CN105920658A - Porous styptic powder and preparation method thereof - Google Patents
Porous styptic powder and preparation method thereof Download PDFInfo
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- CN105920658A CN105920658A CN201610254022.XA CN201610254022A CN105920658A CN 105920658 A CN105920658 A CN 105920658A CN 201610254022 A CN201610254022 A CN 201610254022A CN 105920658 A CN105920658 A CN 105920658A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses porous styptic powder and a preparation method of the porous styptic powder. The preparation method comprises the following steps: rapidly cooling a solution containing a material needing to be crosslinked, carrying out ray irradiation crosslinking under low temperature, and carrying out freeze drying, thus obtaining the porous styptic powder. In the preparation method, superfine small ice crystals are obtained through rapid cooling, during the irradiation, the low temperature is guaranteed, so that the small ice crystals do not melt and are sized after the irradiation. With the adoption of the preparation method, the porous crosslinking material with small pore diameter, large porosity and large specific surface area is obtained; the ray irradiation crosslinking is adopted, in the preparation process, a crosslinking agent is not introduced, therefore, the prepared material has no biotoxicity caused by the crosslinking agent, and therefore, the preparation process is a safe, nontoxic and environmentally friendly production process; the prepared material has good prospects in the fields of hemostatic materials, drug carriers and the like.
Description
Technical field
The invention discloses the preparation method of a kind of porous styptic powder, a kind of preparation process does not introduce the preparation method of the cross linked porous styptic powder of cross-linking agent.
Background technology
Cross linked porous material, because of its high porosity, low-density and be prone to functional modification and loading, has wide application and demand in fields such as organizational project, hemostatic material, medicine and molecular vehicle, living things catalysis and inert fillers.But, owing to needing material shaping after pore-creating, the method for conventionally employed cross-linking agent is difficult to cross-link the solid material of sizing, can only be by freeze-drying method pore-creating, it is thus achieved that material aperture big and specific surface area is little, it is impossible to meet height absorption and the needs of medicine carrying.Additionally, other methods obtaining cross linked porous material need to introduce organic or zest chemical reagent at present, do not meet the field requirements hypotoxic to material such as organizational project, hemostatic material, medicine and molecular vehicle, living things catalysis and inert filler.
Chinese patent CN103265720A discloses a kind of new method preparing cross linked porous chitosan microball, is specifically related to a kind of with 1, and 2-cylohexanediol diglycidyl ether is the method that crosslinked chitosan microsphere prepared by cross-linking agent.With chitosan, 1,2-cylohexanediol diglycidyl ether and chlorinated paraffin are raw material, through dissolve, dispersion balling-up, drilling, cross-link and be dried, prepare cross linked porous chitosan microball.But introducing 1 in preparation process, 2-cylohexanediol diglycidyl ether and chlorinated paraffin two kinds increase the reagent of material toxicity.
Chinese patent CN104861102A discloses the preparation method of a kind of porous crosslinked polystyrene microsphere, and this invention obtains surface micropore, the microsphere of internal macropore by pore, swelling, stable and extraction step.But in preparation process, introduce benzoyl peroxide equally have virose organic reagent as cross-linking agent, acetone as extractant etc. as initiator, divinylbenzene, add the toxicity of material.
Chinese patent CN101574539B discloses a kind of gelfoam and preparation method thereof, forms hydrogel particular by aqueous gelatin solution carries out crosslinking with radiation, and then carries out swelling, and lyophilization obtains.But the cross linked porous gelfoam aperture that this patent obtains is big, focuses primarily upon 20 to 70 microns, causes relatively low specific surface area, limits its application development as high-absorption material.
Summary of the invention
For the problems referred to above, this patent provides a kind of simple process, it is possible to realize, without cross-linking agent, obtaining cross linked porous material by the preparation method of environmental protection.
