CN108066437B - A Chinese medicinal composition and its preparation method - Google Patents
A Chinese medicinal composition and its preparation method Download PDFInfo
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- CN108066437B CN108066437B CN201611003794.2A CN201611003794A CN108066437B CN 108066437 B CN108066437 B CN 108066437B CN 201611003794 A CN201611003794 A CN 201611003794A CN 108066437 B CN108066437 B CN 108066437B
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Classifications
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- A—HUMAN NECESSITIES
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Abstract
本发明公开了一种中药组合物，它是由桑叶、余甘子、山楂、马齿苋、肉桂和苦瓜按一定重量配比所制成。该中药组合物的制备方法是首先将处方药材浸泡，回流提取，过滤，将滤液进行减压浓缩至相对密度1.2～1.3即可，经干燥即为本发明所述中药组合物。本发明中药组合物具有显著降低模型小鼠的血糖值、改善耐糖量，同时能够降低实验小鼠的甘油三酯和总胆固醇，能够应用于普通食品、降糖功能的保健品和治疗糖尿病的药物。The invention discloses a traditional Chinese medicine composition, which is prepared from mulberry leaves, amla, hawthorn, purslane, cinnamon and bitter gourd in a certain weight ratio. The preparation method of the traditional Chinese medicine composition is as follows: firstly soaking the prescription medicinal materials, extracting by reflux, filtering, and concentrating the filtrate under reduced pressure to a relative density of 1.2-1.3, and drying is the traditional Chinese medicine composition of the present invention. The traditional Chinese medicine composition of the invention has the functions of significantly reducing the blood sugar level of the model mice, improving the glucose tolerance, and simultaneously reducing the triglyceride and total cholesterol of the experimental mice, and can be applied to ordinary foods, health products with hypoglycemic function and medicines for treating diabetes .
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with a blood sugar reducing effect and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines.
Background
Diabetes mellitus is a group of metabolic disorder syndromes of sugar, fat and protein which basically change pathophysiology by hyperglycemia caused by insulin secretion defects and/or reduction of biological effects (insulin resistance). That is, diabetes mellitus is characterized mainly by hyperglycemia and urine glucose, and also includes disorders of fat, protein, electrolytes, etc., often leading to serious complications. Briefly, diabetes can be classified into type I diabetes and type II diabetes, as well as other specific types of diabetes. With the increasing incidence of diseases in recent years, diabetes has become a common disease and a frequently encountered disease threatening human health. Up to now, the number of diabetics reaches 4.15 hundred million worldwide, which is 8% higher than the last year. At present, the number of people with diabetes in China becomes the first major country in the world, the number of patients with diabetes is nearly 1.1 hundred million, and the problem of treating and preventing diabetes becomes a key problem in the medical industry in China.
Diabetes is a chronic disease, long and complex in course of disease, and thus difficult to cure radically. At present, western medicines are mostly adopted to treat diabetes, and although the curative effect is quick and direct, the effects are not stable enough, the incidence rate of adverse reactions is high and the like; the traditional Chinese herbal medicine has mild treatment effect, long treatment time and small side effect. Modern researches show that active ingredients contained in part of Chinese herbal medicines have the effect of reducing blood sugar, and polysaccharides are the most, so that research and development of Chinese herbal medicines for treating diabetes become the key of development of new medicines and have great significance.
Mulberry leaf: the folium Mori is leaf of Morus genus plant of Moraceae family, and is bitter, sweet, cold in nature, and enters lung and liver meridians; has the functions of dispelling wind, clearing heat, cooling blood and improving eyesight. The main components of mulberry leaf include flavone, flavone glycoside, alkaloid, polysaccharide, amino acids, vitamins and trace elements. The mulberry leaves are exterior-releasing medicines, and a plurality of research results in recent years show that the mulberry leaves have good blood sugar reducing and oxidation resisting effects, and modern pharmacological research and further experimental verification of sugar tolerance in mice also prove that the mulberry leaves have the effects of inhibiting blood sugar rise and preventing and treating diabetes, wherein the reason is considered to be that the mulberry leaves have close relation with the alpha-glycosidase inhibition effect of polyhydroxy alkaloids in the mulberry leaves, and secondly, flavonoids and polysaccharides also have good inhibition activity.
