CN106729944A - A kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof - Google Patents
A kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof Download PDFInfo
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- CN106729944A CN106729944A CN201611050739.9A CN201611050739A CN106729944A CN 106729944 A CN106729944 A CN 106729944A CN 201611050739 A CN201611050739 A CN 201611050739A CN 106729944 A CN106729944 A CN 106729944A
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- diminishing inflammation
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- 108010022355 Fibroins Proteins 0.000 title claims abstract description 34
- 230000000694 effects Effects 0.000 title claims abstract description 22
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 20
- 230000003467 diminishing effect Effects 0.000 title claims abstract description 20
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 32
- 244000307697 Agrimonia eupatoria Species 0.000 claims abstract description 20
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 235000000125 common agrimony Nutrition 0.000 claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000853 adhesive Substances 0.000 claims abstract description 11
- 230000001070 adhesive effect Effects 0.000 claims abstract description 11
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000006667 Aleurites moluccana Nutrition 0.000 claims abstract description 6
- 241001313857 Bletilla striata Species 0.000 claims abstract description 6
- 229920002101 Chitin Polymers 0.000 claims abstract description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 6
- 244000197580 Poria cocos Species 0.000 claims abstract description 6
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 6
- 235000007215 black sesame Nutrition 0.000 claims abstract description 6
- 244000192479 candlenut Species 0.000 claims abstract description 6
- 239000004203 carnauba wax Substances 0.000 claims abstract description 6
- 235000011187 glycerol Nutrition 0.000 claims abstract description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 11
- 239000004594 Masterbatch (MB) Substances 0.000 claims description 10
- 235000016993 Agrimonia Nutrition 0.000 claims description 5
- 241000206575 Chondrus crispus Species 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 244000144980 herd Species 0.000 claims description 5
- 238000005453 pelletization Methods 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 2
- 235000021360 Myristic acid Nutrition 0.000 claims description 2
- 241000218176 Corydalis Species 0.000 claims 1
- 241000497005 Ixophorus unisetus Species 0.000 claims 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 abstract description 4
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 235000013372 meat Nutrition 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical group CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000002251 absorbable suture material Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000002729 catgut Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000013930 proline Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 235000004400 serine Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
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- Biotechnology (AREA)
- Surgery (AREA)
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- Vascular Medicine (AREA)
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Abstract
The invention discloses a kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof.It is made up of following raw material：60 70 parts of chitin, 30 40 parts of fibroin powder, 28 parts of ethylene glycol, 29 parts of candlenut oil, 10 20 parts of Poria cocos powder, 28 parts of black sesame powder, 5 15 parts of glycerine, 10 20 parts of hairyvein agrimony, 37 parts of palm wax, 5 10 parts of polyethylene glycol mono stearate, first 38 parts of English white, 12 18 parts of Folium Artemisiae Argyi powder, 11 14 parts of bletilla striata powder, 38 parts of adhesive, 5 10 parts of myristic acid, 5 10 parts of OPC.Fibroin albumen suture with easing pain and diminishing inflammation effect that the present invention is provided and preparation method thereof, with good blood compatibility and histocompatbility, mechanical performance is high, with easing pain and diminishing inflammation effect, safely and effectively, degraded absorbs and catabolite is safe to the human body nontoxic, non-stimulated.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of fibroin albumen suture with easing pain and diminishing inflammation effect and its
Preparation method.
Background technology
Operation suture thread refers to that in the middle of surgical operation, the one kind for ligaturing Suture hemostasis and tissue apposition for wound is special
Very use line.Two classes can be divided into according to its biodegradability：Nonabsorable line and absorbable thread.The former have tension intensity it is high,
Be easy to sterilization, the characteristics of tissue reaction is low, but it is non-degradable in vivo, so needing to take out stitches after suture, easily bring secondary
Pain and infection and scar；The latter can be degraded into soluble product in vivo, be absorbed by the body and progressively drain
Go out in vitro, so as to alleviate patient's pain.Preferably absorbable suture material should meet following condition in clinical practice：It is general
Property, aseptic, electroless property, without surface tension, without anaphylaxis and non-carcinogenesis, it is easy to operate, be unfavorable for bacterial growth, knot
When can ensure that knot safety and without abrasion or cut, can resist organize in contraction, suture purpose reach after can be absorbed by tissue
And reaction is slight.But the conventional absorbable suture of medical field is generally catgut, polymer chemistry synthetic thread, is deposited when using
In poor biocompatibility, easily trigger tissue immunity reaction, absorb insufficient and bad mechanical property the problems such as.