For achieving the above object, this patent is realized by techniques below means:
A kind of porous styptic powder of invention, is by needing the solution of cross-linked material to carry out quickly cooling to containing, and then carries out ray low temperature irradiation crosslinking under the conditions of less than zero degrees celsius, then carry out lyophilization acquisition.
The solvent of described solution can be any to crystallize at low temperatures, is increased to room temperature with the liquid that can distil during low pressure, preferably water.
The solute of described solution, i.e. needing cross-linked material can be one or more in sodium carboxymethyl cellulose, Aloe polysaccharide, Fibrin Glue, oxidized cellulose and oxidized regenerated cellulose, a-cyanoacrylate class loading glue, Chitosan-phospholipid complex, starch, agarose, carrageenan, Radix Acaciae senegalis, dextran, alginic acid, alginate and derivant, collagen, gelatin, albumin, fibrin.
The described material needing crosslinking may be dissolved in the solution of water, micromolecular compound solution, growth factor solution, drug solution, polypeptide solution, protein or nucleic acid.
Described solution quality percent is 1% ~ 30%.
The described quickly cooling that carries out solution is to obtain by being positioned in the environment of temperature range-196 DEG C to-10 DEG C by the solution of flow regime.
The described temperature range carrying out low temperature x ray irradiation x is-196 DEG C to 0 DEG C.
Described cross-linking radiation ray uses cobalt-60γray, and caesium-137 gamma-rays or electron beam carry out cross-linking radiation, and irradiation dose is 1 to 100kGy.
The described degree of cross linking of the styptic powder after low temperature x ray irradiation x crosslinking that carries out is in the range of 5% to 90%.
The present invention makes material produce crosslinking by radiation, and relative to uncrosslinked material, its water absorption rate, intensity all promote, and degrade slack-off so that it is be applicable to Absorbable hemostatic material.
The present invention can be grafted realize crosslinking when material is carried out low temperature x ray irradiation x while, be polymerized or sterilization steps.
Porous styptic powder obtained by the present invention can follow-up lift-launch somatomedin, medicine, peptide and protein.
The present invention carries out the porous styptic powder of preparation under the porous styptic powder obtained by low temperature x ray irradiation x crosslinking cross-links relative to room temperature x ray irradiation x under conditions of less than zero degrees celsius, have that aperture is little, specific surface area is big, the advantage that adsorptivity is strong, and relative to the method using cross-linking agent to carry out cross-linking, do not introduce any toxicant, this styptic powder is except as hemostatic material, it is also possible to be used in organizational project, medicine and molecular vehicle, living things catalysis and filler field.
Accompanying drawing illustrates:
Fig. 1 and Fig. 2 is respectively embodiment 3 and the stereoscan photograph of embodiment 5.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention, and wherein embodiment 5 is matched group.
Embodiment 1
15 grams of gelatin are dissolved in 85 grams of water, stir, obtain the gelatin solution of 15%.Pour gelatin solution into mould, put into rapidly chilling in the pre-refrigerator being adjusted to-20 DEG C, preserve 24 hours after room temperature is down to-20 DEG C in making its temperature rapidly, it is transferred quickly to measure in the portable refrigerator (including mixture of ice and water) that temperature is 0 DEG C, it is 30kGy with cobalt-60γray irradiation dose, obtains hydrogel.Hydrogel is transferred to freezer dryer and carries out pre-freeze, pre-freezing temperature is-80 DEG C, then it is dried, obtaining porous material, the porous material obtained is pulverized, with 100 mesh sieve screenings, obtain cross linked porous powder body, the degree of cross linking is 48.7 ± 2.1%, with ASAP 2010BET specific surface tester (Micromeritics
USA) testing, BET specific surface area is 103.71m2/ g, 24h water absorption rate is 2216.0 ± 7.5%.