Emblic leafflower fruit: emblic leafflower fruit is also called emblic leafflower fruit tree and emblic leafflower fruit. Belonging to Euphorbiaceae, root, leaf, fruit and bark can be used as raw materials. The growth form of the plant is deciduous small arbor. Yuganzi is sour and astringent in taste, sweet and cool in nature, and enters lung and stomach meridians. Has effects in promoting salivation, quenching thirst, clearing away heat and toxic materials, resisting aging, scavenging free radicals, resisting cytotoxicity, resisting mutation, tonifying heart, and protecting liver. The fruit contains various amino acids, vitamins, zinc, selenium, etc. In recent years, researches show that the emblic leafflower fruit is rich in various components including vitamin C and E, tannin and SOD, and has strong antioxidant capacity. The emblic leafflower fruit recorded by Chinese pharmacopoeia can produce saliva and slake thirst, promote digestion and invigorate stomach, clear heat and cool blood, and can treat liver and gall diseases, dry mouth, laryngalgia and the like.
Cinnamon: is dried bark of Cinnamomum cassia of Lauraceae, and can be used as perfume. Rou Gui is pungent, sweet and hot in flavor. It enters kidney, spleen, heart and liver meridians. The traditional Chinese medicine has the main functions of tonifying fire and supporting yang, guiding fire to the origin, dispelling cold and relieving pain, and warming and dredging channels and collaterals, and is used for treating cold uterus of male fistula, deficiency-type asthma of kidney, deficiency-type yang floating, dizziness and conjunctival congestion, deficiency-cold vomiting and diarrhea, cold pain and abdominal pain, dysmenorrheal and amenorrhea.
Purslane: sour and cold in flavor. It enters liver and large intestine meridians. The main functions are clearing away heat and toxic material, cooling blood and stopping bleeding.
Bitter gourd: bitter and cold in flavor. Clear heat and remove toxicity, improve eyesight. Can be used for treating heatstroke, fever, toothache, diarrhea, dysentery, and hematochezia.
Hawthorn fruit: is dried mature fruit of Crataegus pinnatifida (lour.) Merr of Rosaceae. Collected in autumn when the fruit is ripe, sliced and dried. Haw is sour, sweet and slightly warm in taste. It enters spleen, stomach and liver meridians. Promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, eliminating turbid pathogen, and reducing blood lipid.
Under the guidance of the thinking of syndrome differentiation and typing, the modern traditional Chinese medicine for treating diabetes adopts the methods of nourishing yin and clearing heat, tonifying qi and nourishing yin, activating blood and dissolving stasis, tonifying kidney and strengthening spleen, soothing liver and regulating qi, tonifying qi and activating blood, tonifying kidney and activating blood and the like, wherein the methods mainly comprise tonifying middle-jiao and qi, clearing heat and nourishing yin, and activating blood and dissolving stasis. Because the traditional Chinese medicine compound treatment can achieve both principal and secondary aspects, the main symptoms are treated, and the complications of diabetes are effectively prevented and treated, the action mechanism and the way of the traditional Chinese medicine compound treatment show the multi-directional and multi-level pharmacological characteristics, the situations of insulin resistance and the like are not easy to generate, and the advantages of the traditional Chinese medicine compound treatment on diabetes and the complications gradually appear. Diabetes belongs to the range of diabetes in traditional Chinese medicine, and belongs to endocrine and metabolic diseases in western medicine, and the main clinical typical symptoms are 'more than three and one less', namely polydipsia, diuresis, polyphagia and emaciation. The current management of diabetes is mainly focused on the elimination of the "more than three or less" symptoms, while the majority of diabetics are accompanied by the phenomena of high triglycerides and cholesterol. Therefore, lowering blood glucose, improving glucose tolerance, and lowering triglycerides and cholesterol are the basis for the current treatment of diabetes and the reduction of complications. The combination of the Chinese medicinal materials by utilizing different action mechanisms of the Chinese medicinal materials has the demand for developing foods, medicaments and health-care products for treating and preventing diabetes.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for improving the sugar tolerance, reducing the fasting blood sugar and reducing the triglyceride and the cholesterol, and also aims to provide the traditional Chinese medicine composition and an application and a preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-70 parts of mulberry leaves, 5-60 parts of phyllanthus emblica, 1-50 parts of hawthorn, 1-30 parts of purslane, 1-25 parts of cinnamon and 1-20 parts of bitter gourds.
Preferably, the mulberry leaf tea contains 20-60 parts by weight of mulberry leaves.
Preferably, the oil-soluble phyllanthus emblica drink contains 10-50 parts by weight of phyllanthus emblica.
Preferably, the hawthorn fruit contains 5-30 parts by weight of hawthorn fruit.