Silk is made up of two parts, the part that peripheral silk collagen is constituted, referred to as silk gum；Inner core is by colloid egg
The white part for constituting turns into fibroin.Wherein fibroin albumen is a kind of tough and tensile and resilient protein.Account for silk fiber total amount
, there is crystal region and noncrystalline domain in 70-80%, main component is aminoacetic acid, alanine, serine, proline, junket in macromolecular
Each amino acid composition of propylhomoserin etc...Fibroin albumen be the fibroin fiber after natural silk degumming is processed into, as cosmetics
A kind of white powder hmw protein of raw material.Fineness is general in 144~400 mesh.Fine and smooth smooth, good permeability, with people
Body skin has good affinity, and with moisture-keeping function, radiation resistance can promote the adhesive force in pigment, color lake.Its is thermally-stabilised
Property is good.It is nonirritant, it is without any side effects.Currently used for the absorbable thread of operation, bad mechanical property, effect is more single.Base
In this, the present invention fibroin and is applied to surgery with combining by by natural Chinese medicinal herb, plant extraction liquid in traditional Chinese medicine
In suture, a kind of fibroin albumen suture with easing pain and diminishing inflammation effect is developed.
The content of the invention
It is an object of the invention to provide a kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof.
To achieve these goals, the invention provides a kind of fibroin albumen suture with easing pain and diminishing inflammation effect, by
The raw material of following parts by weight is made：Chitin 60-70 parts, fibroin powder 30-40 parts, ethylene glycol 2-8 parts, candlenut oil 2-9
Part, Poria cocos powder 10-20 parts, black sesame powder 2-8 parts, glycerine 5-15 parts, hairyvein agrimony 10-20 parts, palm wax 3-7 parts, polyethylene glycol
Monostearate 5-10 parts, first 3-8 parts of English white, Folium Artemisiae Argyi powder 12-18 parts, 11-14 parts of bletilla striata powder, adhesive 3-8 parts, myristic acid
5-10 parts, OPC 5-10 parts.
The hairyvein agrimony is the Hairyvein Agrimonia Herd that dry hairyvein agrimony obtains through ultramicro grinding.
Described adhesive is one or more in sodium carboxymethylcellulose, xanthans, carragheen.
A kind of preparation method of the fibroin albumen suture with easing pain and diminishing inflammation effect, comprises the following steps：By weight
Each raw material is weighed, is added raw materials into reactor, at room temperature after ultrasound 1-6h, then heat and stir 1-3h, be blended
Thing；Blend is extruded, water-cooled, air-dry, pelletizing, obtain master batch；By master batch heating and melting, deaeration and spinneret, form primary fine
Dimension, then by primary filament water-bath succeeding stretch, obtain final product fibroin albumen suture.
The ultrasonic frequency is 28-40KHz, and heating-up temperature is 50-90 DEG C.
Beneficial effects of the present invention：The present invention provide with the fibroin albumen suture of easing pain and diminishing inflammation effect and its preparation
Method, with good blood compatibility and histocompatbility, mechanical performance is high, with easing pain and diminishing inflammation effect, safely and effectively, drop
Solution absorbs and catabolite is safe to the human body nontoxic, non-stimulated.
