CN107789658A - A kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing - Google Patents
A kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
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- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
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- C08J2429/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2429/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2429/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2439/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
- C08J2439/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
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Abstract
The present invention is a kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing, more particularly to electron beam irradiation Chemical Engineering Technology.Dressing is made up of basalis, substrate layer, functional layer, mould release membrance, is close to successively；Substrate layer is polyvinyl alcohol, PVP, gelatin, deionized water are mixed to form the hydrogel that dope is formed through crosslinking electron beam irradiation that can shape；Functional layer is made up of addition low molecular chondroitin sulfate and low molecular weight hyaluronic acid in substrate layer hydrogel；This kind of pure physical means using electron beam irradiation, high molecular crosslink and product sterilizing are synchronously realized, avoid the preparation residual and chemical waste liquid emission problem of chemical crosslink technique, and the pollution problem of ethylene oxide sterilizing；The low molecular chondroitin sulfate and low molecular weight hyaluronic acid of high cost are only used in the thin functional layer in surface, reduce material cost.
Description
Technical field
The present invention relates to the technical field that composite high-molecular material prepares aerogel dressing, more particularly to electron beam irradiation
Work technology.
Background technology
In recent years, the application of hydrogel is increasingly extensive, it is unique the advantages of make it be similarly subjected to pay attention in medical and beauty treatment fields,
New product and its use range are continuously increased.It is obvious as the dry dressing defect of representative using gauze, including permeability too it is high easily
When making the dry and hard surface of a wound, the adhesion surface of a wound, changing mechanical injuries again and severe pain, external environment microorganism can be caused to readily penetrate through,
Very little ratio is accounted in developed country's usage amount, China's medical field is also being popularized using moist dressing, except the surface of a wound is isolated
Protect, avoid outside dressing damage and pain acts on, moreover it is possible to limit the evaporation rate of moisture, also certain permeation functions,
Be advantageous to the growth of granulation under wet environment, be easy to the division of Skin Cell.
Moist dressing includes the polytypes such as hydrogel, hydrocolloid, foam dressing, non-woven fabrics loading, aerogel dressing category
In high-grade kind therein, the various advantages performance of moist dressing is the most prominent, and opaque products therein can directly be seen
Examine surface of a wound situation.The technology of preparing of hydrogel mainly has physical crosslinking, chemical crosslinking, crosslinking with radiation；It is physical crosslinking active force mistake
It is weak, stability, bad mechanical property, be not suitable for surface of a wound application；Chemical crosslinking needs to add initiator, crosslinking agent influence product
Purity, there is potential hazard to the surface of a wound；Radiation cross-linked material is pure, and swelling behavior and mechanical performance can be controlled by dose of radiation, can
Avoid disadvantage mentioned above.
Chondroitin sulfate has a variety of good physiological actions, including wound healing effect, generally by animal cartilage
The relative molecular weight of the chondroitin sulfate extracted in tissue is typically more than 20,000, if to be reduced to 10,000 hereinafter referred to as low for molecular weight
Molecular chondroitin sulfate, it is easier to absorbed, so bioavilability is higher, its medical activity becomes apparent from, including promotees corium fibre
The effect such as Hemapoiesis is tieed up, applicant prepares the side of high-purity low molecular chondroitin sulfate using electron beam technology means
Method has applied for patent of invention, application publication number：CN 105566513.Hyaluronic acid as form organism matrix it is main into
Point, invaded in vivo with water conservation, regulation osmotic pressure, lubricating joint, tissue generation, wound healing, prevention tumour and regulation is thin
Many physiological functions such as born of the same parents' function, it is the hyaluronic acid mean molecule quantity that raw material extracts 100,000-250 ten thousand using animal tissue, point
Son amount below 10,000 be referred to as low molecular weight hyaluronic acid, on skin can rapid osmotic, absorb, have promote blood vessel endothelium
Cell is bred and wound healing, the effect of skin care, and applicant is low using electron beam technology means preparation high-purity
The method of molecular weight hyaluronic acid has applied for patent of invention, application publication number：CN 105646733.