Preferably, the purslane contains 5-20 parts by weight of purslane.
Preferably, the composition contains 5 to 15 parts by weight of cinnamon.
Preferably, the balsam pear beverage contains 5 to 15 parts by weight of balsam pear.
More preferably, the traditional Chinese medicine composition comprises, by weight, 20-60 parts of mulberry leaves, 10-50 parts of emblic leafflower fruits, 5-30 parts of hawthorn fruits, 5-20 parts of purslane, 5-15 parts of cinnamon and 5-15 parts of bitter gourds.
The above-mentioned preferred conditions may be arbitrarily combined on the basis of the common knowledge in the art.
The invention also provides the use of the composition: the invention relates to an application of a composition with the auxiliary blood sugar reducing effect in preparing health-care food and/or functional food and/or medicines. In particular to a health food and/or a functional food and/or a medicament for reducing the symptoms of diabetes and hyperglycemia. The invention also provides health food and/or functional food and/or medicine containing the composition. These health foods and/or functional foods and/or medicines are mainly of oral type.
The invention also provides a method for preparing the health-care food and/or the functional food and/or the medicine, which can be prepared by any one of the following methods:
the method comprises the following steps: weighing the medicinal raw materials, preparing according to a proportion, then crushing and uniformly mixing the raw materials, sieving the mixture by a 20-mesh sieve, and subpackaging the mixture to prepare the substitutional tea;
the method 2 comprises the following steps: weighing the medicinal raw materials according to a proportion, mixing the mulberry leaves and the hawthorn, adding an extraction solvent with the weight about 10 times of that of the medicinal raw materials, soaking, performing reflux extraction for about 2 hours, filtering, storing the filtrate, adding an extraction solvent with the weight about 10 times of that of the residue, performing reflux extraction for 1 hour, filtering, and combining the two filtrates to obtain an extract 1; the extraction solvent can be water or alcohol solution with the mass percent concentration of 0-100%, the alcohol is selected from methanol, ethanol, propanol, isopropanol or n-butanol, and ethanol solution with the mass percent concentration of 60% is preferred. Adding 10 times of water into the rest raw materials except folium Mori and fructus crataegi, soaking for 1 hr, reflux extracting for 2 hr, filtering, collecting filtrate, and storing; adding 10 times of water into the medicine residues, performing reflux extraction for 1 hour, filtering, combining the two filtrates and the extracting solution 1, performing reduced pressure concentration until the relative density is 1.2-1.3, and drying to obtain the traditional Chinese medicine composition. The drying can be vacuum drying, freeze drying or spray drying, and is preferably freeze drying;
the method 3 comprises the following steps: selecting raw materials and preparing the raw materials in proportion; adding water with the weight being 10 times of the weight of the raw materials, soaking for 1 hour, decocting for 2 hours, filtering, collecting filtrate, and storing in another container; adding 10 times of water into the medicine residues, decocting for 1 hour, filtering, combining the two filtrates, concentrating the filtrate until the relative density is 1.2-1.3, and drying to obtain the traditional Chinese medicine composition. The drying may be vacuum drying, freeze drying or spray drying, preferably freeze drying.
The traditional Chinese medicine composition is prepared into different dosage forms by adding pharmaceutically acceptable auxiliary materials when necessary.
The oral administration type can comprise solid granules, tablets, substituted tea and other specific products, and is used for the adjuvant treatment of diabetic patients.
The positive progress effects of the invention are as follows: the novel traditional Chinese medicine composition with the hypoglycemic effect, which takes medical and edible dual-purpose Chinese herbal medicines as main raw materials, is provided, the main raw materials of mulberry leaf, emblic leafflower fruit, hawthorn, balsam pear, cinnamon and purslane complement each other, has the synergistic hypoglycemic effect, is particularly suitable for preventing and treating diabetes, and has the characteristics of good safety and long-term use.
In the composition, the mulberry leaves, the emblic leafflower fruits and the bitter gourds mainly have the functions of reducing blood sugar and regulating blood fat and are components which have main effects aiming at main symptoms in the components; the hawthorn and the purslane have the functions of assisting in reducing blood fat and blood sugar and balancing; cinnamon can reduce postprandial blood sugar, warm yang, tonify qi and adjust the characteristics of the composition.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to limit the scope of the invention. The experimental methods without specifying specific conditions in the following examples were selected according to the conventional methods and conditions, or according to the commercial instructions.