Specific embodiment
Embodiment 1
A kind of fibroin albumen suture with easing pain and diminishing inflammation effect, is prepared from the following raw materials in parts by weight：65 parts of chitin,
35 parts of fibroin powder, 5 parts of ethylene glycol, 5 parts of candlenut oil, 15 parts of Poria cocos powder, 5 parts of black sesame powder, 10 parts of glycerine, 15 parts of hairyvein agrimony,
5 parts of palm wax, 7 parts of polyethylene glycol mono stearate, first 6 parts of English white, 15 parts of Folium Artemisiae Argyi powder, 13 parts of bletilla striata powder, 6 parts of adhesive, meat
7 parts of myristic acid, 7 parts of OPC.
The hairyvein agrimony is the Hairyvein Agrimonia Herd that dry hairyvein agrimony obtains through ultramicro grinding.
Described adhesive is one or more in sodium carboxymethylcellulose, xanthans, carragheen.
Its preparation method is as follows：Each raw material is weighed by weight, in adding raw materials into reactor, ultrasound 1-6h at room temperature
Afterwards, then heat and stir 1-3h, obtain blend；Blend is extruded, water-cooled, air-dry, pelletizing, obtain master batch；By master batch
Heating and melting, deaeration and spinneret, form primary filament, then by primary filament water-bath succeeding stretch, obtain final product fibroin albumen suture.
The ultrasonic frequency is 28-40KHz, and heating-up temperature is 50-90 DEG C.
Embodiment 2
A kind of fibroin albumen suture with easing pain and diminishing inflammation effect, is prepared from the following raw materials in parts by weight：70 parts of chitin,
40 parts of fibroin powder, 8 parts of ethylene glycol, 9 parts of candlenut oil, 20 parts of Poria cocos powder, 8 parts of black sesame powder, 15 parts of glycerine, 20 parts of hairyvein agrimony,
7 parts of palm wax, 10 parts of polyethylene glycol mono stearate, first 8 parts of English white, 18 parts of Folium Artemisiae Argyi powder, 14 parts of bletilla striata powder, 8 parts of adhesive, meat
10 parts of myristic acid, 10 parts of OPC.
The hairyvein agrimony is the Hairyvein Agrimonia Herd that dry hairyvein agrimony obtains through ultramicro grinding.
Described adhesive is one or more in sodium carboxymethylcellulose, xanthans, carragheen.
Its preparation method is as follows：Each raw material is weighed by weight, in adding raw materials into reactor, ultrasound 1-6h at room temperature
Afterwards, then heat and stir 1-3h, obtain blend；Blend is extruded, water-cooled, air-dry, pelletizing, obtain master batch；By master batch
Heating and melting, deaeration and spinneret, form primary filament, then by primary filament water-bath succeeding stretch, obtain final product fibroin albumen suture.
The ultrasonic frequency is 28-40KHz, and heating-up temperature is 50-90 DEG C.
Embodiment 3
A kind of fibroin albumen suture with easing pain and diminishing inflammation effect, is prepared from the following raw materials in parts by weight：65 parts of chitin,
35 parts of fibroin powder, 5 parts of ethylene glycol, 6 parts of candlenut oil, 15 parts of Poria cocos powder, 5 parts of black sesame powder, 10 parts of glycerine, 15 parts of hairyvein agrimony,
5 parts of palm wax, 7 parts of polyethylene glycol mono stearate, first 5 parts of English white, 15 parts of Folium Artemisiae Argyi powder, 12 parts of bletilla striata powder, 6 parts of adhesive, meat
7 parts of myristic acid, 7 parts of OPC.
The hairyvein agrimony is the Hairyvein Agrimonia Herd that dry hairyvein agrimony obtains through ultramicro grinding.
Described adhesive is one or more in sodium carboxymethylcellulose, xanthans, carragheen.
Its preparation method is as follows：Each raw material is weighed by weight, in adding raw materials into reactor, ultrasound 1-6h at room temperature
Afterwards, then heat and stir 1-3h, obtain blend；Blend is extruded, water-cooled, air-dry, pelletizing, obtain master batch；By master batch
Heating and melting, deaeration and spinneret, form primary filament, then by primary filament water-bath succeeding stretch, obtain final product fibroin albumen suture.
The ultrasonic frequency is 28-40KHz, and heating-up temperature is 50-90 DEG C.