Embodiment 2
1 gram of collagen is dissolved in 99 grams of water, stirs, obtain the collagen solution of 1%.Pour collagen solution into mould, put into rapidly and be set as chilling in the ultra cold storage freezer of-70 DEG C so that it is temperature is interior rapidly to be preserved 24 hours after room temperature is down to-70 DEG C, is transferred quickly in the portable refrigerator that temperature is-10 DEG C, with beam radiation irradiation 1kGy, obtain collagen hydrogel.Being transferred to freezer dryer and carry out pre-freeze, pre-freezing temperature is-20 DEG C, and after lyophilization, the porous collagen crosslinking sponge obtained, 24h water absorption rate is 1634.0 ± 279.0%.
Embodiment 3
15 grams of carboxymethyl chitosans are dissolved in 85 grams of water, stir, obtain the carboxymethyl chitosan solution of 15%.Pour solution into mould, put into rapidly in the liquid nitrogen that temperature is-196 DEG C and carry out chilling so that it is temperature is down to-196 DEG C from room temperature rapidly.Then preserve 24 hours, it is transferred quickly in the portable refrigerator that preset temperature is-20 DEG C, using cobalt-60γray irradiation, dosage is 30kGy, is transferred to freezer dryer and carries out pre-freeze, pre-freezing temperature is-70 DEG C, being dried afterwards, the porous material obtained is pulverized, 100 mesh sieve screenings, with ASAP 2010BET specific surface tester (Micromeritics
USA) testing, obtaining BET specific surface area is 52.17m2/ g, the degree of cross linking is 24.6 ± 3.3%, and 24h water absorption rate is 1800.7 ± 10.6%.
Fig. 1 shows the microstructure of the porous powder utilizing the method according to embodiment 3 of scanning electron microscopic observation to prepare.
Embodiment 4
15 grams of carboxymethyl chitosans are dissolved in 85 grams of water, stir, obtain the carboxymethyl chitosan solution of 15%.Pour solution into mould, put into rapidly in the ultra cold storage freezer that temperature is-80 DEG C and carry out chilling so that it is temperature is down to-80 DEG C from room temperature rapidly.Then preserving 24 hours, be transferred quickly in the portable refrigerator that preset temperature is-20 DEG C, use cobalt-60γray irradiation, dosage is 30kGy, obtains hydrogel.Being transferred to freezer dryer and carry out pre-freeze, pre-freezing temperature is-70 DEG C, is dried afterwards, and the porous material obtained is pulverized, 100 mesh sieves screening, with ASAP 2010BET specific surface tester (Micromeritics,
USA) testing, obtaining BET specific surface area is 27.05m2/ g, the degree of cross linking is 29.1 ± 5.5%, and 24h water absorption rate is 1739.3 ± 13.0%.
Embodiment 5
15 grams of carboxymethyl chitosans are dissolved in 85 grams of water, stir, obtain the carboxymethyl chitosan solution of 15%.Solution being poured into mould, uses cobalt-60γray irradiation under room temperature, dosage is 30kGy, obtains hydrogel.Being transferred to freezer dryer and carry out pre-freeze, pre-freezing temperature is-70 DEG C, is dried afterwards, and the porous material obtained is pulverized, 100 mesh sieves screening, with ASAP 2010BET specific surface tester (Micromeritics,
USA) testing, obtaining BET specific surface area is 2.06m2/ g, the degree of cross linking is 34.0 ± 3.1%, and 24h water absorption rate is 1703.3 ± 38.6%.
Fig. 2 shows the microstructure of the porous powder utilizing the method according to embodiment 5 of scanning electron microscopic observation to prepare.
Embodiment 6
10 grams of sodium carboxymethyl cellulose are dissolved in 90 grams of water, stir, obtain the carboxymethylcellulose sodium solution of 10%.Pour solution into mould, put into rapidly chilling in the pre-refrigerator being adjusted to-196 DEG C, its temperature is made to be down to-196 DEG C from room temperature rapidly, preserve 24 hours afterwards, it is transferred quickly to measure in the portable refrigerator that temperature is-10 DEG C, directly use cobalt-60γray irradiation, dosage is 35kGy, the hydrogel obtained is transferred to freezer dryer and carries out pre-freeze, and pre-freezing temperature is-30 DEG C, is dried afterwards, the porous material obtained is pulverized, 100 mesh sieve screenings, obtain cross linked porous powder body, and BET specific surface area is 81.58m2/ g, the degree of cross linking is 9.7 ± 0.6%, and 24h water absorption rate is 912.4 ± 126.9%.
