CN1616116A - Water gel wound dressing containing radiation sensitive agent and preparing method - Google Patents
Water gel wound dressing containing radiation sensitive agent and preparing method Download PDFInfo
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- CN1616116A CN1616116A CN 200410066999 CN200410066999A CN1616116A CN 1616116 A CN1616116 A CN 1616116A CN 200410066999 CN200410066999 CN 200410066999 CN 200410066999 A CN200410066999 A CN 200410066999A CN 1616116 A CN1616116 A CN 1616116A
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Abstract
The aquogel wound dressing containing radiosensitizer has aquogel comprising PVP, PVA, radiosensitizer, plasticizer, pH regulator, water, etc. The components of PVP, PVA, radiosensitizer, plasticizer and pH regulator are dissolved in water to prepare polymer aqua; the aqua is defoamed, poured onto non-woven fabric, frozen to cure and covered with stripping paper; and through cutting, radiating with Co-60 light source in the dosage of 15-65 kGy for chemical reaction and sterilization, the aquogel wound dressing is prepared. The aquogel wound dressing consists of three layers, including aquogel, non-woven fabric and stripping paper. It is suitable for use in protecting and treating wound of burns, scalds, ulcer, cutting, etc.
Description
Technical field
The present invention relates to wound dressing, especially relate to a kind of hydrogel wound dressing that contains radiation sensitive agent, relate to the preparation method of the suitability for industrialized production operation of this wound dressing.
Technical background
Wound dressing has had very big development in nearly decades, many new pattern compress occurred, particularly is that the wound dressing of key component more and more is subject to people's attention with the biological medical polymer material.This class new pattern compress has various ways: film type, foam type, glue build, aquogel type (pasty state or membrane-like), alginate type etc.These products have their own characteristics each, and are applicable to one or more wounds such as scald, burn, chemistry erosion wound, all kinds of ulcer wound, scuffing, incised wound, tearing are hindered, operation wound respectively.
The wound dressing of membrane-like aquogel type is wherein a kind of special wound dressing, and it almost collects the various performances of desirable dressing, as: can control and absorb exudate; Ventilative, saturating wet; Can stop the antibacterial intrusion; Have good compliance, can cosily be attached at wound surface; But carrier, release medicine; Tissue and blood compatibility; Take off and try to please easily adhesion, not desquamation; Have favorable mechanical performance and suitable mechanical strength.It mainly is made up of macromolecular material and water, method by physics or chemistry, make macromolecule produce intramolecularly or intermolecular interlinkage, make hydrogel keep certain shape, purpose is when being used for wound surface, can absorb the transudate of wound surface, and easily take off, without debridement, can not stay the macromolecule residue on the face hindering, avoided wound alienation or the keratinization that causes thus or the reaction that is inflamed.
The current method for preparing hydrogel wound dressing mainly is to carry out physical crosslinking by refrigerated method repeatedly, this method generally to carry out 3-5 time freezing repeatedly, require refrigerated minimum temperature to reach-20 ℃ simultaneously, not only its process is loaded down with trivial details, and also very high to the requirement of equipment.Also have and to carry out irradiation by electron beam or cobalt 60 source and carry out chemical crosslinking, but current approach all is that dissolved macromolecular solution is directly carried out irradiation, this product unit of will seeking survival must have irradiation apparatus, but difficulty is very set up in the application of this equipment, therefore is unfavorable for the industrialization production of technology.And our employing increases freezing equipment in the process of filming, and makes product solidified forming rapidly, is beneficial to serialization production subsequently.Owing to added radiation sensitive agent, can produce better irradiation effect when making product irradiation simultaneously.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of hydrogel wound dressing that contains radiation sensitive agent is provided.The radiation sensitive agent that contains in the wound dressing also can produce and Mulberry Extract under low irradiation bomb intensity fast, and trigger molecule generation interlinkage reaches ideal irradiation effect.
The purpose of this invention is achieved through the following technical solutions: a kind of hydrogel wound dressing, it is made up of for these three layers hydrogel, non-woven fabrics and release paper, it is characterized in that hydrogel is that 1～30% polyvinyl pyrrolidone, 6～20% polyvinyl alcohol, 1～10% radiation sensitive agent, 1～5% plasticizer, 1～3%pH regulator and 60～85% water are formed by mass percent mainly.Further, described radiation sensitive agent mainly is made up of one or more of materials such as hyaluronic acid, cellulose and derivant thereof, Aloe extract, sodium alginate, fibroin albumen, spirulina, gelatin, collagen protein.Further, described plasticizer is glycerol, Polyethylene Glycol or polypropylene glycol.Further, described pH regulator agent is sodium dihydrogen phosphate or triethanolamine.