Claims (5)
1. a kind of fibroin albumen suture with easing pain and diminishing inflammation effect, it is characterised in that by the raw material system of following parts by weight
Into：Chitin 60-70 parts, fibroin powder 30-40 parts, ethylene glycol 2-8 parts, candlenut oil 2-9 parts, Poria cocos powder 10-20 parts, black sesame
Numb powder 2-8 parts, glycerine 5-15 parts, hairyvein agrimony 10-20 parts, palm wax 3-7 parts, polyethylene glycol mono stearate 5-10 parts, corydalis tuber
Powder 3-8 parts, Folium Artemisiae Argyi powder 12-18 parts, 11-14 parts of bletilla striata powder, adhesive 3-8 parts, myristic acid 5-10 parts, OPC 5-10
Part.
2. the fibroin albumen suture with easing pain and diminishing inflammation effect according to claim 1, it is characterised in that：The celestial being
The Hairyvein Agrimonia Herd that crane grass is obtained for dry hairyvein agrimony through ultramicro grinding.
3. the fibroin albumen suture with easing pain and diminishing inflammation effect according to claim 1, it is characterised in that：It is described viscous
Mixture is one or more in sodium carboxymethylcellulose, xanthans, carragheen.
4. a kind of preparation method of the fibroin albumen suture with easing pain and diminishing inflammation effect described in claim 1, its feature exists
In comprising the following steps：Each raw material is weighed by weight, in adding raw materials into reactor, at room temperature after ultrasound 1-6h, so
After heat and stir 1-3h, obtain blend；Blend is extruded, water-cooled, air-dry, pelletizing, obtain master batch；Master batch heating is melted
Change, deaeration and spinneret, form primary filament, then by primary filament water-bath succeeding stretch, obtain final product fibroin albumen suture.
5. the preparation method of the fibroin albumen suture with easing pain and diminishing inflammation effect according to claim 4, its feature exists
In：The ultrasonic frequency is 28-40KHz, and heating-up temperature is 50-90 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611050739.9A CN106729944A (en) | 2016-11-25 | 2016-11-25 | A kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611050739.9A CN106729944A (en) | 2016-11-25 | 2016-11-25 | A kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106729944A true CN106729944A (en) | 2017-05-31 |
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| CN201611050739.9A Pending CN106729944A (en) | 2016-11-25 | 2016-11-25 | A kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224117A (en) * | 2018-10-11 | 2019-01-18 | 天津科技大学 | A kind of production method of the bacteria cellulose operation suture thread of antibacterial |
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| CN1616116A (en) * | 2004-09-29 | 2005-05-18 | 杭州拜康医用产品有限公司 | Water gel wound dressing containing radiation sensitive agent and preparing method |
| CN103301506A (en) * | 2013-06-21 | 2013-09-18 | 苏州大学 | Anticoagulation fibroin membrane and preparation method thereof |
| CN105396170A (en) * | 2015-11-19 | 2016-03-16 | 耿文真 | Medical surgical suture and preparation method thereof |
| CN105999379A (en) * | 2016-06-16 | 2016-10-12 | 湖州科达化工燃料有限公司 | Antisepsis and anti-inflammation medical absorbable suture line |
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| CN1616116A (en) * | 2004-09-29 | 2005-05-18 | 杭州拜康医用产品有限公司 | Water gel wound dressing containing radiation sensitive agent and preparing method |
| CN103301506A (en) * | 2013-06-21 | 2013-09-18 | 苏州大学 | Anticoagulation fibroin membrane and preparation method thereof |
| CN105396170A (en) * | 2015-11-19 | 2016-03-16 | 耿文真 | Medical surgical suture and preparation method thereof |
| CN105999379A (en) * | 2016-06-16 | 2016-10-12 | 湖州科达化工燃料有限公司 | Antisepsis and anti-inflammation medical absorbable suture line |
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| CN109224117A (en) * | 2018-10-11 | 2019-01-18 | 天津科技大学 | A kind of production method of the bacteria cellulose operation suture thread of antibacterial |
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Application publication date: 20170531 |