In the following examples, all medicinal materials and reagents were commercially available products, mulberry leaves were purchased from yozhou city, yokui drug industry ltd, and mulberry leaves were frosted mulberry leaves (product lot No. CF20101008), unless otherwise specified; emblic leafflower fruit is purchased from Shanghai Leying pharmaceutical Co., Ltd (product batch No. LYS 20150911); balsam pear is purchased from Qizhou traditional Chinese medicine decoction pieces Limited company (product batch No. QZ20151110) in Anguo city; herba Portulacae is purchased from QIZHOU Chinese medicinal decoction pieces, Inc. (product batch No. QZ 20151101); cinnamon was purchased from shanghai leine pharmaceutical co ltd (product lot number LYS 20151015); hawthorn is purchased from medicinal materials sales limited in xinde, bozhou city (product batch No. XD 20151101).
Example 1
The invention relates to a preparation method of a composition with the efficacy of reducing blood sugar.
The raw materials of the composition are food materials or materials with homology of medicine and food, and in order to avoid the seasonal limitation of the raw materials in the preparation embodiment, the raw materials are cleaned medicinal material decoction pieces, and the dosage is shown in the following table 1:
TABLE 1 preparation materials of Chinese medicinal composition with blood sugar lowering effect
Weighing the medicinal raw materials according to a proportion, mixing the mulberry leaves and the hawthorn, adding an extraction solvent with the weight about 10 times of that of the medicinal raw materials, soaking, performing reflux extraction for about 2 hours, filtering, storing the filtrate, adding an extraction solvent with the weight about 10 times of that of the dregs of a decoction, performing reflux extraction for 1 hour, filtering, and combining the two filtrates to obtain an extracting solution 1. Adding 10 times of water into the rest raw materials except folium Mori and fructus crataegi, soaking for 1 hr, reflux extracting for 2 hr, filtering, collecting filtrate, and storing; and adding 10 times of water into the medicine residues, performing reflux extraction for 1 hour, filtering, collecting filtrate, combining the two filtrates and the extracting solution 1, performing reduced pressure concentration until the relative density is 1.2-1.3, and performing freeze drying to obtain the Chinese medicinal composition dry powder.
Example 2
This example provides different dosage forms and methods of making the composition product of the present invention comprising mulberry leaf, emblic leafflower fruit, hawthorn, purslane, cinnamon and bitter gourd.
TABLE 2 preparation materials of Chinese medicinal composition with blood sugar lowering effect
The preparation method of the tablet comprises the following steps: weighing the ingredients according to the formula, uniformly mixing the dry powder of the extraction composition, the compressible starch, the sodium carboxymethyl cellulose, the hydroxypropyl methyl cellulose, the calcium sulfate and the maltodextrin, preparing a soft material by using a proper amount of 50% ethanol, granulating by using a 20-mesh sieve, drying at 60 ℃, finishing by using the 20-mesh sieve, adding magnesium stearate, uniformly mixing, and tabletting to obtain tablets with different specifications.
The preparation method of the solid particles comprises the following steps: sieving the dry powder of the extraction composition with a 60-mesh sieve, weighing the ingredients according to the formula, preparing a proper amount of 50% ethanol into soft materials, granulating with a 20-mesh sieve, drying at 60 ℃, and subpackaging 6g per powder to obtain solid granules.
Example 3
The embodiment provides a preparation method of substitutional tea with the efficacy of reducing blood sugar, which comprises the following steps: weighing various ingredients of folium Mori, fructus Phyllanthi, fructus crataegi, herba Portulacae, cortex Cinnamomi and fructus Momordicae Charantiae according to various ratios, pulverizing, sieving with 20-30 mesh sieve, mixing well, and bagging.
Example 4
Comparative example 18g of cinnamon extract (obtained from western Tian Biotechnology Co., Ltd., lot No. TY20150810), 6g of mulberry leaf extract (obtained from Shaanxi Jintai bioengineering Co., Ltd., lot No. JT20151013) and 3g of balsam pear extract (obtained from Shaanxi Jintai bioengineering Co., Ltd., lot No. JT20151118) were purchased and mixed uniformly as described in CN 102727586B, and comparative example extract 1 was obtained.
Example 5
Weighing 32.5g of emblic leafflower fruit, 22.5g of purslane and 15.5g of hawthorn, weighing 10 times of water, soaking for 1 hour, decocting for 2 hours, filtering, collecting filtrate and storing in another container; adding 10 times of water into the medicine residues, decocting for 1 hour, filtering, combining the two filtrates, concentrating the filtrate until the relative density is 1.2-1.3, and freeze-drying to obtain the dry powder of the traditional Chinese medicine composition, namely the comparative example extract 2.