The present invention also aims to provide a kind of preparation method that contains the hydrogel wound dressing of radiation sensitive agent.Owing to added radiation sensitive agent, product can carry out continuous operation production better, and sterilization and molecule interlinkage are finished synchronously.By intermediary freezing solidified process operation can be carried out continuously, and needn't oneself have irradiation bomb, also can carry out the suitability for industrialized production operation of product.
This goal of the invention is achieved through the following technical solutions: a kind of preparation method of hydrogel wound dressing, it is characterized in that, and be divided into following step:
(1) polyvinyl alcohol is dissolved in 90～100 ℃ the water, after the dissolving, is cooled to 50～70 ℃ fully;
(2) polyvinylpyrrolidone, radiation sensitive agent, plasticizer, pH regulator agent are dissolved in above-mentioned solution respectively, make the macromolecule aqueous solution;
(3) after the deaeration, on the film applicator macromolecule aqueous solution is being cast on the non-woven fabrics, freezing curing molding is gone up release paper again, the cutting encapsulation;
(4) use co-60 radiation.
The present invention has following technique effect: the radiation sensitive agent that wound dressing of the present invention contains, not only can make irradiation dose be issued to comparatively ideal irradiation effect in lower situation, and these radiation sensitive agents are that natural macromolecular material has good biocompatibility, can not produce harmful effect and have the wound healing of promotion, hemostasis, convergence wound and antibacterial action skin; Be applicable to the protection and the treatment of wound surface such as burn, scald, all kinds of ulcer wound, tearing wound, incised wound, play accelerated in wounds healing, reduce the effects such as formation of cicatrix.The preparation method of wound dressing of the present invention adopts refrigerated technology, and technical process is oversimplified, and saves cost, and is suitable for the serialization production operation of product.
The specific embodiment
Example 1 is dissolved in the 24g polyvinyl alcohol in the hot water of 95 ℃ of 188g, fully after the dissolving, and cooling solution to 60 ℃, add 180g polyvinylpyrrolidone, 4g sodium carboxymethyl cellulose, 4g Polyethylene Glycol respectively, the triethanolamine solution of 4g1%, fully dissolving stirs, vacuumizing and defoaming after the deaeration, is being cast in the macromolecule aqueous solution on the non-woven fabrics on the film applicator, freezing curing molding, go up release paper again, the cutting encapsulation is with cobalt 60 irradiation, dosage is 35kGy, the degree of cross linking 32% of product.
Example 2 is dissolved in the 160g polyvinyl alcohol in the hot water of 90 ℃ of 212g, fully after the dissolving, and cooling solution to 50 ℃, add 4g polyvinylpyrrolidone, 8g solid Aloe extract, 8g glycerol respectively, 1% sodium dihydrogen phosphate 8g stirs and fully dissolves vacuumizing and defoaming, after the deaeration, on the film applicator macromolecule aqueous solution is being cast on the non-woven fabrics, freezing curing molding is gone up release paper again, the cutting encapsulation, with cobalt 60 irradiation, dosage is 30kGy, the degree of cross linking 45% of product.
Example 3 is dissolved in the 32g polyvinyl alcohol in the hot water of 100 ℃ of 280g, fully after the dissolving, and cooling solution to 70 ℃, add 16g polyvinylpyrrolidone, 40g sodium alginate, 20g glycerol respectively, the sodium dihydrogen phosphate of 12g1% stirs, and fully dissolving stirs, vacuumizing and defoaming after the deaeration, is being cast in the macromolecule aqueous solution on the non-woven fabrics on the film applicator, freezing curing molding, go up release paper again, the cutting encapsulation is with cobalt 60 irradiation, dosage is 35kGy, the degree of cross linking 42% of product.