In current existing relevant electronic beam irradiation technology, the patent document of hydrogel containing polysaccharide material, patent CN
106729960 disclose a kind of chitosan-based hydrogel combine dressing for loading Kaempferol and preparation method thereof, do not contain low point
Sub- polysaccharide, the active force of ultra violet lamp crosslinking is weak, influences mechanical performance；Patent CN 102093582 discloses a kind of radiation and handed over
Join the preparation method of hydrogel, composition is polyglutamic acid, without low-molecular polysaccharide；Patent CN 106492268 discloses a kind of short
The preparation method of peptide/silica/hyaluronic acid composite aquogel, belongs to chemical crosslinking.
The content of the invention
The technical problems to be solved by the invention are, for above-mentioned deficiency, there is provided a kind of compound height of crosslinking electron beam irradiation
The preparation method of molecule aerogel dressing, have product composition pure, same provided with promotion healing functional layer, cross-linking reaction and sterilizing
The overall merits such as step completion.
1. to reach above-mentioned purpose, the technical scheme is that, a kind of crosslinking electron beam irradiation composite high-molecular water-setting
The preparation method of glue dressing, it is characterised in that：The dressing is made up of basalis, substrate layer, functional layer, mould release membrance, successively tightly
Patch；The substrate layer is polyvinyl alcohol, PVP, gelatin, deionized water are mixed to form the dope warp that can shape
The hydrogel that crosslinking electron beam irradiation is formed；The functional layer in the substrate layer hydrogel by adding low molecular chondroitin sulfate
Formed with low molecular weight hyaluronic acid.
2. the substrate layer is identical with the functional layer size, in use, contacting the surface of a wound with functional layer.
3. the basalis is polyurethane pellicle, one side glue, glue surface wants width to go out towards mould release membrance, basalis edge
Substrate layer, width section can bond with mould release membrance, to fixed dressing and the surface of a wound surrounding skin during use；The mould release membrance is
Papery or plastic material, size is identical with basalis, protects the glue surface of hydrogel and basalis in packaging, takes off during use
Remove mould release membrance.
4. the preparation method of the aerogel dressing, it is characterised in that comprise the following steps：
1. prepare substrate layer solution：The polyvinyl alcohol, PVP, gelatin solid powder of certain mass are weighed respectively
End, each add in deionized water, three kinds of respective aqueous solution of composition are made, mass fraction is respectively polyvinyl alcohol 15wt%, gathered
Vinyl pyrrolidone 15wt%, gelatin 30wt%；Fully dissolved in high-pressure steam container respectively, 120 DEG C of temperature, time 2h；
After being completely dissolved, three kinds of solution are mixed by certain volume ratio, and add appropriate amount of deionized water as needed, are configured to base material
Layer mixed solution；The mass fraction of polyvinyl alcohol is 1-3wt% in substrate layer mixed solution, the quality of PVP
Fraction is 1-3wt%, the mass fraction 4-18wt% of gelatin；Preferably mass fraction is respectively 2wt%, 2wt%, 15wt%.
2. function equipment layer solution：The above-mentioned substrate layer mixed solution in part is taken, adds a certain amount of low molecular chondroitin sulfate
With low molecular weight hyaluronic acid solid powder, it is thoroughly mixed, low molecular chondroitin sulfate and low molecular weight hyaluronic acid quality point
Number is respectively the 2wt% of substrate layer mixed solution.
3. evacuation and centrifugal degassing：50 DEG C of constant temperatures carry out evacuation and centrifugal degassing, centrifugal basket to substrate layer and functional layer solution respectively
Fast 3000rpm, time 4min；The step makes solution as clear as crystal.
4. it is coated with：Substrate layer, coating thickness 1.7mm are coated with first using coating machine, and coating table top is blown a cold wind over and made simultaneously
After its rapid shaping, its top is coated 0.3mm functional layers, while blowing a cold wind over makes it be molded rapidly；The step causes substrate layer
Stick and be integrated with functional layer, the low molecular chondroitin sulfate and low molecular weight hyaluronic acid of high cost are only used in the thin function in surface
Layer.
