CN1413206A - 非肽类速激肽受体拮抗剂 - Google Patents

非肽类速激肽受体拮抗剂 Download PDF

Info

Publication number: CN1413206A
Authority: CN; China
Prior art keywords: phenyl; amino; indol; alkyl; ylmethyl
Prior art date: 1999-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN00817549A

Other languages

English (en)

Chinese (zh)

Inventor

D·C·霍维尔

R·A·卢斯维特

M·C·普雷查德

J·拉斐

H·巴斯

K·斯蒂纳

B·希弗迈尔

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-22

Filing date

2000-12-21

Publication date

2003-04-23

2000-02-22 Priority claimed from EP00103665A external-priority patent/EP1127875A1/fr

2000-12-21 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2003-04-23 Publication of CN1413206A publication Critical patent/CN1413206A/zh

Status Pending legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)

CN00817549A 1999-12-22 2000-12-21 非肽类速激肽受体拮抗剂 Pending CN1413206A (zh)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US17154099P	1999-12-22	1999-12-22
US60/171,540		1999-12-22
EP00103665A EP1127875A1 (fr)	2000-02-22	2000-02-22	Procédé de préparation de l'ester méthylique de l'alpha-diméthylaminométhyl-tryptophane
EP00103665.6		2000-02-22

Publications (1)

Publication Number	Publication Date
CN1413206A true CN1413206A (zh)	2003-04-23

Family

ID=26070578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN00817549A Pending CN1413206A (zh)	1999-12-22	2000-12-21	非肽类速激肽受体拮抗剂

Country Status (18)

Country	Link
EP (1)	EP1244653A1 (fr)
JP (1)	JP2003518111A (fr)
KR (1)	KR20020062364A (fr)
CN (1)	CN1413206A (fr)
AP (1)	AP2002002556A0 (fr)
AU (1)	AU2370801A (fr)
BG (1)	BG106804A (fr)
BR (1)	BR0016626A (fr)
CA (1)	CA2399584A1 (fr)
IL (1)	IL150203A0 (fr)
IS (1)	IS6395A (fr)
MA (1)	MA26854A1 (fr)
MX (1)	MXPA02006282A (fr)
NO (1)	NO20022942L (fr)
OA (1)	OA12129A (fr)
PL (1)	PL357650A1 (fr)
SK (1)	SK8862002A3 (fr)
WO (1)	WO2001046176A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010516731A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0655055B1 (fr) *	1992-08-13	2000-11-29	Warner-Lambert Company	Antagonistes de tachykinine
CA2355137A1 (fr) *	1998-12-18	2000-06-29	Martyn Clive Pritchard	Antagonistes des recepteurs nk1 non peptidiques

2000
- 2000-12-21 KR KR1020027008007A patent/KR20020062364A/ko not_active Application Discontinuation
- 2000-12-21 SK SK886-2002A patent/SK8862002A3/sk unknown
- 2000-12-21 OA OA1200200196A patent/OA12129A/en unknown
- 2000-12-21 BR BR0016626-0A patent/BR0016626A/pt not_active Application Discontinuation
- 2000-12-21 CA CA002399584A patent/CA2399584A1/fr not_active Abandoned
- 2000-12-21 CN CN00817549A patent/CN1413206A/zh active Pending
- 2000-12-21 MX MXPA02006282A patent/MXPA02006282A/es unknown
- 2000-12-21 EP EP00987477A patent/EP1244653A1/fr not_active Withdrawn
- 2000-12-21 WO PCT/EP2000/013349 patent/WO2001046176A2/fr active Search and Examination
- 2000-12-21 IL IL15020300A patent/IL150203A0/xx unknown
- 2000-12-21 JP JP2001547086A patent/JP2003518111A/ja active Pending
- 2000-12-21 AP APAP/P/2002/002556A patent/AP2002002556A0/en unknown
- 2000-12-21 AU AU23708/01A patent/AU2370801A/en not_active Abandoned
- 2000-12-21 PL PL00357650A patent/PL357650A1/xx not_active Application Discontinuation
2002
- 2002-05-24 IS IS6395A patent/IS6395A/is unknown
- 2002-06-10 BG BG106804A patent/BG106804A/xx unknown
- 2002-06-14 MA MA26689A patent/MA26854A1/fr unknown
- 2002-06-19 NO NO20022942A patent/NO20022942L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2003518111A (ja)	2003-06-03
OA12129A (en)	2006-05-05
WO2001046176A2 (fr)	2001-06-28
KR20020062364A (ko)	2002-07-25
CA2399584A1 (fr)	2001-06-28
PL357650A1 (en)	2004-07-26
MA26854A1 (fr)	2004-12-20
WO2001046176A3 (fr)	2002-07-04
IS6395A (is)	2002-05-24
SK8862002A3 (en)	2002-11-06
AP2002002556A0 (en)	2002-06-30
BG106804A (en)	2003-03-31
MXPA02006282A (es)	2004-09-06
NO20022942D0 (no)	2002-06-19
AU2370801A (en)	2001-07-03
NO20022942L (no)	2002-06-19
IL150203A0 (en)	2002-12-01
BR0016626A (pt)	2002-11-05
EP1244653A1 (fr)	2002-10-02

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Legal Events

Date	Code	Title
2003-04-23	C06	Publication
2003-04-23	PB01	Publication
2003-10-01	C02	Deemed withdrawal of patent application after publication (patent law 2001)
2003-10-01	WD01	Invention patent application deemed withdrawn after publication