Exemplary the showing of accompanying drawing 1 and Fig. 2 utilizes the microstructure of porous powder prepared by the method according to embodiment 3 and embodiment 5 of scanning electron microscopic observation.Difference except BET specific surface area data, from this stereoscan photograph also it can further be seen that the present invention carries out low temperature x ray irradiation x (embodiment 3) under conditions of less than zero degrees celsius cross-links the specific surface area of preparation-obtained cross linked porous styptic powder more than carrying out room temperature irradiation (embodiment 5) and cross linked porous material that postlyophilization obtains, the present invention carries out low temperature x ray irradiation x (embodiment 3) under conditions of less than zero degrees celsius and cross-links the aperture of preparation-obtained cross linked porous styptic powder less than carrying out room temperature irradiation (embodiment 5) and cross linked porous material that postlyophilization obtains.
It should be noted that; above-described embodiment is only within the scope of the claims preferred, and the protection domain that the scope of its solution concentration, the temperature range of quickly cooling, the temperature range of low temperature x ray irradiation x, pre-freezing temperature scope and irradiation dose are claimed with claim is as the criterion.The change carrying out above-mentioned parameter is apparent to those skilled in the art, and it is without departing from protective scope of the claims.
Under conditions of other conditions are the most identical, the specific surface area of the preparation-obtained cross linked porous styptic powder of the present invention is more than carrying out room temperature irradiation and cross linked porous material that postlyophilization obtains, aperture is less than carrying out room temperature irradiation and cross linked porous material that postlyophilization obtains, and blood coagulation and haemostatic effect are also superior to carrying out room temperature irradiation and cross linked porous material that postlyophilization obtains.
Cross linked porous material prepared by the present invention is not because introducing cross-linking agent or emulsifying agent, and its cytotoxicity is less than the cross linked porous material using cross-linking agent or emulsifying agent to prepare.
Claims (9)
1. porous styptic powder and preparation method thereof, it is characterised in that first pass through and need the solution of cross-linked material to carry out quickly cooling to containing, and then carry out low temperature x ray irradiation x crosslinking under conditions of less than zero degrees celsius, then carry out lyophilization.
Preparation method the most according to claim 1, it is characterised in that needing cross-linked material solution concentration scope is 1% ~ 30%.
Preparation method the most according to claim 1, it is characterised in that the temperature range carrying out quickly cooling is-196 DEG C to-10 DEG C.
Preparation method the most according to claim 1, it is characterised in that the temperature range carrying out low temperature x ray irradiation x is-196 DEG C to 0 DEG C.
Preparation method the most according to claim 1, it is characterised in that the ray carrying out low temperature x ray irradiation x is cobalt-60γray, caesium-137 gamma-rays or beam radiation.
Preparation method the most according to claim 1, it is characterised in that the dosage range carrying out low temperature x ray irradiation x is 1 to 100kGy.
Preparation method the most according to claim 1, it is characterized in that the solute of described solution, the most described cross-linked material are one or more in sodium carboxymethyl cellulose, Aloe polysaccharide, Fibrin Glue, oxidized cellulose and oxidized regenerated cellulose, a-cyanoacrylate class loading glue, Chitosan-phospholipid complex, starch, agarose, carrageenan, Radix Acaciae senegalis, dextran, alginic acid, alginate and derivant, collagen, gelatin, albumin, fibrin.
Preparation method the most according to claim 1, it is characterised in that carrying out cryodesiccated cryogenic temperature scope is-196 DEG C to-10 DEG C.