5. blooming is packed：Above-mentioned moulding material is cut out as tile by required size, substrate layer reclines basilar memebrane, puts respectively
In edge it is wide go out polyurethane pellicle basilar memebrane glue surface center, top covering mould release membrance, release film edge with it is wide go out poly- ammonia
Ester pellicle glue surface is pasted；It is fitted into aluminium foil bag or polybag, seals；The step completes the integral packaging of single products.
6. irradiate：The said goods are irradiated using 10MeV/20kW electron accelerators, dosage 25kGy, the step makes
Substrate layer, the crosslinking of functional layer hydrogel, mechanical performance enhancing, and sterilize simultaneously, meet medical dressing requirement.
The beneficial effects of the invention are as follows：Using electron beam irradiation, a kind of this pure physical means, synchronously realizes high molecular crosslink
Sterilized with product, process simplification, the preparation for avoiding chemical crosslink technique remains and chemical waste liquid emission problem, and oxirane
The pollution problem of sterilizing；Product composition is pure, and transparency is high, is easy to observe the surface of a wound；The low molecular chondroitin sulfate of high cost and
Low molecular weight hyaluronic acid is only used in the thin functional layer in surface, reduces material cost, maximizes and plays wound healing effect.
Brief description of the drawings
The aerogel dressing section structure diagram of Fig. 1 present invention.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Embodiment 1
The polyvinyl alcohol, PVP, gelatin solid powder of certain mass are weighed respectively, each add deionized water
In three kinds of aqueous solution are made, its mass fraction is respectively polyvinyl alcohol 15wt%, PVP 15wt%, gelatin
30wt%；Dissolved respectively in high-pressure steam container, 120 DEG C of temperature, time 2h；After being completely dissolved, three kinds of solution are pressed necessarily
Volume ratio mixes, and adds appropriate amount of deionized water as needed, is configured to substrate layer mixed solution.In the substrate layer mixed solution
The mass fraction of polyvinyl alcohol is 1wt%, and the mass fraction of PVP is 1wt%, the mass fraction 4wt% of gelatin.
The above-mentioned substrate layer solution in part is taken, adds a certain amount of low molecular chondroitin sulfate and low molecular weight hyaluronic acid solid powder
End, it is thoroughly mixed, the mass fraction of low molecular chondroitin sulfate and low molecular weight hyaluronic acid is respectively substrate layer solution
2wt%, make functional layer solution.
Evacuation and centrifugal degassing is carried out to substrate layer and functional layer solution respectively in 50 DEG C of constant temperatures, centrifuge speed 3000rpm,
Time 4min.After deaeration, substrate layer, coating thickness 1.7mm are coated with first using coating machine, coating table top is blown a cold wind over and made simultaneously
After its rapid shaping, its top is coated 0.3mm functional layers, while blowing a cold wind over makes it be molded rapidly.Above-mentioned moulding material is pressed
Required size is cut out sticks basilar memebrane for tile, substrate layer, be respectively placed in edge it is wide go out polyurethane pellicle basilar memebrane glue surface
Center, top covering mould release membrance, its edge is pasted with the polyurethane pellicle glue surface that width goes out；It is fitted into aluminium foil bag or polybag,
The said goods and are irradiated, dosage 25kGy by sealing using 10MeV/20kW electron accelerators, hydrogel is crosslinked and same
When sterilize.
The aerogel dressing obtained is detected, it is sterile, tensile strength 0.008MPa is measured with electronic tension tester, is broken
Elongation 133.7%, it is 106.70g/g to absorb deionized water ability, and it is 10.45g/g to absorb physiological saline ability.
Embodiment 2
Using the identical step of same embodiment 1, unique difference part is in the quality in substrate layer mixed solution is prepared point
Number, the mass fraction of polyvinyl alcohol are 3wt%, and the mass fraction of PVP is 3wt%, the mass fraction of gelatin
18wt%。
The aerogel dressing obtained is detected, it is sterile, tensile strength 0.024MPa is measured with electronic tension tester, is broken
Elongation 97.45%, it is 17.49g/g to absorb deionized water ability, and it is 4.82g/g to absorb physiological saline ability.