Example 4 is dissolved in the 32g polyvinyl alcohol in the hot water of 90 ℃ of 316g, fully after the dissolving, and cooling solution to 70 ℃, add 16g polyvinylpyrrolidone, 16g collagen protein, 4g hyaluronic acid respectively, 12g glycerol, the sodium dihydrogen phosphate of 4g1%, stir and fully dissolve, vacuumizing and defoaming is after the deaeration, on the film applicator macromolecule aqueous solution is being cast on the non-woven fabrics, freezing curing molding is gone up release paper again, the cutting encapsulation, with cobalt 60 irradiation, dosage is 30kGy, the degree of cross linking 26% of product.
Example 5 is dissolved in the 48g polyvinyl alcohol in the hot water of about 100 ℃ of 320g, fully after the dissolving, and cooling solution to 50 ℃, add 12g polyvinylpyrrolidone, 8g spirulina, 4g hyaluronic acid, 4g polypropylene glycol respectively, the triethanolamine solution of 4g1%, fully dissolving stirs, vacuumizing and defoaming after the deaeration, is being cast in the macromolecule aqueous solution on the non-woven fabrics on the film applicator, freezing curing molding, go up release paper again, the cutting encapsulation is with cobalt 60 irradiation, dosage is 35kGy, the degree of cross linking 34% of product.
In above-mentioned enforcement, wherein used radiation sensitive agent can also be fibroin albumen, gelatin.
The foregoing description is used for the present invention that explains, rather than limits the invention, and in the protection domain of spirit of the present invention and claim, any modification and change to the present invention makes all fall into protection scope of the present invention.
Claims (5)
1. hydrogel wound dressing, it is made up of for these three layers hydrogel, non-woven fabrics and release paper, it is characterized in that hydrogel is that 1～30% polyvinyl pyrrolidone, 6～20% polyvinyl alcohol, 1～10% radiation sensitive agent, 1～5% plasticizer, 1～3%pH regulator and 60～85% water are formed by mass percent mainly.
2. hydrogel wound dressing according to claim 1, it is characterized in that described radiation sensitive agent mainly is made up of one or more of materials such as hyaluronic acid, cellulose and derivant thereof, Aloe extract, sodium alginate, fibroin albumen, spirulina, gelatin, collagen protein.
3. hydrogel wound dressing according to claim 1 is characterized in that, described plasticizer can be glycerol, Polyethylene Glycol, polypropylene glycol etc.
4. hydrogel wound dressing according to claim 1 is characterized in that, described pH regulator agent can be sodium dihydrogen phosphate, triethanolamine etc.
5. the preparation method of the described hydrogel wound dressing of claim 1 is characterized in that, is divided into following step:
(1) polyvinyl alcohol is dissolved in 90～100 ℃ the water, after the dissolving, is cooled to 50～70 ℃ fully;
(2) polyvinylpyrrolidone, radiation sensitive agent, plasticizer, pH regulator agent are dissolved in above-mentioned solution respectively, make the macromolecule aqueous solution;
(3) after the deaeration, on the film applicator macromolecule aqueous solution is being cast on the non-woven fabrics, freezing curing molding is gone up release paper again, the cutting encapsulation;
(4) use co-60 radiation.
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| CN 200410066999 CN1616116A (en) | 2004-09-29 | 2004-09-29 | Water gel wound dressing containing radiation sensitive agent and preparing method |
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| CN 200410066999 CN1616116A (en) | 2004-09-29 | 2004-09-29 | Water gel wound dressing containing radiation sensitive agent and preparing method |
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| CN100423786C (en) * | 2006-11-30 | 2008-10-08 | 华南理工大学 | Acyclovir polymer hydrogel dressing and preparation method thereof |
| CN100488572C (en) * | 2006-11-30 | 2009-05-20 | 华南理工大学 | Sulfadiazine salt high-molecular hydrogel dressing and its preparation method |
| CN101053668B (en) * | 2007-05-18 | 2010-05-19 | 河南省科学院同位素研究所有限责任公司 | Nanometer calamine compositing hydrogel wound dressing and its preparation method |
| CN102099060A (en) * | 2008-04-24 | 2011-06-15 | 麦德托尼克公司 | Cold ionizing radiation sterilization |
| CN101554489B (en) * | 2009-05-21 | 2012-08-29 | 西北大学 | Method for preparing blood vessel inner layer scaffold material used for biodegradable tissue engineering |
| CN103495199A (en) * | 2013-10-08 | 2014-01-08 | 山东赛克赛斯药业科技有限公司 | Hydrogel wound dressing for treating laser cauma and burns and scalds as well as preparation method thereof |
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