9. the porous styptic powder prepared according to the method according to any one of claim 1-8, it is characterised in that carry out the specific surface area of described porous styptic powder of low temperature x ray irradiation x crosslinking preparation under conditions of less than zero degrees celsius at 5m2/g-150m2Between/g, it is more than the specific surface area of the porous styptic powder carrying out x ray irradiation x crosslinking preparation under normal temperature condition.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822986A (en) * | 2017-04-07 | 2017-06-13 | 广东海洋大学 | A kind of preparation method of the porous ball hemostatic material of shitosan agar oligosaccharide |
| CN108310448A (en) * | 2018-02-07 | 2018-07-24 | 广州迈普再生医学科技有限公司 | A kind of preparation method of fluid gelatin hemostatic material |
| CN108478855A (en) * | 2018-05-15 | 2018-09-04 | 邵玉芹 | A kind of bleeding-stopping dressing |
| CN109646710A (en) * | 2019-02-14 | 2019-04-19 | 重庆医药高等专科学校 | A kind of hemostatic material and preparation method thereof of clinical department of internal medicine hemostasis |
| CN113134113A (en) * | 2021-04-07 | 2021-07-20 | 赛克赛斯生物科技股份有限公司 | Preparation method of absorbable hemostatic fluid gelatin and absorbable hemostatic fluid gelatin |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022141884A1 (en) * | 2020-12-31 | 2022-07-07 | 广州迈普再生医学科技股份有限公司 | Absorbable hemostatic powder, preparation method therefor and application thereof |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583836A (en) * | 2004-05-27 | 2005-02-23 | 复旦大学 | Preparation of porous sericin sponge material |
| CN1616116A (en) * | 2004-09-29 | 2005-05-18 | 杭州拜康医用产品有限公司 | Water gel wound dressing containing radiation sensitive agent and preparing method |
| US20060135921A1 (en) * | 2003-04-04 | 2006-06-22 | Wiercinski Robert A | Porous particulate collagen sponges |
| CN101053668A (en) * | 2007-05-18 | 2007-10-17 | 河南省科学院同位素研究所有限责任公司 | Nanometer calamine compositing hydrogel wound dressing and its preparation method |
| CN101574539A (en) * | 2009-06-15 | 2009-11-11 | 北京大学 | Gelatin sponge and preparation method thereof |
| CN102068714A (en) * | 2011-01-19 | 2011-05-25 | 北京大学 | Collagen sponge and preparation method thereof |
| CN102167847A (en) * | 2011-01-24 | 2011-08-31 | 杭州电子科技大学 | Chitosan and sulfating grifolan mixed gel freeze-dried sponge, and preparation method and application thereof |
| CN103044703A (en) * | 2013-01-17 | 2013-04-17 | 古元安 | Preparation process of porous hydrogel and non-porous hydrogel |
| CN103804712A (en) * | 2014-01-23 | 2014-05-21 | 北京化工大学常州先进材料研究院 | Preparation of porous and aperture-controllable chitosan microspheres |
| CN104645403A (en) * | 2015-02-06 | 2015-05-27 | 河北途升医疗器械贸易有限公司 | Preparation method of collagen sponge |
| CN104894673A (en) * | 2015-06-04 | 2015-09-09 | 常州大学 | Method for preparing temperature-sensitive crosslinked fiber through low-temperature photopolymerization |
| CN105085768A (en) * | 2015-09-18 | 2015-11-25 | 中广核达胜加速器技术有限公司 | Method for processing high-performance water-absorbent resin through electron beam irradiation |
| CN105107022A (en) * | 2015-09-21 | 2015-12-02 | 东华大学 | Preparation method for nanofiber porous scaffold having compression elasticity in wet state |
-
2016
- 2016-04-23 CN CN201610254022.XA patent/CN105920658B/en not_active Expired - Fee Related
