OA12129A - Non peptide tachykinin receptor antagonists. - Google Patents

Non peptide tachykinin receptor antagonists. Download PDF

Info

Publication number: OA12129A
Authority: OA; OAPI
Prior art keywords: phenyl; ylmethyl; indol; ethyl; arom
Prior art date: 1999-12-22

Application number

OA1200200196A

Other languages

English (en)

Inventor

David Christopher Horwell

Russell Andrew Lewthwaite

Martin Clive Pritchard

Jennifer Raphy

Hubert Barth

Klaus Steiner

Bernd Schiefermayr

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-22

Filing date

2000-12-21

Publication date

2006-05-05

2000-02-22 Priority claimed from EP00103665A external-priority patent/EP1127875A1/fr

2000-12-21 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-05-05 Publication of OA12129A publication Critical patent/OA12129A/en

Links

239000002462 tachykinin receptor antagonist Substances 0.000 title abstract description 7
108090000765 processed proteins & peptides Proteins 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 81
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201000001320 Atherosclerosis Diseases 0.000 claims abstract description 6
206010029113 Neovascularisation Diseases 0.000 claims abstract description 6
206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 4
-1 phenyl,pyridyl Chemical group 0.000 claims description 62
125000000217 alkyl group Chemical group 0.000 claims description 47
229940080818 propionamide Drugs 0.000 claims description 41
238000000034 method Methods 0.000 claims description 34
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 33
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 24
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 21
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 21
125000003545 alkoxy group Chemical group 0.000 claims description 19
229910052736 halogen Inorganic materials 0.000 claims description 19
150000002367 halogens Chemical class 0.000 claims description 19
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
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CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 14
125000001041 indolyl group Chemical group 0.000 claims description 14
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 13
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YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 claims description 10
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VMWJCFLUSKZZDX-UHFFFAOYSA-N n,n-dimethylmethanamine Chemical group [CH2]N(C)C VMWJCFLUSKZZDX-UHFFFAOYSA-N 0.000 claims description 9
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IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 claims description 6
QABYBLFTBSCYHR-UHFFFAOYSA-N 1-(benzotriazol-1-yl)-n,n-dimethylmethanamine Chemical compound C1=CC=C2N(CN(C)C)N=NC2=C1 QABYBLFTBSCYHR-UHFFFAOYSA-N 0.000 claims description 5
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UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 9
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Chemical & Material Sciences (AREA)
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General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Diabetes (AREA)
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Reproductive Health (AREA)
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OA1200200196A 1999-12-22 2000-12-21 Non peptide tachykinin receptor antagonists. OA12129A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17154099P	1999-12-22	1999-12-22
EP00103665A EP1127875A1 (fr)	2000-02-22	2000-02-22	Procédé de préparation de l'ester méthylique de l'alpha-diméthylaminométhyl-tryptophane

Publications (1)

Publication Number	Publication Date
OA12129A true OA12129A (en)	2006-05-05

Family

ID=26070578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200196A OA12129A (en)	1999-12-22	2000-12-21	Non peptide tachykinin receptor antagonists.

Country Status (18)

Country	Link
EP (1)	EP1244653A1 (fr)
JP (1)	JP2003518111A (fr)
KR (1)	KR20020062364A (fr)
CN (1)	CN1413206A (fr)
AP (1)	AP2002002556A0 (fr)
AU (1)	AU2370801A (fr)
BG (1)	BG106804A (fr)
BR (1)	BR0016626A (fr)
CA (1)	CA2399584A1 (fr)
IL (1)	IL150203A0 (fr)
IS (1)	IS6395A (fr)
MA (1)	MA26854A1 (fr)
MX (1)	MXPA02006282A (fr)
NO (1)	NO20022942L (fr)
OA (1)	OA12129A (fr)
PL (1)	PL357650A1 (fr)
SK (1)	SK8862002A3 (fr)
WO (1)	WO2001046176A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010516731A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0655055B1 (fr) *	1992-08-13	2000-11-29	Warner-Lambert Company	Antagonistes de tachykinine
CA2355137A1 (fr) *	1998-12-18	2000-06-29	Martyn Clive Pritchard	Antagonistes des recepteurs nk1 non peptidiques