Embodiment 3
Using the identical step of same embodiment 1, unique difference part is in the quality in substrate layer mixed solution is prepared point
Number, the mass fraction of polyvinyl alcohol are 2wt%, and the mass fraction of PVP is 2wt%, the mass fraction of gelatin
15wt%。
The aerogel dressing obtained is detected, it is sterile, tensile strength 0.026MPa is measured with electronic tension tester, is broken
Elongation 275.13%, the ability for absorbing deionized water are 100.50g/g, and it is 9.99g/g to absorb physiological saline ability.
Claims (4)
- A kind of 1. preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing, it is characterised in that：The dressing by Basalis, substrate layer, functional layer, mould release membrance composition, are close to successively；The substrate layer is polyvinyl alcohol, polyvinylpyrrolidone Ketone, gelatin, deionized water are mixed to form the hydrogel that dope is formed through crosslinking electron beam irradiation that can shape；The functional layer by Low molecular chondroitin sulfate and low molecular weight hyaluronic acid composition are added in the substrate layer hydrogel.
- 2. a kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing as claimed in claim 1, it is special Sign is：The substrate layer is identical with the functional layer size, in use, contacting the surface of a wound with functional layer.
- 3. a kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing as claimed in claim 1, it is special Sign is：The basalis is polyurethane pellicle, one side glue, and glue surface wants width to go out base towards mould release membrance, basalis edge Material layer, width section can bond with mould release membrance；The mould release membrance is papery or plastic material, size and basalis phase Together, the glue surface of hydrogel and basalis is protected in packaging.
- 4. a kind of preparation method of crosslinking electron beam irradiation composite high-molecular aerogel dressing as claimed in claim 1, it is special Sign is, comprises the following steps：1. prepare substrate layer solution：The polyvinyl alcohol, PVP, gelatin solid powder of certain mass are weighed respectively End, each add in deionized water, three kinds of respective aqueous solution of composition are made, mass fraction is respectively polyvinyl alcohol 15wt%, gathered Vinyl pyrrolidone 15wt%, gelatin 30wt%；Fully dissolved in high-pressure steam container respectively, 120 DEG C of temperature, time 2h； After being completely dissolved, three kinds of solution are mixed by certain volume ratio, and add appropriate amount of deionized water as needed, are configured to base material Layer mixed solution；The mass fraction of polyvinyl alcohol is 1-3wt% in substrate layer mixed solution, the quality of PVP Fraction is 1-3wt%, the mass fraction 4-18wt% of gelatin；Preferably mass fraction is respectively 2wt%, 2wt%, 15wt%；2. function equipment layer solution：The above-mentioned substrate layer mixed solution in part is taken, adds a certain amount of low molecular chondroitin sulfate and low Molecular weight hyaluronic acid solid powder, is thoroughly mixed, low molecular chondroitin sulfate and low molecular weight hyaluronic acid mass fraction point Not Wei substrate layer mixed solution 2wt%；3. evacuation and centrifugal degassing：50 DEG C of constant temperatures carry out evacuation and centrifugal degassing, centrifuge speed to substrate layer and functional layer solution respectively 3000rpm, time 4min；4. it is coated with：Substrate layer, coating thickness 1.7mm are coated with first using coating machine, and coating table top is blown a cold wind over and makes its fast simultaneously After rapid-result type, its top is coated 0.3mm functional layers, while blowing a cold wind over makes it be molded