or 3～9 gram/bottles.
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Application publication date: 20120711 |