Example 6
Animal model experiments are carried out on the compositions 1-3 prepared in the example 1 and the comparative example extracts 1-2 prepared in the examples 4 and 5, and the blood sugar reducing effect of the traditional Chinese medicine composition is examined.
Materials and reagents
Experimental animals: ICR mice, SPF grade, weight 22 + -2 g, female and male half, Shanghai Sphall-Bikea laboratory animals Co., Ltd, general feed adaptability feeding 3 d. The breeding conditions are that the temperature is 18-22 ℃ and the relative humidity is 50-60%.
Medicine preparation: compositions 1, 2 and 3 prepared in examples 1-3, which are tan solid powders;
metformin, produced by Shanghai Shigui pharmaceutical Co., Ltd, of China, is used as a positive drug group.
Medicine reagent: alloxan was purchased from Shanghai leaf Biotechnology Ltd and prepared into a 2% solution with physiological saline immediately before use. Blood glucose monitor and related test paper, Sannuo biosensing GmbH.
Feed: the basic feed is provided by the pharmacological center of Shanghai pharmaceutical industry research institute, and the high-fat feed is processed by Shanghai onset Experimental reagents, Inc.
Preparation and classification of experimental diabetes mouse modelGroup of
The mice are adaptively raised for 1 week, 10 ICR mice are randomly selected as a control group and are continuously fed with common feed, the rest mice are fed with high-heat feed, the total molding period is 16 days, the rest mice are fasted overnight without water prohibition for 16 hours, 30mg/kg of intraperitoneal injection of the freshly prepared physiological saline solution of alloxan is continuously injected for 5 days to form an experimental diabetes mouse model, after the mice are raised for 72 hours, the mice are fasted overnight for 12 hours, tail tips are sampled for blood sampling to measure the fasting blood glucose value, the blood glucose value is not lower than 11.1mmoL/L as the standard for successful molding, and the mice which do not cause diabetes are deleted. The groups were divided into 5 groups, i.e. model group, metformin group and present compositions 1 and 2. Then, the administration is started, the traditional Chinese medicine composition is respectively infused with 8.3g of crude drugs/kg, the metformin group is 0.2g/kg, and the model group and the normal group are infused with the same amount of normal saline for 1 time per day for 8 weeks.
Observation method
After the start of molding and 2 weeks, the animals were fed with high-calorie feed and then closely paid attention to the change of body weight, and observed for the eating condition, urine volume, stool, etc. After 6 weeks of administration, a glucose tolerance test was performed, and the results were subjected to statistical analysis.
The experimental results are as follows:
TABLE 1 Effect of the invention on blood glucose, triglycerides and cholesterol in diabetic mice
Δ P <0.05 Δ P <0.01 in comparison with normal group, Δ P <0.05 in comparison with model group, Δ P <0.01 in comparison with model group
As can be seen from the above table, after 8 weeks after molding for 3 weeks, the blood glucose values in the model group were significantly higher than those in the normal group (P < 0.01), and the blood glucose values in the compositions 1, 2 and 3 of the present invention were close to those in the normal group and significantly lower than those in the model group (P < 0.01). The area under the blood glucose curve of the compositions 1, 2 and 3 of the invention is also obviously lower than that of the model group, is closer to that of the normal control group, can obviously improve the glucose tolerance of diabetic mice, and is better than the extracts of the two comparative examples. The model group was significantly higher than the normal control group in terms of triglyceride and total cholesterol, and the compositions 1, 2 and 3 were superior to the extracts of comparative examples 1 and 2 in terms of lowering total cholesterol and triglyceride, closer to the normal control group, and much lower than the model group (P < 0.01).
The invention relates to a traditional Chinese medicine composition with the function of reducing blood sugar, which has the functions of reducing fasting blood sugar of animals, improving sugar tolerance and reducing triglyceride and cholesterol. Meanwhile, the composition improves the symptoms of polydipsia, polyphagia and polyuria of patients, improves the symptoms of yang deficiency, body cold and body weakness of the diabetics, and is a novel composition with the effect of reducing blood sugar; the composition disclosed by the invention has the advantages that the combination of the composition selects food materials or medicinal and edible medicinal materials as raw materials; the invention has no strict requirement on diet, simple preparation method, cheap and easily obtained raw materials and the like.