2000
- 2000-12-21 KR KR1020027008007A patent/KR20020062364A/ko not_active Application Discontinuation
- 2000-12-21 SK SK886-2002A patent/SK8862002A3/sk unknown
- 2000-12-21 OA OA1200200196A patent/OA12129A/en unknown
- 2000-12-21 BR BR0016626-0A patent/BR0016626A/pt not_active Application Discontinuation
- 2000-12-21 CA CA002399584A patent/CA2399584A1/fr not_active Abandoned
- 2000-12-21 CN CN00817549A patent/CN1413206A/zh active Pending
- 2000-12-21 MX MXPA02006282A patent/MXPA02006282A/es unknown
- 2000-12-21 EP EP00987477A patent/EP1244653A1/fr not_active Withdrawn
- 2000-12-21 WO PCT/EP2000/013349 patent/WO2001046176A2/fr active Search and Examination
- 2000-12-21 IL IL15020300A patent/IL150203A0/xx unknown
- 2000-12-21 JP JP2001547086A patent/JP2003518111A/ja active Pending
- 2000-12-21 AP APAP/P/2002/002556A patent/AP2002002556A0/en unknown
- 2000-12-21 AU AU23708/01A patent/AU2370801A/en not_active Abandoned
- 2000-12-21 PL PL00357650A patent/PL357650A1/xx not_active Application Discontinuation
2002
- 2002-05-24 IS IS6395A patent/IS6395A/is unknown
- 2002-06-10 BG BG106804A patent/BG106804A/xx unknown
- 2002-06-14 MA MA26689A patent/MA26854A1/fr unknown
- 2002-06-19 NO NO20022942A patent/NO20022942L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2003518111A (ja)	2003-06-03
WO2001046176A2 (fr)	2001-06-28
KR20020062364A (ko)	2002-07-25
CA2399584A1 (fr)	2001-06-28
PL357650A1 (en)	2004-07-26
MA26854A1 (fr)	2004-12-20
WO2001046176A3 (fr)	2002-07-04
IS6395A (is)	2002-05-24
SK8862002A3 (en)	2002-11-06
CN1413206A (zh)	2003-04-23
AP2002002556A0 (en)	2002-06-30
BG106804A (en)	2003-03-31
MXPA02006282A (es)	2004-09-06
NO20022942D0 (no)	2002-06-19
AU2370801A (en)	2001-07-03
NO20022942L (no)	2002-06-19
IL150203A0 (en)	2002-12-01
BR0016626A (pt)	2002-11-05
EP1244653A1 (fr)	2002-10-02

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EP0586490B1 (fr)	1996-03-20	Derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
AU641535B2 (en)	1993-09-23	Serotonin 5HT1A agonists
WO1995018105A1 (fr)	1995-07-06	Derives de 1,3-dihydroindol-2-one substitues en 3 par un groupe azote comme agonistes et/ou antagonistes de la vasopressine et/ou de l'ocytocine
NO158740B (no)	1988-07-18	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser.
HU215440B (hu)	2000-04-28	Eljárás cikloalkil-szubsztituált glutáramid-származékok és ilyen vegyületeket tartalmazó, magas vérnyomást csökkentő gyógyszerkészítmények előállítására
CA2168233A1 (fr)	1995-02-09	Derives de perhydroisoindole comme antagonistes de la substance p
FR2654726A1 (fr)	1991-05-24	Nouveaux derives de l'isoindolone et leur preparation.
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OA10578A (en)	2002-06-07	Indole derivatives ad nmda antagonists
EP2188253B8 (fr)	2012-04-11	Dérivés de l'indol-2-one disubstitués en 3, leur préparation et leur application en thérapeutique
JPH10501803A (ja)	1998-02-17	チアゾリジン誘導体、それらの製造及びそれらを含有する薬物
EP1259505A2 (fr)	2002-11-27	Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine
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TWI498326B (zh)	2015-09-01	用於製備經取代之嘧啶衍生物之化合物
HU226395B1 (en)	2008-11-28	Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists, pharmaceutical compositions containing them and process for producing them
KR20060130123A (ko)	2006-12-18	프로스타글란딘 ｅ2 작용제 또는 길항제로서의 오르니틴유도체
EP2200981B1 (fr)	2011-12-07	Nouveaux dérivés de carbamoylglycine
OA12129A (en)	2006-05-05	Non peptide tachykinin receptor antagonists.
US9346853B2 (en)	2016-05-24	Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition
US5420283A (en)	1995-05-30	Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide
EP1380591B1 (fr)	2005-11-16	Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
CA2829361A1 (fr)	2012-09-13	Inhibiteurs de la peptide deformylase