rapidly；The step causes substrate layer and work( Ergosphere, which sticks, to be integrated；5. blooming is packed：Above-mentioned moulding material is cut out as tile by required size, substrate layer reclines basilar memebrane, is respectively placed in side Edge it is wide go out polyurethane pellicle basilar memebrane glue surface center, top covering mould release membrance, release film edge with it is wide go out polyurethane half Permeable membrane glue surface is pasted；It is fitted into aluminium foil bag or polybag, seals；6. irradiate：The said goods are irradiated using 10MeV/20kW electron accelerators, dosage 25kGy.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507726A (en) * | 2019-09-20 | 2019-11-29 | 黄宝萍 | A kind of burn-scald medicine, hydrogel application containing the burn-scald medicine and preparation method thereof |
| CN110916900A (en) * | 2018-09-20 | 2020-03-27 | 常州华联保健敷料有限公司 | Hydrogel medical dressing and preparation method thereof |
| CN111499889A (en) * | 2020-05-07 | 2020-08-07 | 南方医科大学珠江医院 | Chondroitin sulfate magnesium hyaluronic acid hydrogel, preparation method and application thereof, and gel product |
| CN112892199A (en) * | 2021-02-02 | 2021-06-04 | 四川酉荃环保科技有限公司 | Purification sheet capable of decomposing formaldehyde for long time |
| CN114922003A (en) * | 2022-04-22 | 2022-08-19 | 安徽文峰新材料科技股份有限公司 | Preparation method of waterproof stain-resistant photographic paper |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2383500Y (en) * | 1999-08-13 | 2000-06-21 | 中国原子能科学研究院 | Hydrogel composite wound dressing |
| CN1616116A (en) * | 2004-09-29 | 2005-05-18 | 杭州拜康医用产品有限公司 | Water gel wound dressing containing radiation sensitive agent and preparing method |
| CN101919761A (en) * | 2009-06-17 | 2010-12-22 | 惠州华阳医疗器械有限公司 | Medical hydrogel incision dressing and preparation method thereof |
| CN103893157A (en) * | 2014-04-09 | 2014-07-02 | 山东赛克赛斯药业科技有限公司 | Hydrogel eye protective pad dressing and preparation method thereof |
| CN105566513A (en) * | 2016-02-02 | 2016-05-11 | 山东蓝孚高能物理技术股份有限公司 | Method for preparing low-molecular chondroitin sulfate through electron beam irradiation |
| CN105646733A (en) * | 2016-02-02 | 2016-06-08 | 山东蓝孚高能物理技术股份有限公司 | Method for preparing lower-molecular hyaluronic acid through electron beam irradiation |
-
2017
- 2017-11-06 CN CN201711076430.1A patent/CN107789658A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2383500Y (en) * | 1999-08-13 | 2000-06-21 | 中国原子能科学研究院 | Hydrogel composite wound dressing |
| CN1616116A (en) * | 2004-09-29 | 2005-05-18 | 杭州拜康医用产品有限公司 | Water gel wound dressing containing radiation sensitive agent and preparing method |
| CN101919761A (en) * | 2009-06-17 | 2010-12-22 | 惠州华阳医疗器械有限公司 | Medical hydrogel incision dressing and preparation method thereof |
| CN103893157A (en) * | 2014-04-09 | 2014-07-02 | 山东赛克赛斯药业科技有限公司 | Hydrogel eye protective pad dressing and preparation method thereof |
| CN105566513A (en) * | 2016-02-02 | 2016-05-11 | 山东蓝孚高能物理技术股份有限公司 | Method for preparing low-molecular chondroitin sulfate through electron beam irradiation |
| CN105646733A (en) * | 2016-02-02 | 2016-06-08 | 山东蓝孚高能物理技术股份有限公司 | Method for preparing lower-molecular hyaluronic acid through electron beam irradiation |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110916900A (en) * | 2018-09-20 | 2020-03-27 | 常州华联保健敷料有限公司 | Hydrogel medical dressing and preparation method thereof |
| CN110507726A (en) * | 2019-09-20 | 2019-11-29 | 黄宝萍 | A kind of burn-scald medicine, hydrogel application containing the burn-scald medicine and preparation method thereof |
| CN111499889A (en) * | 2020-05-07 | 2020-08-07 | 南方医科大学珠江医院 | Chondroitin sulfate magnesium hyaluronic acid hydrogel, preparation method and application thereof, and gel product |
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