Claims (13)
1. A traditional Chinese medicine composition for reducing blood sugar or regulating blood fat is characterized by comprising the following raw materials in parts by weight: 10-70 parts of mulberry leaves, 5-60 parts of phyllanthus emblica, 1-50 parts of hawthorn, 1-30 parts of purslane, 1-25 parts of cinnamon and 1-20 parts of bitter gourds.
2. The traditional Chinese medicine composition according to claim 1, wherein the mulberry leaves account for 20-60 parts by weight.
3. The traditional Chinese medicine composition according to claim 1, wherein the weight portion of the emblic leafflower fruit is 10-50.
4. The traditional Chinese medicine composition as claimed in claim 1, wherein the hawthorn is 5-30 parts by weight.
5. The traditional Chinese medicine composition of claim 1, wherein the purslane is 5-20 parts by weight.
6. The traditional Chinese medicine composition according to claim 1, wherein the cinnamon is 5-15 parts by weight.
7. The traditional Chinese medicine composition according to claim 1, wherein the bitter gourd is 5-15 parts by weight.
8. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 20-60 parts of mulberry leaves, 10-50 parts of phyllanthus emblica, 5-30 parts of hawthorn, 5-20 parts of purslane, 5-15 parts of cinnamon and 5-15 parts of bitter gourd.
9. The use of the Chinese medicinal composition according to any one of claims 1 to 8 in the preparation of health food and/or functional food and/or medicament for lowering blood sugar or regulating blood lipid.
10. The Chinese medicinal composition according to any one of claims 1 to 8, wherein pharmaceutically acceptable excipients are added to prepare different dosage forms.
11. The composition of claim 10, wherein the dosage form is an oral dosage form.
12. The composition of claim 11, wherein the oral dosage form is a solid granule, a tablet, or a tea substitute.
13. The method for preparing the Chinese medicinal composition according to any one of claims 1 to 8, which is one of the following methods:
the method comprises the following steps: weighing the medicinal raw materials, preparing according to a proportion, then crushing and uniformly mixing the raw materials, sieving the mixture by a 20-mesh sieve, and subpackaging the mixture to prepare the substitutional tea;
the method 2 comprises the following steps: weighing the medicinal raw materials according to a proportion, mixing the mulberry leaves and the hawthorn, adding an extraction solvent with the mass being about 10 times of that of the medicinal raw materials, soaking, performing reflux extraction for about 2 hours, filtering, storing the filtrate, adding an extraction solvent with the mass being about 10 times of that of the medicinal residues, performing reflux extraction for 1 hour, filtering, and combining the two filtrates to obtain an extracting solution 1, wherein the extraction solvent can be water or an ethanol solution with the mass percentage concentration of 60%; adding 10 times of water into the rest raw materials except folium Mori and fructus crataegi, soaking for 1 hr, reflux extracting for 2 hr, filtering, collecting filtrate, and storing; adding 10 times of water into the medicine residues, performing reflux extraction for 1 hour, filtering, combining the two filtrates and the extracting solution 1, and performing reduced pressure concentration until the relative density is 1.2-1.3, wherein the drying is vacuum drying, freeze drying or spray drying to obtain the traditional Chinese medicine composition;
the method 3 comprises the following steps: selecting raw materials and preparing the raw materials in proportion; adding water with the weight being 10 times of the weight of the raw materials, soaking for 1 hour, decocting for 2 hours, filtering, collecting filtrate, and storing in another container; adding 10 times of water into the medicine residues, decocting for 1 hour, filtering, combining the two filtrates, concentrating the filtrate until the relative density is 1.2-1.3, and drying to obtain the traditional Chinese medicine composition, wherein the drying is vacuum drying, freeze drying or spray drying.
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| CN102727586A (en) * | 2011-04-02 | 2012-10-17 | 苏州润新生物科技有限公司 | Composition for preventing and treating diabetes |
| CN103610169A (en) * | 2013-11-17 | 2014-03-05 | 陶峰 | Processing method for thick phyllanthus emblica and hawthorn juice |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727586A (en) * | 2011-04-02 | 2012-10-17 | 苏州润新生物科技有限公司 | Composition for preventing and treating diabetes |
| CN103610169A (en) * | 2013-11-17 | 2014-03-05 | 陶峰 | Processing method for thick phyllanthus emblica and hawthorn juice |
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| Title |
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| 马齿苋降血糖作用的研究;林承才等;《福建医药杂志》;19951231;第17卷(第4期);第95、86页，尤其是第86页左栏最后1段 * |
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