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060135921A1 (en) * | 2003-04-04 | 2006-06-22 | Wiercinski Robert A | Porous particulate collagen sponges |
| CN1583836A (en) * | 2004-05-27 | 2005-02-23 | 复旦大学 | Preparation of porous sericin sponge material |
| CN1616116A (en) * | 2004-09-29 | 2005-05-18 | 杭州拜康医用产品有限公司 | Water gel wound dressing containing radiation sensitive agent and preparing method |
| CN101053668A (en) * | 2007-05-18 | 2007-10-17 | 河南省科学院同位素研究所有限责任公司 | Nanometer calamine compositing hydrogel wound dressing and its preparation method |
| CN101574539A (en) * | 2009-06-15 | 2009-11-11 | 北京大学 | Gelatin sponge and preparation method thereof |
| CN102068714A (en) * | 2011-01-19 | 2011-05-25 | 北京大学 | Collagen sponge and preparation method thereof |
| CN102167847A (en) * | 2011-01-24 | 2011-08-31 | 杭州电子科技大学 | Chitosan and sulfating grifolan mixed gel freeze-dried sponge, and preparation method and application thereof |
| CN103044703A (en) * | 2013-01-17 | 2013-04-17 | 古元安 | Preparation process of porous hydrogel and non-porous hydrogel |
| CN103804712A (en) * | 2014-01-23 | 2014-05-21 | 北京化工大学常州先进材料研究院 | Preparation of porous and aperture-controllable chitosan microspheres |
| CN104645403A (en) * | 2015-02-06 | 2015-05-27 | 河北途升医疗器械贸易有限公司 | Preparation method of collagen sponge |
| CN104894673A (en) * | 2015-06-04 | 2015-09-09 | 常州大学 | Method for preparing temperature-sensitive crosslinked fiber through low-temperature photopolymerization |
| CN105085768A (en) * | 2015-09-18 | 2015-11-25 | 中广核达胜加速器技术有限公司 | Method for processing high-performance water-absorbent resin through electron beam irradiation |
| CN105107022A (en) * | 2015-09-21 | 2015-12-02 | 东华大学 | Preparation method for nanofiber porous scaffold having compression elasticity in wet state |
Non-Patent Citations (4)
| Title |
|---|
| HUANG XIN ET AL: "Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing", 《MATERIALS SCIENCE & ENGINEERING. C, MATERIALS FOR BIOLOGICAL APPLICATIONS》 * |
| 刘婷等: "胶原基水凝胶的研究进展", 《全国胶原蛋白提取制备与新产品开发应用新技术、新设备交流研讨会》 * |
| 周英等: "抗菌敷料研究进展", 《中华损伤与修复杂志（电子版）》 * |
| 许零等: "辐照交联胶原支架用于大鼠全层皮肤缺损修复的实验研究", 《中华损伤与修复杂志(电子版)》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822986A (en) * | 2017-04-07 | 2017-06-13 | 广东海洋大学 | A kind of preparation method of the porous ball hemostatic material of shitosan agar oligosaccharide |
| CN108310448A (en) * | 2018-02-07 | 2018-07-24 | 广州迈普再生医学科技有限公司 | A kind of preparation method of fluid gelatin hemostatic material |
| CN108478855A (en) * | 2018-05-15 | 2018-09-04 | 邵玉芹 | A kind of bleeding-stopping dressing |
| CN109646710A (en) * | 2019-02-14 | 2019-04-19 | 重庆医药高等专科学校 | A kind of hemostatic material and preparation method thereof of clinical department of internal medicine hemostasis |
| CN109646710B (en) * | 2019-02-14 | 2019-08-30 | 重庆医药高等专科学校 | A hemostatic material for clinical hemostasis and preparation method thereof |
| CN113134113A (en) * | 2021-04-07 | 2021-07-20 | 赛克赛斯生物科技股份有限公司 | Preparation method of absorbable hemostatic fluid gelatin and absorbable hemostatic fluid gelatin |
| CN113134113B (en) * | 2021-04-07 | 2022-07-01 | 赛克赛斯生物科技股份有限公司 | Preparation method of absorbable hemostatic fluid gelatin and absorbable hemostatic fluid gelatin |
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